Synapse Pathology in Psychiatric and Neurologic Disease

Alzheimer's Disease Is a Synaptic Failure

Selkoe, D. J. (2002) · Science · doi:10.1126/science.1074069 · Cited by 4,420

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

Shankar, G. M., Li, S., Mehta, T. H., Garcia-Munoz, A., Shepardson, N. E., Smith, I., Brett, F. M., Farrell, M. A., Rowan, M. J., Lemere, C. A., et al. (2008) · Nature Medicine · doi:10.1038/nm1782 · Cited by 3,685

AMPA Receptor Trafficking and Synaptic Plasticity

Malinow, R., & Malenka, R. C. (2002) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.25.112701.142758 · Cited by 2,588

THE SYNAPTIC VESICLE CYCLE

Südhof, T. C. (2004) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.26.041002.131412 · Cited by 2,491

Experience-dependent structural synaptic plasticity in the mammalian brain

Holtmaat, A., & Svoboda, K. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2699 · Cited by 1,934

Advances in autism genetics: on the threshold of a new neurobiology

Abrahams, B. S., & Geschwind, D. H. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2346 · Cited by 1,866

Neuroligins and neurexins link synaptic function to cognitive disease

Südhof, T. C. (2008) · Nature · doi:10.1038/nature07456 · Cited by 1,849

Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565

Synaptic plasticity and addiction

Kauer, J. A., & Malenka, R. C. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2234 · Cited by 1,397

The glutamate homeostasis hypothesis of addiction

Kalivas, P. W. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2515 · Cited by 1,350

Epac2-mediated dendritic spine remodeling: Implications for disease

Penzes, P., Woolfrey, K. M., & Srivastava, D. P. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.11.008 · Cited by 49

Nuclear Factor κB-Dependent Neurite Remodeling Is Mediated by Notch Pathway

Bonini, S. A., Ferrari‐Toninelli, G., Uberti, D. L., Montinaro, M., Buizza, L., Lanni, C., Grilli, M., & Memo, M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1113-11.2011 · Cited by 48

Analysis of a Sardinian Multiplex Family with Autism Spectrum Disorder Points to Post-Synaptic Density Gene Variants and Identifies CAPG as a Functionally Relevant Candidate Gene

Bacchelli, E., Loi, E., Cameli, C., Moi, L., Vega-Benedetti, A. F., Blois, S., Fadda, A., Bonora, E., Mattu, S., Fadda, R., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8020212 · Cited by 47

Dendritic Polyglycerol Sulfate Inhibits Microglial Activation and Reduces Hippocampal CA1 Dendritic Spine Morphology Deficits

Maysinger, D., Gröger, D., Lake, A., Licha, K., Weinhart, M., Chang, P. K. ‐., Mulvey, R., Haag, R., & McKinney, R. A. (2015) · Biomacromolecules · doi:10.1021/acs.biomac.5b00999 · Cited by 47

Roles of Gasotransmitters in Synaptic Plasticity and Neuropsychiatric Conditions

Shefa, U., Kim, D., Kim, M., Jeong, N. Y., & Jung, J. (2018) · Neural Plasticity · doi:10.1155/2018/1824713 · Cited by 47

Postnatal development of layer III pyramidal cells in the primary visual, inferior temporal, and prefrontal cortices of the marmoset

Oga, T., Aoi, H., Sasaki, T., Fujita, I., & Ichinohe, N. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00031 · Cited by 46

Binding to and Inhibition of Insulin-Regulated Aminopeptidase by Macrocyclic Disulfides Enhances Spine Density

Diwakarla, S., Nylander, E., Grönbladh, A., Vanga, S. R., Shamsudin, Y., Gutiérrez‐de‐Terán, H., Ng, L., Pham, V., Sävmarker, J., Lundbäck, T., et al. (2016) · Molecular Pharmacology · doi:10.1124/mol.115.102533 · Cited by 44

Low expression of aging-related NRXN3 is associated with Alzheimer disease

Zheng, J., Li, W., Liu, J., Guo, Y., Wang, Q., Li, G., Dai, S., & Huang, J. (2018) · Medicine · doi:10.1097/md.0000000000011343 · Cited by 47

HIV-1 Tat protein variants: Critical role for the cysteine region in synaptodendritic injury

Bertrand, S. J., Aksenova, M. V., Mactutus, C. F., & Booze, R. M. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.06.020 · Cited by 44

