The DOI matches its Crossref record; 118 of the 119 references it cites were found in a registry or an index.
Skin Barrier Defects in Atopic Dermatitis
Open accessAbstract
Atopic dermatitis (AD) is a chronic inflammatory skin condition with complex etiology that is dependent upon interactions between the host and the environment. Acute skin lesions exhibit the features of a Th2-driven inflammatory disorder, and many patients are highly atopic. The skin barrier plays key roles in immune surveillance and homeostasis, and in preventing penetration of microbial products and allergens. Defects that compromise the structural integrity or else the immune function of the skin barrier play a pivotal role in the pathogenesis of AD. This article provides an overview of the array of molecular building blocks that are essential to maintaining healthy skin. The basis for structural defects in the skin is discussed in relation to AD, with an emphasis on filaggrin and its genetic underpinnings. Aspects of innate immunity, including the role of antimicrobial peptides and proteases, are also discussed.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“One of the main genetic factors associated with AD is the mutation in the FLG gene, which produces function impairment leading to a compromised skin barrier.”
From Update on the pathogenesis of atopic dermatitis. (2024) · cites this paper as [49]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Palmer, C. N. A., Irvine, A. D., Terron-Kwiatkowski, A., Zhao, Y., Liao, H., Lee, S. P., Goudie, D. R., Sandilands, A., Campbell, L. E., Smith, F. J. D., et al. (2006) · Nature Genetics · doi:10.1038/ng1767 · Cited by 2,978
Human epithelial cells trigger dendritic cell–mediated allergic inflammation by producing TSLP
Soumelis, V., Reche, P. A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M. F., Ho, S., Antonenko, S. V., Lauerma, A., et al. (2002) · Nature Immunology · doi:10.1038/ni805 · Cited by 2,221
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
Filaggrin Mutations Associated with Skin and Allergic Diseases
Irvine, A. D., McLean, W. H. I., & Leung, D. Y. M. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1011040 · Cited by 1,217
Cytokine modulation of atopic dermatitis filaggrin skin expression
Howell, M. D., Kim, B. E., Gao, P., Grant, A. V., Boguniewicz, M., DeBenedetto, A., Schneider, L., Beck, L. A., Barnes, K. C., & Leung, D. Y. M. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2007.04.031 · Cited by 1,084
Imokawa, G., Abe, A., Jin, K., Higaki, Y., Kawashima, M., & Hidano, A. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12470233 · Cited by 1,040
Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris
Smith, F. J. D., Irvine, A. D., Terron-Kwiatkowski, A., Sandilands, A., Campbell, L., Zhao, Y., Liao, H., Evans, A. T., Goudie, D. R., Lewis‐Jones, S., et al. (2006) · Nature Genetics · doi:10.1038/ng1743 · Cited by 1,026
Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome
Chavanas, S., Bodemer, C., Rochat, A., Hamel‐Teillac, D., Ali, M., Irvine, A. D., Bonafé, J., WILKINSON, J. D., Taı̈eb, A., Barrandon, Y., et al. (2000) · Nature Genetics · doi:10.1038/75977 · Cited by 851
γ-Secretase-mediated proteolysis in cell-surface-receptor signalling
Fortini, M. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm910 · Cited by 827
Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions
Wan, H., Winton, H. L., Soeller, C., Tovey, E. R., Gruenert, D. C., Thompson, P. J., Stewart, G. A., Taylor, G. W., Garrod, D. R., Cannell, M. B., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5844 · Cited by 775
