Depression and immune function

Kiecolt-Glaser, Janice K; Glaser, Ronald

doi:10.1016/s0022-3999(02)00309-4

Cited by 571Tryptophan and brain disordersStress Responses and CortisolHealth disparities and outcomes

Depression and immune function

Kiecolt-Glaser, Janice K, Glaser, Ronald·2002·Journal of Psychosomatic Research

DOI 10.1016/s0022-3999(02)00309-4

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Abstract

Objective The increased morbidity and mortality associated with depression is substantial. In this paper, we review evidence suggesting that depression contributes to disease and death through immune dysregulation.Method This review focuses on recent human studies addressing the impact of depression on immune function, and the health consequences of those changes.Results There is growing evidence that depression can directly stimulate the production of proinflammatory cytokines that influence a spectrum of conditions associated with aging, including cardiovascular disease, osteoporosis, arthritis, type 2 diabetes, certain cancers, periodontal disease, frailty, and functional decline. Additionally, depression can down-regulate the cellular immune response; as a consequence, processes such as prolonged infection and delayed wound healing that fuel sustained proinflammatory cytokine production may be promoted by depression.Conclusions These direct and indirect processes pose the greatest health risks for older adults who already show age-related increases in proinflammatory cytokine production. Thus, aging interacts with depression to enhance risks for morbidity and mortality.

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Comorbid depression is often associated with a worse course of physical disorders, partly because depression is often associated with non-adherence to treatment regimens.
“comorbid depression is often associated with a worse course of the physical disorder.114–116 A number of reasons could be involved here, but one of the most consistently documented is that depression is often associated with non-adherence to treatment regimens.112, 117, 118”
From The Costs of Depression (2012) · cites this paper as [112]

Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504 · see citing works
C-Reactive Protein, Interleukin 6, and Risk of Developing Type 2 Diabetes Mellitus
Pradhan, A. D. (2001) · JAMA · doi:10.1001/jama.286.3.327 · Cited by 4,433 · see citing works
Effect of Statin Therapy on C-Reactive Protein Levels
Albert, M. A., Danielson, E., Rifai, N., Ridker, P. M., & for the PRINCE Investigators (2001) · JAMA · doi:10.1001/jama.286.1.64 · Cited by 1,642 · see citing works
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488 · see citing works
Emotion, plasticity, context, and regulation: Perspectives from affective neuroscience.
Davidson, R. J., Jackson, D. C., & Kalin, N. H. (2000) · Psychological Bulletin · doi:10.1037/0033-2909.126.6.890 · Cited by 1,322 · cited 1× · see citing works
“Depression can affect health through many pathways; these influences may occur through health behaviors or compliance with medical regimens, as well as through alterations in the functioning of the central nervous system (CNS), immune, endocrine, and cardiovascular systems [5–8].”
Background
Age-Associated Increased Interleukin-6 Gene Expression, Late-Life Diseases, and Frailty
Ershler, W. B., & Keller, E. T. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.245 · Cited by 1,282 · see citing works
Annual Review of Gerontology and Geriatrics
Maddox, G. L., & Lawton, M. P. (1988) · Springer eBooks · doi:10.1007/978-3-662-38443-5 · Cited by 1,215 · see citing works
The Pathophysiologic Roles of Interleukin-6 in Human Disease
Papanicolaou, D. A., Wilder, R. L., Manolagas, S. C., & Chrousos, G. P. (1998) · Annals of Internal Medicine · doi:10.7326/0003-4819-128-2-199801150-00009 · Cited by 1,146 · see citing works
Slowing of wound healing by psychological stress
Kiecolt-Glaser, J. K., Marucha, P. T., Mercado, A. M., Malarkey, W. B., & Glaser, R. (1995) · The Lancet · doi:10.1016/s0140-6736(95)92899-5 · Cited by 1,104 · see citing works
Self-citation
Serum IL‐6 Level and the Development of Disability in Older Persons
Ferrucci, L., Harris, T. B., Guralnik, J. M., Tracy, R. P., Corti, M., Cohen, H. J., Penninx, B., Pahor, M., Wallace, R., & Havlik, R. J. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01583.x · Cited by 809 · see citing works
Chronic stress alters the immune response to influenza virus vaccine in older adults.
Kiecolt-Glaser, J. K., Glaser, R., Gravenstein, S., Malarkey, W. B., & Sheridan, J. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.7.3043 · Cited by 789 · see citing works
Self-citation
THE EFFECTS OF PSYCHOLOGICAL STRESS ON HUMANS: INCREASED PRODUCTION OF PRO-INFLAMMATORY CYTOKINES AND Th1-LIKE RESPONSE IN STRESS-INDUCED ANXIETY
Maes, M., Song, C., Lin, A., De Jongh, R., Van Gastel, A., Kenis, G., Bosmans, E., De Meester, I., Benoy, I., Neels, H., et al. (1998) · Cytokine · doi:10.1006/cyto.1997.0290 · Cited by 772 · see citing works
INCREASED SERUM IL-6 AND IL-1 RECEPTOR ANTAGONIST CONCENTRATIONS IN MAJOR DEPRESSION AND TREATMENT RESISTANT DEPRESSION
Maes, M., Bosmans, E., De Jongh, R., Kenis, G., Vandoolaeghe, E., & Neels, H. (1997) · Cytokine · doi:10.1006/cyto.1997.0238 · Cited by 728 · see citing works
Exploring the effect of depression on physical disability: longitudinal evidence from the established populations for epidemiologic studies of the elderly
Penninx, B. W., Leveille, S., Ferrucci, L., van Eijk, J. T., & Guralnik, J. M. (1999) · American Journal of Public Health · doi:10.2105/ajph.89.9.1346 · Cited by 570 · see citing works
Types of stressors that increase susceptibility to the common cold in healthy adults.
Cohen, S., Frank, E., Doyle, W. J., Skoner, D. P., Rabin, B. S., & Jack M., J. G. (1998) · Health Psychology · doi:10.1037//0278-6133.17.3.214 · Cited by 531 · see citing works
Minor and Major Depression and the Risk of Death in Older Persons
Penninx, B. W. J. H., Geerlings, S. W., Deeg, D. J. H., van Eijk, J. T. M., van Tilburg, W., & Beekman, A. T. F. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.10.889 · Cited by 524 · see citing works
Chronic Infections and the Risk of Carotid Atherosclerosis
Kiechl, S. J., Egger, G., Mayr, M., Wiedermann, C. J., Bonora, E., Oberhollenzer, F., Muggeo, M., Xu, Q., Wick, G., Poewe, W. H., et al. (2001) · Circulation · doi:10.1161/01.cir.103.8.1064 · Cited by 508 · see citing works
