Lifelong environmental enrichment in rats: impact on emotional behavior, spatial memory vividness, and cholinergic neurons over the lifespan.

Anxiety, defence and the elevated plus-maze.

Rodgers, R., & Dalvi, A. (1997) · Neuroscience and Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00058-9 · Cited by 1,028 · see citing works

Persistence of Long-Term Memory Storage Requires a Late Protein Synthesis- and BDNF- Dependent Phase in the Hippocampus

Bekinschtein, P., Cammarota, M., Igaz, L. M., Bevilaqua, L. R. M., Izquierdo, I., & Medina, J. H. (2007) · Neuron · doi:10.1016/j.neuron.2006.11.025 · Cited by 633 · see citing works

New neurons in the dentate gyrus are involved in the expression of enhanced long‐term memory following environmental enrichment

Bruel‐Jungerman, E., Laroche, S., & Rampon, C. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.03875.x · Cited by 505 · see citing works

Environmental enrichment in mice decreases anxiety, attenuates stress responses and enhances natural killer cell activity

Benaroya‐Milshtein, N., Hollander, N., Apter, A., Kukulansky, T., Raz, N., Wilf, A., Yaniv, I., & Pick, C. G. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03587.x · Cited by 439 · see citing works

Environmental Enrichment Modifies the PKA-Dependence of Hippocampal LTP and Improves Hippocampus-Dependent MemoryPreprint

Duffy, S. N., Craddock, K. J., Abel, T. G., & Nguyen, P. (2001) · Learning & Memory · doi:10.1101/lm.36301 · Cited by 342 · see citing works

Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats.

Baxter, M. G., Bucci, D. J., Gorman, L. K., Wiley, R. G., & Gallagher, M. (2013) · Behavioral Neuroscience · doi:10.1037/a0033939 · Cited by 331 · see citing works

Differential effects of enrichment on learning and memory function in NR2B transgenic mice

Tang, Y., Wang, H., Feng, R., Kyin, M., & Tsien, J. Z. (2001) · Neuropharmacology · doi:10.1016/s0028-3908(01)00122-8 · Cited by 330 · see citing works

Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice

Frick, K. M., & Fernandez, S. M. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00138-0 · Cited by 303 · see citing works

Dissociable effects of isolation rearing and environmental enrichment on exploration, spatial learning and HPA activity in adult rats

Schrijver, N. C. A., Bahr, N. I., Weiss, I. C., & Würbel, H. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00790-6 · Cited by 294 · see citing works

Effect of Environmental Enrichment on Stress Related Systems in Rats

Moncek, F., Duncko, R., Johansson, B. B., & Jezova, D. (2004) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2004.01173.x · Cited by 282 · see citing works

Upregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory

Suzuki, A., Fukushima, H., Mukawa, T., Toyoda, H., Wu, L.-J., Zhao, M.-G., Xu, H., Shang, Y., Endoh, K., Iwamoto, T., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3257-10.2011 · Cited by 250 · see citing works

Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats.

Baxter, M. G., Bucci, D. J., Gorman, L. K., Wiley, R. G., & Gallagher, M. (1995) · Behavioral Neuroscience · doi:10.1037/0735-7044.109.4.714 · Cited by 248 · see citing works

A refined method for sequential blood sampling by tail incision in rats

Fluttert, M., Dalm, S., & Oitzl, M. S. (2000) · Laboratory Animals · doi:10.1258/002367700780387714 · Cited by 227 · see citing works

Dissociation of Hippocampal and Striatal Contributions to Spatial Navigation in the Water Maze

Devan, B. D., Goad, E. H., & Petri, H. L. (1996) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.0072 · Cited by 223 · see citing works

Spatial learning and memory at defined points of the estrous cycle: Effects on performance of a hippocampal-dependent task.

Berry, B. J. L., McMahan, R., & Gallagher, M. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.2.267 · Cited by 212 · see citing works

Lifelong corticosterone level determines age-related decline in neurogenesis and memory

Montaron, M., Drapeau, E., Dupret, D., Kitchener, P., Aurousseau, C., Moal, M. L., Piazza, P. V., & Abrous, D. N. (2005) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.02.014 · Cited by 204 · see citing works

Sex Dimorphisms in the Rate of Age-Related Decline in Spatial Memory: Relevance to Alterations in the Estrous Cycle

Markowska, A. L. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-18-08122.1999 · Cited by 203 · see citing works

Production of new cells in the rat dentate gyrus over the lifespan: relation to cognitive decline

Bizon, J. L., & Gallagher, M. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02733.x · Cited by 200 · see citing works