Cited by
Sorted by citations
He, H., Suryawanshi, H., Morozov, P. S., Gay-Mimbrera, J., DUCA, E. D., Kim, H. J., Kameyama, N., Estrada, Y. D., Der, E. B., Krueger, J. G., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.01.042 · Cited by 510
Czarnowicki, T., Krueger, J. G., & Guttman‐Yassky, E. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.04.004 · Cited by 265
The skin microbiome of vertebrates
Stegelmeier, A. A., Hoffmann, A. R., & Neufeld, J. D. (2019) · Microbiome · doi:10.1186/s40168-019-0694-6 · Cited by 240
Esaki, H., Ewald, D. A., Ungar, B., Rozenblit, M., Zheng, X., Xu, H., Estrada, Y. D., Peng, X., Mitsui, H., Litman, T., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2014.10.037 · Cited by 220
Skin Barrier Damage and Itch: Review of Mechanisms, Topical Management and Future Directions
Yosipovitch, G., Misery, L., Proksch, E., Metz, M., Ständer, S., & Schmelz, M. (2019) · Acta Dermato Venereologica · doi:10.2340/00015555-3296 · Cited by 185
The IL-4, IL-13 and IL-31 pathways in atopic dermatitis
Dubin, C., DUCA, E. D., & Guttman-Yassky, E. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1940962 · Cited by 197
The epithelial barrier theory and its associated diseases
Sun, N., Öğülür, İ., Mitamura, Y., Yazıcı, D., Pat, Y., Bu, X., Li, M., Zhu, X., Babayev, H., Ardıçlı, S., et al. (2024) · Allergy · doi:10.1111/all.16318 · Cited by 190
He, H., Olesen, C. M., Pavel, A. B., Clausen, M., Wu, J., Estrada, Y. D., Zhang, N., Agner, T., & Guttman‐Yassky, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01768 · Cited by 136
Mild atopic dermatitis lacks systemic inflammation and shows reduced nonlesional skin abnormalities
He, H., DUCA, E. D., Diaz, A., Kim, H. J., Gay-Mimbrera, J., Zhang, N., Wu, J., Beaziz, J., Estrada, Y. D., Krueger, J. G., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.08.041 · Cited by 127
Skin barrier in atopic dermatitis: beyond filaggrin
Zaniboni, M. C., Samorano, L. P., Orfali, R. L., & Aoki, V. (2016) · Anais Brasileiros de Dermatologia · doi:10.1590/abd1806-4841.20164412 · Cited by 123
Overcome the barriers of the skin: exosome therapy
Yang, G. H., Lee, Y. B., Kang, D., Choi, E.-J., Nam, Y., Lee, K. H., You, H., Kang, H. J., An, S., & Jeon, H. (2021) · Biomaterials Research · doi:10.1186/s40824-021-00224-8 · Cited by 126
Der p 11 Is a Major Allergen for House Dust Mite-Allergic Patients Suffering from Atopic Dermatitis
Banerjee, S., Resch, Y., Chen, K., Swoboda, I., Focke-Tejkl, M., Blatt, K., Novak, N., Wickman, M. C., van Hage, M., Ferrara, R., et al. (2014) · Journal of Investigative Dermatology · doi:10.1038/jid.2014.271 · Cited by 107
Emollient treatment of atopic dermatitis: latest evidence and clinical considerations
Hon, K. E., Kung, J. S. C., Ng, W. G. G., & Leung, T. F. (2018) · Drugs in Context · doi:10.7573/dic.212530 · Cited by 112
Current Insights into Immunology and Novel Therapeutics of Atopic Dermatitis
Kader, H. A., Azeem, M., Jwayed, S. A., Al-Shehhi, A., Tabassum, A., Ayoub, M. A., Hetta, . F., Waheed, Y., Iratni, R., Aldhaheri, A., et al. (2021) · Cells · doi:10.3390/cells10061392 · Cited by 98
Tape Stripping Technique for Stratum Corneum Protein Analysis
Clausen, M., Slotved, H., Krogfelt, K. A., & Agner, T. (2016) · Scientific Reports · doi:10.1038/srep19918 · Cited by 87
Staphylococcal Biofilms in Atopic Dermatitis
Gonzalez, T., Myers, J. M. B., Herr, A. B., & Hershey, G. K. K. (2017) · Current Allergy and Asthma Reports · doi:10.1007/s11882-017-0750-x · Cited by 109
