CoChat
Sign Up
Cited by 89Fatty Acid Research and HealthInflammatory mediators and NSAID effectsExercise and Physiological Responses

Effects of dietary arachidonic acid on human immune response

Kelley, Darshan S., Taylor, Peter C., Nelson, Gary J., Schmidt, Perla C., Mackey, Bruce E., Kyle, David·1997·Lipids
DOI 10.1007/s11745-997-0059-3
Open this paper in CoChat — free account

Abstract

Arachidonic acid (AA) is a precursor of eicosanoids, which influence human health and the in vitro activity of immune cells. We therefore examined the effects of dietary AA on the immune response (IR) of 10 healthy men living at our metabolic suite for 130 d. All subjects were fed a basal diet containing 27 energy percentage (en%) fat, 57 en% carbohydrate, and 16 en% protein (AA, 200 mg/d) for the first and last 15 d of the study. Additional AA (1.5 g/d) was incorporated into the diet of six men from day 16 to 65 while the remaining four subjects continued to eat the basal diet. The diets of the two groups were crossed-over from day 66 to 115. In vitro indexes of IR were examined using the blood samples drawn on days 15, 58, 65, 108, 115, and 127. The subjects were immunized with the measles/mumps/rubella vaccine on day 35 and with the influenza vaccine on day 92. Dietary AA did not influence many indexes of IR (peripheral blood mononuclear cell proliferation in response to phytohemagglutinin, Concanavalin A, pokeweed, measles/mumps/rubella, and influenza vaccines prior to immunization, and natural killer cell activity). The post-immunization proliferation in response to influenza vaccine was about fourfold higher in the group receiving high-AA diet compared to the group receiving low-AA diet (P = 0.02). Analysis of variance of the data pooled from both groups showed that the number of circulating granulocytes was significantly (P = 0.03) more when the subjects were fed the high-AA diet than when they were fed the low-AA diet. The small increases in granulocyte count and the in vitro proliferation in response to influenza vaccine caused by dietary AA may not be of clinical significance. However, the lack of any adverse effects on IR indicates that supplementation with AA may be done safely when needed for other health reasons.

Integrity signals

Registry

Crossref · 10.1007/s11745-997-0059-3

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Several training interventions did not change basal IL-6 or CRP concentrations.

    “Several training interventions have not produced changes in basal IL-6 or CRP concentrations (213 -218) , while significant reductions in inflammatory markers have been observed following training without changes in BMI or body fat in elderly participants (219,220) .”

    From Dietary factors and low-grade inflammation in relation to overweight and obesity (2011) · cites this paper as [216]

  • Eicosanoids derived from n-3 PUFAs are less biologically active than n-6 PUFAs and have weaker affinity for eicosanoid receptors.

    “This divergent behaviour is due to the fact that eicosanoids derived from n-3 PUFAs are less biologically active than n-6 PUFAs, and possess a weaker affinity for eicosanoid receptors [63,64,65].”

    From Potential Roles of n-3 PUFAs during Skeletal Muscle Growth and Regeneration (2018) · cites this paper as [63]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Kelley, D. S., Taylor, P. C., Nelson, G. J., Schmidt, P. C., Mackey, B. E., & Kyle, D.
Affiliations
  • Agricultural Research Service (US)
  • Western Human Nutrition ARS, USDA P.O. Box 29997, Presidio of San Francisco CAResearch Center 94129
ORCID
Venue
Lipids
Publisher
Wiley
Published
1997-04
Volume
32
Issue
4
Pages
449-456
ISSN
  • 0024-4201 (ISSN-L)
  • 1558-9307
DOI
10.1007/s11745-997-0059-3
OpenAlex
W2015958613
Cited by
89
References
36
Citations by year
2026: 2 · 2023: 1 · 2022: 4 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 4 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 3
FWCI
6.03
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Lipids (publishedVersion)
  • PubMed (publishedVersion)
Funders
University of California, Davis
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords
arachidonic acid, dietary supplementation, immune response, eicosanoids, peripheral blood mononuclear cell proliferation, NK cell cytotoxicity, MMR vaccine, granulocyte count, phytohemagglutinin, concanavalin A, Phytolacca americana, healthy men
MeSH terms
Adult, Antibody Formation, Cell Division, Cells, Cultured, Dietary Fats, Fatty Acids, Food, Fortified, Humans, Hypersensitivity, Delayed, Killer Cells, Natural, Lymphocytes, Male, Phenotype, Arachidonic Acid, Lymphocyte Count

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review