Inflammation of the Embryonic Choroid Plexus Barrier following Maternal Immune Activation
Open accessAbstract
The choroid plexus (ChP) regulates brain development by secreting instructive cues and providing a protective brain barrier. Here, we show that polyI:C-mediated maternal immune activation leads to an inflammatory response in the developing embryonic mouse brain that manifests as pro-inflammatory cerebrospinal fluid (CSF) and accumulation of ChP macrophages. Elevation of CSF-CCL2 was sufficient to drive ChP immune cell recruitment, activation, and proliferation. In addition, ChP macrophages abandoned their regular tiling pattern and relocated to the ChP-free margin where they breached the weakened epithelial barrier. We further found that these immune cells entered from the ChP into the brain via anatomically specialized "hotspots" at the distal tips of ChP villi. In vivo two-photon imaging demonstrated that surveillance behaviors in ChP macrophages had already emerged at this early stage of embryogenesis. Thus, the embryonic ChP forms a functional brain barrier that can mount an inflammatory response to external insults.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Systemic chronic inflammation resulting from immunosenescence and non-neurotropic viral infection compels immune cells in the peripheral blood to penetrate the blood-brain barrier and choroid plexus and enter the brain; immune cells originating from the cranial bone marrow migrate to the meninges, thereby promoting neuroinflammation and neuronal dysfunction while inhibiting neurogenesis, and thisc
“Finally, the systemic chronic inflammation resulting from immunosenescence and non-neurotropic viral infection compels immune cells in the peripheral blood to penetrate the blood-brain barrier (BBB) and choroid plexus and enter the brain,345,346 Additionally, immune cells originating from the cranial bone marrow migrate to the meninges,347 thereby promoting neuroinflammation and neuronal”
From Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances (2025) · cites this paper as [346]
Cx3cr1-GFP-expressing cells tiled across the ChP, with the subset expressing SLC40A1 located proximal to major vessels.
“Cx3cr1-GFP-expressing cells tiled across the ChP (Figure 5E; Cui et al., 2020), with the subset expressing SLC40A1 located proximal to major vessels, suggesting roles in regulating iron homeostasis (Figure 5F).”
From A cellular and spatial map of the choroid plexus across brain ventricles and ages (2021) · cites this paper as Cui et al., 2020
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
Nimmerjahn, A., Kirchhoff, F., & Helmchen, F. (2005) · Science · doi:10.1126/science.1110647 · Cited by 5,827 · see citing works
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089 · cited 1× · see citing works
“During brain development, microglia exhibit a phagocytic transcriptomic profile, and regulate neurogenesis and synapse refinement (Cunningham et al., 2013; Kracht et al., 2020; Schafer et al., 2012; Squarzoni et al., 2014; Wilton et al., 2019).”
BackgroundATP mediates rapid microglial response to local brain injury in vivo
Davalos, D., Grutzendler, J., Yang, G., Kim, J. V., Zuo, Y., Jung, S., Littman, D. R., Dustin, M. L., & Gan, W.-B. (2005) · Nature Neuroscience · doi:10.1038/nn1472 · Cited by 3,913 · see citing works
Hammond, T. R., Dufort, C., Dissing-Olesen, L., Giera, S., Young, A., Wysoker, A., Walker, A. J., Segel, M., Nemesh, J., Saunders, A., et al. (2018) · doi:10.1101/406140 · Cited by 2,225 · see citing works
Neuroglial activation and neuroinflammation in the brain of patients with autism
Vargas, D. L., Nascimbene, C., Krishnan, C., Zimmerman, A. W., & Pardo, C. A. (2005) · Annals of Neurology · doi:10.1002/ana.20315 · Cited by 2,149 · cited 7× · see citing works
“CSF from ASD patients display hallmarks of neuroinflammation including increased CCL2 expression (Ashwood et al., 2006; Vargas et al., 2005).”
