Glia and immune cell signaling in bipolar disorder: insights from neuropharmacology and molecular imaging to clinical application
Open accessAbstract
Bipolar disorder (BD) is a debilitating mental illness characterized by severe fluctuations in mood, sleep, energy and executive functioning. Pharmacological studies of selective serotonin reuptake inhibitors and the monoamine system have helped us to clinically understand bipolar depression. Mood stabilizers such as lithium and valproic acid, the first-line treatments for bipolar mania and depression, inhibit glycogen synthase kinase-3 beta (GSK-3β) and regulate the Wnt pathway. Recent investigations suggest that microglia, the resident immune cells of the brain, provide a physiological link between the serotonin system and the GSK-3β/Wnt pathway through neuroinflammation. We review the pharmacological, translational and brain imaging studies that support a role for microglia in regulating neurotransmitter synthesis and immune cell activation. These investigations provide a model for microglia involvement in the pathophysiology and phenotype of BD that may translate into improved therapies.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activation of Gi-coupled pathways on pvMΦs via 5-HT1B receptors is a potential mechanism for the regulation of macrophage polarization and inflammatory responses by tonic 5-HT release within the DRN.
“Activation of Gi-coupled pathways on pvMΦs via 5-HT1B receptors is also a potential mechanism for the regulation of macrophage polarization and inflammatory responses by tonic 5-HT release within the DRN, which may be relevant to the increasing importance of neuroinflammatory pathways in the etiology of psychiatric disorders (Brisch et al., 2017; Howerton et al., 2014; Watkins et al., 2014).”
From Molecular and anatomical organization of the dorsal raphe nucleus (2019) · cites this paper as Watkins et al., 2014
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Kessler, R. C., Chiu, W. T., Demler, O., & Walters, E. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.6.617 · Cited by 12,052 · see citing works
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Inflammation and Its Discontents: The Role of Cytokines in the Pathophysiology of Major Depression
Miller, A. H., Maletic, V., & Raison, C. L. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.11.029 · Cited by 3,848 · see citing works
Anterior Cingulate Cortex, Error Detection, and the Online Monitoring of Performance
Carter, C. S., Braver, T. S., Barch, D. M., Botvinick, M. M., Noll, D., & Cohen, J. D. (1998) · Science · doi:10.1126/science.280.5364.747 · Cited by 3,273 · see citing works
The mechanisms of action of PPARs
Berger, J., & Moller, D. E. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.104018 · Cited by 2,659 · see citing works
A molecular mechanism for the effect of lithium on development.
Klein, P. S., & Melton, D. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.16.8455 · Cited by 2,305 · see citing works
Braissant, O., Foufelle, F., Scotto, C., Dauça, M., & Wahli, W. (1996) · Endocrinology · doi:10.1210/endo.137.1.8536636 · Cited by 2,217 · see citing works
Drevets, W. C., Price, J. L., & Furey, M. L. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0189-x · Cited by 2,209 · see citing works
Consensus Nomenclature for <i>in vivo</i> Imaging of Reversibly Binding Radioligands
Innis, R. B., Cunningham, V. J., Delforge, J., Fujita, M., Gjedde, A., Gunn, R. N., Holden, J., Houle, S., Huang, S.-C., Ichise, M., et al. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600493 · Cited by 1,955 · see citing works
Glial reduction in the subgenual prefrontal cortex in mood disorders
Öngür, D., Drevets, W. C., & Price, J. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13290 · Cited by 1,525 · see citing works
Papadopoulos, V., Baraldi, M., Guilarte, T. R., Knudsen, T. B., Lacapère, J.-J., Lindemann, P., Norenberg, M. D., Nutt, D., Weizman, A., Zhang, M.-R., et al. (2006) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2006.06.005 · Cited by 1,389 · see citing works
Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression
Goodwin, F. K., & Jamison, K. R. (2007) · Medical Entomology and Zoology · Cited by 1,325 · see citing works
The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar Depression
McGuffin, P., Rijsdijk, F., Andrew, M., Sham, P., Katz, R., & Cardno, A. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.5.497 · Cited by 1,243 · see citing works
Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
Felger, J. C., & Lotrich, F. E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.060 · Cited by 1,180 · see citing works
Genome Scan Meta-Analysis of Schizophrenia and Bipolar Disorder, Part II: Schizophrenia
Lewis, C. M., Levinson, D. F., Wise, L. H., DeLisi, L. E., Straub, R. E., Hovatta, I., Williams, N. M., Schwab, S. G., Pulver, A. E., Faraone, S. V., et al. (2003) · The American Journal of Human Genetics · doi:10.1086/376549 · Cited by 1,134 · see citing works
