Management of recurrent vulvovaginal candidiasis: Unresolved issues

Maintenance Fluconazole Therapy for Recurrent Vulvovaginal Candidiasis

Sobel, J. D., Wiesenfeld, H. C., Martens, M., Danna, P., Hooton, T. M., Rompalo, A., Sperling, M., Livengood, C., Horowitz, B., Von Thron, J., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033114 · Cited by 487 · see citing works

Hepatic Injury Associated With Ketoconazole Therapy

Lewis, J. H., Zimmerman, H. J., Benson, G. D., & Ishak, K. G. (1984) · Gastroenterology · doi:10.1016/s0016-5085(84)80021-9 · Cited by 394 · see citing works

Epidemiology and pathogenesis of recurrent vulvovaginal candidiasis

Sobel, J. D. (1985) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(85)80003-x · Cited by 332 · see citing works

Recurrent Vulvovaginal Candidiasis

Sobel, J. D. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612043152305 · Cited by 219 · see citing works

Treatment of vaginitis caused by Candida glabrata: use of topical boric acid and flucytosine

Sobel, J. D., Chaim, W., Nagappan, V., & Leaman, D. (2003) · American Journal of Obstetrics and Gynecology · doi:10.1067/s0002-9378(03)00726-9 · Cited by 206 · see citing works

Treatment of complicated Candida vaginitis: Comparison of single and sequential doses of fluconazole

Sobel, J. D., Kapernick, P. S., Zervos, M., Reed, B. D., Hooton, T., Soper, D., Nyirjesy, P., Heine, M. W., Willems, J., Panzer, H., et al. (2001) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2001.115116 · Cited by 158 · see citing works

The epidemiology of vulvovaginal candidiasis: risk factors.

Foxman, B. (1990) · American Journal of Public Health · doi:10.2105/ajph.80.3.329 · Cited by 133 · see citing works

Frequency of interleukin-4 (IL-4) -589 gene polymorphism and vaginal concentrations of IL-4, nitric oxide, and mannose-binding lectin in women with recurrent vulvovaginal candidiasis

Babula, O., Lazdane, G., Kroica, J., Linhares, I. M., Ledger, W. J., & Witkin, S. S. (2005) · Clinical Infectious Diseases · doi:10.1086/429246 · Cited by 130 · see citing works

Fluconazole Susceptibility of Vaginal Isolates Obtained from Women with Complicated Candida Vaginitis: Clinical Implications

Sobel, J. D., Zervos, M., Reed, B. D., Hooton, T. M., Soper, D. E., Nyirjesy, P., Heine, M. W., Willems, J., & Panzer, H. (2002) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.47.1.34-38.2003 · Cited by 118 · see citing works

Vaginitis Due to Candida krusei: Epidemiology, Clinical Aspects, and Therapy

Singh, S., Sobel, J. D., Bhargava, P., Boikov, D. A., & Vazquez, J. A. (2002) · Clinical Infectious Diseases · doi:10.1086/343826 · Cited by 97 · see citing works

History and new insights into host defense against vaginal candidiasis

Fidel, P. L. (2004) · Trends in Microbiology · doi:10.1016/j.tim.2004.03.006 · Cited by 85 · see citing works

The Evolution ofCandidaSpecies and Fluconazole Susceptibility among Oral and Vaginal Isolates Recovered from Human Immunodeficiency Virus (HIV)–Seropositive and At‐Risk HIV‐Seronegative Women

Sobel, J. D., Ohmit, S. E., Schuman, P. C., Klein, R. S., Mayer, K. H., Duerr, A. C., Vázquez, J. A., & Rompalo, A. M. (2001) · The Journal of Infectious Diseases · doi:10.1086/317936 · Cited by 83 · see citing works

Fluconazole levels in plasma and vaginal secretions of patients after a 150-milligram single oral dose and rate of eradication of infection in vaginal candidiasis

Houang, E. T., Chappatte, O., Byrne, D., Macrae, P. V., & Thorpe, J. E. (1990) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.34.5.909 · Cited by 76 · see citing works

Recurrent allergic vulvovaginitis: Treatment with Candida albicans allergen immunotherapy

Rigg, D., Miller, M. M., & Metzger, W. J. (1990) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(90)90380-p · Cited by 75 · see citing works

Fungicidal Activity of Fluconazole against <i>Candida albicans</i> in a Synthetic Vagina-Simulative Medium

Moosa, M.-Y. S., Sobel, J. D., Elhalis, H., Du, W., & Akins, R. A. (2004) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.48.1.161-167.2004 · Cited by 70 · see citing works

