Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 222

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

Interventions to Improve Medication Adherence in Hypertensive Patients: Systematic Review and Meta-analysis

Open access
Conn, Vicki S., Ruppar, Todd M., Chase, Jo-Ana D., Enriquez, Maithe, Cooper, Pamela S.·2015·Current Hypertension Reports
DOI 10.1007/s11906-015-0606-5
Open this paper in CoChat — free account

Abstract

This systematic review applied meta-analytic procedures to synthesize medication adherence interventions that focus on adults with hypertension. Comprehensive searching located trials with medication adherence behavior outcomes. Study sample, design, intervention characteristics, and outcomes were coded. Random-effects models were used in calculating standardized mean difference effect sizes. Moderator analyses were conducted using meta-analytic analogues of ANOVA and regression to explore associations between effect sizes and sample, design, and intervention characteristics. Effect sizes were calculated for 112 eligible treatment-vs.-control group outcome comparisons of 34,272 subjects. The overall standardized mean difference effect size between treatment and control subjects was 0.300. Exploratory moderator analyses revealed interventions were most effective among female, older, and moderate- or high-income participants. The most promising intervention components were those linking adherence behavior with habits, giving adherence feedback to patients, self-monitoring of blood pressure, using pill boxes and other special packaging, and motivational interviewing. The most effective interventions employed multiple components and were delivered over many days. Future research should strive for minimizing risks of bias common in this literature, especially avoiding self-report adherence measures.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1007/s11906-015-0606-5

Cites

15 of 15 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 15 references

Research works printed but not linked: 146

  1. Burnier M. Managing ‘resistance’: is adherence a target for treatment? Curr Opin Nephrol Hypertens. 2014;23:439–43. This paper documents the importance of inadequate medication adherence in resistant hypertension. · DOI
  2. Christensen A, Osterberg LG, Hansen EH. Electronic monitoring of patient adherence to oral antihypertensive medical treatment: a systematic review. J Hypertens. 2009;27:1540–51. · DOI
  3. De Geest S, Ruppar T, Berben L, Schonfeld S, Hill MN. Medication non-adherence as a critical factor in the management of presumed resistant hypertension: a narrative review. EuroIntervention. 2014;9:1102–9. This article explains the role of nonadherence to medications in resistant hypertension. · DOI
  4. Erdine S, Arslan E. Monitoring treatment adherence in hypertension. Curr Hypertens Rep. 2013;15:269–72. · DOI
  5. Wofford MR, Minor DS. Hypertension: issues in control and resistance. Curr Hypertens Rep. 2009;11:323–8. · DOI
  6. Vrijens B, Vincze G, Kristanto P, Urquhart J, Burnier M. Adherence to prescribed antihypertensive drug treatments: longitudinal study of electronically compiled dosing histories. BMJ. 2008;336:1114–7. · DOI · Paper page
  7. Jung O, Gechter JL, Wunder C, Paulke A, Bartel C, Geiger H, et al. Resistant hypertension? Assessment of adherence by toxicological urine analysis. J Hypertens. 2013;31:766–74. · DOI · Paper page
  8. Bramlage P, Hasford J. Blood pressure reduction, persistence and costs in the evaluation of antihypertensive drug treatment—a review. Cardiovasc Diabetol. 2009;8:18. · DOI
  9. Lewis LM. Factors associated with medication adherence in hypertensive blacks: a review of the literature. J Cardiovasc Nurs. 2012;27:208–19. · DOI
  10. Lewis LM, Ogedegbe C, Ogedegbe G. Enhancing adherence of antihypertensive regimens in hypertensive African-Americans: current and future prospects. Expert Rev Cardiovasc Ther. 2012;10:1375–80. · DOI
  11. Matthes J, Albus C. Improving adherence with medication: a selective literature review based on the example of hypertension treatment. Deutsches Arzteblatt Int. 2014;111:41–7.
  12. Takiya LN, Peterson AM, Finley RS. Meta-analysis of interventions for medication adherence to antihypertensives. Ann Pharmacother. 2004;38:1617–24. · DOI
  13. Glynn LG, Murphy AW, Smith SM, Schroeder K, Fahey T. Interventions used to improve control of blood pressure in patients with hypertension. Cochrane Database Syst Rev. 2010;3, CD005182. doi: 10.1002/14651858.CD005182.pub4 . · DOI · Paper page
  14. Jayasinghe J. Non-adherence in the hypertensive patient: can nursing play a role in assessing and improving compliance? Can J Cardiovasc Nurs. 2009;19:7–12.