IL-1β is an essential mediator of the antineurogenic and anhedonic effects of stress
Koo, J. W., & Duman, R. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708092105 · Cited by 862 · see citing works
Straub, R. E., Jiang, Y., MacLean, C. J., Ma, Y., Webb, B. T., Myakishev, M. V., Harris‐Kerr, C., Wormley, B., Sadek, H., Kadambi, B., et al. (2002) · The American Journal of Human Genetics · doi:10.1086/341750 · Cited by 857 · see citing works
Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells
Rajkowska, G. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00950-1 · Cited by 822 · see citing works
Brain inflammation and adult neurogenesis: The dual role of microglia
Ekdahl, C. T., Kokaia, Z., & Lindvall, O. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.06.052 · Cited by 801 · see citing works
Subtype-Specific Alterations of γ-Aminobutyric Acid and Glutamatein Patients With Major Depression
Sanacora, G., Gueorguieva, R. V., Epperson, C. N., Wu, Y., Appel, M., Rothman, D. L., Krystal, J. H., & Mason, G. F. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.7.705 · Cited by 796 · see citing works
Owen, D. R., Yeo, A. J., Gunn, R. N., Song, K., Wadsworth, G., Lewis, A., Rhodes, C., Pulford, D. J., Bennacef, I., Parker, C. A., et al. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.147 · Cited by 779 · see citing works
Mao, Y., Ge, X., Frank, C. L., Madison, J. M., Koehler, A. N., Doud, M. K., Tassa, C., Berry-Scott, E., Soda, T., Singh, K. K., et al. (2009) · Cell · doi:10.1016/j.cell.2008.12.044 · Cited by 768 · see citing works
Whole-genome association study of bipolar disorder
Sklar, P. B., Smoller, J. W., Fan, J., Ferreira, M. A. R., Perlis, R. H., Chambert, K., Nimgaonkar, V. L., McQueen, M. B., Faraone, S. V., Kirby, A. W., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002151 · Cited by 691 · see citing works
Heyes, M. P., Saito, K., Crowley, J. S., DAVIS, L. E., Demitrack, M. A., Der, M. G., Dilling, L. A., Elia, J., Kruesi, M. J. P., Lackner, A. A., et al. (1992) · Brain · doi:10.1093/brain/115.5.1249 · Cited by 682 · see citing works
Kendler, K. S., Kuhn, J. W., Vittum, J., Prescott, C. A., & Riley, B. P. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.529 · Cited by 669 · see citing works
Collier, D. A., Stöber, G., Li, T., Heils, A., Catalano, M., Bella, D. D., Arranz, M. J., Murray, R. M., Vallada, H., Bengel, D., et al. (1996) · PubMed · Cited by 665 · see citing works
Geddes, J. R., Burgess, S., Hawton, K., Jamison, K., & Goodwin, G. M. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.217 · Cited by 661 · see citing works
Ichise, M., Liow, J., Lu, J., Takano, A., Modell, K. J., Toyama, H., Suhara, T., Suzuki, K., Innis, R. B., & Carson, R. E. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000085441.37552.ca · Cited by 651 · see citing works
Craddock, N. J., & Sklar, P. B. (2013) · The Lancet · doi:10.1016/s0140-6736(13)60855-7 · Cited by 635 · see citing works
Organization of the human serotonin transporter gene
Lesch, K., Balling, U., Groß, J., Strauss, K. M., Wolozin, B. L., Murphy, D. L., & Riederer, P. F. (1994) · Journal of Neural Transmission · doi:10.1007/bf01276434 · Cited by 628 · see citing works
Gliogenesis and Glial Pathology in Depression
Rajkowska, G., & Miguel-Hidalgo, J. J. (2007) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152707780619326 · Cited by 612 · see citing works
Rajkowska, G., Halaris, A. E., & Selemon, L. D. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01080-0 · Cited by 572 · see citing works
Steiner, J., Walter, M., Gos, T., Guillemin, G. J., Bernstein, H.-G., Sarnyai, Z., Mawrin, C., Brisch, R., Bielau, H., zu Schwabedissen, L., et al. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-94 · Cited by 568 · see citing works
Cytokines and psychopathology: Lessons from interferon-α
Capuron, L., & Miller, A. H. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.02.009 · Cited by 562 · see citing works
Zhu, C.-B., Blakely, R. D., & Hewlett, W. A. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301029 · Cited by 549 · see citing works
Kynurenine pathway in major depression: Evidence of impaired neuroprotection
Myint, A.-M., Kim, Y. K., Verkerk, R., Scharpé, S., Steinbusch, H., & Leonard, B. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.07.013 · Cited by 527 · see citing works
Inflammation and the Phenomenology, Pathophysiology, Comorbidity, and Treatment of Bipolar Disorder
Goldstein, B. I., Kemp, D. E., Soczynska, J. K., & McIntyre, R. S. (2009) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.08r04505 · Cited by 510 · see citing works
Low glial numbers in the amygdala in major depressive disorder
Bowley, M. P., Drevets, W. C., Öngür, D., & Price, J. L. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01404-x · Cited by 503 · see citing works