Chronic stress in elderly carers of dementia patients and antibody response to influenza vaccination
Vedhara, K., Cox, N. K., Wilcock, G. K., Perks, P., Hunt, M., Anderson, S., Lightman, S. L., & Shanks, N. M. (1999) · The Lancet · doi:10.1016/s0140-6736(98)06098-x · Cited by 496 · see citing works
Exposure to physical and psychological stressors elevates plasma interleukin 6: Relationship to the activation of hypothalamic-pituitary-adrenal axis
Zhou, D., Kusnecov, A. W., Shurin, M. R., DePaoli, M., & Rabin, B. S. (1993) · Endocrinology · doi:10.1210/endo.133.6.8243274 · Cited by 494 · see citing works
Mucosal Wound Healing Is Impaired by Examination Stress
Marucha, P. T., Kiecolt‐Glaser, J. K., & Favagehi, M. (1998) · Psychosomatic Medicine · doi:10.1097/00006842-199805000-00025 · Cited by 492 · see citing works
Self-citation
The Association of Plasma IL-6 Levels With Functional Disability in Community-Dwelling Elderly
Cohen, H. J., Pieper, C. F., Harris, T., Rao, K. M. K., & Currie, M. S. (1997) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/52a.4.m201 · Cited by 476 · see citing works
Effects of Psychological and Social Factors on Organic Disease: A Critical Assessment of Research on Coronary Heart Disease
Krantz, D. S., & McCeney, M. K. (2002) · Annual Review of Psychology · doi:10.1146/annurev.psych.53.100901.135208 · Cited by 469 · see citing works
Toward an Understanding of Frailty
Hamerman, D. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-11-199906010-00022 · Cited by 441 · see citing works
Cross-sectional and Prospective Relationships of Interleukin-6 and C-Reactive Protein With Physical Performance in Elderly Persons: MacArthur Studies of Successful Aging
Taaffe, D. R., Harris, T. B., Ferrucci, L., Rowe, J., & Seeman, T. E. (2000) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/55.12.m709 · Cited by 438 · cited 2× · see citing works
“In fact, more globally, chronic inflammation has been suggested as one key biological mechanism that may fuel declines in physical function leading to frailty, disability, and, ultimately, death [12,39].”
Background
Types of stressors that increase susceptibility to the common cold in healthy adults.
Cohen, S., Frank, E., Doyle, W. J., Skoner, D. P., Rabin, B. S., & Gwaltney, J. M. (1998) · Health Psychology · doi:10.1037/0278-6133.17.3.214 · Cited by 388 · see citing works
Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events
Maes, M., Lin, A.-H., Delmeire, L., Van Gastel, A., Kenis, G., De Jongh, R., & Bosmans, E. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00131-0 · Cited by 387 · see citing works
Stress-induced modulation of the immune response to recombinant hepatitis B vaccine.
Glaser, R., Kiecolt‐Glaser, J. K., Bonneau, R. H., Malarkey, W. B., Kennedy, S., & Hughes, J. (1992) · Psychosomatic Medicine · doi:10.1097/00006842-199201000-00005 · Cited by 354 · see citing works
Self-citation
Interleukin‐6 Serum Levels in Depressed Patients before and after Treatment with Fluoxetine
Sluzewska, A., RYBAKOWSKI, J. K., Łaciak, M., Mackiewicz, A., Sobieska, M., & WIKTOROWICV, K. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb32372.x · Cited by 306 · see citing works
Life stress, mood disturbance, and elevated interleukin-6 in healthy older women
Lutgendorf, S. K., Garand, L., Buckwalter, K. C., Reimer, T. T., Hong, S.-Y., & Lubaroff, D. M. (1999) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/54.9.m434 · Cited by 305 · cited 1× · see citing works
“Importantly, both depressive symptoms and syndromal depression are associated with heightened plasma IL-6 levels [16].”
Background
Chronic Stress Modulates the Immune Response to a Pneumococcal Pneumonia Vaccine
Glaser, R., Sheridan, J., Malarkey, W. B., MacCallum, R. C., & Kiecolt-Glaser, J. K. (2000) · Psychosomatic Medicine · doi:10.1097/00006842-200011000-00010 · Cited by 295 · see citing works
Self-citation
Association of Interleukin‐6 and Other Biologic Variables with Depression in Older People Living in the Community
Dentino, A. N., Pieper, C. F., Rao, K. M. K., Currie, M. S., Harris, T., Blazer, D. G., & Cohen, H. J. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01894.x · Cited by 287 · see citing works