Long-term continuous, but not daily, environmental enrichment reduces spatial memory decline in aged male mice

BENNETT, J., McRae, P. A., Levy, L. J., & Frick, K. M. (2005) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.09.003 · Cited by 198 · see citing works

Septohippocampal Acetylcholine: Involved in but not Necessary for Learning and Memory?Preprint

Parent, M. B., & Baxter, M. G. (2004) · Learning & Memory · doi:10.1101/lm.69104 · Cited by 194 · see citing works

Environmental enrichment: Effects on spatial memory and hippocampal CREB immunoreactivity

Williams, B. M., Luo, Y. M., Ward, C. P., Redd, K. J., Gibson, R., Kuczaj, S. A., & McCoy, J. G. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00543-1 · Cited by 191 · see citing works

Environmental influences on brain neurotrophins in rats

Pham, T. M., Winblad, B. G., Granholm, A., & Mohammed, A. H. S. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00783-9 · Cited by 184 · see citing works

Reliability, Distribution, and Validity of Age-Related Cognitive Deficits in the Morris Water Maze

Lindner, M. D. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1997.3782 · Cited by 182 · see citing works

Reproductive Senescence in Female Rats: A Longitudinal Study of Individual Differences in Estrous Cycles and Behavior1

LeFevre, J., & McClintock, M. K. (1988) · Biology of Reproduction · doi:10.1095/biolreprod38.4.780 · Cited by 170 · see citing works

Méthodes statistiques en sciences humaines

Howell, D., Bestgen, Y., Yzerbyt, V. Y., & Rogier, M. (2008) · Digital Access to Libraries · Cited by 162 · see citing works

Spatial reference and working memory across the lifespan of male Fischer 344 rats

Bizon, J. L., LaSarge, C. L., Montgomery, K. S., McDermott, A. N., Setlow, B., & Griffith, W. H. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.004 · Cited by 157 · see citing works

Effects of enriched environments with different durations and starting times on learning capacity during aging in rats assessed by a refined procedure of the Hebb‐Williams maze task

Kobayashi, S., Ohashi, Y., & Ando, S. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10442 · Cited by 148 · see citing works

Emotional changes related to age in rats—a behavioral analysis

Boguszewski, P. M., & Zagrodzka, J. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00018-9 · Cited by 148 · see citing works

Long-term treadmill exposure protects against age-related neurodegenerative change in the rat hippocampus.

O'Callaghan, R. M., Griffin, É. W., & Kelly, Á. M. (2009) · Hippocampus · doi:10.1002/hipo.20591 · Cited by 146 · see citing works

Age-related decline in water maze learning and memory in rats: strain differences

Wyss, J. M. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00132-9 · Cited by 143 · see citing works

Successful Aging: Focus on Cognitive and Emotional Health

Depp, C. A., Vahia, I. V., & Jeste, D. V. (2010) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.121208.131449 · Cited by 136 · see citing works

Stability of Spatial Working Memory across the Estrous Cycle of Long–Evans Rats

Stackman, R. W., Blasberg, M. E., Langan, C. J., & Clark, A. S. (1997) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1996.3753 · Cited by 134 · see citing works

Long-term exposure to environmental enrichment since youth prevents recognition memory decline and increases synaptic plasticity markers in aging

Leal‐Galicia, P., Castañeda‐Bueno, M., Quiroz‐Baez, R., & Arias, C. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.07.005 · Cited by 123 · see citing works

Hypothalamic–pituitary–adrenal axis function and corticosterone receptor expression in behaviourally characterized young and aged Long–Evans rats

Bizon, J. L., Helm, K. A., Han, J., Chun, H., Pucilowska, J. B., Lund, P. K., & Gallagher, M. (2001) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2001.01781.x · Cited by 115 · see citing works

Environmental Enrichment Delays the Onset of Memory Deficits and Reduces Neuropathological Hallmarks in a Mouse Model of Alzheimer-Like Neurodegeneration

Berardi, N., Braschi, C., Capsoni, S., Cattaneo, A., & Maffei, L. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11312 · Cited by 110 · see citing works

Immunohistochemical and neurochemical correlates of learning deficits in aged rats

Stemmelin, J., Lazarus, C., Cassel, S. L., Kelche, C. R., & Cassel, J. (2000) · Neuroscience · doi:10.1016/s0306-4522(99)00561-8 · Cited by 109 · see citing works

Age-dependent effects of environmental enrichment on spatial reference memory in male mice

Harburger, L. L., Lambert, T. J., & Frick, K. M. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2007.07.009 · Cited by 106 · see citing works

