Maternal Immune Activation Increases Neonatal Mouse Cortex Thickness and Cell Density
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MIA strongly upregulates cell cycle gene expression and cell proliferation, and may cause brain overgrowth.
“MIA strongly upregulates cell cycle gene expression and cell proliferation, and may cause brain overgrowth [127–129].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [129]
Similar to some ASD cases, MIA induces overproduction of neurons, and increases cortical thickness and brain size as seen in many toddlers with ASD.
“Similar to some ASD cases, MIA induces overproduction of neurons [129], and increases cortical thickness [129, 130] and brain size [130] as seen in many toddlers with ASD [5, 8, 10, 13, 14, 18].”
From The ASD Living Biology: from cell proliferation to clinical phenotype (2019) · cites this paper as [129]
MIA alters proliferation of cortical neural progenitor cells, laminar allocation of neurons, increased cortical thickness, increased cell density and patches of cortical dysplasia.
“MIA alters proliferation of cortical neural progenitor cells, laminar allocation of neurons, increased cortical thickness, increased cell density and patches of cortical dysplasia.32, 38, 42”
From Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder (2018) · cites this paper as [38]
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- Authors
- Smith, S. E. P., Elliott, R. M., & Anderson, M. P.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Anderson, Matthew P.
- Venue
- Journal of Neuroimmune Pharmacology
- Published
- 2012-05-09
- Volume
- 7
- Issue
- 3
- Pages
- 529-532
- ISSN
- 1557-1890 (ISSN-L)
- 1557-1904
- PMC
- PMC3672058
- OpenAlex
- W1991899211
- Cited by
- 34
- References
- 19
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 1 · 2012: 1
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neuroimmune Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R21NS070295, K02NS054674, R01NS081916, R01NS057444)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- maternal immune activation, autism spectrum disorder, schizophrenia, maternal infection, influenza, cortical thickness, neuronal density, Purkinje cells, cerebellum, environmental risk factors, offspring behavior, social interaction, anxiety, prepulse inhibition, latent inhibition, neurodevelopmental disorders
- MeSH terms
- Animals, Animals, Newborn, Cell Count, Cerebral Cortex, Female, Maternal-Fetal Exchange, Organ Size, Poly I-C, Pregnancy, Prenatal Exposure Delayed Effects, Mice
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