Kim, S. H., Seong, G.-S., & Choung, S. (2020) · Nutrients · doi:10.3390/nu12010249 · Cited by 81
Trends in Atopic Dermatitis—From Standard Pharmacotherapy to Novel Drug Delivery Systems
Souto, E. B., Dias-Ferreira, J., Oliveira, J., Sánchez‐López, E., López-Machado, A., Espina, M., García, M. L., Souto, S. B., Martins‐Gomes, C., & Silva, A. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225659 · Cited by 76
Comparative Analysis of the Microbiome across the Gut–Skin Axis in Atopic Dermatitis
Park, D. H., Kim, J. W., Park, H., & Hahm, D. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084228 · Cited by 82
Contribution of Malassezia spp. to the development of atopic dermatitis
Nowicka, D., & Nawrot, U. (2019) · Mycoses · doi:10.1111/myc.12913 · Cited by 74
The Initiation of Th2 Immunity Towards Food Allergens
Ellenbogen, Y., Jiménez‐Saiz, R., Spill, P., Chu, D. K., Waserman, S., & Jordana, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051447 · Cited by 71
Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis
Rinaldi, A. O., Korsfeldt, A., Ward, S., Burla, D., Dreher, A., Gautschi, M., Stolpe, B., Tan, G., Bersuch, E., Melin, D., et al. (2021) · Allergy · doi:10.1111/all.14842 · Cited by 69
JAK-STAT Inhibitors in Atopic Dermatitis from Pathogenesis to Clinical Trials Results
Szalus, K., Trzeciak, M., & Nowicki, R. J. (2020) · Microorganisms · doi:10.3390/microorganisms8111743 · Cited by 68
Oral Janus kinase inhibitors for atopic dermatitis
Mikhaylov, D., Ungar, B., Renert‐Yuval, Y., & Guttman‐Yassky, E. (2023) · Annals of Allergy Asthma & Immunology · doi:10.1016/j.anai.2023.01.020 · Cited by 66
Update on the pathogenesis of atopic dermatitis.
Criado, P. R., Miot, H. A., Bueno-Filho, R., Ianhez, M., Criado, R. F. J., & de Castro, C. C. S. (2024) · Anais brasileiros de dermatologia · doi:10.1016/j.abd.2024.06.001 · Cited by 66
Human organoid biofilm model for assessing antibiofilm activity of novel agents
Wu, B. C., Haney, E. F., Akhoundsadegh, N., Pletzer, D., Trimble, M. J., Adriaans, A. E., Nibbering, P. H., & Hancock, R. E. W. (2021) · npj Biofilms and Microbiomes · doi:10.1038/s41522-020-00182-4 · Cited by 63
Liew, W. C., Sundaram, G. M., Quah, S., Lum, G. G., Tan, J. S. L., Ramalingam, R., Common, J., Tang, M. B. Y., Lane, E. B., Thng, S. T. G., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.02.007 · Cited by 60
Gonzalez, T., Stevens, M. L., kyzy, A. B., Alarcón, R., He, H., Kroner, J. W., Spagna, D., Grashel, B., Sidler, E., Martin, L. J., et al. (2020) · Allergy · doi:10.1111/all.14489 · Cited by 59
Epigenetic regulation in the pathogenesis of non-melanoma skin cancer
Kashyap, M. P., Sinha, R., Mukhtar, M. S., & Athar, M. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.11.009 · Cited by 57
Dębińska, A. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10112506 · Cited by 52
Mikhaylov, D., DUCA, E. D., Olesen, C. M., He, H., Wu, J., Ungar, B., Estrada, Y. D., Zhang, N., Chowdhury, M., Clausen, M., et al. (2021) · Dermatitis · doi:10.1097/der.0000000000000764 · Cited by 49
Warners, M. J., Vlieg‐Boerstra, B., Verheij, J., van Hamersveld, P. H. P., van Rhijn, B. D., van Ampting, M. T. J., Harthoorn, L. F., de Jonge, W. J., Smout, A. J. P. M., & Bredenoord, A. J. (2017) · The American Journal of Gastroenterology · doi:10.1038/ajg.2017.107 · Cited by 49
van Bilsen, J. H. M., Sienkiewicz‐Szłapka, E., Lozano‐Ojalvo, D., Willemsen, L. E. M., Antunes, C. M., Molina, E., Smit, J. J., Wróblewska, B., Wichers, H. J., Knol, E. F., et al. (2017) · Clinical and Translational Allergy · doi:10.1186/s13601-017-0152-0 · Cited by 53