Prevalence of Vaginal Colonization by Drug‐Resistant<i>Candida</i>Species in College‐Age Women with Previous Exposure to Over‐the‐Counter Azole Antifungals

Mathema, B., Cross, E., Dun, E., Park, S., Bedell, J., Slade, B., Williams, M., Riley, L., Chaturvedi, V., & Perlin, D. S. (2001) · Clinical Infectious Diseases · doi:10.1086/322600 · Cited by 65 · see citing works

Symptomatic Vulvovaginitis Due to Fluconazole-Resistant Candida albicans in a Female Who Was Not Infected with Human Immunodeficiency Virus

Sobel, J. D., & Vazquez, J. A. (1996) · Clinical Infectious Diseases · doi:10.1093/clinids/22.4.726 · Cited by 63 · see citing works

Pathogenesis of recurrent vulvovaginal candidiasis

Sobel, J. D. (2002) · Current Infectious Disease Reports · doi:10.1007/s11908-002-0038-7 · Cited by 59 · see citing works

Evolution of Antifungal Susceptibility among<i>Candida</i>Species Isolates Recovered from Human Immunodeficiency Virus–Infected Women Receiving Fluconazole Prophylaxis

Vazquez, J. A., Peng, G., Sobel, J. D., Steele‐Moore, L., Schuman, P., Holloway, W., Neaton, J. D., & (CPCRA), T. T. B. C. P. F. C. R. O. A. (2001) · Clinical Infectious Diseases · doi:10.1086/322641 · Cited by 57 · see citing works

Recurrent genital candidosis in women and the effect of intermittent prophylactic treatment

Davidson, F., & Mould, R. F. (1978) · Sexually Transmitted Infections · doi:10.1136/sti.54.3.176 · Cited by 55 · see citing works

Hyposensitisation in the management of recurring vaginal candidiasis.

Rosedale, N., & Browne, K. (1979) · PubMed · Cited by 42 · see citing works

Vaginal Candida parapsilosis: pathogen or bystander?

Nyirjesy, P., Alexander, A. B., & Weitz, M. V. (2005) · PubMed · doi:10.1080/10647440400025603 · Cited by 38 · see citing works

Vaginal Candida parapsilosis: Pathogen or Bystander?

Nyirjesy, P., Alexander, A. B., & Weitz, M. V. (2005) · Infectious Diseases in Obstetrics and Gynecology · doi:10.1155/2005/401530 · Cited by 37 · see citing works

Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial

Russo, R., Karadja, E., & Seta, F. D. (2018) · Beneficial Microbes · doi:10.3920/bm2018.0075 · Cited by 116 · see citing works

Efficacy of the Clinical Agent VT-1161 against Fluconazole-Sensitive and -Resistant Candida albicans in a Murine Model of Vaginal Candidiasis

Garvey, E. P., HOEKSTRA, W., Schotzinger, R. J., Sobel, J. D., Lilly, E. A., & Fidel, P. L. (2015) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00185-15 · Cited by 83 · see citing works

Recurrent vulvovaginitis

Powell, A. M., & Nyirjesy, P. (2014) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2014.07.006 · Cited by 74 · see citing works

Candida vaginitis: virulence, host response and vaccine prospects

Bernardis, F. D., Graziani, S., Tirelli, F., & Antonopoulou, S. (2017) · Medical Mycology · doi:10.1093/mmy/myx139 · Cited by 71 · see citing works

Clinical challenges in diagnosis and treatment of recurrent vulvovaginal candidiasis

Neal, C. M., & Martens, M. G. (2022) · SAGE Open Medicine · doi:10.1177/20503121221115201 · Cited by 56 · see citing works

Weekly fluconazole therapy for recurrent vulvovaginal candidiasis: a systematic review and meta-analysis

da Rosa, M. I., Silva, B. R., Pires, P. S., Silva, F. R., Silva, N. C., Silva, F. R., Souza, S. L., Madeira, K., Panatto, A. P. R., & Medeiros, L. R. (2012) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2012.12.001 · Cited by 51 · see citing works

Treatment for recurrent vulvovaginal candidiasis (thrush)

Cooke, G., Watson, C., Deckx, L., Pirotta, M., Smith, J., & van Driel, M. L. (2022) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009151.pub2 · Cited by 48 · see citing works

Epidemiology and Antifungal Susceptibilities of Yeasts Causing Vulvovaginitis in a Teaching Hospital

Gamarra, S. P., Morano, S., Dudiuk, C., Mancilla, E., Nardin, M. E., Méndez, E., & García‐Effrón, G. (2014) · Mycopathologia · doi:10.1007/s11046-014-9780-2 · Cited by 48 · see citing works

