The DOI matches its Crossref record; 118 of the 119 references it cites were found in a registry or an index.
Skin Barrier Defects in Atopic Dermatitis
Open accessAbstract
Atopic dermatitis (AD) is a chronic inflammatory skin condition with complex etiology that is dependent upon interactions between the host and the environment. Acute skin lesions exhibit the features of a Th2-driven inflammatory disorder, and many patients are highly atopic. The skin barrier plays key roles in immune surveillance and homeostasis, and in preventing penetration of microbial products and allergens. Defects that compromise the structural integrity or else the immune function of the skin barrier play a pivotal role in the pathogenesis of AD. This article provides an overview of the array of molecular building blocks that are essential to maintaining healthy skin. The basis for structural defects in the skin is discussed in relation to AD, with an emphasis on filaggrin and its genetic underpinnings. Aspects of innate immunity, including the role of antimicrobial peptides and proteases, are also discussed.
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“One of the main genetic factors associated with AD is the mutation in the FLG gene, which produces function impairment leading to a compromised skin barrier.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [49]
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Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
Soumelis, V., Reche, P. A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M. F., Ho, S., Antonenko, S. V., Lauerma, A., et al. (2002) · Nature Immunology · doi:10.1038/ni805 · Cited by 2,221
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
Filaggrin Mutations Associated with Skin and Allergic Diseases
Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011040 · Cited by 1,217
Cytokine modulation of atopic dermatitis filaggrin skin expression
Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084
Imokawa, G., Abe, A., Jin, K., Higaki, Y., Kawashima, M., & Hidano, A. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470233 · Cited by 1,040
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
Smith, F. J. D., Irvine, A. D., Terron-Kwiatkowski, A., Sandilands, A., Campbell, L., Zhao, Y., Liao, H., Evans, A. T., Goudie, D. R., Lewis‐Jones, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1743 · Cited by 1,026
Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome
Chavanas, S., Bodemer, C., Rochat, A., Hamel‐Teillac, D., Ali, M., Irvine, A. D., Bonafé, J., WILKINSON, J. D., Taı̈eb, A., Barrandon, Y., et al. (2000) · Nature Genetics · doi:10.1038/75977 · Cited by 851
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
Fortini, M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm910 · Cited by 827
Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions
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Items 201–201 of 201
Ahn, Y., Gu, M. J., Park, H.-Y., Baek, S. J., Jeong, S. U., Ha, S. K., & 김동환 (2026) · Pharmaceutical Biology · doi:10.1080/13880209.2026.2748088
Metadata
- Authors
- Agrawal, R., & Woodfolk, J. A.
- Affiliations
- University of Virginia Health System (US)
- Corresponding author
- Woodfolk, Judith A.
- ORCID
- Woodfolk, Judith A.
- Venue
- Current Allergy and Asthma Reports
- Published
- 2014-03-16
- Volume
- 14
- Issue
- 5
- Pages
- 433-433
- ISSN
- 1529-7322 (ISSN-L)
- 1534-6315
- PMC
- PMC4034059
- OpenAlex
- W2070316318
- Cited by
- 201
- References
- 119
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 29 · 2023: 13 · 2022: 18 · 2021: 31 · 2020: 22 · 2019: 14 · 2018: 15 · 2017: 16 · 2016: 6 · 2015: 8 · 2014: 3
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Current Allergy and Asthma Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI052196)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059058)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- atopic dermatitis, skin barrier, filaggrin, type 2 inflammation, innate immunity, antimicrobial peptides, proteolytic enzymes, skin barrier dysfunction, atopy, host-environment interactions
- MeSH terms
- Filaggrin Proteins, Animals, Dermatitis, Atopic, Humans, Lipid Bilayers, Peptide Hydrolases, Protease Inhibitors, Skin, Tight Junctions
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