Immunological Aspects of Skin Aging in Atopic Dermatitis
Bocheva, G., Slominski, R. M., & Slominski, A. T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115729 · Cited by 53
Schell, S. L., Schneider, A. M., & Nelson, A. M. (2021) · Experimental Dermatology · doi:10.1111/exd.14398 · Cited by 46
In vivo expression of antimicrobial peptides in atopic dermatitis
Clausen, M., Slotved, H., Krogfelt, K. A., Andersen, P. S., & Agner, T. (2015) · Experimental Dermatology · doi:10.1111/exd.12831 · Cited by 44
Atopic dermatitis: pathogenesis and therapeutic intervention
Yue, C., Zhou, H., Wang, X., Yu, J., Hu, Y., Zhou, P., Zhao, F., Zeng, F., Li, G., Li, Y., et al. (2024) · MedComm · doi:10.1002/mco2.70029 · Cited by 52
Alalaiwe, A. S., Lin, Y., Lin, C.-H., Wang, P., Lin, J.-Y., & Fang, J. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.126955 · Cited by 42
Montenegro, L., Panico, A. M., Santagati, L. M., Siciliano, E. A., Intagliata, S., & Modica, M. N. (2018) · Nanomaterials · doi:10.3390/nano9010043 · Cited by 40
Ahn, S., An, S., Lee, M. Y., Lee, E., Pyo, J. J., Kim, J. H., Ki, M. W., Jin, S. H., Ha, J., & Noh, M. (2019) · Archives of Toxicology · doi:10.1007/s00204-019-02462-1 · Cited by 41
New and Emerging Therapies for Pediatric Atopic Dermatitis
Nguyen, H. L., Anderson, K., & Tollefson, M. M. (2019) · Pediatric Drugs · doi:10.1007/s40272-019-00342-w · Cited by 41
Döge, N., Avetisyan, A., Hadam, S., Pfannes, E. K. B., Rancan, F., Blume‐Peytavi, U., & Vogt, A. (2016) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2016.12.012 · Cited by 39
Pseudomonas Aeruginosa Theft Biofilm Require Host Lipids of Cutaneous Wound
Sinha, M., Ghosh, N., Wijesinghe, D. S., Mathew‐Steiner, S. S., Das, A., Singh, K., Masry, M. S. E., Khanna, S., Inoue, H., Yamazaki, K., et al. (2021) · Annals of Surgery · doi:10.1097/sla.0000000000005252 · Cited by 37
Guillot, A. J., Jornet-Mollá, E., Landsberg, N., Milián-Guimerá, C., Montesinos, M. C., Garrigues, T., & Melero, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13030418 · Cited by 37
Skabytska, Y., Kaesler, S., Volz, T., & Biedermann, T. (2015) · Seminars in Immunopathology · doi:10.1007/s00281-015-0544-y · Cited by 37
Lee, S. H., Bae, I., Choi, H., Choi, H. W., Oh, S., Marinho, P. A., Min, D. J., Kim, D.-Y., Lee, T. R., Lee, C. S., et al. (2018) · Archives of Dermatological Research · doi:10.1007/s00403-018-1883-z · Cited by 36
The Skin as a Route of Allergen Exposure: Part I. Immune Components and Mechanisms
Smith, A. R., Knaysi, G. A., Wilson, J. M., & Wiśniewski, J. (2017) · Current Allergy and Asthma Reports · doi:10.1007/s11882-017-0674-5 · Cited by 38
Topical therapy of atopic dermatitis with a focus on pimecrolimus
Luger, T. A., Paller, A. S., Irvine, A. D., Sidbury, R., Eichenfield, L. F., Werfel, T., & Bieber, T. R. M. (2021) · Journal of the European Academy of Dermatology and Venereology · doi:10.1111/jdv.17272 · Cited by 42
Schoos, A. M., Chawes, B., Bønnelykke, K., Stokholm, J., Rasmussen, M. A., & Bisgaard, H. F. (2021) · Allergy · doi:10.1111/all.15108 · Cited by 34
Targeting Interleukin 13 for the Treatment of Atopic Dermatitis
Lytvyn, Y., & Gooderham, M. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15020568 · Cited by 39
Nowicka, D., & Grywalska, E. (2018) · Analytical Cellular Pathology · doi:10.1155/2018/1956403 · Cited by 35
Nanocrystals for Improved Drug Delivery of Dexamethasone in Skin Investigated by EPR Spectroscopy
