Cited by 84Iron Metabolism and DisordersLipid metabolism and biosynthesisTrace Elements in Health

Different degrees of moderate iron deficiency modulate lipid metabolism of rats

Stangl, Gabriele I., Kirchgessner, Manfred·1998·Lipids

Abstract

Severe iron deficiency affects lipid metabolism. To investigate whether moderate iron depletion also alters lipid variables-including lipid levels in serum and liver, hepatic lipogenesis, and fatty acid composition indicative of an impaired desaturation-we carried out experiments with rats fed 9, 13, and 18 mg iron/kg diet over a total of 5 wk. The study also included three pair-fed control groups and an ad libitum control group, fed with 50 mg iron/kg diet. The iron-depleted rats were classified as iron-deficient on the basis of reduced serum iron, hemoglobin concentration, and hematocrit. All moderately iron-deficient rats had significantly lower cholesterol concentrations in liver and serum lipoproteins than their pair-fed controls. Rats with the lowest dietary iron supply had higher concentrations of hepatic phosphatidylcholine (PC) and phosphatidylethanolamine (PE), lower activities of glucose-6-phosphate dehydrogenase, malic enzyme and fatty acid synthase, and higher triacylglycerol concentrations in serum lipoproteins than the corresponding pair-fed control rats. Moderate iron deficiency also depressed the serum phospholipid level. Moreover, several consistent significant differences in fatty acid composition of hepatic PC and PE occurred within moderate iron deficiency, which indicate impaired desaturation by delta-9 and delta-6 desaturases of saturated and essential fatty acids. We conclude that lipid variables, including cholesterol in liver and serum lipoproteins as well as fatty acid desaturation, reflect the gradations of iron status best and can be used as an indicator of the degree of moderate iron deficiency.

Integrity signals

Registry

Crossref · 10.1007/s11745-998-0285-8

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Stangl, G. I., & Kirchgessner, M.
Affiliations
Technical University of Munich (DE)
Corresponding author
Stangl, Gabriele I.
Venue
Lipids
Publisher
Wiley
Published
1998-09
Volume
33
Issue
9
Pages
889-895
ISSN
  • 0024-4201 (ISSN-L)
  • 1558-9307
OpenAlex
W2025996961
Cited by
84
References
38
Citations by year
2026: 4 · 2025: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2021: 5 · 2020: 3 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 6 · 2014: 7 · 2013: 3 · 2012: 7
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Locations
  • Lipids (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
lipid metabolism, hepatic lipogenesis, fatty acid desaturation, delta-9 desaturase, delta-6 desaturase, serum cholesterol, hepatic phospholipids, phosphatidylcholine, phosphatidylethanolamine, triglycerides, fatty acid composition, dietary iron restriction
MeSH terms
Iron Deficiencies, Animals, Fatty Acids, Lipids, Lipoproteins, Liver, Male, Phospholipids, Weight Gain, Rats, Sprague-Dawley, Lipid Metabolism, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review