  15. Morgado MP, Morgado SR, Mendes LC, Pereira LJ, Castelo-Branco M. Pharmacist interventions to enhance blood pressure control and adherence to antihypertensive therapy: review and meta-analysis. Am J Health Syst Pharm. 2011;68:241–53. · DOI · Paper page
  16. World Health Organization. Adherence to long-term therapies: evidence for action. Geneva: World Health Organization; 2003.
  17. Borenstein M, Hedges L, Higgins JPT, Rothstein H. Introduction to meta-analysis. West Sussex: Wiley; 2009. · DOI · Paper page
  18. Sutton AJ. Publication bias. In: Cooper H, Hedges L, Valentine J, editors. The handbook of research synthesis and meta-analysis. 2nd ed. New York: Russell Sage; 2009. p. 435–52.
  19. Rothstein HR, Hopewell S. Grey literature. In: Cooper H, Hedges L, Valentine J, editors. The handbook of research synthesis and meta-analysis. 2nd ed. New York: Russell Sage; 2009. p. 103–25.
  20. White H. Scientific communication and literature retrieval. In: Cooper H, Hedges L, Valentine J, editors. The handbook of research synthesis and meta-analysis. 2nd ed. New York: Russell Sage; 2009. p. 51–71.
  21. Dickersin K, Scherer R, Lefebvre C. Identifying relevant studies for systematic reviews. BMJ. 1994;309:1286–91. · DOI · Paper page
  22. Easterbrook PJ. Directory of registries of clinical trials. Stat Med. 1992;11:363–423. · DOI
  23. Langham J, Thompson E, Rowen K. Identification of randomized controlled trials from the emergency medicine literature: comparison of hand searching versus MEDLINE searching. Ann Emerg Med. 1999;34:25–34. · DOI
  24. Wood JA. Methodology for dealing with duplicate study effects in a meta-analysis. Orgn Res Methods. 2008;11:79–95. · DOI · Paper page
  25. Devine E. Issues and challenges in coding interventions for meta-analysis of prevention research. Meta-analysis of drug abuse prevention programs. Rockville: National Institute on Drug Abuse; 1997.
  26. Orwin R, Vevea J. Evaluating coding decisions. In: Cooper H, Hedges L, Valentine J, editors. The handbook of research synthesis and meta-analysis. 2nd ed. New York: Russell Sage; 2009. p. 177–203.
  27. Lipsey M, Wilson D. Practical meta-analysis. Thousand Oaks: Sage; 2001.
  28. Raudenbush S. Random effects models. In: Cooper H, Hedges L, Valentine J, editors. The handbook of research synthesis and meta-analysis. 2nd ed. New York: Russell Sage; 2009. p. 295–315.
  29. Hedges L, Olkin I. Statistical methods for meta-analysis. Orlando: Academic; 1985.
  30. Conn VS, Hafdahl AR, Mehr DR, LeMaster JW, Brown SA, Nielsen PJ. Metabolic effects of interventions to increase exercise in adults with type 2 diabetes. Diabetologia. 2007;50:913–21. · DOI
  31. Shadish W, Haddock C. Combining estimates of effect size. In: Cooper H, Hedges L, Valentine J, editors. The handbook of research synthesis and meta-analysis. 2nd ed. New York: Russell Sage; 2009. p. 257–77.
  32. Nony P, Cucherat M, Haugh MC, Boissel JP. Critical reading of the meta-analysis of clinical trials. Therapie. 1995;50:339–51.
  33. Helmer D, Savoie I, Green C, Kazanjian A. Evidence-based practice: extending the search to find material for the systematic review. Bull Med Libr Assoc. 2001;89:346–52.
  34. Conn VS, Rantz MJ. Research methods: managing primary study quality in meta-analyses. Res Nurs Health. 2003;26:322–33. · DOI
  35. de Vet HC, de Bie RA, van der Heijden GJ, Verhagen AP, Sijpkes P, Kipschild P. Systematic review on the basis of methodological criteria. Physiotherapy. 1997;1997:284–9. · DOI
  36. Valentine J. Judging the quality of primary research. In: Cooper H, Hedges L, Valentine J, editors. The handbook of research synthesis and meta-analysis. 2nd ed. New York: Russell Sage; 2009. p. 129–46.