BackgroundInfluentialPericytes are required for blood–brain barrier integrity during embryogenesis
Daneman, R., Zhou, L., Kebede, A. A., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09513 · Cited by 2,128 · see citing works
Microglia and macrophages in brain homeostasis and disease
Li, Q., & Barres, B. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.125 · Cited by 1,999 · see citing works
Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6
Smith, S. E. P., Li, J., Garbett, K., Mirnics, K., & Patterson, P. H. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2178-07.2007 · Cited by 1,605 · see citing works
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
Choi, G. B., Yim, Y. S., Wong, H., Kim, S., Kim, H., Kim, S. V., Hoeffer, C. A., Littman, D. R., & Huh, J. R. (2016) · Science · doi:10.1126/science.aad0314 · Cited by 1,214 · see citing works
Reboldi, A., Coisne, C., Baumjohann, D., Benvenuto, F., Bottinelli, D., Lira, S., Uccelli, A., Lanzavecchia, A., Engelhardt, B., & Sallusto, F. (2009) · Nature Immunology · doi:10.1038/ni.1716 · Cited by 1,206 · see citing works
Maternal immune activation: Implications for neuropsychiatric disorders
Estes, M. L., & McAllister, A. K. (2016) · Science · doi:10.1126/science.aag3194 · Cited by 1,206 · cited 1× · see citing works
“Immune system disturbances during development increase the susceptibility of offspring to multiple neurodevelopmental disorders (Ashwood et al., 2006; Estes and McAllister, 2016; Knuesel et al., 2014; Patterson, 2011).”
BackgroundMicroglia development follows a stepwise program to regulate brain homeostasis
Matcovitch-Natan, O., Winter, D. R., Giladi, A., Vargas Aguilar, S., Spinrad, A., Sarrazin, S., Ben-Yehuda, H., David, E., Zelada González, F., Perrin, P., et al. (2016) · Science · doi:10.1126/science.aad8670 · Cited by 1,180 · see citing works
Spatial Point Patterns: Methodology and Applications with R
Baddeley, A. J., Rubak, E., & Turner, R. (2015) · VBN Forskningsportal (Aalborg Universitet) · Cited by 1,088 · see citing works
Mfsd2a is critical for the formation and function of the blood-brain barrier
Ben-Zvi, A., Lacoste, B., Kur, E., Andreone, B. J., Mayshar, Y., Yan, H., & Gu, C. (2014) · Nature · doi:10.1038/nature13324 · Cited by 1,037 · see citing works
Lu, B., RUTLEDGE, B. J., Gu, L., Fiorillo, J., Lukacs, N. W., Kunkel, S. L., North, R. J., Gerard, C. J., & Rollins, B. J. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.4.601 · Cited by 1,017 · see citing works
Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex
Cunningham, C. L., Martínez-Cerdeño, V., & Noctor, S. C. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3441-12.2013 · Cited by 976 · see citing works
The movers and shapers in immune privilege of the CNS
Engelhardt, B., Vajkoczy, P., & Weller, R. O. (2017) · Nature Immunology · doi:10.1038/ni.3666 · Cited by 893 · see citing works
Maternal immune activation and abnormal brain development across CNS disorders
Knuesel, I., Chicha, L., Britschgi, M., Schobel, S. A., Bodmer, M., Hellings, J. A., Toovey, S., & Prinssen, E. P. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.187 · Cited by 880 · see citing works
Morgan, J. T., Chana, G., Pardo, C. A., Achim, C., Semendeferi, K., Buckwalter, J., Courchesne, E., & Everall, I. P. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.05.024 · Cited by 749 · see citing works
Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring
Kim, S., Kim, H., Yim, Y. S., Ha, S., Atarashi, K., Tan, T. G., Longman, R. S., Honda, K., Littman, D. R., Choi, G. B., et al. (2017) · Nature · doi:10.1038/nature23910 · Cited by 678 · see citing works
Balancing cell adhesion and Wnt signaling, the key role of β-catenin
Brembeck, F. H., Rosário, M., & Birchmeier, W. (2005) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2005.12.007 · Cited by 668 · see citing works
Malkova, N. V., Yu, C. Z., Hsiao, E. Y., Moore, M. J., & Patterson, P. H. (2012) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.01.011 · Cited by 662 · see citing works
Microglia Modulate Wiring of the Embryonic Forebrain
Squarzoni, P., Oller, G., Hoeffel, G., Pont‐Lezica, L., Rostaing, P., Low, D., Bessis, A., Ginhoux, F., & Garel, S. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.042 · Cited by 655 · see citing works
The cerebrospinal fluid provides a proliferative niche for neural progenitor cells
Lehtinen, M. K., Zappaterra, M. W., Chen, X., Yang, Y. J., Hill, A. D., Lun, M., Maynard, T., Gonzalez, D., Kim, S., Ye, P., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.01.023 · Cited by 648 · see citing works
Self-citationAging-induced type I interferon response at the choroid plexus negatively affects brain function
Baruch, K., Deczkowska, A., David, E., Castellano, J. M., Miller, O., Kertser, A., Berkutzki, T., Barnett-Itzhaki, Z., Bezalel, D., Wyss-Coray, T., et al. (2014) · Science · doi:10.1126/science.1252945 · Cited by 615 · see citing works
The immune response in autism: a new frontier for autism research
Ashwood, P., Wills, S., & Van de Water, J. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1205707 · Cited by 528 · see citing works
Maternal infection and immune involvement in autism
Patterson, P. H. (2011) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2011.03.001 · Cited by 520 · see citing works
Barrier Mechanisms in the Developing Brain
Saunders, N. R., Liddelow, S. A., & Dzięgielewska, K. M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00046 · Cited by 514 · see citing works
In vivo three-photon imaging of activity of GCaMP6-labeled neurons deep in intact mouse brain
Ouzounov, D., Wang, T.-Y., Wang, M.-R., Feng, D., Horton, N. G., Hernández, J. C. C., Cheng, Y.-T., Reimer, J., Tolias, A., Nishimura, N., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4183 · Cited by 467 · see citing works
Madry, C., Kyrargyri, V., Arancibia-Cárcamo, I. L., Jolivet, R., Kohsaka, S., Bryan, R. M., & Attwell, D. (2018) · Neuron · doi:10.1016/j.neuron.2017.12.002 · Cited by 464 · see citing works
Ghersi-Egea, J.-F., Strazielle, N., Catala, M., Silva-Vargas, V., Doetsch, F., & Engelhardt, B. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1807-1 · Cited by 436 · see citing works
Enteric Salmonellosis Disrupts the Microbial Ecology of the Murine Gastrointestinal Tract
Barman, M., Unold, D., Shifley, K., Amir, E., Hung, K.-C., Bos, N. A., & Salzman, N. H. (2007) · Infection and Immunity · doi:10.1128/iai.01432-07 · Cited by 428 · see citing works
Macrophages at CNS interfaces: Ontogeny and function in health and disease
Kierdorf, K., Masuda, T., Jordão, M. J. C., & Prinz, M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0201-x · Cited by 416 · see citing works
Monocyte Chemoattractant Protein-1 Regulation of Blood–Brain Barrier Permeability
Stamatovic, S. M., Shakui, P., Keep, R. F., Moore, B. B., Kunkel, S. L., van Rooijen, N., & Andjelkovic, A. V. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600055 · Cited by 415 · see citing works
Retinoic acid from the meninges regulates cortical neuron generation.