Depression as a risk factor for cardiac events in established coronary heart disease: A review of possible mechanisms
Carney, R. M., Freedland, K. E., Rich, M. W., & Jaffe, A. S. (1995) · Annals of Behavioral Medicine · doi:10.1007/bf02895063 · Cited by 260 · see citing works
Exercise and Circadian Rhythm-Induced Variations in Plasma Cortisol Differentially Regulate Interleukin-1β (IL-1β), IL-6, and Tumor Necrosis Factor-α (TNFα) Production in Humans: High Sensitivity of TNFα and Resistance of IL-6
DeRijk, R. H., Michelson, D., Karp, B., Petrides, J. S., Galliven, E., Deuster, P., Paciotti, G. F., Gold, P. W., & Sternberg, E. M. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4041 · Cited by 250 · see citing works
Treatment of Depression With Antiglucocorticoid Drugs
Wolkowitz, O. M., & Reus, V. I. (1999) · Psychosomatic Medicine · doi:10.1097/00006842-199909000-00011 · Cited by 205 · see citing works
Stress-Induced Susceptibility to Bacterial Infection During Cutaneous Wound Healing
Rojas, I. G., Padgett, D. A., Sheridan, J. F., & Marucha, P. T. (2002) · Brain Behavior and Immunity · doi:10.1006/brbi.2000.0619 · Cited by 204 · see citing works
NEUROENDOCRINE AND IMMUNE SYSTEM INTERACTIONS IN STRESS AND DEPRESSION
Miller, A. H. (1998) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(05)70015-0 · Cited by 177 · see citing works
Cytokines and depression: fortuitous or causative association?
Dantzer, R., Wollman, E., Vitkovic, L., & Yirmiya, R. (1999) · Molecular Psychiatry · doi:10.1038/sj.mp.4000572 · Cited by 174 · see citing works
On the Inseparability of Mental and Physical Health in Aged Persons Lessons From Depression and Medical Comorbidity
Katz, I. R. (1996) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199624410-00001 · Cited by 158 · see citing works
Chronic stress alters the immune response to influenza virus vaccine in older adults
Kiecolt-Graser, J. (1996) · Medical Entomology and Zoology · Cited by 151 · see citing works
Influence of psychological stress on immune-inflammatory variables in normal humans. Part II. Altered serum concentrations of natural anti-inflammatory agents and soluble membrane antigens of monocytes and T lymphocytes
Song, C., Kenis, G., Gastel, A. V., Bosmans, E., Lin, A., Jong, R. D., Neels, H. M., Scharpé, S., Janča, A., Yasukawa, K., et al. (1999) · Psychiatry Research · doi:10.1016/s0165-1781(99)00012-8 · Cited by 86 · see citing works
Cytokine Antagonists in Aged Subjects and Their Relation With Cellular Immunity
Catania, A. P., Airaghi, L., Motta, P., Manfredi, M. G., Annoni, G., Pettenati, C., Brambilla, F., & Lipton, J. M. (1997) · The Journals of Gerontology Series A · doi:10.1093/gerona/52a.2.b93 · Cited by 85 · see citing works
Editorial: In Search of the Underlying Mechanisms of Frailty
Cohen, H. J. (2000) · The Journals of Gerontology Series A · doi:10.1093/gerona/55.12.m706 · Cited by 82 · see citing works
Exercise and Circadian Rhythm-Induced Variations in Plasma Cortisol Differentially Regulate Interleukin-1 (IL-1 ), IL-6, and Tumor Necrosis Factor- (TNF ) Production in Humans: High Sensitivity of TNF and Resistance of IL-6
DeRijk, R. H. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.7.2182 · Cited by 77 · see citing works
Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine
Karalis, K. P., Kontopoulos, E., Muglia, L. J., & Majzoub, J. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.12.7093 · Cited by 64 · see citing works
Cytokines in Aging and Muscle Homeostasis
Holloszy, J. O., & Cannon, J. G. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.special_issue.120 · Cited by 58 · see citing works
Immunology and Infectious Disease
Burns, E. A., & Goodwin, J. S. (1990) · Springer eBooks · doi:10.1007/978-1-4757-2093-8_25 · Cited by 43 · see citing works
Methodological issues in behavioral immunology research with humans.
Kiecolt-Glaser, J., & Glaser, R. (1988) · Brain, behavior, and immunity · doi:10.1016/0889-1591(88)90007-4 · Cited by 31 · see citing works
Self-citation
Does Depression Kill?
Wulsin, L. R. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.12.1731 · Cited by 26 · see citing works