Rapid Estradiol Modulation of Neuronal Connectivity and Its Implications for Disease

Srivastava, D. P., & Penzes, P. (2011) · Frontiers in Endocrinology · doi:10.3389/fendo.2011.00077 · Cited by 46

Myosin IIb controls actin dynamics underlying the dendritic spine maturation

Koskinen, M., Bertling, E., Hotulainen, R., Tanhuanpää, K., & Hotulainen, P. (2014) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2014.05.008 · Cited by 44

GSK-3β and MMP-9 Cooperate in the Control of Dendritic Spine Morphology

Kondratiuk, I., Łęski, S., Urbańska, M., Biecek, P., Devijver, H., Lechat, B., LEUVEN, F. V., Kaczmarek, L., & Jaworski, T. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9625-0 · Cited by 45

Developmental Plasticity of the Dendritic Compartment: Focus on the Cytoskeleton

Urbańska, M., Swiech, L. J., & Jaworski, J. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_12 · Cited by 42

The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

Zeng, F., Ma, X., Zhu, L., Xu, Q., Zeng, Y., Gao, Y., Li, G., Guo, T., Zhang, H., Tang, X., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000525 · Cited by 43

Oxytocin and serotonin in the modulation of neural function: Neurobiological underpinnings of autism-related behavior

Zhao, F., Zhang, H., Wang, P., Cui, W., Xu, K., Chen, D., Hu, M., Li, Z., Geng, X., & Wei, S. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.919890 · Cited by 44

Up-regulation of Ras/Raf/ERK1/2 signaling impairs cultured neuronal cell migration, neurogenesis, synapse formation, and dendritic spine development

Yang, K., Cao, F., Sheikh, A. M., Malik, M. N., Wen, G. Y., Wei, H., Brown, W. T., & Li, X. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0420-7 · Cited by 43

Altered brain morphology and functional connectivity reflect a vulnerable affective state after cumulative multigenerational stress in rats

McCreary, J. K., Truica, L. S., Friesen, B., Yao, Y., Olson, D. M., Kovalchuk, I., Cross, A. R., & Metz, G. A. S. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.046 · Cited by 45

Long-Term Changes in Cognition and Physiology after Low-Dose 16O Irradiation

Howe, A. K., Kiffer, F. C., Alexander, T. C., Sridharan, V., Wang, J., Ntagwabira, F., Rodriguez, A., Boerma, M., & Allen, A. R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20010188 · Cited by 43

Conserved regulation of neurodevelopmental processes and behavior by FoxP in Drosophila

Castells‐Nobau, A., Eidhof, I., Fencková, M., Brenman‐Suttner, D. B., Gooyert, J. M. S.-D., Christine, S., Schellevis, R. L., van der Laan, K. J., Quentin, C., van Ninhuijs, L., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211652 · Cited by 43

Genetically encoded fluorescent sensors for imaging neuronal dynamics in vivo

Day‐Cooney, J., Dalangin, R., Zhong, H., & Mao, T. (2022) · Journal of Neurochemistry · doi:10.1111/jnc.15608 · Cited by 43

A Murine Model of Variant Late Infantile Ceroid Lipofuscinosis Recapitulates Behavioral and Pathological Phenotypes of Human Disease

Morgan, J. P., Magee, H., Wong, A. P., Nelson, T., Koch, B., Cooper, J. D., & Weimer, J. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078694 · Cited by 41

Deubiquitinases in Neurodegeneration

Bello, A. I., Goswami, R., Brown, S. L., Costanzo, K. M., Shores, T., Allan, S. K., Odah, R., & Mohan, R. D. (2022) · Cells · doi:10.3390/cells11030556 · Cited by 42

Reestablishing Neuronal Networks in the Aged Brain by Stem Cell Factor and Granulocyte-Colony Stimulating Factor in a Mouse Model of Chronic Stroke

Cui, L., Murikinati, S. R., Wang, D., Zhang, X., Duan, W., & Zhao, L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0064684 · Cited by 39

In Vivo Dopamine Detection and Single Unit Recordings Using Intracortical Glassy Carbon Microelectrode Arrays