  37. Adeyemo A, Tayo BO, Luke A, Ogedegbe O, Durazo-Arvizu R, Cooper RS. The Nigerian antihypertensive adherence trial: a community-based randomized trial. J Hypertens. 2013;31:201–7. · DOI
  38. Aguwa CN, Ukwe CV, Ekwunife OI. Effect of pharmaceutical care programme on blood pressure and quality of life in a Nigerian pharmacy. Pharm World Sci. 2008;30:107–10. · DOI
  39. Al Owaish RA. Compliance with, and effectiveness of, specialized care of hypertension in Kuwait [dissertation]. Chapel Hill, NC: University of North Carolina; 1985.
  40. Alhalaiqa F, Deane KHO, Nawafleh AH, Clark A, Gray R. Adherence therapy for medication non-compliant patients with hypertension: a randomised controlled trial. J Hum Hypertens. 2012;26:117–26. · DOI
  41. Amado Guirado E, Pujol Ribera E, Pacheco Huergo V, Borras JM. Knowledge and adherence to antihypertensive therapy in primary care: results of a randomized trial. Gac Sanit. 2011;25:62–7. · DOI
  42. Austin DL. Selected nursing interventions for noncompliant hypertensive patients [dissertation]. Denton, TX: Texas Women’s University; 1986.
  43. Avanzini F, Corsetti A, Maglione T, Alli C, Colombo F, Torri V, et al. Simple, shared guidelines raise the quality of antihypertensive treatment in routine care. Am Heart J. 2002;144:726–32. · DOI
  44. Becker LA, Glanz K, Sobel E, Mossey J, Zinn SL, Knott KA. A randomized trial of special packaging of antihypertensive medications. J Fam Pract. 1986;22:357–61.
  45. Beeson SA. The effect of teaching by the nurse on patient knowledge of medications and compliant behavior [master’s thesis]. Greensboro, NC: University of North Carolina; 1977.
  46. Beune EJ, van Charante EP M, Beem L, Mohrs J, Agyemang CO, Ogedegbe G, et al. Culturally adapted hypertension education (CAHE) to improve blood pressure control and treatment adherence in patients of African origin with uncontrolled hypertension: cluster-randomized trial. PLoS One. 2014;9:e90103. · DOI
  47. Blenkinsopp A, Phelan M, Bourne J, Dakhil N. Extended adherence support by community pharmacists for patients with hypertension: a randomised controlled trial. Int J Pharm Pract. 2000;8:165–75. · DOI
  48. Bogner H, de Vries H. Integration of depression and hypertension treatment: a pilot, randomized controlled trial. Ann Fam Med. 2008;6:295–301. · DOI
  49. Boissel JP, Meillard O, Perrin-Fayolle E, Ducruet T, Alamercery Y, Sassano P, et al. Comparison between a bid and a tid regimen: improved compliance with no improved antihypertensive effect. Eur J Clin Pharmacol. 1996;50:63–7. · DOI
  50. Bosworth HB, Olsen MK, Neary A, Orr M, Grubber J, Svetkey L, et al. Take Control of Your Blood Pressure (TCYB) study: a multifactorial tailored behavioral and educational intervention for achieving blood pressure control. Patient Educ Couns. 2008;70:338–47. · DOI · Paper page
  51. Burrelle TN. Evaluation of an interdisciplinary compliance service for elderly hypertensives. J Geriatr Drug Ther. 1986;1:23–51.
  52. Carter BL, Doucette WR, Franciscus CL, Ardery G, Kluesner KM, Chrischilles EA. Deterioration of blood pressure control after discontinuation of a physician-pharmacist collaborative intervention. Pharmacotherapy. 2010;30:228–35. · DOI
  53. Cooper LA, Roter DL, Carson KA, Bone LR, Larson SM, Miller 3rd ER, et al. A randomized trial to improve patient-centered care and hypertension control in underserved primary care patients. J Gen Intern Med. 2011;26:1297–304. · DOI · Paper page
  54. Erickson SR, Ascione FJ, Kirking DM. Utility of electronic device for medication management in patients with hypertension: a pilot study. J Am Pharm Assoc (2003). 2005;45:88–91. · DOI
  55. Evans CE, Haynes RB, Birkett NJ, Gilbert JR, Taylor DW, Sackett DL, et al. Does a mailed continuing education program improve physician performance? Results of a randomized trial in antihypertensive care. JAMA. 1986;255:501–4. · doi:10.1001/jama.1986.03370040075027 · Paper page
  56. Fernandez S, Scales KL, Pineiro JM, Schoenthaler AM, Ogedegbe G. A senior center-based pilot trial of the effect of lifestyle intervention on blood pressure in minority elderly people with hypertension. J Am Geriatr Soc. 2008;56:1860–6. · DOI
