The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Incorporation of n‐3 fatty acids into plasma lipid fractions, and erythrocyte membranes and platelets during dietary supplementation with fish, fish oil, and docosahexaenoic acid‐rich oil among healthy young men
Abstract
The effects of n‐3 fatty acid supplementation in the form of fresh fish, fish oil, and docosahexaenoic acid (DHA) oil on the fatty acid composition of plasma lipid fractions, and platelets and erythrocyte membranes of young healthy male students were examined. Altogether 59 subjects (aged 19–32 yr, body mass index 16.8–31.3 kg/m 2) were randomized into the following diet groups: (i) control group; (ii) fish diet group eating fish meals five times per week [0.38±0.04 g eicosapentaenoic acid (EPA) and 0.67±0.09 g DHA per day]; (iii) DHA oil group taking algae‐derived DHA oil capsules (1.68 g/d DHA oil group taking algae‐derived DHA oil capsules (1.68 g/d DHA in triglyceride form); and (iv) fish oil group (1.33 g EPA and 0.95 g DHA/d as free fatty acids) for 14 wk. The fatty acid composition of plasma lipids, platelets, and erythrocyte membranes was analyzed by gas chromatography. The subjects kept 4‐d food records four times during the study to estimate the intake of nutrients. In the fish diet, in DHA oil, and in fish oil groups, the amounts of n‐3 fatty acids increased and those of n‐6 fatty acids decreased significantly in plasma lipid fractions and in platelets and erythrocyte membranes. A positive relationship was shown between the total n‐3 polyunsaturated fatty acids (PUFA) and EPA and DHA intake and the increase in total n‐3 PUFA and EPA and DHA in all lipid fractions analyzed. DHA was preferentially incorporated into phospholipid (PL) and triglyceride (TG) and there was very little uptake in cholesterol ester (CE), while EPA was preferentially incorporated into PL and CE. The proportion of EPA in plasma lipids and platelets and erythrocyte membranes increased also by DHA supplementation, and the proportion of linoleic acid increased in platelets and erythrocyte membranes in the DHA oil group as well. These results suggest retroconversion of DHA to EPA and that DHA also interferes with linoleic acid metabolism.
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“Dietary DHA is preferentially esterified into TGs”
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“while EPA is more evenly esterified into TGs, cholesterol esters and phospholipids.”
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Cites
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Distribution, interconversion, and dose response of n-3 fatty acids in humans.
Arterburn, L. M., Hall, E. B., & Oken, H. (2006) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.6.1467s · Cited by 1,162
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Metadata
- Authors
- Vidgren, H. M., Ågren, J. J., Schwab, U., Rissanen, T., Hänninen, O., & Uusitupa, M. I. J.
- Affiliations
- University of Eastern Finland (FI)
- Department of Physiology University of Kuopio Kuopio Finland
- Corresponding author
- Vidgren, Helvi M.
- Venue
- Lipids
- Publisher
- Wiley
- Published
- 1997-07
- Volume
- 32
- Issue
- 7
- Pages
- 697-705
- ISSN
- 0024-4201 (ISSN-L)
- 1558-9307
- OpenAlex
- W2047504901
- Cited by
- 236
- References
- 44
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 1 · 2021: 5 · 2020: 5 · 2019: 13 · 2018: 8 · 2017: 8 · 2016: 11 · 2015: 10 · 2014: 15 · 2013: 11 · 2012: 17
- FWCI
- 4.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Lipids (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Academy of Finland
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- omega-3 fatty acids, docosahexaenoic acid, eicosapentaenoic acid, fish oil, fish diet, dietary supplementation, erythrocyte membrane, platelets, phospholipids, triglycerides, cholesterol esters, linoleic acid metabolism, retroconversion, omega-6 fatty acids, young men
- MeSH terms
- Adult, Animals, Blood Platelets, Cholesterol Esters, Dietary Fats, Docosahexaenoic Acids, Eating, Erythrocyte Membrane, Fatty Acids, Fish Oils, Fishes, Food, Fortified, Humans, Lipids, Male, Phospholipids, Triglycerides, Eicosapentaenoic Acid, Fatty Acids, Omega-3
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