Bipolar and major depressive disorder: Neuroimaging the developmental-degenerative divide
Savitz, J., & Drevets, W. C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.01.004 · Cited by 494 · see citing works
Capuron, L., Ravaud, A., Neveu, P. J., Miller, A. H., Maes, M., & Dantzer, R. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4000995 · Cited by 473 · see citing works
Glial cell abnormalities in major psychiatric disorders: the evidence and implications
Cotter, D. R., Pariante, C. M., & Everall, I. P. (2001) · Brain Research Bulletin · doi:10.1016/s0361-9230(01)00527-5 · Cited by 465 · see citing works
Neural sensitivity to social rejection is associated with inflammatory responses to social stress
Slavich, G. M., Way, B. M., Eisenberger, N. I., & Taylor, S. E. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1009164107 · Cited by 418 · see citing works
O'Brien, W. T., Harper, A. D., Jove, F. A., Woodgett, J. R., Maretto, S., Piccolo, S., & Klein, P. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4753-03.2004 · Cited by 415 · see citing works
Endophenotypes in the Genetic Analyses of Mental Disorders
Cannon, T. D., & Keller, M. C. (2006) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.2.022305.095232 · Cited by 399 · see citing works
Tynan, R. J., Weidenhofer, J., Hinwood, M., Cairns, M. J., Day, T. A., & Walker, F. R. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.12.011 · Cited by 382 · see citing works
Brydon, L., Harrison, N. A., Walker, C., Steptoe, A., & Critchley, H. D. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.12.007 · Cited by 381 · see citing works
Role of GSK3β in behavioral abnormalities induced by serotonin deficiency
Beaulieu, J.-M., Zhang, X., Rodriguiz, R. M., Sotnikova, T. D., Cools, M. J., Wetsel, W. C., Gainetdinov, R. R., & Caron, M. G. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711496105 · Cited by 368 · see citing works
Mixed-Affinity Binding in Humans with 18-kDa Translocator Protein Ligands
Owen, D. R., Gunn, R. N., Rabiner, E. A., Bennacef, I., Fujita, M., Kreisl, W. C., Innis, R. B., Pike, V. W., Reynolds, R., Matthews, P. M., et al. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.110.079459 · Cited by 361 · see citing works
Chen, P.-S., Peng, G.-S., Li, G., Yang, S., Wu, X., Wang, C. C., Wilson, B. C., Lu, R.-B., Gean, P.-W., Chuang, D.-M., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001893 · Cited by 352 · see citing works
Drevets, W. C., Öngür, D., & Price, J. L. (1998) · Molecular Psychiatry · doi:10.1038/sj.mp.4000370 · Cited by 352 · see citing works
In vivo radioligand binding to translocator protein correlates with severity of Alzheimer’s disease
Kreisl, W. C., Lyoo, C. H., McGwier, M., Snow, J., Jenko, K. J., Kimura, N., Corona, W., Morse, C. L., Zoghbi, S. S., Pike, V. W., et al. (2013) · Brain · doi:10.1093/brain/awt145 · Cited by 350 · see citing works
Beumer, W., Gibney, S. M., Drexhage, R. C., Pont-Lezica, L., Doorduin, J., Klein, H. C., Steiner, J., Connor, T. J., Harkin, A., Versnel, M. A., et al. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0212100 · Cited by 347 · see citing works
DelBello, M. P., Zimmerman, M. E., Mills, N. P., Getz, G. E., & Strakowski, S. M. (2004) · Bipolar Disorders · doi:10.1046/j.1399-5618.2003.00087.x · Cited by 344 · see citing works
Prickaerts, J., Moechars, D., Cryns, K., Lenaerts, I., van Craenendonck, H., Goris, I., Daneels, G., Bouwknecht, J. A., & Steckler, T. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5216-05.2006 · Cited by 341 · see citing works
Padmos, R. C., Hillegers, M. H. J., Knijff, E. M., Vonk, R., Bouvy, A., Staal, F. J. T., de Ridder, D., Kupka, R. W., Nolen, W. A., & Drexhage, H. A. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.4.395 · Cited by 336 · see citing works
Bhagwagar, Z., Wylezinska, M., Jezzard, P., Evans, J., Ashworth, F., Sule, A., Matthews, P. M., & Cowen, P. J. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.048 · Cited by 304 · see citing works
Banati, R. B., Myers, R., & Kreutzberg, G. W. (1997) · Journal of Neurocytology · doi:10.1023/a:1018567510105 · Cited by 296 · see citing works
Wong, M.-L., Dong, C., Maestre-Mesa, J., & Licinio, J. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.59 · Cited by 295 · see citing works
Wichers, M., & Maes, M. H. J. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0402 · Cited by 288 · see citing works
Cellular Plasticity Cascades: Targets for the Development of Novel Therapeutics for Bipolar Disorder
Zarate, C. A., Singh, J. B., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.021 · Cited by 276 · see citing works
Kreisl, W. C., Fujita, M., Fujimura, Y., Kimura, N., Jenko, K. J., Kannan, P., Hong, J. S., Morse, C. L., Zoghbi, S. S., Gladding, R. L., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.11.056 · Cited by 275 · see citing works
Reference and target region modeling of [11C]-(R)-PK11195 brain studies.