  57. Fletcher SW, Appel FA, Bourgeois MA. Management of hypertension. Effect of improving patient compliance for follow-up care. J Am Med Assoc. 1975;233:242–4. · doi:10.1001/jama.1975.03260030032016
  58. Friedberg JP, Rodriguez MA, Watsula ME, Lin I, Wylie-Rosett J, Allegrante JP, et al. Effectiveness of a tailored behavioral intervention to improve hypertension control: primary outcomes of a randomized controlled trial. Hypertension. 2015;65:440–6. · DOI
  59. Gomez-Marcos M, Garcia-Ortiz L, Gonzalez-Elena LJ, Ramos-Delgado E, Gonzalez-Garcia AM, Parra-Sanchez J. Effectiveness of a quality improvement intervention in blood pressure control in primary care. Rev Clin Esp. 2006;206:428–34. · doi:10.1157/13093467
  60. Gonzalez-Fernandez RA, Rivera M, Torres D, Quiles J, Jackson A. Usefulness of a systemic hypertension in-hospital educational program. Am J Cardiol. 1990;65:1384–6. · DOI
  61. Hacihasanoğlu R, Gözüm S. The effect of patient education and home monitoring on medication compliance, hypertension management, healthy lifestyle behaviours and BMI in a primary health care setting. J Clin Nurs. 2011;20:692–705. · DOI
  62. Harowski KJ. The effect of problem solving training on compliance to a medical regimen for hypertension [dissertation]. Missoula, MT: University of Montana; 1983.
  63. Harper DC. Application of Orem’s theoretical constructs to self-care medication behaviors in the elderly. Adv Nurs Sci. 1984;6:29–46. · doi:10.1097/00012272-198404000-00008
  64. Hawkins DW, Fiedler FP, Douglas HL, Eschbach RC. Evaluation of a clinical pharmacist in caring for hypertensive and diabetic patients. Am J Hosp Pharm. 1979;36:1321–5.
  65. Haynes RB, Sackett DL, Gibson ES, Taylor DW, Hackett BC, Roberts RS, et al. Improvement of medication compliance in uncontrolled hypertension. Lancet. 1976;1:1265–8. · DOI · Paper page
  66. Hess PL, Reingold JS, Jones J, Fellman MA, Knowles P, Ravenell JE, et al. Barbershops as hypertension detection, referral, and follow-up centers for black men. Hypertension. 2007;49:1040–6. · DOI
  67. Hunt JS, Siemienczuk J, Pape G, Rozenfeld Y, MacKay J, LeBlanc BH, et al. A randomized controlled trial of team-based care: impact of physician-pharmacist collaboration on uncontrolled hypertension. J Gen Intern Med. 2008;23:1966–72. · DOI · Paper page
  68. Inui TS, Yourtee EL, Williamson JW. Improved outcomes in hypertension after physician tutorials. A controlled trial. Ann Intern Med. 1976;84:646–51. · DOI · Paper page
  69. Jafar TH, Hatcher J, Poulter N, Islam M, Hashmi S, Qadri Z, et al. Community-based interventions to promote blood pressure control in a developing country: a cluster randomized trial. Ann Intern Med. 2009;151:593–601. · DOI · Paper page
  70. Johnson AL, Taylor DW, Sackett DL, Dunnett CW, Shimizu AG. Self-recording of blood pressure in the management of hypertension. Can Med Assoc J. 1978;119:1034–9.
  71. Kauric-Klein Z. Improving blood pressure control in end stage renal disease through a supportive educative nursing intervention. Nephrol Nurs J. 2012;39:217–28.
  72. Kim KB, Han HR, Huh B, Nguyen T, Lee H, Kim MT. The effect of a community-based self-help multimodal behavioral intervention in korean american seniors with high blood pressure. Am J Hypertens. 2014;27:1199–208. · DOI
  73. Kim MT, Kim E, Han H, Jeong S, Lee JE, Park HJ, et al. Mail education is as effective as in-class education in hypertensive Korean patients. J Clin Hypertens. 2008;10:176–84. · DOI
  74. Kobalava Z, Villevalde S, Isikova KH, Pavlova E. Impact of integrated approach on blood pressure control in non adherent motivated. 20th European Meeting on Hypertension; Oslo, Norway. pp. e329. Accessed. · doi:10.1097/01.hjh.0000379199.15787.6e
  75. Leung LB, Busch AM, Nottage SL, Arellano N, Glieberman E, Busch NJ, et al. Approach to antihypertensive adherence: a feasibility study on the use of student health coaches for uninsured hypertensive adults. Behav Med. 2012;38:19–27. · DOI
  76. Levine DM, Green LW, Deeds SG, Chwalow J, Russell RP, Finlay J. Health education for hypertensive patients. J Am Med Assoc. 1979;241:1700. · DOI · Paper page
  77. Logan AG, Milne BJ, Achber C. A comparison of community and occupationally provided antihypertensive care. J Occup Environ Med. 1982;24:901–6.