Castagnola, E., Vahidi, N. W., Nimbalkar, S., Rudraraju, S., Thielk, M., Zucchini, E., Cea, C., Carli, S., Gentner, T. Q., Ricci, D., et al. (2018) · MRS Advances · doi:10.1557/adv.2018.98 · Cited by 40

hsa-let-7c miRNA Regulates Synaptic and Neuronal Function in Human Neurons

McGowan, H., Mirabella, V. R., Hamod, A., Karakhanyan, A., Mlynaryk, N., Moore, J. C., Tischfield, J. A., Hart, R. P., & Pang, Z. P. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00019 · Cited by 37

Emerging themes in GABAergic synapse development

Kuzirian, M. S., & Paradis, S. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.07.002 · Cited by 40

Acute modulation of the cholinergic system in the mouse brain detected by pharmacological resting-state functional MRI

Shah, D., Blockx, I., Guns, P., Deyn, P. P. D., Dam, D. V., Jonckers, E., y Palacios, R. D., Verhoye, M., & der Linden, A. V. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.01.009 · Cited by 39

Rescue of impaired late–phase long-term depression in a tau transgenic mouse model

Ahmed, T., Blum, D. L., Burnouf, S., Demeyer, D., Buée‐Scherrer, V., D’Hooge, R., Buée, L., & Balschun, D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.015 · Cited by 45

Synapses in the spotlight with synthetic optogenetics

Berlin, S., & Isacoff, E. Y. (2017) · EMBO Reports · doi:10.15252/embr.201744010 · Cited by 38

Glucocorticoid Suppresses Dendritic Spine Development Mediated by Down-Regulation of Caldesmon Expression

Tanokashira, D., Morita, T., Hayashi, K., Mayanagi, T., Fukumoto, K., Kubota, Y., Yamashita, T., & Sobue, K. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2380-12.2012 · Cited by 36

Hidden synaptic differences in a neural circuit underlie differential behavioral susceptibility to a neural injury

Sakurai, A., Tamvacakis, A. N., & Katz, P. S. (2014) · eLife · doi:10.7554/elife.02598 · Cited by 35

Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations

Lee, Y., Kang, H., Lee, B., Zhang, Y., Kim, Y., Kim, S., Kim, W.-K., & Han, K. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00110 · Cited by 37

Synaptic structural protein dysfunction leads to altered excitation inhibition ratios in models of autism spectrum disorder

Howell, B. W., & Smith, K. M. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2018.11.019 · Cited by 35

Biomarkers of synaptic degeneration in Alzheimer’s disease

Cheng, Q., Fan, Y., Zhang, P., Liu, H., Han, J., Yu, Q., Wang, X., Wu, S., & Lu, Z. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102642 · Cited by 38

Proteomic Profiling in the Brain of CLN1 Disease Model Reveals Affected Functional Modules

Tikka, S., Monogioudi, E., Gotsopoulos, A., Soliymani, R., Pezzini, F., Scifo, E., Uusi-Rauva, K., Tyynelä, J., Baumann, M., Jalanko, A., et al. (2015) · NeuroMolecular Medicine · doi:10.1007/s12017-015-8382-6 · Cited by 36

Maintenance of Dendritic Spine Morphology by Partitioning-Defective 1b through Regulation of Microtubule Growth

Hayashi, K., Suzuki, A., Hirai, S.-I., Kurihara, Y., Hoogenraad, C. C., & Ohno, S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0751-11.2011 · Cited by 36

Postnatal development of dendritic structure of layer III pyramidal neurons in the medial prefrontal cortex of marmoset

Sasaki, T., Aoi, H., Oga, T., Fujita, I., & Ichinohe, N. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0853-2 · Cited by 32

Central nervous system-penetrating antiretrovirals impair energetic reserve in striatal nerve terminals

Stauch, K. L., Emanuel, K. M., Lamberty, B. G., Morsey, B., & Fox, H. S. (2017) · Journal of NeuroVirology · doi:10.1007/s13365-017-0573-5 · Cited by 33

ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors

Huang, Y., Huang, J., Zhou, Q., Yang, C., Yang, C., Mei, W.-Y., Zhang, L., Zhang, Q., Hu, L., Hu, Y., et al. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00972-4 · Cited by 35

Molecular Motors in Cargo Trafficking and Synapse Assembly

van den Berg, R., & Hoogenraad, C. C. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-3-7091-0932-8_8 · Cited by 33

A simple reproducible and time saving method of semi-automatic dendrite spine density estimation compared to manual spine counting

Orłowski, D., & Bjarkam, C. R. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.05.009 · Cited by 34