Lohan, S. B., Saeidpour, S., Colombo, M., Staufenbiel, S., Unbehauen, M. L., Wolde-Kidan, A., Netz, R. R., Bodmeier, R. A., Haag, R., Teutloff, C., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12050400 · Cited by 32
Rouaud, P., Boudier, D., Marchand, L., Barruche, V., Bordes, S., Coppin, H., Roth, M., & Closs, B. (2015) · British Journal of Dermatology · doi:10.1111/bjd.14012 · Cited by 31
2% Crisaborole topical ointment for the treatment of mild-to-moderate atopic dermatitis
Cheape, A. C., & Murrell, D. F. (2017) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2017.1304820 · Cited by 30
Kalailingam, P., Tan, H., Jain, N. K., Sng, M. K., Chan, J. S. K., Tan, N. S., & Thanabalu, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-07125-8 · Cited by 30
Verzeaux, L., Vyumvuhore, R., Boudier, D., Guillou, M. L., Bordes, S., Essendoubi, M., Manfait, M., & Closs, B. (2017) · Experimental Dermatology · doi:10.1111/exd.13388 · Cited by 29
Park, S. H., An, J. E., Jang, S., Kim, J. Y., Lee, J. W., & Kim, H. K. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.112015 · Cited by 29
Chemokines and Innate Lymphoid Cells in Skin Inflammation
Sun, Z., Vattepu, R., & Zhang, S. (2021) · Cells · doi:10.3390/cells10113074 · Cited by 29
Scratching damages tight junctions through the Akt–claudin 1 axis in atopic dermatitis
Hu, X., Tang, Y., Ju, Y., Zhang, X. Y., Yan, J.-Y., Wang, C., Yang, Y., Zhu, C., Tang, Z., Zhou, Y., et al. (2020) · Clinical and Experimental Dermatology · doi:10.1111/ced.14380 · Cited by 28
Potential of Tamanu (Calophyllum inophyllum) Oil for Atopic Dermatitis Treatment
Pribowo, A., Girish, J., Gustiananda, M., Nandhira, R. G., & Hartrianti, P. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6332867 · Cited by 32
Chen, L., Lin, K.-R., Chen, Y., Chiang, Y.-J., Ho, K.-C., Shen, L.-F., Song, I.-W., Liu, K.-M., Yang‐Yen, H., Chen, Y., et al. (2019) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2019.09.017 · Cited by 24
Evaluation of hand hygiene and onset of hand eczema after the outbreak of SARS-CoV-2 in Munich
Kendziora, B., Guertler, A., Ständer, L. M., Frey, S., French, L. E., Wollenberg, A., & Reinholz, M. (2020) · European Journal of Dermatology · doi:10.1684/ejd.2020.3923 · Cited by 25
In Vitro Effects of Dehydrotrametenolic Acid on Skin Barrier Function
Choi, E., Kang, Y., Hwang, S.-H., Kim, J. K., Hong, Y. D., Park, W.-S., Kim, D. H., Kim, E., & Cho, J. Y. (2019) · Molecules · doi:10.3390/molecules24244583 · Cited by 26
Ahn, H. S., Kim, H. J., Na, C., Jang, D. S., Shin, Y., & Lee, S. H. (2021) · Plants · doi:10.3390/plants10081669 · Cited by 24
Nugroho, W. T., Sawitri, S., Astindari, A., Utomo, B., Listiawan, M. Y., Ervianti, E., & Astari, L. (2023) · Indian Journal of Dermatology · doi:10.4103/ijd.ijd_991_22 · Cited by 24
Lin, L., Xie, M., Chen, X., Yu, Y., Liu, Y., Lei, K., Wang, D., Zeng, J., Zhou, J., Zhang, L., et al. (2018) · Experimental Dermatology · doi:10.1111/exd.13698 · Cited by 23
Animal Models of Allergic Diseases
Santoro, D., & Marsella, R. (2014) · Veterinary Sciences · doi:10.3390/vetsci1030192 · Cited by 23
Kim, H.-J., Lee, E., Lee, M. Y., Ahn, S., Kim, J.-M., Liu, J., Jin, S. H., Ha, J., Bae, I., Lee, T. R., et al. (2017) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2017.11.021 · Cited by 23
Kan, L. L., Li, P., Hon, S. S.-M., Lai, A. Y.-T., Li, A., Wong, K. C., Huang, D., & Wong, C. K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25136913 · Cited by 22
