Obstructive sleep apnea and dyslipidemia: evidence and underlying mechanism
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Introduction Over the past half century, evidence has been accumulating on the emergence of obstructive sleep apnea (OSA), the most prevalent sleep-disordered breathing, as a major risk factor for cardiovascular disease. A significant body of research has been focused on elucidating the complex interplay between OSA and cardiovascular risk factors, including dyslipidemia, obesity, hypertension, and diabetes mellitus that portend increased morbidity and mortality in susceptible individuals. Conclusion Although a clear causal relationship of OSA and dyslipidemia is yet to be demonstrated, there is increasing evidence that chronic intermittent hypoxia, a major component of OSA, is independently associated and possibly the root cause of the dyslipidemia via the generation of stearoyl-coenzyme A desaturase-1 and reactive oxygen species, peroxidation of lipids, and sympathetic system dysfunction. The aim of this review is to highlight the relationship between OSA and dyslipidemia in the development of atherosclerosis and present the pathophysiologic mechanisms linking its association to clinical disease. Issues relating to epidemiology, confounding factors, significant gaps in research and future directions are also discussed.
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There is increasing evidence that an association exists between OSA and dyslipidemia.
“there is increasing evidence that an association exists(131).”
From Sleep: important considerations for the prevention of cardiovascular disease (2016) · cites this paper as [131]
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- Authors
- Adedayo, A. M., Olafiranye, O., Smith, D., Hill, A., Zizi, F., Brown, C., & Jean-Louis, G.
- Affiliations
- SUNY Downstate Health Sciences University (US)
- Yale University (US)
- University of South Alabama (US)
- Corresponding author
- Olafiranye, Oladipupo
- Venue
- Sleep and Breathing
- Published
- 2012-08-18
- Volume
- 18
- Issue
- 1
- Pages
- 13-18
- ISSN
- 1520-9512 (ISSN-L)
- 1522-1709
- PMC
- PMC4805366
- OpenAlex
- W2117765532
- Cited by
- 182
- References
- 69
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 11 · 2023: 15 · 2022: 25 · 2021: 12 · 2020: 9 · 2019: 16 · 2018: 13 · 2017: 6 · 2016: 14 · 2015: 18 · 2014: 9 · 2013: 7 · 2012: 4
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Sleep And Breathing (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R25HL105444, R01HL095799)
- National Institute on Minority Health and Health Disparities (R01MD004113)
- Topics
- Health Sciences › Medicine › Physiology › Obstructive Sleep Apnea Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Medicine › Pharmacology › Apelin-related biomedical research
- Keywords
- obstructive sleep apnea, dyslipidemia, intermittent hypoxia, stearoyl-CoA desaturase 1, reactive oxygen species, lipid peroxidation, sympathetic dysfunction, atherosclerosis, cardiovascular risk, pathophysiological mechanisms
- MeSH terms
- Animals, Hypoxia, Disease Models, Animal, Humans, Cholesterol, HDL, Risk Factors, Stearoyl-CoA Desaturase, Sympathetic Nervous System, Lipid Peroxidation, Comorbidity, Reactive Oxygen Species, Oxidative Stress, Sleep Apnea, Obstructive, Dyslipidemias, Atherosclerosis, Rats
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