Turkheimer, F., Edison, P., Pavese, N., Roncaroli, F., Anderson, A. N., Hammers, A., Gerhard, A., Hinz, R., Tai, Y., & Brooks, D. J. (2007) · PubMed · Cited by 275 · see citing works
Imaging the serotonin transporter during major depressive disorder and antidepressant treatment
Meyer, J. H. (2007) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0709 · Cited by 273 · see citing works
The Lifetime Cost of Bipolar Disorder in the US: An Estimate for New Cases in 1998
Begley, C. E., Annegers, J. F., Swann, A. C., Lewis, C., Coan, S., Schnapp, W. B., & Bryant-Comstock, L. (2001) · PharmacoEconomics · doi:10.2165/00019053-200119050-00004 · Cited by 265 · see citing works
Meyer, J. H., Houle, S., Sagrati, S., Carella, A., Hussey, D. F., Ginovart, N., Goulding, V. S., Kennedy, J. L., & Wilson, A. A. (2004) · Archives of General Psychiatry · doi:10.1001/archpsyc.61.12.1271 · Cited by 265 · see citing works
Ridker, P. M. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.dec.s253-s259 · Cited by 264 · see citing works
The role of GSK‐3 in synaptic plasticity
Peineau, S., Bradley, C. A., Taghibiglou, C., Doherty, A., Bortolotto, Z. A., Wang, Y. T., & Collingridge, G. L. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.2 · Cited by 263 · see citing works
Drexhage, R. C., Knijff, E. M., Padmos, R. C., Heul-Nieuwenhuijzen, L. V. D., Beumer, W., Versnel, M. A., & Drexhage, H. A. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.144 · Cited by 263 · see citing works
Chen, P. S., Wang, C.-C., Bortner, C. D., Peng, G.-S., Wu, X., Pang, H., Lu, R.-B., Gean, P.-W., Chuang, D.-M., & Hong, J.-S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.06.053 · Cited by 262 · see citing works
Cellular Plasticity Cascades in the Pathophysiology and Treatment of Bipolar Disorder
Schloesser, R. J., Huang, J. Y., Klein, P. S., & Manji, H. K. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301575 · Cited by 256 · see citing works
Cytokines in bipolar disorder: A systematic review and meta-analysis
Munkholm, K., Vinberg, M., & Vedel Kessing, L. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.06.010 · Cited by 256 · see citing works
Barrientos, R. M., Sprunger, D. B., Campeau, S., Higgins, E. A., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00564-5 · Cited by 251 · see citing works
Kreisl, W. C., Jenko, K. J., Hines, C. S., Lyoo, C. H., Corona, W., Morse, C. L., Zoghbi, S. S., Hyde, T. M., Kleinman, J. E., Pike, V. W., et al. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.131 · Cited by 251 · see citing works
Miller, C. L., Llenos, I. C., Dulay, J. R., & Weis, S. (2006) · Brain Research · doi:10.1016/j.brainres.2005.12.056 · Cited by 240 · see citing works
Bull, S. J., Huezo-Diaz, P., Binder, E. B., Cubells, J. F., Ranjith, G., Maddock, C., Miyazaki, C., Alexander, N., Hotopf, M., Cleare, A. J., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2008.48 · Cited by 228 · see citing works
Age and neuroinflammation: a lifetime of psychoneuroimmune consequences
Godbout, J. P., & Johnson, R. W. (2009) · Immunology and Allergy Clinics of North America · doi:10.1016/j.iac.2009.02.007 · Cited by 224 · see citing works
Anterior Cingulate Activation and Error Processing During Interferon-Alpha Treatment
Capuron, L., Pagnoni, G., Demetrashvili, M., Woolwine, B. J., Nemeroff, C. B., Berns, G. S., & Miller, A. H. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.03.033 · Cited by 222 · see citing works
Cannon, D. M., Ichise, M., Rollis, D., Klaver, J. M., Gandhi, S. K., Charney, D. S., Manji, H. K., & Drevets, W. C. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.016 · Cited by 219 · see citing works
Ginovart, N., Wilson, A. A., Meyer, J. H., Hussey, D., & Houle, S. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200111000-00010 · Cited by 209 · see citing works
Strakowski, S. M., Adler, C. M., Holland, S. K., Mills, N. P., DelBello, M. P., & Eliassen, J. C. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.9.1697 · Cited by 209 · see citing works
Serretti, A., & Mandelli, L. (2008) · Molecular Psychiatry · doi:10.1038/mp.2008.29 · Cited by 199 · see citing works
Antidepressants inhibit interferon-γ-induced microglial production of IL-6 and nitric oxide