  78. Ma C, Zhou Y, Zhou W, Huang C. Evaluation of the effect of motivational interviewing counselling on hypertension care. Patient Educ Couns. 2014;95:231–7. · DOI
  79. Magadza C, Radloff SE, Srinivas SC. The effect of an educational intervention on patients’ knowledge about hypertension, beliefs about medicines, and adherence. Res Social Adm Pharm. 2009;5:363–75. · DOI
  80. Marquez Contreras E, Casado Martinez JJ, Celotti Gomez B, Gascon Vivo J, Martin de Pablos JL, Gil Rodriguez R, et al. Treatment compliance in arterial hypertension. A 2-year intervention trial through health education. Aten Primaria. 2000;26:5–10. · DOI
  81. Marquez Contreras E, de la Figuera von Wichmann M, Gil Guillen V, Ylla-Catala A, Figueras M, Balana M, et al. Effectiveness of an intervention to provide information to patients with hypertension as short text messages and reminders sent to their mobile phone (HTA-Alert). Aten Primaria. 2004;34:399–405. · DOI · Paper page
  82. Marquez Contreras E, Martel Claros N, Gil Guillen V, Martin De Pablos JL, De la Figuera Von Wichman M, Casado Martinez JJ, et al. Non-pharmacological intervention as a strategy to improve antihypertensive treatment compliance. Aten Primaria. 2009;41:501–10. · DOI
  83. Marquez Contreras E, Vegazo Garca O, Claros NM, Gil Guillen V, de la Figuera von Wichmann M, Casado Martinez J, et al. Efficacy of telephone and mail intervention in patient compliance with antihypertensive drugs in hypertension. ETECUM-HTA study. Blood Press. 2005;14:151–8. · DOI
  84. Márquez-Contreras E, Martell-Claros N, Gil-Guillén V, Wichmann MF-V, Casado-Martínez JJ, Martin-de Pablos JL, et al. Efficacy of a home blood pressure monitoring programme on therapeutic compliance in hypertension: the EAPACUM-HTA study. J Hypertens. 2006;24:169–75. · DOI · Paper page
  85. Martin MY, Kim YI, Kratt P, Litaker MS, Kohler CL, Schoenberger YM, et al. Medication adherence among rural, low-income hypertensive adults: a randomized trial of a multimedia community-based intervention. Am J Health Promot. 2011;25:372–8. · DOI
  86. McGillicuddy JW, Gregoski MJ, Weiland AK, Rock RA, Brunner-Jackson BM, Patel SK, et al. Mobile health medication adherence and blood pressure control in renal transplant recipients: a proof-of-concept randomized controlled trial. JMIR Res Protoc. 2013;2, e32. doi: 10.2196/resprot.2633 . · DOI · Paper page
  87. McKenney JM, Brown ED, Necsary R, Reavis HL. Effect of pharmacist drug monitoring and patient education on hypertensive patients. Contemp Pharm Pract. 1978;1:50–6.
  88. McKenney JM, Slining JM, Henderson HR, Devins D, Barr M. The effect of clinical pharmacy services on patients with essential hypertension. Circulation. 1973;48:1104–11. · DOI · Paper page
  89. Mehos BM, Saseen JJ, MacLaughlin EJ. Effect of pharmacist intervention and initiation of home blood pressure monitoring in patients with uncontrolled hypertension. Pharmacotherapy. 2000;20:1384–9. · DOI · Paper page
  90. Mitchell ML. Effects of a self-efficacy intervention on adherence to antihypertensive regimens [dissertation]. Rochester, NY: University of Rochester; 1993.