Best Practice & Research Clinical Obstetrics and Gynaecology

Needleman, S. J., & Powell, M. E. B. (2014) · Cited by 48 · see citing works

Studies of Immune Responses in Candida vaginitis

Bernardis, F. D., Arancia, S., Sandini, S., Graziani, S., & Norelli, S. (2015) · Pathogens · doi:10.3390/pathogens4040697 · Cited by 47 · see citing works

Probiotics

Mizock, B. A. (2015) · Disease-a-Month · doi:10.1016/j.disamonth.2015.03.011 · Cited by 40 · see citing works

Detecting and treating common sexually transmitted diseases

Hay, P., & Ugwumadu, A. H. N. (2009) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2009.06.008 · Cited by 25 · see citing works

In Vitro Antifungal Activities of D11-2040, a .BETA.-1,6-Glucan Inhibitor, with or without Currently Available Antifungal Drugs

Kitamura, A., Someya, K., Okumura, R., Hata, M., Takeshita, H., & Nakajima, R. (2010) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.33.192 · Cited by 20 · see citing works

Oteseconazole: a long-awaited diversification of the antifungal arsenal to manage recurrent vulvovaginal candidiasis (RVVC)

Vandecruys, P., Baldewijns, S., Sillen, M., Genechten, W. V., & Dijck, P. V. (2023) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2023.2233696 · Cited by 15 · see citing works

Treating and Protecting against Recurrent Vulvovaginal Candidiasis Using the Vaginal Epithelial Cell Membrane-Based Photoimmunotherapeutic Nanoplatform

Wang, L., Lin, Y., Liu, S., Jin, C., Huang, Y., Liang, H., Sun, X., Zhang, K. X., Chen, H., Zhang, X., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c16974 · Cited by 14 · see citing works

La vulvovaginitis candidiásica recurrente

Cararach, M., Delgado, R. C., Armengol, E. D., García, E. M., Escoriza, J. C. M., Palacios, S., & Torres-Rodrı́guez, J. M. (2012) · Progresos de Obstetricia y Ginecología · doi:10.1016/j.pog.2012.05.014 · Cited by 14 · see citing works

A representative of arylcyanomethylenequinone oximes effectively inhibits growth and formation of hyphae in Candida albicans and influences the activity of protein kinases in vitro

Masłyk, M., Janeczko, M., Demchuk, O. M., Boguszewska‐Czubara, A., Golczyk, H., Sierosławska, A., Rymuszka, A., Martyna, A., & Kubiński, K. (2017) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2017.12.004 · Cited by 13 · see citing works

Nifuratel-Nystatin combination for the treatment of mixed infections of bacterial vaginosis, vulvovaginal candidiasis, and trichomonal vaginitis

Obiero, J. A., Rulisa, S., Ogongo, P., & Wiysonge, C. S. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd013012 · Cited by 11 · see citing works

In vitro activities of the tetrazole VT-1161 compared with itraconazole and fluconazole against Cryptococcus and non- albicans Candida species

Wang, L., Zhang, M., Guo, J., Guo, W., Zhong, N., Shen, H., Cai, J., Zhu, Z., & Wu, W. (2021) · Mycologia · doi:10.1080/00275514.2021.1913949 · Cited by 10 · see citing works

Recurrent Vulvovaginal Infections: Etiology, Diagnosis, Treatment and Management

Singh, J., Kalia, N., & Kaur, M. (2018) · Springer eBooks · doi:10.1007/978-981-13-1577-0_14 · Cited by 7 · see citing works

Elevated vaginal heparan sulfate correlates with impaired neutrophil killing of Candida albicans in women with vulvovaginal candidiasis

Yano, J., Woznicki, N. A., Sobel, J. D., Meyaski‐Schluter, M., & Fidel, P. L. (2026) · Infection and Immunity · doi:10.1128/iai.00709-25 · Cited by 6 · see citing works

Treatment for recurrent vulvovaginal candidiasis (thrush)

Cooke, G., Watson, C., Smith, J., Pirotta, M., & van Driel, M. L. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009151 · Cited by 6 · see citing works

Les sécrétions vaginales

Bohbot, J.-M. (2008) · Pelvi-périnéologie · doi:10.1007/s11608-008-0169-x · Cited by 6 · see citing works

Identification and characteristics of Candida spp . in vaginal secretion of pregnant and non-pregnant patients

Aguilar, G., Araujo, P., Godoy, E., Falcón, M., Centurión, M. G., Ortíz, R. A., Brítez, M., & Martínez, M. (2017) · Memorias del Instituto de Investigaciones en Ciencias de la Salud · doi:10.18004/mem.iics/1812-9528/2017.015(03)06-012 · Cited by 5 · see citing works