Actin quantum automata: Communication and computation in molecular networks

Siccardi, S., & Adamatzky, A. (2015) · Nano Communication Networks · doi:10.1016/j.nancom.2015.01.002 · Cited by 33

Excitatory/Inhibitory Imbalance Underlies Hippocampal Atrophy in Individuals With 22q11.2 Deletion Syndrome With Psychotic Symptoms

Mancini, V., Saleh, M. G., Delavari, F., Bagautdinova, J., & Eliez, S. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.03.021 · Cited by 32

A Novel Role of Proline Oxidase in HIV-1 Envelope Glycoprotein-induced Neuronal Autophagy

Pandhare, J., Dash, S., Jones, B., Villalta, F., & Dash, C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.652776 · Cited by 33

Association study of the CNS patterning genes and autism in Han Chinese in Taiwan

Chien, Y., Wu, Y., Chiu, Y., Liu, S.-K., Tsai, W., Lin, P., Chen, C., Gau, S. S., & Chien, W. (2011) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2011.04.010 · Cited by 33

An embryonic culture system for the investigation of striatal medium spiny neuron dendritic spine development and plasticity

Penrod, R. D., Kourrich, S., Kearney, E., Thomas, M. J., & Lanier, L. M. (2011) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2011.05.029 · Cited by 35

Neuroplastin 65 mediates cognitive functions via excitatory/inhibitory synapse imbalance and ERK signal pathway

Amuti, S., Tang, Y., Wu, S., Liu, L., Huang, L., Zhang, H., Li, H., Jiang, F., Wang, G., Liu, X., et al. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.11.020 · Cited by 33

Cognitive impairments associated with alterations in synaptic proteins induced by the genetic loss of adenosine A 2A receptors in mice

Moscoso‐Castro, M., López‐Cano, M., Gracia‐Rubio, I., Ciruela, F., & Valverde, O. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.08.027 · Cited by 33

Maternal Diabetes Alters Expression of MicroRNAs that Regulate Genes Critical for Neural Tube Development

Ramya, S., Shyamasundar, S., Bay, B., & Dheen, S. T. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00237 · Cited by 33

Prenatal Zinc Deficient Mice as a Model for Autism Spectrum Disorders

Sauer, A. K., Hagmeyer, S., & Grabrucker, A. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23116082 · Cited by 35

Glutamate receptors and learning and memory

Gécz, J. (2010) · Nature Genetics · doi:10.1038/ng1110-925 · Cited by 31

Efficacy of Repetitive Transcranial Magnetic Stimulation (rTMS) Combined with Psychological Interventions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Xu, X., Xu, M., Su, Y., Cao, T. V., Nikolin, S., Moffa, A. H., Loo, C. K. A., & Martin, D. M. (2023) · Brain Sciences · doi:10.3390/brainsci13121665 · Cited by 32

Developmental profiling of ASD-related shank3 transcripts and their differential regulation by valproic acid in zebrafish

Liu, C., Peng, X., Hu, C.-C., Li, C., Li, Q., & Xu, X. (2016) · Development Genes and Evolution · doi:10.1007/s00427-016-0561-4 · Cited by 33

The functional genetic link of NLGN4X knockdown and neurodevelopment in neural stem cells

Shi, L., Chang, X., Zhang, P., Coba, M. P., Lu, W., & Wang, K. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt226 · Cited by 29

Immunoglobulin-Like Receptors and Their Impact on Wiring of Brain Synapses

Cameron, S., & McAllister, A. K. (2018) · Annual Review of Genetics · doi:10.1146/annurev-genet-120417-031513 · Cited by 28

Predicting the prevalence of complex genetic diseases from individual genotype profiles using capsule networks

Luo, X., Kang, X., & Schönhuth, A. (2023) · Nature Machine Intelligence · doi:10.1038/s42256-022-00604-2 · Cited by 29

Significant Changes in Plasma Alpha-Synuclein and Beta-Synuclein Levels in Male Children with Autism Spectrum Disorder

Sriwimol, W., & Limprasert, P. (2018) · BioMed Research International · doi:10.1155/2018/4503871 · Cited by 34

Presynaptic Mechanisms of Lead Neurotoxicity: Effects on Vesicular Release, Vesicle Clustering and Mitochondria Number