Hashioka, S., Klegeris, A., Monji, A., Kato, T., Sawada, M., McGeer, P. L., & Kanba, S. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.03.022 · Cited by 198 · see citing works
Sodium valproate inhibits production of TNF-α and IL-6 and activation of NF-κB
Ichiyama, T., Okada, K., Lipton, J. M., Matsubara, T., Hayashi, T., & Furukawa, S. (2000) · Brain Research · doi:10.1016/s0006-8993(99)02439-7 · Cited by 196 · see citing works
Molecular imaging of microglia/macrophages in the brain
Venneti, S., Lopresti, B. J., & Wiley, C. A. (2012) · Glia · doi:10.1002/glia.22357 · Cited by 189 · see citing works
Couch, Y., Anthony, D. C., Dolgov, O., Revischin, A., Festoff, B., Santos, A. I., Steinbusch, H. W., & Strekalova, T. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.12.017 · Cited by 187 · see citing works
The serotonin transporter is a potential susceptibility factor for bipolar affective disorder
Collier, D. A., Arranz, M. J., Sham, P. C., Battersby, S., Vallada, H., Gill, P., Aitchison, K. J., Sodhi, M., Li, T., Roberts, G. W., et al. (1996) · Neuroreport · doi:10.1097/00001756-199607080-00030 · Cited by 187 · see citing works
Microglia as modulators of cognition and neuropsychiatric disorders
Blank, T., & Prinz, M. (2012) · Glia · doi:10.1002/glia.22372 · Cited by 185 · see citing works
Myers, R., Manjil, L. G., Cullen, B. M., Price, G. W., Frackowiak, R. S. J., & Cremer, J. E. (1991) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1991.64 · Cited by 182 · see citing works
Brain-derived neurotrophic factor and neuroplasticity in bipolar disorder
Kapczinski, F., Frey, B. N., Kauer-Sant’Anna, M., & Grassi-Oliveira, R. (2008) · Expert Review of Neurotherapeutics · doi:10.1586/14737175.8.7.1101 · Cited by 181 · see citing works
The Wnt Signaling Pathway in Bipolar Disorder
Gould, T. D., & Manji, H. K. (2002) · The Neuroscientist · doi:10.1177/107385802237176 · Cited by 173 · see citing works
TNF-α as a molecular target in bipolar disorder
Brietzke, E., & Kapczinski, F. (2008) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2008.01.006 · Cited by 163 · see citing works
Boutin, H., Chauveau, F., Thominiaux, C., Grégoire, M., James, M. L., Trébossen, R., Hantraye, P., Dollé, F., Tavitian, B., & Kassiou, M. (2007) · Journal of Nuclear Medicine · doi:10.2967/jnumed.106.036764 · Cited by 161 · see citing works
Beumer, W., Drexhage, R. C., de Wit, H., Versnel, M. A., Drexhage, H. A., & Cohen, D. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.001 · Cited by 161 · see citing works
Dickerson, F., Stallings, C. R., Origoni, A. E., Boronow, J. J., & Yolken, R. H. (2007) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2007.02.018 · Cited by 157 · see citing works
Wilson, A. A., Ginovart, N., Hussey, D. F., Meyer, J., & Houle, S. (2002) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(02)00316-5 · Cited by 157 · see citing works
Serotonin transporter binding in patients with mood disorders: a PET study with [11C](+)McN5652
Ichimiya, T., Suhara, T., Sudo, Y., Okubo, Y., Nakayama, K., Nankai, M., Inoue, M., Yasuno, F., Takano, A., Maeda, J., et al. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01351-8 · Cited by 153 · see citing works
Yasuno, F., Kosaka, J., Ota, M., Higuchi, M., Ito, H., Fujimura, Y., Nozaki, S., Takahashi, S., Mizukami, K., Asada, T., et al. (2012) · Psychiatry Research: Neuroimaging · doi:10.1016/j.pscychresns.2011.08.013 · Cited by 148 · see citing works
Savitz, J., Frank, M. B., Victor, T., Bebak, M., Marino, J. H., Bellgowan, P. S. F., McKinney, B. A., Bodurka, J., Kent Teague, T., & Drevets, W. C. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.007 · Cited by 146 · see citing works
Association studies of bipolar disorder at the human serotonin transporter gene (hSERT; 5HTT)
Rees, M. I., Norton, N., Jones, I. R., McCandless, F., Scourfield, J., Holmans, P., Moorhead, S., Feldman, E., Sadler, S., Cole, T. J., et al. (1997) · Molecular Psychiatry · doi:10.1038/sj.mp.4000256 · Cited by 146 · see citing works
Otte, C., McCaffery, J. M., Ali, S., & Whooley, M. A. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.06101617 · Cited by 146 · see citing works
Knijff, E. M., Breunis, M. N., Kupka, R., de Wit, H. J., Ruwhof, C., Akkerhuis, G. W., Nolen, W. A., & Drexhage, H. A. (2007) · Bipolar Disorders · doi:10.1111/j.1399-5618.2007.00444.x · Cited by 146 · see citing works