Effects of Age on the Generalization and Incubation of Memory in the F344 RatPreprint

Houston, F. P., Stevenson, G. D., McNaughton, B. L., & Barnes, C. A. (1999) · Learning & Memory · doi:10.1101/lm.6.2.111 · Cited by 104 · see citing works

Dorsal hippocampal CREB is both necessary and sufficient for spatial memoryPreprint

Sekeres, M. J., Neve, R. L., Frankland, P. W., & Josselyn, S. A. (2010) · Learning & Memory · doi:10.1101/lm.1785510 · Cited by 104 · see citing works

Environmental enrichment effects in social investigation in rats are gender dependent

Peña-López, Y., Prunell, M., DIMITSANTOS, V., Nadal, R. A., & Escorihuela, R. M. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.07.007 · Cited by 102 · see citing works

Differential and Age‐Dependent Effects of Maternal Deprivation on the Hypothalamic‐Pituitary‐Adrenal Axis of Brown Norway Rats from Youth to Senescence

Workel, J. O., Oitzl, M. S., Fluttert, M., Lesscher, H. M. B., Karssen, A. M., & de Kloet, E. R. (2001) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2001.00668.x · Cited by 102 · see citing works

Enriched environment influences hormonal status and hippocampal brain derived neurotrophic factor in a sex dependent manner

Bakoš, J., Hlaváčová, N., Rajman, M., Ondičová, K., Koros, C., Kitraki, E., Steinbusch, H. W. M., & Ježová, D. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.08.054 · Cited by 96 · see citing works

Attention and memory in aged rats: Impact of lifelong environmental enrichment.

Harati, H., Majchrzak, M., Cosquer, B., Galani, R., Kelche, C., Cassel, J., & Barbelivien, A. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.012 · Cited by 94 · see citing works

Male Fischer 344/N rats show a progressive central impairment of the hypothalamic-pituitary-adrenal axis with advancing age

Cizza, G., Calogero, A. E., Brady, L. S., Bagdy, G., Bergamini, E., Blackman, M. R., Chrousos, G. P., & Gold, P. W. (1994) · Endocrinology · doi:10.1210/endo.134.4.8137722 · Cited by 86 · see citing works

Cholinergic markers in aged cognitively impaired long-evans rats

Aubert, I., Rowe, W. B., Meaney, M. J., Gauthier, S. G., & Quirion, R. (1995) · Neuroscience · doi:10.1016/0306-4522(95)00056-o · Cited by 81 · see citing works

Neurobiological substrates of behavioral decline: Models and data analytic strategies for individual differences in aging

Baxter, M. G., & Gallagher, M. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00011-5 · Cited by 77 · see citing works

Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats

Lacalle, S. D., Cooper, J. D., Svendsen, C. N., Dunnett, S. B., & Sofroniew, M. V. (1996) · Neuroscience · doi:10.1016/0306-4522(96)00239-4 · Cited by 76 · see citing works

Septo-hippocampal cholinergic and neurotrophin markers in age-induced cognitive decline

Sugaya, K., Greene, R., Personett, D. A., Robbins, M., Kent, C., Bryan, D., Skiba, E., Gallagher, M., & McKinney, M. (1998) · Neurobiology of Aging · doi:10.1016/s0197-4580(98)00072-4 · Cited by 74 · see citing works

Hippocampal dysfunction during aging I: deficits in memory consolidation.

Ward, M. T., Oler, J., & Markus, E. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00045-7 · Cited by 67 · see citing works

Decline in visual attention and spatial memory in aged rats

Muir, J. L., Fischer, W., & Björklund, A. (1999) · Neurobiology of Aging · doi:10.1016/s0197-4580(99)00098-6 · Cited by 65 · see citing works

Both the dorsal hippocampus and the dorsolateral striatum are needed for rat navigation in the Morris water maze

Miyoshi, E., Lovato, E. C. W., Bortolanza, M., Boschen, S. L., Canteras, N. S., Izquierdo, I., & Cunha, C. D. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.09.011 · Cited by 63 · see citing works

The behavioral effects of enriched housing are not altered by serotonin depletion but enrichment alters hippocampal neurochemistry

Galani, R., Berthel, M.-C., Lazarus, C., Majchrzak, M. J., Barbelivien, A., Kelche, C. R., & Cassel, J. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.03.009 · Cited by 63 · see citing works

Environmental enrichment increases responding to contextual cues but decreases overall conditioned fear in the rat

Barbelivien, A., Herbeaux, K., Oberling, P., Kelche, C. R., Galani, R., & Majchrzak, M. J. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.01.012 · Cited by 59 · see citing works

