Metabolic syndrome and major depressive disorder: Co-occurrence and pathophysiologic overlap
Abstract
The metabolic syndrome and its components are associated with depressive symptomatology. This article discusses the rate of co-occurrence and the points of pathophysiologic commonality between the metabolic syndrome and major depressive disorder.
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Changes in appetite and energy balance may have negative effects on cognition because interference in the metabolism of glucose may lead to insulin resistance, abnormal neurotransmitter turnover, mitochondrial dysfunction, energy deficits, and changes in neural plasticity.
“The pathways whereby this effect occurs are opaque; changes in appetite and energy balance may have negative effects on cognition because interference in the metabolism of glucose may lead to insulin resistance [84], abnormal neurotransmitter turnover, mitochondrial dysfunction, and energy deficits, as well as changes in neural plasticity [85].”
From Cognitive remission: a novel objective for the treatment of major depression? (2016) · cites this paper as [84]
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- Authors
- McIntyre, R. S., Rasgon, N. L., Kemp, D. E., Nguyen, H. T., Law, C. W. Y., Taylor, V. H., Woldeyohannes, H. O., Alsuwaidan, M. T., Soczynska, J. K., Kim, B., Lourenco, M. T., Kahn, L. S., & Goldstein, B. I.
- Affiliations
- University Health Network (CA)
- Corresponding author
- McIntyre, Roger S.
- ORCID
- Venue
- Current Diabetes Reports
- Published
- 2009-02
- Volume
- 9
- Issue
- 1
- Pages
- 51-59
- ISSN
- 1534-4827 (ISSN-L)
- 1539-0829
- OpenAlex
- W2105099085
- Cited by
- 127
- References
- 64
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 4 · 2022: 6 · 2021: 5 · 2020: 4 · 2019: 4 · 2018: 9 · 2017: 5 · 2016: 10 · 2015: 11 · 2014: 10 · 2013: 13 · 2012: 8
- FWCI
- 1.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Diabetes Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- metabolic syndrome, major depressive disorder, comorbidities, pathophysiology, depressive symptoms, insulin resistance, inflammation
- MeSH terms
- Bipolar Disorder, Depressive Disorder, Diseases in Twins, Female, Humans, Risk Factors, Oxidative Stress, Mood Disorders, Metabolic Syndrome
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