Iwashita, A., Muramatsu, Y., Yamazaki, T., Muramoto, M., Kita, Y., Yamazaki, S., Mihara, K., Moriguchi, A., & Matsuoka, N. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.115758 · Cited by 140 · see citing works
Oquendo, M. A., Hastings, R., Huang, Y.-Y., Simpson, N. R., Ogden, R. T., Hu, X., Goldman, D. A., Arango, V., Heertum, R. L. V., Mann, J. J., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.2.201 · Cited by 140 · see citing works
Positron Emission Tomography Imaging of Neuroinflammation
Cagnin, A., Kassiou, M., Meikle, S. R., & Banati, R. B. (2007) · Neurotherapeutics · doi:10.1016/j.nurt.2007.04.006 · Cited by 137 · see citing works
Reimold, M., Batra, A., Knobel, A., Smolka, M. N., Zimmer, A., Mann, K. F., Solbach, C., Reischl, G., Schwärzler, F., Gründer, G., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002149 · Cited by 131 · see citing works
Initial Evaluation of 11C-DPA-713, a Novel TSPO PET Ligand, in Humans
Endres, C. J., Pomper, M. G., James, M. L., Uzuner, Ö., Hammoud, D. A., Watkins, C. C., Reynolds, A., Hilton, J., Dannals, R. F., & Kassiou, M. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.062265 · Cited by 131 · see citing works
Self-citationCytokine production in bipolar affective disorder patients under lithium treatment
Boufidou, F., Nikolaou, C., Alevizos, B., Liappas, I. A., & Christodoulou, G. N. (2004) · Journal of Affective Disorders · doi:10.1016/j.jad.2004.01.007 · Cited by 130 · see citing works
Mental Health Service Use by Elderly Patients With Bipolar Disorder and Unipolar Major Depression
Bartels, S. J., Forester, B. P., Miles, K. M., & Joyce, T. (2000) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200005000-00011 · Cited by 129 · see citing works
Ridker, P. M. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00372.x · Cited by 128 · see citing works
Metabolic syndrome and major depressive disorder: Co-occurrence and pathophysiologic overlap
McIntyre, R. S., Rasgon, N. L., Kemp, D. E., Nguyen, H. T., Law, C. W. Y., Taylor, V. H., Woldeyohannes, H. O., Alsuwaidan, M. T., Soczynska, J. K., Kim, B., et al. (2009) · Current Diabetes Reports · doi:10.1007/s11892-009-0010-0 · Cited by 127 · see citing works
Parsey, R. V., KENT, J. M., Oquendo, M. A., Richards, M., Pratap, M., Cooper, T. B., Arango, V., & Mann, J. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.08.010 · Cited by 119 · see citing works
Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS
Hammoud, D. A., Endres, C. J., Chander, A., Guilarte, T. R., Wong, D. F., Sacktor, N. C., McArthur, J. C., & Pomper, M. G. (2005) · Journal of NeuroVirology · doi:10.1080/13550280500187351 · Cited by 115 · see citing works
Self-citationMood-stabilizing drugs: mechanisms of action
Schloesser, R. J., Martinowich, K., & Manji, H. K. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.009 · Cited by 115 · see citing works
Horikawa, H., Kato, T., Mizoguchi, Y., Monji, A., Seki, Y., Ohkuri, T., Gotoh, L., Yonaha, M., Ueda, T., Hashioka, S., et al. (2010) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.015 · Cited by 113 · see citing works
Positron emission tomography: imaging and quantification of neurotransporter availability
Laruelle, M. A. (2002) · Methods · doi:10.1016/s1046-2023(02)00085-3 · Cited by 113 · see citing works
Cerullo, M. A., Fleck, D. E., Eliassen, J. C., Smith, M. S., DelBello, M. P., Adler, C. M., & Strakowski, S. M. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.01002.x · Cited by 111 · see citing works
Neuroimaging in bipolar disorder: A critical review of current findings
Keener, M. T., & Phillips, M. L. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0070-2 · Cited by 111 · see citing works
Matigian, N., Windus, L. C. E., Smith, H., Filippich, C., Pantelis, C., McGrath, J. J., Mowry, B. J., & Hayward, N. K. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001998 · Cited by 106 · see citing works
Tryptophan breakdown pathway in bipolar mania
Myint, A.-M., Kim, Y., Verkerk, R. M., Park, S. H., Scharpé, S., Steinbusch, H. W. M., & Leonard, B. E. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.12.008 · Cited by 106 · see citing works
The nature of bipolar disorder.