Combined Damage to Entorhinal Cortex and Cholinergic Basal Forebrain Neurons, Two Early Neurodegenerative Features Accompanying Alzheimer's Disease: Effects on Locomotor Activity and Memory Functions in Rats

Traissard, N., Herbeaux, K., Cosquer, B., Jeltsch‐David, H., Ferry, B., Galani, R., Pernon, A., Majchrzak, M. J., & Cassel, J. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301116 · Cited by 58 · see citing works

Continuous enriched environment improves learning and memory in adult NMRI mice through theta burst-related-LTP independent mechanisms but is not efficient in advanced aged animals

Bouët, V., Fréret, T., Dutar, P., Billard, J., & Boulouard, M. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.04.006 · Cited by 58 · see citing works

Exposure to environmental enrichment elicits differential hippocampal cell proliferation: Role of individual responsiveness to anxiety

Leal‐Galicia, P., Saldı́var-González, A., Morimoto, S., & Arias, C. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20322 · Cited by 55 · see citing works

Do Norway rats (Rattus norvegicus) synchronize their estrous cycles?

Schank, J. C. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(00)00395-4 · Cited by 54 · see citing works

Rescue of cognitive aging by long-lasting environmental enrichment exposure initiated before median lifespan

Fréret, T., Billard, J., Schumann‐Bard, P., Dutar, P., Dauphin, F., Boulouard, M., & Bouët, V. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.028 · Cited by 52 · see citing works

Individual Differences in Spatial Memory and Striatal ChAT Activity among Young and Aged Rats

Colombo, P. J., & Gallagher, M. (1998) · Neurobiology of Learning and Memory · doi:10.1006/nlme.1998.3857 · Cited by 47 · see citing works

Aging causes partial loss of basal forebrain but no loss of pontine reticular cholinergic neurons

Baskerville, K. A., Kent, C., Nicolle, M. M., Gallagher, M., & McKinney, M. (2006) · NeuroReport · doi:10.1097/wnr.0b013e32800fef5a · Cited by 44 · see citing works

Environmental Enrichment‐Behavior‐Oxidative Stress Interactions in the Aged Rat: Issues for a Therapeutic Approach in Human Aging

Fernández, C. I., COLLAZO, J., Bauzá, Y., Castellanos, M. R., & LÓPEZ, O. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.012 · Cited by 44 · see citing works

Decreased anxiety levels related to aging

Torras-García, M., Costa‐Miserachs, D., Coll-Andreu, M., & Portell-Cortés, I. (2005) · Experimental Brain Research · doi:10.1007/s00221-005-2240-y · Cited by 44 · see citing works

Age-related qualitative shift in emotional behaviour: Paradoxical findings after re-exposure of rats in the elevated-plus maze

Bessa, J. M., de Oliveira, M. A. R., Cerqueira, J., Almeida, O. F. X., & Sousa, N. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.03.005 · Cited by 44 · see citing works

Selective cholinergic lesions in the rat nucleus basalis magnocellularis with limited damage in the medial septum specifically alter attention performance in the five-choice serial reaction time task

Harati, H., Barbelivien, A., Cosquer, B., Majchrzak, M. J., & Cassel, J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.01.031 · Cited by 43 · see citing works

Microdialysis without acetylcholinesterase inhibition reveals an age-related attenuation in stimulated cortical acetylcholine release

Herzog, C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(02)00226-9 · Cited by 43 · see citing works

Evaluation of an improved automated analysis of freezing behaviour in rats and its use in trace fear conditioning

Marchand, A. R., Luck, D., & Scala, G. D. (2003) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(03)00076-1 · Cited by 40 · see citing works

Environmental enrichment improves recent but not remote memory in association with a modified brain metabolic activation profile in adult mice

Léger, M., Bouët, V., Fréret, T., Darmaillacq, A., Dacher, M., Dauphin, F., Boulouard, M., & Schumann‐Bard, P. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.11.022 · Cited by 39 · see citing works

Age-related alterations in emotional behaviors and amygdalar corticotropin-releasing factor (CRF) and CRF-binding protein expression in aged Fischer 344 rats

Pisarska, M. M., Mulchahey, J. J., Welge, J. A., Geracioti, T. D., & Kasckow, J. W. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02606-8 · Cited by 36 · see citing works

Muscarinic receptor/G-protein coupling is reduced in the dorsomedial striatum of cognitively impaired aged rats

Nieves-Martinez, E., Haynes, K. A., Childers, S. R., Sonntag, W. E., & Nicolle, M. M. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.10.048 · Cited by 30 · see citing works

Jacques Anis, Texte et Ordinateur. L’écriture réinventée ?

