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Circulating SIRT1 Increases After Intragastric Balloon Fat Loss in Obese Patients

Mariani, Stefania, Fiore, Daniela, Persichetti, Agnese, Basciani, Sabrina, Lubrano, Carla, Poggiogalle, Eleonora, Genco, Alfredo, Donini, Lorenzo Maria, Gnessi, Lucio·2016·Obesity Surgery
DOI 10.1007/s11695-015-1859-4
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Abstract

Background Sirtuins (SIRTs), ubiquitous deacetylases, are main regulators of energy homeostasis and metabolism. SIRT1 has a positive impact on obesity, diabetes mellitus, liver steatosis, and other metabolic disorders. Lean subjects have higher expression of SIRT1 in the adipose tissue compared to obese. However, it is not known whether weight loss associates with changes in blood SIRT1. We evaluated the effect of weight loss on circulating SIRT1, metabolic parameters, and body composition. Methods Thirty-two obese subjects were studied before and 6 months after BioEnterics® Intragastric Balloon (BIB®) [22 patients, BMI 41.82 ± 6.28 kg/m(2)] or hypocaloric diet [10 patients, BMI 38.95 ± 6.90 kg/m(2)]. Plasma SIRT1, body composition, measures of metabolic syndrome (waist circumference, fasting plasma glucose, blood pressure, HDL cholesterol, triglycerides), and inflammation markers (ESR, CRP, fibrinogen) were recorded. Results SIRT1 levels showed a significant increase, together with a significant reduction of BMI, excess body weight, and total fat mass either after BIB or diet intervention. The percent excess body weight loss was 33.73 ± 19.06 and 22.08 ± 11.62 % after BIB and diet, respectively, a trend toward a metabolic and inflammatory amelioration was observed with both treatments. Negative correlation between SIRT1 and % fat mass (BIB, ρ = -0.537, p = 0.017; diet, ρ = -0.638, p = 0.047) was also seen. Conclusions The reduction of fat mass associates with increased plasm…

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Research works printed but not linked: 26

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Metadata

Authors
Mariani, S., Fiore, D., Persichetti, A., Basciani, S., Lubrano, C., Poggiogalle, E., Genco, A., Donini, L. M., & Gnessi, L.
Venue
Obesity Surgery
Publisher
Springer Science and Business Media LLC
Published
2015-09-04
Volume
26
Issue
6
Pages
1215-1220
ISSN
  • 0960-8923
  • 1708-0428
DOI
10.1007/s11695-015-1859-4
Cited by
34
References
1
Language
en
Licence
www.springer.com/tdm (tdm)

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