Cited by 127Diabetes, Cardiovascular Risks, and LipoproteinsTreatment of Major DepressionTryptophan and brain disorders

Metabolic syndrome and major depressive disorder: Co-occurrence and pathophysiologic overlap

McIntyre, Roger S., Rasgon, Natalie L., Kemp, David E., Nguyen, Ha T., Law, Candy W. Y., Taylor, Valerie H., Woldeyohannes, Hanna O., Alsuwaidan, Mohammad T. +5 more·2009·Current Diabetes Reports

Abstract

The metabolic syndrome and its components are associated with depressive symptomatology. This article discusses the rate of co-occurrence and the points of pathophysiologic commonality between the metabolic syndrome and major depressive disorder.

Integrity signals

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Crossref · 10.1007/s11892-009-0010-0

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64 of 64 references verified0 citation errors · 0 not checkable

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  • Changes in appetite and energy balance may have negative effects on cognition because interference in the metabolism of glucose may lead to insulin resistance, abnormal neurotransmitter turnover, mitochondrial dysfunction, energy deficits, and changes in neural plasticity.

    “The pathways whereby this effect occurs are opaque; changes in appetite and energy balance may have negative effects on cognition because interference in the metabolism of glucose may lead to insulin resistance [84], abnormal neurotransmitter turnover, mitochondrial dysfunction, and energy deficits, as well as changes in neural plasticity [85].”

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Authors
McIntyre, R. S., Rasgon, N. L., Kemp, D. E., Nguyen, H. T., Law, C. W. Y., Taylor, V. H., Woldeyohannes, H. O., Alsuwaidan, M. T., Soczynska, J. K., Kim, B., Lourenco, M. T., Kahn, L. S., & Goldstein, B. I.
Affiliations
University Health Network (CA)
Corresponding author
McIntyre, Roger S.
Venue
Current Diabetes Reports
Published
2009-02
Volume
9
Issue
1
Pages
51-59
ISSN
  • 1534-4827 (ISSN-L)
  • 1539-0829
OpenAlex
W2105099085
Cited by
127
References
64
Citations by year
2026: 4 · 2025: 2 · 2024: 4 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 9 · 2017: 5 · 2016: 10 · 2015: 11 · 2014: 10 · 2013: 13 · 2012: 8
FWCI
1.75
Type
journal article
Language
en
Open access
closed
Locations
  • Current Diabetes Reports (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
metabolic syndrome, major depressive disorder, comorbidities, pathophysiology, depressive symptoms, insulin resistance, inflammation
MeSH terms
Bipolar Disorder, Depressive Disorder, Diseases in Twins, Female, Humans, Risk Factors, Oxidative Stress, Mood Disorders, Metabolic Syndrome

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