Chattopadhyay, D., Sinha, M., Kapoor, A., Kumar, M., Singh, K., Mathew‐Steiner, S. S., & Sen, C. K. (2024) · Scientific Reports · doi:10.1038/s41598-024-74426-0 · Cited by 21
Stabilization and Topical Skin Delivery of Framework Nucleic Acids using Ionic Liquids
Tanner, E. E. L., Wiraja, C., Curreri, C. A., Xu, C., & Mitragotri, S. (2020) · Advanced Therapeutics · doi:10.1002/adtp.202000041 · Cited by 21
The Role of Photoprotection in Optimizing the Treatment of Atopic Dermatitis
Piquero-Casals, J., Carrascosa, J., Morgado-Carrasco, D., Narda, M., Trullàs, C., Granger, C., & Fabbrocini, G. (2021) · Dermatologic Therapy · doi:10.1007/s13555-021-00495-y · Cited by 19
Fang, Y., Yang, S., Lee, C., Aljuffali, I. A., Kao, H.-C., & Fang, J. (2015) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2015.12.006 · Cited by 21
Mellett, M. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104147 · Cited by 22
Nowicka, D., Chilicka, K., & Dzieńdziora-Urbińska, I. (2022) · Pathogens · doi:10.3390/pathogens11010071 · Cited by 20
Prebiotics in atopic dermatitis prevention and management
Lee, Y. H., Verma, N. K., & Thanabalu, T. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104352 · Cited by 19
Park, S., Saw, S. N., Li, X., Paknezhad, M., Coppola, D., Dinish, U. S., Attia, A. B. E., Yew, Y. W., Thng, S. T. G., Lee, H. K., et al. (2021) · Biomedical Optics Express · doi:10.1364/boe.415105 · Cited by 21
Advanced In Vitro Three-Dimensional Skin Models of Atopic Dermatitis
Jang, H., Lee, J. B., & Yoon, J. (2023) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-023-00532-1 · Cited by 22
Wei, J., Gerlich, J., Vogelberg, C., von Mutius, E., Windstetter, D., Genuneit, J., Weinmayr, G., Nowak, D., & Radon, K. (2015) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-015-1078-2 · Cited by 17
The emerging role of skin microbiome in atopic dermatitis and its clinical implication
Stalder, J. ‐., Fluhr, J. W., Foster, T., Glatz, M., & Proksch, E. (2018) · Journal of Dermatological Treatment · doi:10.1080/09546634.2018.1516030 · Cited by 17
Grainyhead‐like transcription factors: guardians of the skin barrier
Deng, Z., Cangkrama, M., Butt, T., Jane, S. M., & Carpinelli, M. R. (2021) · Veterinary Dermatology · doi:10.1111/vde.12956 · Cited by 16
Kwon, Y., Kang, Y. J., Kwon, J., Cho, S., Kim, J., Le, T. T., Hwang, H., Deshar, B., Kim, M.-J., Kim, J. Y., et al. (2023) · Allergy · doi:10.1111/all.15967 · Cited by 16
Özdemіr, E., & Öksüz, L. (2024) · Archives of Microbiology · doi:10.1007/s00203-024-04134-w · Cited by 18
Kim, D. Y., Won, K., Hwang, D. I., Kim, N. Y., Kim, B., & Lee, H. M. (2022) · Molecules · doi:10.3390/molecules27051560 · Cited by 18
LGI 3 promotes human keratinocyte differentiation via the Akt pathway
Kim, I. W., Jeong, H., Kwon, N. S., Baek, K. J., Yun, H., & Kim, D. (2018) · Experimental Dermatology · doi:10.1111/exd.13766 · Cited by 16
Jang, A.-Y., Choi, J., Rod–in, W., Choi, K. Y., Lee, D.-H., & Park, W. J. (2024) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.2312.12002 · Cited by 15
Anagawa-Nakamura, A., Ryoke, K., Yasui, Y., Shoda, T., & Sugai, S. (2020) · Toxicologic Pathology · doi:10.1177/0192623320970896 · Cited by 15
Skin Barrier Dysfunction and the Atopic March
Clausen, M., Agner, T., & Thomsen, S. F. (2015) · Current Treatment Options in Allergy · doi:10.1007/s40521-015-0056-y · Cited by 15
Pelota Regulates Epidermal Differentiation by Modulating BMP and PI3K/AKT Signaling Pathways
Elkenani, M., Nyamsuren, G., Raju, P., Liakath‐Ali, K., Hamdaoui, A., Kata, A., Dressel, R., Klonisch, T. C., Watt, F. M., Engel, W., et al. (2016) · Journal of Investigative Dermatology · doi:10.1016/j.jid.2016.04.020 · Cited by 15
