The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Saturated Fatty Acids and Risk of Coronary Heart Disease: Modulation by Replacement Nutrients
Open accessAbstract
Despite the well-established observation that substitution of saturated fats for carbohydrates or unsaturated fats increases low-density lipoprotein (LDL) cholesterol in humans and animal models, the relationship of saturated fat intake to risk for atherosclerotic cardiovascular disease in humans remains controversial. A critical question is what macronutrient should be used to replace saturated fat. Substituting polyunsaturated fat for saturated fat reduces LDL cholesterol and the total cholesterol to high-density lipoprotein cholesterol ratio. However, replacement of saturated fat by carbohydrates, particularly refined carbohydrates and added sugars, increases levels of triglyceride and small LDL particles and reduces high-density lipoprotein cholesterol, effects that are of particular concern in the context of the increased prevalence of obesity and insulin resistance. Epidemiologic studies and randomized clinical trials have provided consistent evidence that replacing saturated fat with polyunsaturated fat, but not carbohydrates, is beneficial for coronary heart disease. Therefore, dietary recommendations should emphasize substitution of polyunsaturated fat and minimally processed grains for saturated fat.
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Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials
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Siri-Tarino, P. W., Sun, Q., Hu, F. B., & Krauss, R. M. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27725 · Cited by 1,253
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“Indeed, the polyunsaturated fat to saturated fat ratio has been strongly and inversely associated with CHD risk [56].”
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Cited by
de Souza, R. J., Mente, A., Maroleanu, A., Cozma, A. I., Ha, V., Kishibe, T., Uleryk, E., Budylowski, P., Schünemann, H., Beyene, J., et al. (2015) · BMJ · doi:10.1136/bmj.h3978 · Cited by 1,424
Gluten free diet and nutrient deficiencies: A review
Vici, G., Belli, L., Biondi, M., & Polzonetti, V. (2016) · Clinical Nutrition · doi:10.1016/j.clnu.2016.05.002 · Cited by 522
Mansoor, N., Vinknes, K. J., Veierød, M. B., & Retterstøl, K. (2016) · British Journal of Nutrition · doi:10.1017/s0007114515004699 · Cited by 439
Kratz, M., Baars, T., & Guyenet, S. (2013) · European Journal of Nutrition · doi:10.1007/s00394-012-0418-1 · Cited by 422
The western diet and lifestyle and diseases of civilization
Carrera-Bastos, P., Fontes, O'Keefe, Lindeberg, & Cordain (2011) · Research Reports in Clinical Cardiology · doi:10.2147/rrcc.s16919 · Cited by 342
Metadata
- Authors
- Siri-Tarino, P. W., Sun, Q., Hu, F. B., & Krauss, R. M.
- Venue
- Current Atherosclerosis Reports
- Published
- 2010-08-14
- Volume
- 12
- Issue
- 6
- Pages
- 384-390
- ISSN
- 1523-3804 (ISSN-L)
- 1534-6242
- OpenAlex
- W2129924014
- Cited by
- 407
- References
- 17
- FWCI
- 12.15
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Siri-Tarino, P. W., Sun, Q., Hu, F. B., & Krauss, R. M. (2010). Saturated Fatty Acids and Risk of Coronary Heart Disease: Modulation by Replacement Nutrients. Current Atherosclerosis Reports. https://doi.org/10.1007/s11883-010-0131-6
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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