Manji, H. K., & Lenox, R. H. (2000) · PubMed · Cited by 104 · see citing works
Bipolar disorder and polymorphisms in the dysbindin gene (DTNBP1)
Raybould, R., Green, E., MacGregor, S., Gordon‐Smith, K., Heron, J., Hyde, S., Caesar, S., Nikolov, I., Williams, N. M., Jones, L. A., et al. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.01.018 · Cited by 101 · see citing works
Omega-3 fatty acids for bipolar disorder
Montgomery, P., & Richardson, A. J. (2008) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005169.pub2 · Cited by 101 · see citing works
Depression following pegylated interferon-alpha: Characteristics and vulnerability
Lotrich, F. E., Rabinovitz, M., Gironda, P., & Pollock, B. G. (2007) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2007.05.013 · Cited by 100 · see citing works
The effects of lithium on ex vivo cytokine production
Rapaport, M. H., & Manji, H. K. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01144-1 · Cited by 98 · see citing works
Effects of Tryptophan Depletion on the Serotonin Transporter in Healthy Humans
Praschak-Rieder, N., Wilson, A. A., Hussey, D., Carella, A., Wei, C. W., Ginovart, N., Schwarz, M., Zach, J., Houle, S., & Meyer, J. H. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.04.038 · Cited by 90 · see citing works
Frankle, W. G., Slifstein, M., Gunn, R. N., Huang, Y. H., Hwang, D., Darr, E. A., Narendran, R., Abi‐Dargham, A., & Laruelle, M. A. (2006) · PubMed · Cited by 84 · see citing works
Banati, R. B. (2002) · Journal of Physiology-Paris · doi:10.1016/s0928-4257(02)00018-9 · Cited by 84 · see citing works
Alterations in kynurenine precursor and product levels in schizophrenia and bipolar disorder
Miller, C. L., Llenos, I. C., Cwik, M. F., Walkup, J. T., & Weis, S. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.01.013 · Cited by 79 · see citing works
Halleskog, C., & Schulte, G. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12250 · Cited by 79 · see citing works
Fujimura, Y., Zoghbi, S. S., Siméon, F. G., Taku, A. K., Pike, V. W., Innis, R. B., & Fujita, M. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.060186 · Cited by 78 · see citing works
Effects of lithium on lipopolysaccharide-induced inflammation in rat primary glia cells
Nahman, S., Belmaker, R., & Azab, A. N. (2011) · Innate Immunity · doi:10.1177/1753425911421512 · Cited by 72 · see citing works
Association Study of Wnt Signaling Pathway Genes in Bipolar Disorder
Zandi, P. P. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.7.785 · Cited by 71 · see citing works
Schulze, T. G., Buervenich, S., Badner, J. A., Steele, C. J. M., Detera‐Wadleigh, S. D., Dick, D. M., Foroud, T., Cox, N. J., MacKinnon, D. F., Potash, J. B., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.04.004 · Cited by 68 · see citing works
Halleskog, C., & Schulte, G. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.12.006 · Cited by 62 · see citing works
Beasley, C. L. (2002) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00376-0 · Cited by 61 · see citing works
PET [11C]DASB Imaging of Serotonin Transporters in Patients with Alcoholism
Brown, A. K., George, D. T., Fujita, M., Liow, J., Ichise, M., Hibbeln, J. R., Ghose, S., Sangare, J., Hommer, D., & Innis, R. B. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00261.x · Cited by 59 · see citing works
A Retrospective Analysis of Risk and Protective Factors for Natural Death in Bipolar Disorder
Tsai, S., Lee, C.-H., Kuo, C., & Chen, C. (2005) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v66n1215 · Cited by 57 · see citing works
The Wnt Pathway in Mood Disorders
Sani, G., Napoletano, F., Forte, A. M., Kotzalidis, G. D., Panaccione, I., Porfiri, G. M., Simonetti, A., Caloro, M., Girardi, N., Telesforo, C. L., et al. (2012) · Current Neuropharmacology · doi:10.2174/157015912803217279 · Cited by 55 · see citing works
Kilander, M. B. C., Halleskog, C., & Schulte, G. (2011) · Acta Physiologica · doi:10.1111/j.1748-1716.2011.02324.x · Cited by 47 · see citing works
Gulyás, B. Z., Tóth, M., Vas, Á., et al. (2011) · Current Radiopharmaceuticals · doi:10.2174/1874471011205010019 · Cited by 47 · see citing works
Hammoud, D. A., Endres, C. J., Hammond, E. R., Uzuner, Ö., Brown, A. M., Nath, A., Kaplin, A. I., & Pomper, M. G. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.10.037 · Cited by 40 · see citing works
Self-citationThe genetics of psychotic bipolar disorder
Goes, F. S., Sanders, L. L. O., & Potash, J. B. (2008) · Current Psychiatry Reports · doi:10.1007/s11920-008-0030-5 · Cited by 39 · see citing works