KLF feedback loops in innate immunity
Salmon, J. M., Adams, H. R., Magor, G. W., & Perkins, A. C. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1606277 · Cited by 13
Biological agents targeting interleukin-13 for atopic dermatitis
Chiricozzi, A., Gori, N., Maurelli, M., Gisondi, P., Caldarola, G., SIMONE, C. D., Peris, K., & Girolomoni, G. (2022) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2022.2035356 · Cited by 14
Hsa-mir-144-3p expression is increased in umbilical cord serum of infants with atopic dermatitis
Dissanayake, E., Inoue, Y., Ochiai, S., Eguchi, A., Nakano, T., Yamaide, F., Hasegawa, S., Kojima, H., Suzuki, H., Mori, C., et al. (2018) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2018.09.024 · Cited by 14
Brøgger, P., Blom, L. H., Simonsen, S., Thyssen, J. P., & Skov, L. (2019) · Scandinavian Journal of Immunology · doi:10.1111/sji.12835 · Cited by 14
Current and emerging biologics for the treatment of pediatric atopic dermatitis
Ghamrawi, R. I., Bell, K. A., Balogh, E. A., Strowd, L. C., & Feldman, S. R. (2020) · Expert Opinion on Biological Therapy · doi:10.1080/14712598.2021.1840548 · Cited by 14
Lee, H. R., Kim, T. H., Oh, S. H., & Lee, J. H. (2018) · Journal of Biomaterials Science Polymer Edition · doi:10.1080/09205063.2018.1477317 · Cited by 13
An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study
Afghani, J., Traidl‐Hoffmann, C., Schmitt‐Kopplin, P., Reiger, M., & Mueller, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23158791 · Cited by 13
Kim, Y., Cho, N., Cheon, S., & Kim, K. K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.08.120 · Cited by 13
zDHHC-Mediated S-Palmitoylation in Skin Health and Its Targeting as a Treatment Perspective
Abdulrahman, F. A., Benford, K. A., Lin, G., Maroun, A. J., Sammons, C., Shirzad, D. N., Tsai, H., Brunt, V. L. V., Jones, Z. W., Marquez, J. E., et al. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041673 · Cited by 13
Plessis, D., Gouws, C., & Nieto, D. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1391259 · Cited by 13
Singh, C. K., Mintie, C. A., Ndiaye, M. A., Chhabra, G., Roy, S., Sullivan, R., Longley, B. J., Schieke, S. M., & Ahmad, N. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1051472 · Cited by 12
Metadata
- Authors
- Agrawal, R., & Woodfolk, J. A.
- Affiliations
- University of Virginia Health System (US)
- Corresponding author
- Woodfolk, Judith A.
- ORCID
- Woodfolk, Judith A.
- Venue
- Current Allergy and Asthma Reports
- Published
- 2014-03-16
- Volume
- 14
- Issue
- 5
- Pages
- 433-433
- ISSN
- 1529-7322 (ISSN-L)
- 1534-6315
- PMC
- PMC4034059
- OpenAlex
- W2070316318
- Cited by
- 201
- References
- 119
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 29 · 2023: 13 · 2022: 18 · 2021: 31 · 2020: 22 · 2019: 14 · 2018: 15 · 2017: 16 · 2016: 6 · 2015: 8 · 2014: 3
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Current Allergy and Asthma Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI052196)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR059058)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- atopic dermatitis, skin barrier, filaggrin, type 2 inflammation, innate immunity, antimicrobial peptides, proteolytic enzymes, skin barrier dysfunction, atopy, host-environment interactions
- MeSH terms
- Filaggrin Proteins, Animals, Dermatitis, Atopic, Humans, Lipid Bilayers, Peptide Hydrolases, Protease Inhibitors, Skin, Tight Junctions
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
