Omega-6 Fatty Acids and Risk for Cardiovascular Disease: A Science Advisory From the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention
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There was little evidence of effect modification by circulating ω-6 PUFAs (LA or AA).
“We also found little evidence of effect modification by circulatingω-6 PUFAs (LA or AA), which have been hypothesized but never found in humans to reduce cardiovascular benefits of ω-3 PUFAs.55”
From ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease: Pooling Project of 19 Cohort Studies (2016) · cites this paper as [55]
Not enough data are available to make a recommendation regarding optimal n-3:n-6 fatty acid ratio.
“Not enough data are available to make a recommendation regarding the optimal n-3:n-6 fatty acid ratio.182,183”
From 2016 ESC/EAS Guidelines for the Management of Dyslipidaemias (2016) · cites this paper as [182]
LA appears to have anti-inflammatory and insulin-sensitizing effects.
“Indeed, LA appears to have anti-inflammatory and insulin-sensitizing effects.363-365”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [364]
Both n-3 and n-6 polyunsaturated fats are beneficial, little interaction between them is evident, and their ratio is not a practical metric to evaluate health effects.
“Because both n-3 and n-6 polyunsaturated fats are beneficial, little interaction between them is evident, and their ratio is not a practical metric to evaluate health effects.364, 374”
From Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review (2016) · cites this paper as [364]
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Self-citation
- Authors
- Harris, W. S., Mozaffarian, D., Rimm, E., Kris-Etherton, P., Rudel, L. L., Appel, L. J., Engler, M. M., Engler, M. B., & Sacks, F.
- ORCID
- Venue
- Circulation
- Published
- 2009-02-17
- Volume
- 119
- Issue
- 6
- Pages
- 902-907
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2105953302
- Cited by
- 794
- References
- 79
- Citations by year
- 2026: 22 · 2025: 34 · 2024: 25 · 2023: 28 · 2022: 27 · 2021: 44 · 2020: 49 · 2019: 31 · 2018: 48 · 2017: 52 · 2016: 44 · 2015: 53 · 2014: 69 · 2013: 68 · 2012: 60
- FWCI
- 63.57
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- omega-6 fatty acids, cardiovascular risk, dietary fatty acids, polyunsaturated fatty acids
- MeSH terms
- American Heart Association, Cardiovascular Diseases, Dose-Response Relationship, Drug, Humans, Risk, United States, Fatty Acids, Omega-6
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