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Protective effects of kefir against deltamethrin-induced hepatotoxicity in rats
Abstract
Deltamethrine (DLM) is a synthetic pyrethroid with broad spectrum activities against acaricides and insects. Widely used for agricultural and veterinary purposes, its human and animal exposure occurs by ingestion of contaminated water and food and leads to serious health problems. Kefir is fermented milk with numerous health favors counting restorative properties of bacterial flora, immune system stimulation, cholesterol reduction, as well as anti-mutagenic and anti-tumor properties. The present study was undertaken to examine the hepatoprotective and antioxidant potential of kefir against DLM toxicity in male Wistar albino rats. DLM-treated animals revealed a significant increase in serum biochemical parameters as well as hepatic protein and lipid oxidations but caused an inhibition in antioxidant enzymes. Additionally, we have observed an increase in hepatocyte DNA damages. This toxic effect was confirmed by histological study. Kefir administration normalized the elevated serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin (T bilirubin), and cholesterol. It also reduced DLM-induced protein carbonyl (PC) and malondialdehyde (MDA) formations. Furthermore, Kefir treatment restored catalase (CAT) and superoxide dismutase (SOD) activities. The co-treatment as well as the pre-treatment by kefir showed an improvement of oxidative status as well as suppressed inflammation and DNA damages. However, the pre-treatment seems to be the most efficient. Therefore, it could be concluded that kefir is a natural product able to protect against the hepatotoxic effects of DLM by its free radical-scavenging and potent antioxidant activity.
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In the citing paper
“These protein and lipid peroxidation disorders indicate oxidative stress and toxicity development by the pesticide.”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [31]
In the citing paper
“This finding indicates that kefir has a good antioxidant capacity (31), being a potential tool in the prevention and treatment of liver damage caused or mediated by oxidative stress.”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [31]
In the citing paper
“It was concluded that kefir was not only able to revert the inflammatory condition but did not generate any damage, since the group treated with kefir alone obtained similar results to the control group.”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [31]
In the citing paper
“This finding indicates that kefir has a good antioxidant capacity (31), being a potential tool in the prevention and treatment of liver damage caused or mediated by oxidative stress.”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [31]
In the citing paper
“On the other hand, kefir was not able to induce oxidative stress by itself, and was able to revert the inflammatory condition (31).”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [31]
In the citing paper
“Furthermore, the supply of pesticide and kefir was able to decrease the levels of carbonylated protein and malondialdehyde, as well as increasing the levels of catalase and superoxide dismutase when compared to the group that received only deltamethrine.”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [31]
In the citing paper
“In Wistar rats, the authors observed that deltamethrine altered liver parameters, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, and cholesterol, when compared to control groups without the pesticide; however, with kefir intake, these parameters were lower.”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [31]
In the citing paper
“In Wistar rats, the authors observed that deltamethrine altered liver parameters, such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), bilirubin, and cholesterol, when compared to control groups without the pesticide; however, with kefir intake, these parameters were lower.”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [31]
In the citing paper
“Less histological and DNA damage was also observed in groups treated with pesticide and kefir when compared to the groups that received only deltamethrine, with this histological and genetic disarchitecture resulting from the inflammatory process previously described.”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [31]
In the citing paper
“On the other hand, kefir was not able to induce oxidative stress by itself, and was able to revert the inflammatory condition (31).”
From Kefir and Intestinal Microbiota Modulation: Implications in Human Health (2021) · cites this paper as [31]
Citations
Cites
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Ismaiel, A. A., Ghaly, M. F., & El-Naggar, A. K. (2011) · Current Microbiology · doi:10.1007/s00284-011-9901-9 · Cited by 81
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Sorted by citations
Kefir and Intestinal Microbiota Modulation: Implications in Human Health
Peluzio, M. D. C. G., Dias, M. D. M. E., Martinez, J. A., & Milagro, F. I. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.638740 · Cited by 92
Metadata
- Authors
- El Golli-Bennour, E., Timoumi, R., Annaibi, E., Mokni, M., Omezzine, A., Bacha, H., & Abid-Essefi, S.
- Affiliations
- University of Monastir (TN)
- Hôpital Farhat Hached (TN)
- Hôpital Sahloul (TN)
- Venue
- Environmental Science and Pollution Research
- Published
- 2019-05-07
- Volume
- 26
- Issue
- 18
- Pages
- 18856-18865
- ISSN
- 0944-1344 (ISSN-L)
- 1614-7499
- OpenAlex
- W2944470214
- Cited by
- 31
- References
- 4
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 5 · 2022: 6 · 2021: 9 · 2020: 5 · 2019: 2
- FWCI
- 5.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Environmental Science and Pollution Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Paraquat toxicity studies and treatments
- Keywords
- kefir, deltamethrin, pyrethroid toxicity, hepatotoxicity, hepatoprotection, antioxidant activity, oxidative stress, lipid peroxidation, protein carbonylation, DNA damage, catalase, superoxide dismutase, pretreatment, fermented milk, insecticide exposure
- MeSH terms
- Kefir, Alanine Transaminase, Animals, Antioxidants, Aspartate Aminotransferases, Environmental Pollutants, Humans, Liver Function Tests, Male, Nitriles, Pyrethrins, Lipid Peroxidation, Rats, Wistar, Oxidative Stress, Protective Agents, Rats, Chemical and Drug Induced Liver Injury
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