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The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Sirt1 protects against high-fat diet-induced metabolic damage

Pfluger, Paul T., Herranz, Daniel, Velasco-Miguel, Susana, Serrano, Manuel, Tschöp, Matthias H.·2008·Proceedings of the National Academy of Sciences
DOI 10.1073/pnas.0802917105
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Abstract

The identification of new pharmacological approaches to effectively prevent, treat, and cure the metabolic syndrome is of crucial importance. Excessive exposure to dietary lipids causes inflammatory responses, deranges the homeostasis of cellular metabolism, and is believed to constitute a key initiator of the metabolic syndrome. Mammalian Sirt1 is a protein deacetylase that has been involved in resveratrol-mediated protection from high-fat diet-induced metabolic damage, but direct proof for the implication of Sirt1 has remained elusive. Here, we report that mice with moderate overexpression of Sirt1 under the control of its natural promoter exhibit fat mass gain similar to wild-type controls when exposed to a high-fat diet. Higher energy expenditure appears to be compensated by a parallel increase in food intake. Interestingly, transgenic Sirt1 mice under a high-fat diet show lower lipid-induced inflammation along with better glucose tolerance, and are almost entirely protected from hepatic steatosis. We present data indicating that such beneficial effects of Sirt1 are due to at least two mechanisms: induction of antioxidant proteins MnSOD and Nrf1, possibly via stimulation of PGC1α, and lower activation of proinflammatory cytokines, such as TNFα and IL-6, via down-modulation of NFκB activity. Together, these results provide direct proof of the protective potential of Sirt1 against the metabolic consequences of chronic exposure to a high-fat diet.

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Crossref · 10.1073/pnas.0802917105

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  • Knockdown or knockout of SIRT1 in the mouse liver or transgenic overexpression of SIRT1 in mice results in altered lipid/cholesterol levels in serum and the liver.

    “knockdown or knockout of SIRT1 in the mouse liver or transgenic overexpression of SIRT1 in mice results in altered lipid/cholesterol levels in serum and the liver (Li et al. 2007;Rodgers and Puigserver 2007;Pfluger et al. 2008;Erion et al. 2009;Purushotham et al. 2009).”

    From Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP (2010) · cites this paper as Pfluger et al. 2008

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Research works printed but not linked: 28

  1. 10.1210/er.2006-0041 · DOI
  2. 10.1038/nrd2136 · DOI
  3. 10.1016/j.cell.2007.04.001 · DOI
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  10. 10.1007/s00018-006-6192-6 · DOI
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  19. 10.1038/nrd2060 · DOI · Paper page
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Metadata

Authors
Pfluger, P. T., Herranz, D., Velasco-Miguel, S., Serrano, M., & Tschöp, M. H.
Affiliations
  • *Department of Psychiatry, Obesity Research Center, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45237; and
  • Spanish National Cancer Research Center (CNIO), 28029 Madrid, Spain
Venue
Proceedings of the National Academy of Sciences
Publisher
National Academy of Sciences
Published
2008-07-15
Volume
105
Issue
28
Pages
9793-9798
ISSN
  • 0027-8424
  • 1091-6490
DOI
10.1073/pnas.0802917105
Cited by
818
References
15
Language
en

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