Smith, G. S., Kahn, A., Sacher, J., Rusjan, P., van Eimeren, T., Flint, A., & Wilson, A. A. (2011) · The American Journal of Geriatric Psychiatry · doi:10.1097/jgp.0b013e318227f83f · Cited by 32 · see citing works
Radiation Dosimetry and Biodistribution of the TSPO Ligand11C-DPA-713 in Humans
Endres, C. J., Coughlin, J. M., Gage, K. L., Watkins, C. C., Kassiou, M., & Pomper, M. G. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.094565 · Cited by 31 · see citing works
Self-citationDepression diagnoses following the identification of bipolar disorder: costly incongruent diagnoses
Stensland, M. D., Schultz, J. F., & Frytak, J. R. (2010) · BMC Psychiatry · doi:10.1186/1471-244x-10-39 · Cited by 27 · see citing works
The Neurobiology of Bipolar Disorder: Findings Using Human Postmortem Central Nervous System Tissue
Dean, B. (2004) · Australian & New Zealand Journal of Psychiatry · doi:10.1080/j.1440-1614.2004.01319.x · Cited by 23 · see citing works
Genes and Neuroimaging: Advances in Psychiatric Research
Gallinat, J., Bauer, M., & Heinz, A. (2008) · Neurodegenerative Diseases · doi:10.1159/000135612 · Cited by 16 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Microglia in physiology and disease
Wolf, S. A., Boddeke, H. W. G. M., & Kettenmann, H. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034406 · Cited by 1,426 · see citing works
The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders
Réus, G. Z., Fries, G. R., Stertz, L., Badawy, M., Passos, I. C., Barichello, T., Kapczinski, F., & Quevedo, J. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.05.018 · Cited by 594 · see citing works
Molecular and anatomical organization of the dorsal raphe nucleus
Huang, K. W., Ochandarena, N. E., Philson, A. C., Hyun, M., Birnbaum, J. E., Cicconet, M., & Sabatini, B. L. (2019) · eLife · doi:10.7554/elife.46464 · Cited by 267 · see citing works
Diversity and plasticity of microglial cells in psychiatric and neurological disorders
Nakagawa, Y., & Chiba, K. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.06.010 · Cited by 208 · see citing works
Bipolar Disorder: Role of Inflammation and the Development of Disease Biomarkers
Muneer, A. (2016) · Psychiatry Investigation · doi:10.4306/pi.2016.13.1.18 · Cited by 187 · see citing works
Millan, M. J., Goodwin, G. M., Meyer-Lindenberg, A., & Ove Ögren, S. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.01.016 · Cited by 132 · see citing works
Barbosa, I. G., Rocha, N. P., Assis, F., Vieira, E. L. M., Soares, J. C., Bauer, M. E., & Teixeira (2015) · International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyu021 · Cited by 101 · see citing works
C-Reactive Protein: A Differential Biomarker For Major Depressive Disorder and Bipolar II Disorder
Chang, H. H., Wang, T.-Y., Lee, I. H., Lee, S.-Y., Chen, K. C., Huang, S.-Y., Yang, Y. K., Lu, R.-B., & Chen, P. S. (2017) · The World Journal of Biological Psychiatry · doi:10.3109/15622975.2016.1155746 · Cited by 61 · see citing works
Korkmaz, Ş. A., & Kızgın, S. (2023) · Current Medical Research and Opinion · doi:10.1080/03007995.2023.2260302 · Cited by 33 · see citing works
Wang, T.-Y., Lee, S.-Y., Chen, S.-L., Chang, Y.-H., Wang, L.-J., Chen, P. S., Chen, S.-H., Chu, C.-H., Huang, S.-Y., Tzeng, N.-S., et al. (2016) · Scientific Reports · doi:10.1038/srep27431 · Cited by 21 · see citing works
- Authors
- Watkins, C. C., Sawa, A., & Pomper, M. G.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Watkins, C C
- Venue
- Translational Psychiatry
- Published
- 2014-01-21
- Volume
- 4
- Issue
- 1
- Pages
- e350-e350
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC3905229
- OpenAlex
- W2070899132
- Cited by
- 100
- References
- 148
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 6 · 2019: 11 · 2018: 6 · 2017: 9 · 2016: 18 · 2015: 11 · 2014: 8
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc-nd
- www.springer.com/tdm (unspecified)
- Locations
- Translational Psychiatry (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Johns Hopkins University
- National Institute of Mental Health (T32MH015330, P50MH094268)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K08HD073315)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- bipolar disorder, microglia, neuroinflammation, immune cell signaling, glycogen synthase kinase-3β, Wnt signaling, lithium, valproic acid, mood stabilizers, serotonergic system, bipolar depression, bipolar mania, neurotransmitter synthesis, neuroimaging
- MeSH terms
- Bipolar Disorder, Humans, Inflammation, Neuropharmacology, Signal Transduction, Microglia, Molecular Imaging
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review