Siegenthaler, J. A., Ashique, A. M., Zarbalis, K., Patterson, K. P., Hecht, J. H., Kane, M. A., Folias, A. E., Choe, Y., May, S. R., Kume, T., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.004 · Cited by 402 · see citing works
Activation of the maternal immune system induces endocrine changes in the placenta via IL-6
Hsiao, E. Y., & Patterson, P. H. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.12.017 · Cited by 402 · see citing works
A cellular and spatial map of the choroid plexus across brain ventricles and ages
Dani, N., Herbst, R. H., McCabe, C., Green, G. S., Kaiser, K., Head, J. P., Cui, J., Shipley, F. B., Jang, A., Dionne, D., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.003 · Cited by 388 · see citing works
Self-citationStamatovic, S. M., Keep, R. F., Kunkel, S. L., & Andjelkovic, A. V. (2003) · Journal of Cell Science · doi:10.1242/jcs.00755 · Cited by 381 · see citing works
Rudolph, M. D., Graham, A. M., Feczko, E., Miranda-Dominguez, O., Rasmussen, J. M., Nardos, R., Entringer, S., Wadhwa, P. D., Buss, C., & Fair, D. A. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0128-y · Cited by 374 · see citing works
Murakami, T., Felinski, E. A., & Antonetti, D. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.016766 · Cited by 369 · see citing works
Schwartz, M., & Baruch, K. (2014) · The EMBO Journal · doi:10.1002/embj.201386609 · Cited by 349 · see citing works
Neuron-glia signaling in synapse elimination
Wilton, D. K., Dissing-Olesen, L., & Stevens, B. (2019) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-070918-050306 · Cited by 332 · see citing works
Bilbo, S. D., Block, C. L., Bolton, J. L., Hanamsagar, R., & Tran, P. K. (2017) · Experimental Neurology · doi:10.1016/j.expneurol.2017.07.002 · Cited by 323 · see citing works
Reversing behavioural abnormalities in mice exposed to maternal inflammation
Shin Yim, Y., Park, A., Berrios, J., Lafourcade, M., Pascual, L. M., Soares, N., Yeon Kim, J., Kim, S., Kim, H., Waisman, A., et al. (2017) · Nature · doi:10.1038/nature23909 · Cited by 303 · see citing works
Microglia and Memory: Modulation by Early-Life Infection
Williamson, L. L., Sholar, P. W., Mistry, R. S., Smith, S. H., & Bilbo, S. D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3688-11.2011 · Cited by 274 · see citing works
Jones, K. L., Croen, L. A., Yoshida, C. K., Heuer, L., Hansen, R., Zerbo, O., DeLorenze, G. N., Kharrazi, M., Yolken, R., Ashwood, P., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.77 · Cited by 260 · see citing works
Human fetal microglia acquire homeostatic immune-sensing properties early in development
Kracht, L., Borggrewe, M., Eskandar, S., Brouwer, N., Lopes, S. M. C. D. S., Laman, J. D., Scherjon, S. A., Prins, J. R., Kooistra, S. M., & Eggen, B. J. L. (2020) · Science · doi:10.1126/science.aba5906 · Cited by 208 · see citing works
Emergence and Developmental Roles of the Cerebrospinal Fluid System
Fame, R. M., & Lehtinen, M. K. (2020) · Developmental Cell · doi:10.1016/j.devcel.2020.01.027 · Cited by 199 · see citing works
Self-citationBolton, J. L., Marinero, S., Hassanzadeh, T., Natesan, D., Le, D., Belliveau, C., Mason, S. N., Auten, R. L., & Bilbo, S. D. (2017) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2017.00010 · Cited by 154 · see citing works
Physiology and molecular biology of barrier mechanisms in the fetal and neonatal brain
Saunders, N. R., Dzięgielewska, K. M., Møllgård, K., & Habgood, M. D. (2018) · The Journal of Physiology · doi:10.1113/jp275376 · Cited by 151 · see citing works
Ek, C. J., Dzięgielewska, K. M., Stolp, H. B., & Saunders, N. R. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.20885 · Cited by 150 · see citing works
Stolp, H. B., Dzięgielewska, K. M., Ek, C. J., Potter, A., & Saunders, N. R. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04483.x · Cited by 146 · see citing works