Jeandillou, J.-F. (1999) · Linx · doi:10.4000/linx.800 · Cited by 21 · see citing works

Spatial reference- (not working- or procedural-) memory performance of aged rats in the water maze predicts the magnitude of sulpiride-induced facilitation of acetylcholine release by striatal slices

Cassel, J., Lazaris, A., Birthelmer, A., & Jackisch, R. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.05.032 · Cited by 17 · see citing works

Effect of aging on 24-hour pattern of stress hormones and leptin in rats

Cano, P., Cardinali, D. P., Spinedi, E., & Esquifino, A. I. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.06.001 · Cited by 12 · see citing works

Enhancement of auditory fear conditioning after housing in a complex environment is attenuated by prior treatment with amphetaminePreprint

Briand, L. A., Robinson, T. E., & Maren, S. (2005) · Learning & Memory · doi:10.1101/lm.95905 · Cited by 12 · see citing works

Environmental cue saliency influences the vividness of a remote spatial memory in rats

Lopez, J., de Vasconcelos, A. P., & Cassel, J. (2008) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2008.02.003 · Cited by 12 · see citing works

Prolonged initiation latency in Morris water maze learning in rats with ibotenic acid lesions to medial striatum: effects of systemic and intranigral muscimol administration

Shirakawa, K., & Ichitani, Y. (2004) · Brain Research · doi:10.1016/j.brainres.2004.10.008 · Cited by 7 · see citing works

Untitled work

Lepage (1998) · doi:10.1002/(sici)1098-1063(1998)8:4

Individual differences in behavioural plasticities

Stamps, J. A. (2015) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12186 · Cited by 329 · see citing works

Adding fuel to the fire: the impact of stress on the ageing brain

Prenderville, J. A., Kennedy, P. J., Dinan, T. G., & Cryan, J. F. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.001 · Cited by 136 · see citing works

Environmental enrichment and the sensory brain: The role of enrichment in remediating brain injury

Alwis, D. S., & Rajan, R. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00156 · Cited by 129 · see citing works

The Neuroprotective Effects of Experience on Cognitive Functions: Evidence from Animal Studies on the Neurobiological Bases of Brain Reserve

Gelfo, F., Mandolesi, L., Serra, L., Sorrentino, G., & Caltagirone, C. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.07.065 · Cited by 113 · see citing works

Transformation of cortical and hippocampal neural circuit by environmental enrichment

Hirase, H., & Shinohara, Y. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.09.031 · Cited by 91 · see citing works

Late-Life Environmental Enrichment Induces Acetylation Events and Nuclear Factor κB-Dependent Regulations in the Hippocampus of Aged Rats Showing Improved Plasticity and Learning

Neidl, R., Schneider‐Anthony, A., Bousiges, O., Majchrzak, M. J., Barbelivien, A., de Vasconcelos, A. P., Dorgans, K., Doussau, F., Loeffler, J., Cassel, J., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3239-15.2016 · Cited by 77 · see citing works

Environmental enrichment in female rodents: Considerations in the effects on behavior and biochemical markers

Girbovan, C., & Plamondon, H. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.07.018 · Cited by 76 · see citing works

A second wind for the cholinergic system in Alzheimer’s therapy

Douchamps, V., & Mathis, C. (2017) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000300 · Cited by 58 · see citing works

Environmental Enrichment and Physical Exercise Attenuate the Depressive-Like Effects Induced by Social Isolation Stress in Rats

Brenes, J. C., Fornaguera, J., & Sequeira‐Cordero, A. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00804 · Cited by 55 · see citing works

Environmental enrichment cognitive neuroprotection in an experimental model of cerebral ischemia: biochemical and molecular aspects

Gonçalves, L. V., Herlinger, A. L., Ferreira, T. A. A., Coitinho, J. B., Pires, R. G. W., & Martins-Silva, C. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.04.023 · Cited by 52 · see citing works

DARPP‐32 in the orchestration of responses to positive natural stimuli

Scheggi, S., Montis, M. G. D., & Gambarana, C. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14558 · Cited by 42 · see citing works

Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood

Kentrop, J., Smid, C. R., Achterberg, E. J. M., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Joëls, M., & van der Veen, R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00193 · Cited by 41 · see citing works

The impact of environmental and social factors on learning abilities: a meta‐analysis

Lambert, C. T., & Guillette, L. M. (2021) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12783 · Cited by 39 · see citing works

Molecular mechanisms underlying the neuroprotection of environmental enrichment in Parkinson’s disease