Zhang, X., Guariglia, S. R., McGlothan, J. L., Stansfield, K. H., Stanton, P. K., & Guilarte, T. R. (2015) · PLoS ONE · doi:10.1371/journal.pone.0127461 · Cited by 29

The Role of Synaptic Dysfunction in Alzheimer’s Disease

Pei, Y. A., Davies, J., Zhang, M., & Zhang, H. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191334 · Cited by 29

Epilepsy-causing STX1B mutations translate altered protein functions into distinct phenotypes in mouse neurons

Vardar, G., Gerth, F., Schmitt, X. J., Rautenstrauch, P., Trimbuch, T., Schubert, J., Lerche, H., Rosenmund, C., & Freund, C. (2020) · Brain · doi:10.1093/brain/awaa151 · Cited by 29

Addictive drugs modify neurogenesis, synaptogenesis and synaptic plasticity to impair memory formation through neurotransmitter imbalances and signaling dysfunction

Rezayof, A., Ghasemzadeh, Z., & Sahafi, O. H. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105572 · Cited by 29

The Drosophila Transcription Factor Adf-1 (nalyot) Regulates Dendrite Growth by Controlling FasII and Staufen Expression Downstream of CaMKII and Neural Activity

Timmerman, C., Suppiah, S., Gurudatta, B. V., Yang, J., Banerjee, C., Sandstrom, D. J., Corces, V. G., & Sanyal, S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1760-13.2013 · Cited by 29

Beyond Fluorescent Proteins: Hybrid and Bioluminescent Indicators for Imaging Neural Activities

Wang, A., Feng, J., Li, Y., & Zou, P. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00455 · Cited by 28

Diagnostic performance of increased prolidase activity in schizophrenia

Güneş, M., Bulut, M., Demir, S., İbiloğlu, A. O., Kaya, M., Atlı, A., Kaplan, İ., Camkurt, M. A., & Sır, A. (2015) · Neuroscience Letters · doi:10.1016/j.neulet.2015.12.036 · Cited by 27

Shared genetic links between frontotemporal dementia and psychiatric disorders

Li, C., Pang, D., Lin, J., Yang, T., & Shang, H. (2022) · BMC Medicine · doi:10.1186/s12916-022-02335-y · Cited by 28

Altered Synaptic Properties During Integration of Adult-Born Hippocampal Neurons Following a Seizure Insult

Jackson, J., Chugh, D., Nilsson, P. G., Wood, J. C., Carlström, K. E., Lindvall, O., & Ekdahl, C. T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035557 · Cited by 27

Repetitive Transcranial Magnetic Stimulation (rTMS) Modulates Hippocampal Structural Synaptic Plasticity in Rats

Li, Y., Li, L., & Pan, W. (2018) · Physiological Research · doi:10.33549/physiolres.933772 · Cited by 26

Low Doses of Arsenic in a Mouse Model of Human Exposure and in Neuronal Culture Lead to S-Nitrosylation of Synaptic Proteins and Apoptosis via Nitric Oxide

Amal, H., Gong, G., Yang, H., Joughin, B. A., Wang, X., Knutson, C. G., Kartawy, M., Халиулин, И. Г., Wishnok, J. S., & Tannenbaum, S. R. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113948 · Cited by 26

NMDA receptor agonists reverse impaired psychomotor and cognitive functions associated with hippocampal Hbegf-deficiency in mice

Sasaki, K., Omotuyi, O. I., Ueda, M., Shinohara, K., & Ueda, H. (2015) · Molecular Brain · doi:10.1186/s13041-015-0176-0 · Cited by 26

Neuronal Actin Dynamics, Spine Density and Neuronal Dendritic Complexity Are Regulated by CAP2

Kumar, A., Paeger, L., Kosmas, K., Kloppenburg, P., Noegel, A. A., & Peche, V. S. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00180 · Cited by 25

Potent PDZ-Domain PICK1 Inhibitors that Modulate Amyloid Beta-Mediated Synaptic Dysfunction

Lin, E. Y.-S., Silvian, L. F., Marcotte, D. J., Banos, C. C., Jow, F., Chan, T. R., Arduini, R. M., Qian, F., Baker, D. P., Bergeron, C., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-31680-3 · Cited by 24

VolRoverN: Enhancing Surface and Volumetric Reconstruction for Realistic Dynamical Simulation of Cellular and Subcellular Function