We have got you ‘covered’: how the meninges control brain development
Siegenthaler, J. A., & Pleasure, S. J. (2011) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.12.005 · Cited by 145 · see citing works
A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases
Garzia, L., Kijima, N., Morrissy, A. S., Antonellis, P. D., Stücklin, A. G., Holgado, B., Wu, X., Wang, X., Parsons, M., Zayne, K., et al. (2018) · Cell · doi:10.1016/j.cell.2018.01.038 · Cited by 145 · see citing works
Abdallah, M. W., Larsen, N., Grove, J., Nørgaard‐Pedersen, B., Thorsen, P., Mortensen, E. L., & HOUGAARD, D. M. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.09.003 · Cited by 124 · see citing works
Nelson, L. H., & Lenz, K. M. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.09.006 · Cited by 120 · see citing works
Shipley, F. B., Dani, N., Xu, H., Deister, C., Cui, J., Head, J. P., Sadegh, C., Fame, R. M., Shannon, M. L., Flores, V. I., et al. (2020) · Neuron · doi:10.1016/j.neuron.2020.08.024 · Cited by 118 · see citing works
Self-citationStolp, H. B., Dzięgielewska, K. M., Ek, C. J., Habgood, M. D., Lane, M. A., Potter, A., & Saunders, N. R. (2005) · Cell and Tissue Research · doi:10.1007/s00441-005-1088-6 · Cited by 110 · see citing works
Chau, K. F., Springel, M. W., Broadbelt, K. G., Park, H., Topal, S., Lun, M. P., Mullan, H., Maynard, T. M., Steen, H., LaMantia, A., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.11.015 · Cited by 101 · see citing works
Self-citationWu, C., Wen, C. Y., Shieh, J., & Ling, E. (1992) · Europe PMC (PubMed Central) · Cited by 94 · see citing works
Downregulation of ribosome biogenesis during early forebrain development
Chau, K. F., Shannon, M. L., Fame, R. M., Fonseca, E., Mullan, H., Johnson, M. B., Sendamarai, A. K., Springel, M. W., Laurent, B., & Lehtinen, M. K. (2018) · eLife · doi:10.7554/elife.36998 · Cited by 94 · see citing works
Self-citationEk, C. J., Habgood, M. D., Dzięgielewska, K. M., & Saunders, N. R. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10661 · Cited by 92 · see citing works
Cerebrospinal fluid and the early brain development of autism
Shen, M. D. (2018) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-018-9256-7 · Cited by 90 · see citing works
T lymphocytes and cytotoxic astrocyte blebs correlate across autism brains
DiStasio, M., Nagakura, I., Nadler, M. J. S., & Anderson, M. P. (2019) · Annals of Neurology · doi:10.1002/ana.25610 · Cited by 78 · see citing works
Liddelow, S. A., Temple, S., Møllgård, K., Gehwolf, R., Wagner, A., Bauer, H., Bauer, H., Phoenix, T. N., Dzięgielewska, K. M., & Saunders, N. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033554 · Cited by 76 · see citing works
Reduced ventricular proliferation in the foetal cortex following maternal inflammation in the mouse
Stolp, H. B., Turnquist, C., Dzięgielewska, K. M., Saunders, N. R., Anthony, D. C., & Molnár, Z. (2011) · Brain · doi:10.1093/brain/awr237 · Cited by 72 · see citing works
Howe, C. L., LaFrance‐Corey, R. G., Goddery, E. N., Johnson, R. K., & Mirchia, K. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1015-2 · Cited by 72 · see citing works
Ek, C. J., Habgood, M. D., Dzięgielewska, K. M., et al. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00841.x · Cited by 67 · see citing works
Direct image reconstruction from a Fourier intensity pattern using HERALDO
Guizar‐Sicairos, M., & Fienup, J. R. (2008) · Optics Letters · doi:10.1364/ol.33.002668 · Cited by 60 · see citing works
Kowash, H. M., Potter, H. G., Edye, M. E., Prinssen, E. P. M., Bandinelli, S., Neill, J. C., Hager, R., & Glazier, J. D. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.006 · Cited by 58 · see citing works
Albumin transfer across the choroid plexus of South American opossum (Monodelphis domestica).