Ribeiro, F. M., Pires, R. G. W., Ferreira, T. A. A., Presti‐Silva, S. M., & Simões, A. T. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.360264 · Cited by 37 · see citing works

Maternal exposure to environmental enrichment before and during gestation influences behaviour of rat offspring in a sex-specific manner

Zuena, A. R., Zinni, M., Giuli, C., Cinque, C., Alemà, G., Giuliani, A., Catalani, A., Casolini, P., & Cozzolino, R. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.010 · Cited by 37 · see citing works

Postoperative Cognitive Dysfunction and the Protective Effects of Enriched Environment: A Systematic Review

Hua, M., & Jia, M. (2020) · Neurodegenerative Diseases · doi:10.1159/000513196 · Cited by 36 · see citing works

Environmental enrichment as a therapeutic avenue for anxiety in aged Wistar rats: Effect on cat odor exposition and GABAergic interneurons

Sampedro‐Piquero, P., Castilla‐Ortega, E., Zancada-Menéndez, C., Santín, L. J., & Begega, A. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.032 · Cited by 36 · see citing works

Exposure to an enriched environment up to middle age allows preservation of spatial memory capabilities in old age

Fuchs, F., Cosquer, B., Penazzi, L., Mathis, C., Kelche, C. R., Majchrzak, M. J., & Barbelivien, A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.11.019 · Cited by 34 · see citing works

Impact of enriched environment during adolescence on adult social behavior, hippocampal synaptic density and dopamine D2 receptor expression in rats

Gabriel, P., Mastracchio, T.-A., Bordner, K. A., & Jeffrey, R. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113133 · Cited by 34 · see citing works

Rethinking the Reserve with a Translational Approach: Novel Ideas on the Construct and the Interventions

Serra, L., Gelfo, F., Petrosini, L., Domenico, C. D., Bozzali, M., & Caltagirone, C. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180609 · Cited by 32 · see citing works

Neuroplasticity-related correlates of environmental enrichment combined with physical activity differ between the sexes

Kokras, N., Sotiropoulos, I., Besinis, D., Tzouveka, E. L., Almeida, O. F. X., Sousa, N., & Dalla, C. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.11.1107 · Cited by 29 · see citing works

Environmental enrichment and the aging brain: is it time for standardization?

Balietti, M., & Conti, F. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104728 · Cited by 26 · see citing works

Effects of Environmental Enrichment in Maternally Separated Rats: Age and Sex-Specific Outcomes

Doreste-Méndez, R., Ríos-Ruiz, E. J., Rivera-López, L. L., Gutierrez, A., & Torres-Reverón, A. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00198 · Cited by 21 · see citing works

Improvements in Behavior and Immune Function and Increased Life Span of Old Mice Cohabiting With Adult Animals

Garrido, A., Cruces, J., Ceprián, N., & la Fuente, M. D. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly043 · Cited by 20 · see citing works

The differential effects of brief environmental enrichment following social isolation in rats

Guven, E. B., Pranic, N. M., & Ünal, G. (2022) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-022-00989-y · Cited by 19 · see citing works

A short social interaction between adult and old mice improves the homeostatic systems and increases healthy longevity

Cerro, E. D., Ceprián, N., Félix, J., & la Fuente, M. D. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111653 · Cited by 15 · see citing works

Short-term enriched environment exposure facilitates fear extinction in adult rats: The NPY-Y1 receptor modulation

Lach, G., Bicca, M. A., Hoeller, A. A., Santos, E. C. D. S., Costa, A. P., & de Lima, T. C. M. (2015) · Neuropeptides · doi:10.1016/j.npep.2015.10.001 · Cited by 15 · see citing works

Gene by Environment Interplay in Cognitive Aging

Reynolds, C. A., Finkel, D., & Zavala, C. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7447-0_6 · Cited by 14 · see citing works

Long-Term Music Exposure Prevents Age-Related Cognitive Deficits in Rats Independently of Hippocampal Neurogenesis.

Rizzolo, L., Leger, M., Corvaisier, S., Groussard, M., Platel, H., Bouet, V., Schumann-Bard, P., & Freret, T. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa247 · Cited by 9 · see citing works

PDE5 Inhibition Improves Object Memory in Standard Housed Rats but Not in Rats Housed in an Enriched Environment: Implications for Memory Models?