  91. Moore JM, Shartle D, Faudskar L, Matlin OS, Brennan TA. Impact of a patient-centered pharmacy program and intervention in a high-risk group. J Manag Care Pharm. 2013;19:228–36. · DOI
  92. Morgado M, Rolo S, Castelo-Branco M. Pharmacist intervention program to enhance hypertension control: a randomised controlled trial. Int J Clin Pharm. 2011;33:132–40. · DOI
  93. Muhlhauser I, Sawicki P, Didjurgeit U, Jorgens V, Berger M. Uncontrolled hypertension in type 1 diabetes: assessment of patients’ desires about treatment and improvement of blood pressure control by a structured treatment and teaching programme. Diabet Med. 1988;5:693–8. · DOI
  94. Murray MD, Harris LE, Overhage JM, Zhou X, Eckert GJ, Smith FE, et al. Failure of computerized treatment suggestions to improve health outcomes of outpatients with uncomplicated hypertension: results of a randomized controlled trial. Pharmacotherapy. 2004;24:324–37. · DOI
  95. Ogedegbe G, Chaplin W, Schoenthaler A, Statman D, Berger D, Richardson T, et al. A practice-based trial of motivational interviewing and adherence in hypertensive African Americans. Am J Hypertens. 2008;21:1137–43. · DOI · Paper page
  96. Ogedegbe G, Tobin JN, Fernandez S, Cassells A, Diaz-Gloster M, Khalida C, et al. Counseling African Americans to control hypertension: cluster-randomized clinical trial main effects. Circulation. 2014;129:2044–51. · DOI
  97. Oliver S, Jones J, Leonard D, Crabbe A, Delkhah Y, Nesbitt S. Improving adherence with amlodipine/atorvastatin therapy: IMPACT study. J Clin Hypertens. 2011;13:598–604. doi: 10.1111/j.1751-7176.2011.00478.x . · DOI
  98. Oparah AC, Adje DUO, Enato EF. Outcomes of pharmaceutical care intervention to hypertensive patients in a Nigerian community pharmacy. Int J Pharm Pract. 2006;14:115–22. · DOI
  99. Oser M. Evaluation of a bibliotherapy intervention for improving patients’ adherence to antihypertensive medications [dissertation]. Reno, NV: University of Nevada; 2008.
  100. Park JJ, Kelly P, Carter BL, Burgess PP. Comprehensive pharmaceutical care in the chain setting. J Am Pharm Assoc. 1996;NS36:443–51. · DOI
  101. Park YH, Chang H, Kim J, Kwak JS. Patient‐tailored self‐management intervention for older adults with hypertension in a nursing home. J Clin Nurs. 2013;22:710–22. · DOI
  102. Patel S, Jacobus-Kantor L, Marshall L, Ritchie C, Kaplinski M, Khurana PS, et al. Mobilizing your medications: an automated medication reminder application for mobile phones and hypertension medication adherence in a high-risk urban population. J Diabetes Sci Technol. 2013;7:630–9. · DOI
  103. Pertusa Martínez S, Quirce F, Saavedra MD, Merino J. Evaluation of 3 strategies to improve therapeutic compliance of patients with essential hypertension. Aten Primaria. 1998;22:670–1.
  104. Pierce JP, Watson DS, Knights S, Gliddon T, Williams S, Watson R. A controlled trial of health education in the physician’s office. Prev Med. 1984;13:185–94. · DOI
  105. Pippalla RS. An impact assessment of pharmacist counseling on pharmaceutical care of hypertensives: interrelationships of compliance, quality of life, and therapeutic outcomes, with some policy perspectives [dissertation]. Morgantown, WV: University of West Virginia; 1994.
  106. Pladevall M, Brotons C, Gabriel R, Arnau A, Suarez C, Marquez E, et al. Multicenter cluster-randomized trial of a multifactorial intervention to improve antihypertensive medication adherence and blood pressure control among patients at high cardiovascular risk (the COM99 study). Circulation. 2010;122:1183–91. · DOI
  107. Planas L, Crosby KM, Mitchell KD, Farmer KC. Evaluation of a hypertension medication therapy management program in patients with diabetes. J Am Pharm Assoc (2003). 2009;49:164–70. · DOI
  108. Powell KW. Strategy to improve blood pressure control and medication adherence [dissertation]. Chicago, IL: Rush University; 2002.
  109. Resnick B, Shaughnessy M, Galik E, Scheve A, Fitten R, Morrison T, et al. Pilot testing of the PRAISEDD intervention among African-American and low-income older adults. J Cardiovasc Nurs. 2009;24:352–61. · DOI
  110. Rinfret S, Lussier M, Peirce A, Duhamel F, Cossette S, Lalonde L, et al. The impact of a multidisciplinary information technology-supported program on blood pressure control in primary care. Circulation. 2009;2:170–7.
  111. Robinson JD, Segal R, Lopez LM, Doty RE. Impact of a pharmaceutical care intervention on blood pressure control in a chain pharmacy practice. Ann Pharmacother. 2010;44:88–96. · DOI
  112. Roca-Cusachs A, Sort D, Altimira J, Bonet R, Guilera E, Monmany J, et al. The impact of a patient education programme in the control of hypertension. J Hum Hypertens. 1991;5:437–41.
