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Cited by 292Diabetes and associated disordersDiabetes Management and ResearchGenetic Associations and Epidemiology

The DOI matches its Crossref record; 90 of the 92 references it cites were found in a registry or an index.

The Emerging Global Epidemic of Type 1 Diabetes

Tuomilehto, Jaakko·2013·Current Diabetes Reports
DOI 10.1007/s11892-013-0433-5
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Abstract

Type 1 diabetes mellitus (T1D) can occur at any age, with a peak in incidence around puberty. Classification between T1D and type 2 diabetes becomes more challenging with increasing age of onset of T1D over time develops in genetically predisposed individuals. The main susceptibility is conferred with human leukocyte antigen (HLA) genes. Some of the geographic variation in incidence and familial aggregation is explained by differences in HLA haplotypes. In many populations, the incidence is somewhat higher in males than in females, and a 1.3- to 2.0-fold male excess in incidence after about 15 years of age exists in most populations. The incidence of childhood-onset T1D varies markedly among countries. East Asian and native American populations have low incidences (approximately 0.1-8 per 100 000/year), while the highest rates are found in Finland (>60 per 100 000/year), Sardinia (40 per 100 000/year), and Sweden (47 per 100 000/year). The risk is highest in European-derived populations. About 10 %-20 % of newly diagnosed childhood cases of T1D have an affected first-degree relative. Those with an affected sibling or parent have a cumulative risk of 3 %-7 % up to about 20 years of age, as compared with <1 % in the general population. The cumulative incidence among the monozygotic co-twins of persons with T1D is less than 50 %. Thus, the majority of genetically predisposed people do not develop T1D. Studies assessing temporal trends have shown that the incidence of childhood-o…

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Research works printed but not linked: 2

  1. •• International Diabetes Feferation. IDF Diabetes Atlas. 5th edition. Brussels 2012. IDF updates the global estimates for each country nowadays every year and provides projections for the future numbers of people with diabetes in the world. A very important and useful document.
  2. Miettinen M, Kinnunen L, Keinänen-Kiukaanniemi S, et al. Prevalence of vitamin D insufficiency in Finnish adult population. Suomen Lääkäril. 2013;68:29–33. in Finnish with English Summary.

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Metadata

Authors
Tuomilehto, J.
Affiliations
Universität für Weiterbildung Krems (AT)
Corresponding author
Tuomilehto, Jaakko
ORCID
Tuomilehto, Jaakko
Venue
Current Diabetes Reports
Publisher
Springer Science and Business Media LLC
Published
2013-09-27
Volume
13
Issue
6
Pages
795-804
ISSN
  • 1534-4827 (ISSN-L)
  • 1539-0829
DOI
10.1007/s11892-013-0433-5
OpenAlex
W1997449038
Cited by
292
References
92
Citations by year
2026: 6 · 2025: 15 · 2024: 13 · 2023: 27 · 2022: 31 · 2021: 21 · 2020: 32 · 2019: 26 · 2018: 29 · 2017: 32 · 2016: 25 · 2015: 18 · 2014: 17
FWCI
13.26
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Current Diabetes Reports (publishedVersion)
  • PubMed (publishedVersion)
  • STM:n Hallinnonalan avoin julkaisuarkisto (Julkari) (submittedVersion)
  • WOS
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
type 1 diabetes, diabetes incidence, childhood-onset diabetes, HLA haplotypes, genetic susceptibility, familial aggregation, sex differences in incidence, geographic variation in incidence, incidence trends, age of onset, environmental risk factors
MeSH terms
Diabetes Mellitus, Type 1, Female, Humans, Male, Incidence, Age of Onset, Age Distribution, Sex Distribution

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