Akkerman, S., Prickaerts, J., Bruder, A. K., Wolfs, K. H. M., Vry, J. D., Vanmierlo, T., & Blokland, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111692 · Cited by 12 · see citing works

Late enrichment maintains accurate recent and remote spatial memory only in aged rats that were unimpaired when middle agedPreprint

Fuchs, F., Herbeaux, K., Aufrere, N., Kelche, C. R., Mathis, C., Barbelivien, A., & Majchrzak, M. J. (2016) · Learning & Memory · doi:10.1101/lm.041236.115 · Cited by 12 · see citing works

Developmental effects of environmental enrichment on selective and auditory sustained attention

Korkhin, A., Zubedat, S., Aga‐Mizrachi, S., & Avital, A. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104479 · Cited by 10 · see citing works

Social experience during adolescence in female rats increases 50 kHz ultrasonic vocalizations in adulthood, without affecting anxiety‐like behavior

Emmerson, M. G., Spencer, K. A., & Brown, G. R. (2019) · Developmental Psychobiology · doi:10.1002/dev.21906 · Cited by 9 · see citing works

The Influence of Environmental Enrichment on Affective and Neural Consequences of Social Isolation Across Development

Akinbo, O. I., McNeal, N., Hylin, M. J., Hite, N. J., Dagner, A., & Grippo, A. J. (2022) · Affective Science · doi:10.1007/s42761-022-00131-8 · Cited by 8 · see citing works

Fatty acid-binding protein 5 differentially impacts dopamine signaling independent of sex and environment

Richardson, B., Hamilton, J., Roeder, N. M., Thanos, K. Z., Marion, M., & Thanos, P. K. (2023) · Addiction Neuroscience · doi:10.1016/j.addicn.2023.100118 · Cited by 8 · see citing works

Retrieval of allocentric spatial memories is preserved up to thirty days and does not require higher brain metabolic demands

Zorzo, C., Arias, J. L., & Méndez, M. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107312 · Cited by 8 · see citing works

Behavioral impact of experience based on environmental enrichment: Influence of age and duration of exposure in male NMRI mice

Mesa‐Gresa, P., Ramos‐Campos, M., & Redolat, R. (2021) · Developmental Psychobiology · doi:10.1002/dev.22093 · Cited by 7 · see citing works

Prematurely aging female mice improve their behavioural response, immunity, redox state, and lifespan after a short social interaction with non-prematurely aging mice

Cerro, E. D., Félix, J., & la Fuente, M. D. (2022) · Biogerontology · doi:10.1007/s10522-022-09968-9 · Cited by 7 · see citing works

A bibliometric analysis of studies on environmental enrichment spanning 1967–2024: patterns and trends over the years

Singhal, G., & Baune, B. T. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1501377 · Cited by 6 · see citing works

PET Measures of D1, D2, and DAT Binding Are Associated With Heightened Tactile Responsivity in Rhesus Macaques: Implications for Sensory Processing Disorder

Schneider, M. L., Moore, C. F., Ahlers, E. O., Barnhart, T. E., Christian, B. T., DeJesus, O. T., Engle, J. W., Holden, J. E., Larson, J. A., Moirano, J. M., et al. (2019) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2019.00029 · Cited by 5 · see citing works

Laboratory animal welfare:

Massari, C. H. D. A. L., Martins, N. O., Jozala, Â. F., Grotto, D., & Gerenutti, M. (2019) · Brazilian Journal of Veterinary Research and Animal Science · doi:10.11606/issn.1678-4456.bjvras.2018.145008 · Cited by 4 · see citing works

Intermittent working memory training during adulthood protects against age-related long-term spatial reference memory decline in rats

Barbelivien, A., Durieux, L., Seys, E., & Majchrzak, M. J. (2023) · GeroScience · doi:10.1007/s11357-023-00993-1 · Cited by 3 · see citing works

The Ultimate Benefits of Learning

Baker, K., & Melfi, V. A. (2019) · Wiley eBooks · doi:10.1002/9781118968543.ch3 · Cited by 3 · see citing works

Memory network and cognitive reserve are associated with preserved and stimulated cholinergic neurotransmission

Boccalini, C., Perani, D., & Garibotto, V. (2025) · Handbook of clinical neurology · doi:10.1016/b978-0-443-19088-9.00014-7 · Cited by 2 · see citing works

Potential resilience treatments for orangutans (Pongo spp.): Lessons from a scoping review of interventions in humans and other animals

Bridgeland-Stephens, L., Thorpe, S. K. S., & Chappell, J. (2023) · Animal Welfare · doi:10.1017/awf.2023.97 · Cited by 1 · see citing works

Effect of prenatal and postnatal environmental enrichment on laboratory rats' welfare