Knott, G. W., Dzięgielewska, K. M., Habgood, M. D., Li, Z. S., & Saunders, N. R. (1997) · The Journal of Physiology · doi:10.1113/jphysiol.1997.sp021919 · Cited by 51 · see citing works
A cellular and spatial map of the choroid plexus across brain ventricles and agesPreprint
Dani, N., Herbst, R. H., Habib, N., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/627539 · Cited by 46 · see citing works
Self-citationHaddad, M. R., Donsante, A., Zerfas, P. M., & Kaler, S. G. (2013) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2013.27 · Cited by 40 · see citing works
Fame, R. M., Shannon, M. L., Chau, K. F., Head, J. P., & Lehtinen, M. K. (2019) · Development · doi:10.1242/dev.182857 · Cited by 38 · see citing works
Self-citationChen, X., He, Y., Tian, Y., Wang, Y., Wu, Z., Lan, T., Wang, H., Cheng, K., & Xie, P. P. (2020) · Human Gene Therapy · doi:10.1089/hum.2019.300 · Cited by 38 · see citing works
Maternal Immune Activation Increases Neonatal Mouse Cortex Thickness and Cell Density
Smith, S. E. P., Elliott, R. M., & Anderson, M. P. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9372-1 · Cited by 34 · see citing works
Ben‐Reuven, L., & Reiner, O. (2019) · Molecular Psychiatry · doi:10.1038/s41380-019-0594-y · Cited by 30 · see citing works
MEIS-WNT5A axis regulates development of fourth ventricle choroid plexus
Kaiser, K., Jang, A., Kompaníková, P., Lun, M. P., Procházka, J., Machoň, O., Dani, N., Procházková, M., Laurent, B., Gyllborg, D., et al. (2021) · Development · doi:10.1242/dev.192054 · Cited by 29 · see citing works
Self-citationIn vivo Calcium Imaging of Evoked Calcium Waves in the Embryonic Cortex
Yuryev, M. V., Pellegrino, C., Jokinen, V. P., et al. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00500 · Cited by 22 · see citing works
Zappaterra, M. W., LaMantia, A., Walsh, C. A., et al. (2013) · Journal of Visualized Experiments · doi:10.3791/50333 · Cited by 19 · see citing works
MEIS-WNT5A axis regulates development of 4 th ventricle choroid plexusPreprint
Kaiser, K., Jang, A., Lun, M. P., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.07.082370 · Cited by 5 · see citing works
Zappaterra, M. W., LaMantia, A. S., Walsh, C. A., et al. (2013) · Journal of Visualized Experiments · doi:10.3791/50333-v · Cited by 5 · see citing works
Shipley, F. B., Dani, N., Xu, H., et al. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3554055 · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
A cellular and spatial map of the choroid plexus across brain ventricles and ages
Dani, N., Herbst, R. H., McCabe, C., Green, G. S., Kaiser, K., Head, J. P., Cui, J., Shipley, F. B., Jang, A., Dionne, D., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.003 · Cited by 388 · see citing works
Self-citationAntiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances
Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02145-7 · Cited by 165 · see citing works
Mechanisms of myeloid cell entry to the healthy and diseased central nervous system
Amann, L., Masuda, T., & Prinz, M. (2023) · Nature Immunology · doi:10.1038/s41590-022-01415-8 · Cited by 50 · see citing works
- Authors
- Cui, J., Shipley, F. B., Shannon, M. L., Alturkistani, O., Dani, N., Webb, M. D., Sugden, A. U., Andermann, M. L., & Lehtinen, M. K.
- Affiliations
- Boston Children's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Lehtinen, Maria K.
- ORCID
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2020-12
- Volume
- 55
- Issue
- 5
- Pages
- 617-628.e6
- ISSN
- 1534-5807 (ISSN-L)
- PMC
- PMC7725967
- OpenAlex
- W3091787096
- Cited by
- 128
- References
- 83
- Citations by year
- 2026: 20 · 2025: 28 · 2024: 32 · 2023: 19 · 2022: 11 · 2021: 17 · 2020: 1
- FWCI
- 4.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- New York Stem Cell Foundation
- Dana Foundation (R01 DK109930, DP2 DK105570)
- Pew Charitable Trusts
- McKnight Foundation
- Simons Foundation (402089)
- National Science Foundation (T32 5T32DK007516)
- American Foundation for Aging Research
- Simons Foundation Autism Research Initiative (R01 NS088566, RF1DA048790)
- National Institutes of Health (T32 HL110852, RF1DA048790)
- Topics
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
- Keywords
- choroid plexus, maternal immune activation, poly(I:C), embryonic brain development, cerebrospinal fluid, MCP-1, choroid plexus macrophages, choroid plexus epithelium, macrophage migration, neuroinflammation, brain barriers
- MeSH terms
- Animals, Calcium-Binding Proteins, Cerebrospinal Fluid, Choroid Plexus, Inflammation, Macrophage Activation, Mice, Inbred C57BL, Microfilament Proteins, Signal Transduction, Up-Regulation, Inflammation Mediators, Chemokine CCL2, Tight Junctions, Imaging, Three-Dimensional, Cell Proliferation, Receptors, CCR2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