  113. Rodriguez MA. Is behavior change sustainable for diet, exercise, and medication adherence? [dissertation]. New York, NY: Yeshiva University; 2011.
  114. Roumie CL, Elasy TA, Greevy R, Griffin MR, Liu X, Stone WJ, et al. Improving blood pressure control through provider education, provider alerts, and patient education: a cluster randomized trial. Ann Intern Med. 2006;145:165–75. · DOI · Paper page
  115. Ruppar TM. Randomized pilot study of a behavioral feedback intervention to improve medication adherence in older adults with hypertension. J Cardiovasc Nurs. 2010;25:470–9. · DOI
  116. Saleem F, Hassali MA, Shafie AA, Ul Haq N, Farooqui M, Aljadhay H, et al. Pharmacist intervention in improving hypertensionrelated knowledge, treatment medication adherence and health-related quality of life: a non-clinical randomized controlled trial. Health Expect. 2013. doi: 10.1111/hex.12101 . · DOI
  117. Santschi V, Rodondi N, Bugnon O, Burnier M. Impact of electronic monitoring of drug adherence on blood pressure control in primary care: a cluster 12-month randomised controlled study. Eur J Intern Med. 2008;19:427–34. · DOI
  118. Saunders LD, Irwig LM, Gear JS, Ramushu DL. A randomized controlled trial of compliance improving strategies in Soweto hypertensives. Med Care. 1991;29:669–78. · DOI
  119. Schroeder K, Fahey T, Hollinghurst S, Peters TJ. Nurse-led adherence support in hypertension: a randomized controlled trial. Fam Pract. 2005;22:144–51. · DOI
  120. Sicras-Mainar A, Ibanez J, Firas X, Bulto C, Costa A, Majos N et al. Evaluation of Telemedicine Program (ITHACA): innovation in the treatment of arterial hypertension increasing the compliance and adherence. International Society for Pharmacoeconomics and Outcomes Research 17th Annual Meeting; Washington, D.C. pp. A528. Accessed. · doi:10.1016/j.jval.2012.08.1829
  121. Skaer TL, Sclar DA, Markowski DJ, Won JKH. Effect of value-added utilities in promoting prescription refill compliance among patients with hypertension. Curr Ther Res Clin Exp. 1993;53:251–5. · DOI
  122. Solomon DK, Portner TS, Bass GE, Gourley DR, Gourley GA, Holt JM, et al. Clinical and economic outcomes in the hypertension and COPD arms of a multicenter outcomes study. J Am Pharm Assoc. 1998;38:574–85. · DOI
  123. Sookaneknun P, Richards RM, Sanguansermsri J, Teerasut C. Pharmacist involvement in primary care improves hypertensive patient clinical outcomes. Ann Pharmacother. 2004;38:2023–8. · DOI
  124. Stewart A, Noakes T, Eales C, Shepard K, Becker P, Veriawa Y. Adherence to cardiovascular risk factor modification in patients with hypertension. Cardiovasc J South Afr. 2005;16:102–7.
  125. Svarstad BL, Kotchen JM, Shireman TI, Brown RL, Crawford SY, Mount JK, et al. Improving refill adherence and hypertension control in black patients: Wisconsin TEAM trial. J Am Pharm Assoc (2003). 2013;53:520–9. · DOI
  126. van de Steeg-van Gompel CHPA, Wensing M, De Smet PAGM. Implementation of adherence support for patients with hypertension despite antihypertensive therapy in general practice: a cluster randomized trial. Am J Hypertens. 2010;23:1038–45. · DOI
  127. Vivian EM. Improving blood pressure control in a pharmacist-managed hypertension clinic. Pharmacotherapy. 2002;22:1533–40. · DOI · Paper page
  128. Walker CC. An educational intervention for hypertension management in older African Americans. Ethn Dis. 2000;10:165–74.
  129. Wang J, Wu J, Yang J, Zhuang Y, Chen J, Qian W, et al. Effects of pharmaceutical care interventions on blood pressure and medication adherence of patients with primary hypertension in China. Clin Res Regul Aff. 2011;28:1–6. · DOI
  130. Wentzlaff DM, Carter BL, Ardery G, Franciscus CL, Doucette WR, Chrischilles EA, et al. Sustained blood pressure control following discontinuation of a pharmacist intervention. J Clin Hypertens. 2011;13:431–7. · DOI
  131. Werner RT, Sr. The effects of health education on the compliance of hypertensive patients to medical regimens [dissertation]. Philadelphia, PA: Temple University; 1979.