Abdelghany, A. K., Abdel-Azeem, N. M., Mostafa, A. S., & Emeash, H. H. (2016) · Journal of Veterinary Medical Research · doi:10.21608/jvmr.2016.43213 · Cited by 1 · see citing works

Çevre Faktörü ve Ergoterapi: Teori ve Model Yaklaşımları

BİLSEL, B. A., & Bektaş, S. A. (2021) · İstanbul Gelişim Üniversitesi Sağlık Bilimleri Dergisi · doi:10.38079/igusabder.995196 · Cited by 1 · see citing works

The NR2B subunit and differential rearing: the role of the amygdala and hippocampus in the acquisition of Pavlovian conditioned fear

Reinhardt, E. K. (2015)

Enriquecimento ambiental, ansiedade, cognição e neurogênese hipocampal

Goulart, C. D. S. (2014) · doi:10.11606/d.41.2014.tde-09032015-090835

Bases moleculares envolvidas na neuroproteção causada pela exposição a um ambiente enriquecido em modelo animal de isquemia cerebral

Martins-Silva, C., Massensini, A. R., Nogueira, B. V., & Pires, R. G. W. (2018)

El misterioso caso de la tapa que baja

Samaranch, O. (2010) · Monitor educador

Early Onset Memory Deficit of WMI Rats Compared to Their Nearly Isogenic WLIs Is Reversed by Enriched Environment in Females

Ji, M. T., Przybyl, K. J., Harter, A. M., Nemesh, M., Jenz, S. T., Yamazaki, A., Kim, C., Mulligan, M. K., Chen, H., & Redei, E. E. (2025) · Genes Brain & Behavior · doi:10.1111/gbb.70027

The effect of sertraline and voluntary exercise during pregnancy on litter characteristics and postpartum affective behaviour in rat dams

Jarbou, N. S., Mairinger, O., Kulen, E., Mushahwar, L., Walpole, S. J., Matthews, J., Maksour, S., Weston–Green, K., Dottori, M., & Newell, K. A. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111520

Factor of Environment and Occupational Therapy: Theory and Model Approaches

BİLSEL, B. A., & Aydöner, S. (2021) · DergiPark (Istanbul University)

Ultrastructural, molecular and functional heterogeneities of cerebellar granule cell presynaptic terminals

Dorgans, K. (2017) · theses.fr (ABES) · doi:10.70675/031e34e5zd5b7z4debzab0dzcd77f69b8c71

Effets d'une exposition chronique à la musique sur le vieillissement chez le rat Wistar

Rizzolo, L. (2018) · theses.fr (ABES) · doi:10.70675/b4e3a0b2z946ez4fbdz9e46zb94e136f5df6

Functional and morphological alterations in animal models of valproic acid exposure

Encarnación-Sánchez, J. L., González‐Flores, O., García‐Juárez, M., Aguilar-Pérez, C., Dorantes-Barrios, C. J., Tlachi-López, J. L., Pfaus, J. G., & Domínguez‐Ordóñez, R. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106772

Environmental enrichment as a multisystem modulator of neurotransmitter function: mechanisms, plasticity, and therapeutic implications

Singhal, G., & Baune, B. T. (2026) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2026.1927924

Attention and memory in aged rats: Impact of lifelong environmental enrichment.

Harati, H., Majchrzak, M., Cosquer, B., Galani, R., Kelche, C., Cassel, J., & Barbelivien, A. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2009.03.012 · Cited by 94 · see citing works

Late enrichment maintains accurate recent and remote spatial memory only in aged rats that were unimpaired when middle agedPreprint

Fuchs, F., Herbeaux, K., Aufrere, N., Kelche, C. R., Mathis, C., Barbelivien, A., & Majchrzak, M. J. (2016) · Learning & Memory · doi:10.1101/lm.041236.115 · Cited by 12 · see citing works

Effects of Environmental Enrichment on Spatial Memory and Neurochemistry in Middle-Aged MicePreprint

Frick, K. M., Stearns, N. A., Pan, J.-Y., & Berger-Sweeney, J. E. (2003) · Learning & Memory · doi:10.1101/lm.50703 · Cited by 164 · see citing works

In aged rats, differences in spatial learning and memory influence the response to late-life Environmental Enrichment

Balietti, M., Pugliese, A., & Conti, F. (2020) · Experimental Gerontology · doi:10.1016/j.exger.2020.111225 · Cited by 8 · see citing works

Age-dependent effects of environmental enrichment on brain networks and spatial memory in Wistar rats

Sampedro‐Piquero, P., Begega, A., Zancada-Menéndez, C., Cuesta, M., & Arias, J. L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.003 · Cited by 31 · see citing works