Edwards, J., Daniel, E., Kinney, J. P., Bartol, T., B, T. J. S. A., Johnston, D., Harris, K. M., & Bajaj, C. (2013) · Neuroinformatics · doi:10.1007/s12021-013-9205-2 · Cited by 22

Utilizing induced pluripotent stem cells (iPSCs) to understand the actions of estrogens in human neurons

Shum, C., Macedo, S. C., Warre-Cornish, K. M., Cocks, G. D., Price, J., & Srivastava, D. P. (2015) · Hormones and Behavior · doi:10.1016/j.yhbeh.2015.06.014 · Cited by 24

From Angiotensin IV to Small Peptidemimetics Inhibiting Insulin-Regulated Aminopeptidase

Hallberg, M., & Larhed, M. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.590855 · Cited by 23

The Sexual Dimorphic Synapse: From Spine Density to Molecular Composition

Uhl, M., Schmeißer, M. J., & Schumann, S. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.818390 · Cited by 22

Non-Canonical Splicing and Its Implications in Brain Physiology and Cancer

Pitolli, C., Marini, A., Sette, C., & Pagliarini, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052811 · Cited by 23

Dysregulation of complement system in neuropsychiatric disorders: A mini review

Sierra, D. P., Tripathi, A., & Pillai, A. (2022) · Biomarkers in Neuropsychiatry · doi:10.1016/j.bionps.2022.100056 · Cited by 24

USP5/Leon deubiquitinase confines postsynaptic growth by maintaining ubiquitin homeostasis through Ubiquilin

Wang, C.-H., Huang, Y., Chen, P., Cheng, Y.-J., Kao, H.-H., Pi, H., & Chien, C. (2017) · eLife · doi:10.7554/elife.26886 · Cited by 20

A Novel Egr-1-Agrin Pathway and Potential Implications for Regulation of Synaptic Physiology and Homeostasis at the Neuromuscular Junction

MacDonald, R., Barbat‐Artigas, S., Cho, C., Peng, H., Shang, J., Moustaine, A., Carbonetto, S., Robitaille, R., Chalifour, L. E., & Paudel, H. K. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00258 · Cited by 22

Neural Organoids, a Versatile Model for Neuroscience

Lee, J., & Sun, W. (2022) · Molecules and Cells · doi:10.14348/molcells.2022.2019 · Cited by 22

In vivo relationship between serotonin 1A receptor binding and gray matter volume in the healthy brain and in major depressive disorder

Zanderigo, F., Pantazatos, S. P., Rubin‐Falcone, H., Ogden, R. T., Thapa-Chhetry, B., Sullivan, G. M., Oquendo, M. A., Miller, J. M., & Mann, J. J. (2018) · Brain Structure and Function · doi:10.1007/s00429-018-1649-6 · Cited by 20

Immunofluorescent characterization of innervation and nerve-immune cell neighborhood in mouse thymus

Al-Shalan, H. A. M., Hu, D., Nicholls, P. K., Greene, W. K., & Ma, B. (2019) · Cell and Tissue Research · doi:10.1007/s00441-019-03052-4 · Cited by 20

Constitutive Knockout of Kalirin-7 Leads to Increased Rates of Cocaine Self-Administration

Kiraly, D. D., Nemirovsky, N. E., LaRese, T. P., Tomek, S. E., Yahn, S. L., Olive, M. F., Eipper, B. A., & Mains, R. E. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.087106 · Cited by 19

Characterization of patients with major psychiatric disorders with AMPA receptor positron emission tomography

Hatano, M., Nakajima, W., Tani, H., Uchida, H., Miyazaki, T., Arisawa, T., Takada, Y., Tsugawa, S., Sano, A., Nakano, K., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02785-1 · Cited by 20

ADAP1/Centaurin-α1 Negatively Regulates Dendritic Spine Function and Memory Formation in the Hippocampus

Szatmari, E. M., Moran, C., Cohen, S. J., Jacob, A., Parra-Bueno, P., Kamasawa, N., Guerrero‐Given, D., Klein, M., Stackman, R. W., & Yasuda, R. (2020) · eNeuro · doi:10.1523/eneuro.0111-20.2020 · Cited by 18

Gene expression profiling predicts pathways and genes associated with Parkinson’s disease

Liu, S., Zhang, Y., Bian, H., & Li, X. (2015) · Neurological Sciences · doi:10.1007/s10072-015-2360-5 · Cited by 20