Validade do diagnóstico clínico de candidiase vulvovaginal

Zimmermmann, J. B., Paiva, O. A., Costa, A. C. D. S. S., de Sousa, A. M. G. V., Chagas, A. R., & de Lima, A. A. C. (2009) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 3 · see citing works

Experience With a Non-Hormonal Centella Asiatica, Hyaluronic Acid and Prebiotic-Based Vaginal Gel in Women With Recurrent Vulvovaginal Candidiasis: Case Studies

Amorós, M. A. P., Palma, J. C. M., Esteve, M., Salado, M., Macatangga, M. G., Benítez, G. A., Luque, P., & Cortés, J. (2023) · Clinical Medicine Insights Case Reports · doi:10.1177/11795476231161170 · Cited by 2 · see citing works

Etiología de la candidiasis vulvovaginal recidivante en la Atención Primaria de Salud en Santa Catarina, Brasil

Basso, R., da Silva, N. L., Pereira, K. B., Mezzari, A., & Fuentefría, A. M. (2012) · Americanae (AECID Library) · Cited by 2 · see citing works

Activities of fluconazole in combination with terbinafine against non-albicans Candida species isolated from the patients with recurrent vulvovaginal candidiasis in comparison with ciclopirox olamine

Ameri, S., Falahati, M., Kordbache, P., Zaini, F., Moghadam, P. R., Farahyar, S., Shojaei, E. S., & مقدم, ص. ا. (2015) · Bimonthly Journal of Hormozgan University of Medical Sciences · Cited by 2 · see citing works

Silver Sucrose Octasulfate (IASOS™) as a Valid Active Ingredient into a Novel Vaginal Gel against Human Vaginal Pathogens: In Vitro Antimicrobial Activity Assessment

Marianelli, C., Petrucci, P., Comelli, M. C., & Calderini, G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097791 · Cited by 2 · see citing works

Avaliação do tratamento antifúngico oral e tópico-oral para a candidíase vulvovaginal

Zimmermmann, J. B., Freitas, C. L., Perígolo, L. F., Campos, P. C., Mourão, R. D. P. C., Bicalho, S. N., & de Rezende, D. F. (2010) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 1 · see citing works

Urethritis, Vulvovaginitis, and Cervicitis

Braverman, P. K. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-2702-9.00053-2 · Cited by 1 · see citing works

Aspects on chronic stress and glucose metabolism in women with recurrent vulvovaginal candidiasis and in women with localized provoked vulvodynia

Ehrström, S. (2007) · Figshare

Aus der Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe der

München, L.-M.-U. (2015)

Old Wine in a New Bottle-Focus on Candidial Vaccine

saran, P. (2018) · Investigations in Gynecology Research & Womens Health (IGRWH) · doi:10.31031/igrwh.2018.02.000528

Best Practice & Research Clinical Obstetrics and Gynaecology

Hay, P., & Ugwumadu, A. H. N. (2009)

Recurrent Vulvovaginitis

Toeima, E. (2021) · Cambridge University Press eBooks · doi:10.1017/9781108582322.025

Superficial Candidosis

Richardson, M. D., & Warnock, F. D. W. (2012) · Wiley eBooks · doi:10.1002/9781118321492.ch5

Vulvovaginal candidiasis

LInhares, I., Haddad, J. M., Fukazawa, E. I., & Baracat, E. C. (2020) · doi:10.5680/lhuii000053

Reply

Sobel, J. D. (2016) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2016.11.1025

Effectiveness of fluconazole for suppressive maintenance therapy in patients with RVVC: A randomized placebo-controlled study

Bolouri (2010) · Iranian journal of pharmaceutical research · doi:10.22037/ijpr.2010.827 · Cited by 15 · see citing works

Management of Recurrent Vulvo-Vaginal Candidosis as a Chronic Illness

Donders, G. G. G., Bellen, G., & Mendling, W. (2010) · Gynecologic and Obstetric Investigation · doi:10.1159/000314022 · Cited by 83 · see citing works

Management of recurrent vulvovaginal candidosis: Narrative review of the literature and European expert panel opinion

Donders, G., Sziller, I. O., Paavonen, J., Hay, P., de Seta, F., Bohbot, J. M., Kotarski, J., Vives, J. A., Szabo, B., Cepuliené, R., et al. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.934353 · Cited by 82 · see citing works

Long term outcomes of women with recurrent vulvovaginal candidiasis after a course of maintenance fluconazole

Crouss, T. M., Sobel, J. D., Smith, K., & Nyirjesy, P. (2017) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2017.08.047