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Howren, M. B., Lamkin, D. M., & Suls, J. (2009) · Psychosomatic Medicine · doi:10.1097/psy.0b013e3181907c1b · Cited by 2,766 · see citing works
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Reiche, E. M. V., Nunes, S. O. V., & Morimoto, H. K. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01597-9 · Cited by 1,364 · see citing works
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Barth, J., Schumacher, M., & Herrmann-Lingen, C. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000146332.53619.b2 · Cited by 1,358 · see citing works
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Umberson, D., Crosnoe, R., & Reczek, C. (2010) · Annual Review of Sociology · doi:10.1146/annurev-soc-070308-120011 · Cited by 1,226 · see citing works
Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis
Knol, M. J., Twisk, J. W. R., Beekman, A. T. F., Heine, R. J., Snoek, F. J., & Pouwer, F. (2006) · Diabetologia · doi:10.1007/s00125-006-0159-x · Cited by 974 · see citing works
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Wohleb, E. S., Hanke, M. L., Corona, A. W., Powell, N. D., Stiner, L. M., Bailey, M. T., Nelson, R. J., Godbout, J. P., & Sheridan, J. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0450-11.2011 · Cited by 638 · see citing works
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Black, M. C. (2011) · American Journal of Lifestyle Medicine · doi:10.1177/1559827611410265 · Cited by 500 · see citing works
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Karavidas, M. K., Lehrer, P. M., Vaschillo, E., Vaschillo, B., Marin, H., Buyske, S., Malinovsky, I., Radvanski, D., & Hassett, A. (2007) · Applied Psychophysiology and Biofeedback · doi:10.1007/s10484-006-9029-z · Cited by 440 · see citing works
Aerobic exercise, but not flexibility/resistance exercise, reduces serum IL-18, CRP, and IL-6 independent of β-blockers, BMI, and psychosocial factors in older adults
Kohut, M. L., McCann, D. A., Russell, D. W., Konopka, D. N., Cunnick, J. E., Franke, W. D., Castillo, M. C., Reighard, A. E., & Vanderah, E. (2006) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2005.12.002 · Cited by 436 · see citing works
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Wager, T. D., Waugh, C. E., Lindquist, M., Noll, D. C., Fredrickson, B. L., & Taylor, S. F. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.043 · Cited by 402 · see citing works
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Black sheep get the blues: a psychobiological model of social rejection and depression
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Depression gets old fast: do stress and depression accelerate cell aging?
Wolkowitz, O. M., Epel, E. S., Reus, V. I., & Mellon, S. H. (2010) · Depression and Anxiety · doi:10.1002/da.20686 · Cited by 298 · see citing works
Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice
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Prins, B. P., Abbasi, A., Wong, A., Vaez, A., Nolte, I., Franceschini, N., Stuart, P. E., Guterriez Achury, J., Mistry, V., Bradfield, J. P., et al. (2016) · PLOS Medicine · doi:10.1371/journal.pmed.1001976 · Cited by 199 · see citing works
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Addressing the tuberculosis–depression syndemic to end the tuberculosis epidemic
Sweetland, A. C., Kritski, A., Oquendo, M. A., Sublette, M. E., Norcini Pala, A., Silva, L. R. B., Karpati, A., Silva, E. C., Moraes, M. O., Silva, J. R. L. E., et al. (2017) · The International Journal of Tuberculosis and Lung Disease · doi:10.5588/ijtld.16.0584 · Cited by 177 · see citing works
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Depression, cortisol, and suppressed cell-mediated immunity in metastatic breast cancer
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Polyunsaturated fatty acids, neuroinflammation and well being
Layé, S. (2010) · Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA) · doi:10.1016/j.plefa.2010.02.006 · Cited by 167 · see citing works
Maternal stress, nutrition and physical activity: Impact on immune function, CNS development and psychopathology
Marques, A. H., Bjørke-Monsen, A.-L., Teixeira, A. L., & Silverman, M. N. (2015) · Brain Research · doi:10.1016/j.brainres.2014.10.051 · Cited by 166 · see citing works
Glucocorticoid Dysregulations and Their Clinical Correlates: From Receptors to Therapeutics
Marques, A. H., Silverman, M. N., & Sternberg, E. M. (2009) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2009.04987.x · Cited by 158 · see citing works
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Herbert, J., & Lucassen, P. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.12.001 · Cited by 150 · see citing works
Depression and the risk of severe infections: prospective analyses on a nationwide representative sample
Andersson, N. W., Goodwin, R. D., Okkels, N., Gustafsson, L. N., Taha, F., Cole, S. W., & Munk-Jørgensen, P. (2016) · International Journal of Epidemiology · doi:10.1093/ije/dyv333 · Cited by 139 · see citing works
Replication and reproducibility issues in the relationship between C-reactive protein and depression: A systematic review and focused meta-analysis
Horn, S. R., Long, M. M., Nelson, B. W., Allen, N. B., Fisher, P. A., & Byrne, M. L. (2018) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2018.06.016 · Cited by 129 · see citing works
Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
Ruiz-Grosso, P., Cachay, R., de la Flor, A., Schwalb, A., & Ugarte-Gil, C. (2020) · PLOS ONE · doi:10.1371/journal.pone.0227472 · Cited by 134 · see citing works
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Koyanagi, A., Vancampfort, D., Carvalho, A. F., DeVylder, J. E., Haro, J. M., Pizzol, D., Veronese, N., & Stubbs, B. (2017) · BMC Medicine · doi:10.1186/s12916-017-0975-5 · Cited by 131 · see citing works
Metabolic syndrome and major depressive disorder: Co-occurrence and pathophysiologic overlap