  132. Wong MC, Liu KQ, Wang HH, Lee CL, Kwan MW, Lee KW, et al. Effectiveness of a pharmacist-led drug counseling on enhancing antihypertensive adherence and blood pressure control: a randomized controlled trial. J Clin Pharmacol. 2013;53:753–61. doi: 10.1002/jcph.101 . · DOI
  133. Zillich AJ, Sutherland JM, Kumbera PA, Carter BL. Hypertension outcomes through blood pressure monitoring and evaluation by pharmacists (HOME study). J Gen Intern Med. 2005;20:1091–6. · DOI
  134. Mullen PD, Green LW, Persinger GS. Clinical trials of patient education for chronic conditions: a comparative meta-analysis of intervention types. Prev Med. 1985;14:753–81. · DOI · Paper page
  135. Peterson AM, Takiya L, Finley R. Meta-analysis of trials of interventions to improve medication adherence. Am J Health Syst Pharm. 2003;60:657–65. · DOI · Paper page
  136. Conn VS, Hafdahl AR, Cooper PS, Ruppar TM, Mehr DR, Russell CL. Interventions to improve medication adherence among older adults: meta-analysis of adherence outcomes among randomized controlled trials. Gerontologist. 2009;49:447–62. · DOI · Paper page
  137. Chase J, Bogener J, Ruppar T, Conn V. The effectiveness of medication adherence interventions among patients with coronary artery disease: a meta-analysis. J Cardiovasc Nurs. 2015. doi: 10.1097/JCN.0000000000000259 . · DOI
  138. Conn V, Ruppar T, Enriquez M, Cooper P. Medication adherence interventions that target subjects with adherence problems: systematic review and meta-analysis. Res Social Adm Pharm. In press. · DOI
  139. Conn V, Enriquez M, Ruppar T, Chan K. Cultural relevance in medication adherence interventions with underrepresented adults: systematic review and meta-analysis of outcomes. Prev Med. 2014;69:239–47. · DOI
  140. Perreault S, Dragomir A, White M, Lalonde L, Blais L, Berard A. Better adherence to antihypertensive agents and risk reduction of chronic heart failure. J Intern Med. 2009;266:207–18. · DOI
  141. Lowy A, Munk VC, Ong SH, Burnier M, Vrijens B, Tousset EP, et al. Effects on blood pressure and cardiovascular risk of variations in patients’ adherence to prescribed antihypertensive drugs: role of duration of drug action. Int J Clin Pract. 2011;65:41–53. · DOI
  142. Mancia G, Messerli F, Bakris G, Zhou Q, Champion A, Pepine CJ. Blood pressure control and improved cardiovascular outcomes in the International Verapamil SR-Trandolapril Study. Hypertension. 2007;50:299–305. · DOI · Paper page
  143. Roebuck MC, Liberman JN, Gemmill-Toyama M, Brennan TA. Medication adherence leads to lower health care use and costs despite increased drug spending. Health Aff (Millwood). 2011;30:91–9. · DOI · Paper page
  144. Iuga AO, McGuire MJ. Adherence and health care costs. Risk Manag Healthc Policy. 2014;7:35–44.
  145. Shimizu M, Shibasaki S, Kario K. The value of home blood pressure monitoring. Curr Hypertens Rep. 2006;8:363–7. · DOI
  146. Conn VS, Groves PS. Protecting the power of interventions through proper reporting. Nurs Outlook. 2011;59:318–25. · DOI

Cited by

See all 222

Metadata

Authors
Conn, V. S., Ruppar, T. M., Chase, J.-A. D., Enriquez, M., & Cooper, P. S.
Venue
Current Hypertension Reports
Publisher
Springer Science and Business Media LLC
Published
2015-11-11
Volume
17
Issue
12
Pages
94-94
ISSN
  • 1522-6417 (ISSN-L)
  • 1534-3111
DOI
10.1007/s11906-015-0606-5
OpenAlex
W2202040401
Cited by
222
References
15
FWCI
2.92
Type
journal article
Language
en
Open access
green
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Interventions to Improve Medication Adherence in Hypertensive Patients: Systematic Review and Meta-analysis. https://app.cochat.ai/papers/10.1007/s11906-015-0606-5
The paper
Conn, V. S., Ruppar, T. M., Chase, J.-A. D., Enriquez, M., & Cooper, P. S. (2015). Interventions to Improve Medication Adherence in Hypertensive Patients: Systematic Review and Meta-analysis. Current Hypertension Reports. https://doi.org/10.1007/s11906-015-0606-5

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.