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The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Hepatocyte-Specific Deletion of SIRT1 Alters Fatty Acid Metabolism and Results in Hepatic Steatosis and Inflammation

Purushotham, Aparna, Schug, Thaddeus T., Xu, Qing, Surapureddi, Sailesh, Guo, Xiumei, Li, Xiaoling·2009·Cell Metabolism
DOI 10.1016/j.cmet.2009.02.006PMC PMC2668535
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Crossref · 10.1016/j.cmet.2009.02.006

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  • Sirt1 regulates plasma LDL-cholesterol.

    “These studies suggest that Sirt1 regulates plasma LDL-cholesterol.”

    From The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression (2015) · cites this paper as [7]

    The Results section reports higher liver cholesterol in SIRT1-deficient mice, and the Discussion describes altered hepatic cholesterol metabolism. Those passages support a role for SIRT1 in cholesterol metabolism, but they do not establish regulation of plasma LDL-cholesterol; the Methods mention measuring serum cholesterol, not LDL-cholesterol specifically. Page numbers are unavailable in our copy. (LLM, conf=0.82)

    Experimental — accuracy not yet measured

  • Hepatic deletion of Sirt1 in C57BL/6 mice fed a high-cholesterol diet induced mild hypercholesterolemia.

    “Hepatic deletion of Sirt1 in C57BL/6 mice fed a high-cholesterol diet induced mild hypercholesterolemia.7”

    From The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression (2015) · cites this paper as [7]

    The Animal experiments section describes liver-specific SIRT1 knockout mice on a C57BL/6 background, and the Results describe feeding them a western diet containing cholesterol. The Results and Discussion report increased cholesterol in the liver, but do not establish the claimed mild hypercholesterolemia (elevated blood cholesterol). No page numbers are available in our copy. (LLM, conf=0.84)

    Experimental — accuracy not yet measured

  • In primary hepatocytes from SIRT1 LKO mice, nuclear SREBP-1c levels increase when SIRT1 is absent.

    “we performed immunofluorescence studies on primary hepatocytes isolated from wild-type or SIRT1 LKO mice (Purushotham et al. 2009), and found that, similar to SREBP-1a and SREBP-2, nuclear SREBP-1c levels increased when SIRT1 was absent (Fig. 6C).”

    From Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP (2010) · cites this paper as Purushotham et al. 2009

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Citations

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Metadata

Authors
Purushotham, A., Schug, T. T., Xu, Q., Surapureddi, S., Guo, X., & Li, X.
Venue
Cell Metabolism
Publisher
Elsevier BV
Published
2009-04
Volume
9
Issue
4
Pages
327-338
ISSN
1550-4131
DOI
10.1016/j.cmet.2009.02.006
PMC
PMC2668535
Cited by
1,003
References
15
Language
en
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