McIntyre, R. S., Rasgon, N. L., Kemp, D. E., Nguyen, H. T., Law, C. W. Y., Taylor, V. H., Woldeyohannes, H. O., Alsuwaidan, M. T., Soczynska, J. K., Kim, B., et al. (2009) · Current Diabetes Reports · doi:10.1007/s11892-009-0010-0 · Cited by 127 · see citing works
Glucocorticoid sensitivity in humans-interindividual differences and acute stress effects
Rohleder, N., Wolf, J. M., & Kirschbaum, C. (2003) · Stress · doi:10.1080/1025389031000153658 · Cited by 118 · see citing works
Symptoms of Postpartum Depression Associated with Elevated Levels of Interleukin-1 Beta During the First Month Postpartum
Corwin, E. J., Johnston, N., & Pugh, L. (2008) · Biological Research For Nursing · doi:10.1177/1099800408323220 · Cited by 111 · see citing works
Imipramine attenuates neuroinflammatory signaling and reverses stress-induced social avoidance
Ramirez, K., Shea, D. T., McKim, D. B., Reader, B. F., & Sheridan, J. F. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.01.016 · Cited by 108 · see citing works
GABAergic modulation with classical benzodiazepines prevent stress-induced neuro-immune dysregulation and behavioral alterations
Ramirez, K., Niraula, A., & Sheridan, J. F. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.08.011 · Cited by 101 · see citing works
Social defeat promotes a reactive endothelium in a brain region-dependent manner with increased expression of key adhesion molecules, selectins and chemokines associated with the recruitment of myeloid cells to the brain
Sawicki, C. M., McKim, D. B., Wohleb, E. S., Jarrett, B. L., Reader, B. F., Norden, D. M., Godbout, J. P., & Sheridan, J. F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.10.004 · Cited by 101 · see citing works
Depression among patients with tuberculosis: determinants, course and impact on pathways to care and treatment outcomes in a primary care setting in southern Ethiopia—a study protocol
Ambaw, F., Mayston, R., Hanlon, C., & Alem, A. (2015) · BMJ Open · doi:10.1136/bmjopen-2015-007653 · Cited by 75 · see citing works
Daily negative mood affects fasting glucose in type 2 diabetes
Skaff, M. M., Mullan, J. T., Almeida, D. M., Hoffman, L., Masharani, U., Mohr, D., & Fisher, L. (2009) · Health Psychology · doi:10.1037/a0014429 · Cited by 72 · see citing works
Glucocorticoid receptor dimerization is required for proper recovery of LPS-induced inflammation, sickness behavior and metabolism in mice
Silverman, M. N., Mukhopadhyay, P., Belyavskaya, E., Tonelli, L. H., Revenis, B. D., Doran, J. H., Ballard, B. E., Tam, J., Pacher, P., & Sternberg, E. M. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.131 · Cited by 64 · see citing works
Depression as sickness behavior? A test of the host defense hypothesis in a high pathogen population
Stieglitz, J., Trumble, B. C., Thompson, M. E., Blackwell, A. D., Kaplan, H., & Gurven, M. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.05.008 · Cited by 62 · see citing works
Multisystem resiliency moderates the major depression-telomere length association: findings from the Heart and Soul Study
Puterman, E., Epel, E. S., Lin, J., Blackburn, E. H., Gross, J. J., Whooley, M. A., & Cohen, B. E. (2013) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2013.05.008 · Cited by 61 · see citing works
The experience of pain severity and pain interference in vulvodynia patients: The role of cognitive-behavioural factors, psychological distress and fatigue
Chisari, C., & Chilcot, J. (2017) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2016.12.010 · Cited by 58 · see citing works
Do symptoms of depression predict telomere length? Evidence from the west of Scotland twenty-07 study
Phillips, A. C., Robertson, T., Carroll, D., Der, G., Shiels, P. G., McGlynn, L., & Benzeval, M. (2013) · Psychosomatic Medicine · doi:10.1097/psy.0b013e318289e6b5 · Cited by 55 · see citing works
The Effects of Childhood and Adolescent Adversity on Substance Use Disorders and Poor Health in Early Adulthood
Wolitzky-Taylor, K., Sewart, A., Vrshek-Schallhorn, S., Zinbarg, R., Mineka, S., Hammen, C., Bobova, L., Adam, E. K., & Craske, M. G. (2017) · Journal of Youth and Adolescence · doi:10.1007/s10964-016-0566-3 · Cited by 51 · see citing works
Population impact of depression either as a risk factor or consequence of type 2 diabetes in adults: a meta-analysis of longitudinal studies
Hasan, S. S., Clavarino, A. M., Mamun, A. A., Doi, S. A. R., & Kairuz, T. (2013) · Asian Journal of Psychiatry · doi:10.1016/j.ajp.2013.09.008 · Cited by 34 · see citing works
Interaction between job stress and the BDNF Val66Met polymorphism affects depressive symptoms in Chinese healthcare workers
He, S.-C., Wu, S., Wang, C., Du, X.-D., Yin, G., Jia, Q., Zhang, Y., Wang, L., Soares, J. C., & Zhang, X. Y. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.04.089 · Cited by 28 · see citing works
Decreased osteoprotegerin and increased bone turnover in young female patients with major depressive disorder and a lifetime history of anorexia nervosa
Kahl, K. G., Rudolf, S., Dibbelt, L., Stoeckelhuber, B. M., Gehl, H.-B., Hohagen, F., & Schweiger, U. (2005) · Osteoporosis International · doi:10.1007/s00198-004-1711-5 · Cited by 27 · see citing works
Inflammatory markers and incident depression: evidence in a population-based prospective study
Shi, R., Gwee, X., Chua, D. Q., Tan, C. T., Yap, K. B., Larbi, A., Lu, Y., & Ng, T. P. (2022) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2022.105806 · Cited by 23 · see citing works
Factors influencing risk of premature mortality in community cases of depression: a meta-analytic review
Baxter, A. J., Page, A., & Whiteford, H. A. (2011) · Epidemiology Research International · doi:10.1155/2011/832945 · Cited by 21 · see citing works
Vitamin D3 as adjunctive therapy in the treatment of depression in tuberculosis patients: a short-term pilot randomized double-blind controlled study
Zhang, L., Wang, S., Zhu, Y., & Yang, T. (2018) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s183039 · Cited by 16 · see citing works

MicroRNA-345-3p is a potential biomarker and ameliorates rheumatoid arthritis by reducing the release of proinflammatory cytokines
Ma, J., Zhao, W., Pei, X., et al. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-03797-3 · Cited by 3 · see citing works
Dihydrocapsaicin suppresses proinflammatory cytokines expression by enhancing nuclear factor IA in a NF-κB-dependent manner
Zhao, J., Hu, Y., Huang, C., et al. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.06.002 · Cited by 21 · see citing works
Effects of Proinflammatory Cytokines in the Heart
Zhang, C. (2004) · Life Science Research
Induction of inducible nitric oxide synthase and proinflammatory cytokines expression by o,p′-DDT in macrophages
Kim, J. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2003.12.001 · Cited by 45 · see citing works
Proinflammatory Cytokines Mediate GPCR Dysfunction
Mohan, M. L., Vasudevan, N. T., & Prasad, S. V. N. (2017) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000456 · Cited by 21 · see citing works

Authors: Kiecolt-Glaser, J. K., & Glaser, R.
Affiliations: The Ohio State University (US)
Venue: Journal of Psychosomatic Research
Publisher: Elsevier BV
Published: 2002-10
Volume: 53
Issue: 4
Pages: 873-876
ISSN: 0022-3999 (ISSN-L)
DOI: 10.1016/s0022-3999(02)00309-4
OpenAlex: W2097318458
Cited by: 571
References: 48
Citations by year: 2026: 14 · 2025: 17 · 2024: 14 · 2023: 16 · 2022: 21 · 2021: 21 · 2020: 29 · 2019: 23 · 2018: 28 · 2017: 24 · 2016: 31 · 2015: 32 · 2014: 36 · 2013: 37 · 2012: 24
FWCI: 1.48
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Journal of Psychosomatic Research (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k02mh001467-05, 5r37mh042096-15)
National Institute on Aging (P01AG016321, P01 AG-16321)
National Institute of Mental Health (K02 MH01467, R37 MH42096)
National Institute of Dental and Craniofacial Research (P50 DE17811)
National Center for Research Resources (M01-RR0034, M01RR000034)
Topics: Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Social Sciences › Health › Health disparities and outcomes
Keywords: depression, immune function, immune dysregulation, inflammatory cytokines, aging, older adults, cardiovascular disease, osteoporosis, arthritis, type 2 diabetes, cancer, periodontal disease, frailty, cell-mediated immunity, wound healing, morbidity and mortality
MeSH terms: Aging, C-Reactive Protein, Cardiovascular Diseases, Depressive Disorder, Diabetes Mellitus, Health Status Indicators, Humans, Inflammation, Health Behavior, Interleukin-6

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