Ubiquitin and Ubiquitin-Like Proteins in the Critical Equilibrium between Synapse Physiology and Intellectual Disability

Folci, A., Mirabella, F., & Fossati, M. (2020) · eNeuro · doi:10.1523/eneuro.0137-20.2020 · Cited by 22

The antipsychotic landscape: dopamine and beyond

Morrison, P. D., & Murray, R. M. (2018) · Therapeutic Advances in Psychopharmacology · doi:10.1177/2045125317752915 · Cited by 19

Parquetina nigrescens and Spondias mombin protects against neurochemical alterations in the scopolamine model of cognitive dysfunction

Ademosun, A. O., Popoola, T. V., Oboh, G., & Fasakin, O. W. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14213 · Cited by 19

Disruption of Ninjurin1 Leads to Repetitive and Anxiety-Like Behaviors in Mice

Le, H., Ahn, B. J., Lee, H. S., Shin, A., Chae, S., Lee, S. Y., Shin, M. W., Lee, E.-J., Cha, J., Son, T., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0207-6 · Cited by 21

Kalirin-7 is a Key Player in the Formation of Excitatory Synapses in Hippocampal Neurons

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The Metallome as a Link Between the “Omes” in Autism Spectrum Disorders

Stanton, J. E., Malijauskaite, S., McGourty, K., & Grabrucker, A. M. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.695873 · Cited by 16

A commonly carried genetic variant, rs9616915, in SHANK3 gene is associated with a reduced risk of autism spectrum disorder: replication in a Chinese population

Shao, S., Xu, S., Yang, J., Zhang, T., He, Z., Sun, Z., & Song, R. (2014) · Molecular Biology Reports · doi:10.1007/s11033-013-3005-5 · Cited by 18

Reconstitution of synaptic Ion channels from rodent and human brain in Xenopus oocytes: a biochemical and electrophysiological characterization

Mazzo, F., Zwart, R., Serratto, G. M., Gardinier, K. M., Porter, W. J., Reel, J. K., Maraula, G., & Sher, E. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13675 · Cited by 17

Exonic resequencing of the DLGAP3 gene as a candidate gene for schizophrenia

Li, J.-M., Lu, C.-L., Cheng, M.-C., Luu, S.-U., Hsu, S.-H., & Chen, C. (2013) · Psychiatry Research · doi:10.1016/j.psychres.2012.12.015 · Cited by 17

The need for a comprehensive molecular characterization of autism spectrum disorders

Broek, J. A. C., Brombacher, E., Stelzhammer, V., Guest, P. C., Rahmoune, H., & Bahn, S. (2013) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114571300117x · Cited by 17

Synaptic vesicle-omics in mice captures signatures of aging and synucleinopathy

Gao, V., Chlebowicz, J., Gaskin, K., Briano, J. A., Komer, L. E., Pineda, A., Jhalani, S., Ahmad, S., Uwaifo, E., Black, L. S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59441-7 · Cited by 18

Model-Based Closed-Loop Suppression of Parkinsonian Beta Band Oscillations Through Origin Analysis

Su, F., Chen, M., Zu, L., Li, S., & Li, H. (2021) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2021.3056544 · Cited by 16

Distinctive PSA-NCAM and NCAM Hallmarks in Glutamate-Induced Dendritic Atrophy and Synaptic Disassembly

Podestá, M. F., Yam, P. T., Codagnone, M. G., Uccelli, N. A., Colman, D., & Reinés, A. G. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108921 · Cited by 16

Stroke and neuroplasticity

Damulin, I. V., & Ekusheva, E. V. (2014) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2014114121136-142 · Cited by 16

DOI 10.1007/s11910-010-0104-8 Synapse Pathology in Psychiatric and Neurologic Disease

van Spronsen, M., & Hoogenraad, C. C. (2010)

Dendritic spine pathology in neuropsychiatric

Cahill, M. E., Jones, K. A., VanLeeuwen, J., & Woolfrey, K. M. (2011) · Cited by 2

Microanatomy of dendritic spines: emerging principles of synaptic pathology in psychiatric and neurological disease

Blanpied, T. A., & Ehlers, M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.10.006 · Cited by 187

Synaptic activity in X‐linked mental retardation: a thorny issue

Martina, M. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.226019

Giant spines and enlarged synapses induced in Purkinje cells by malnutrition

Chen, S., & Hillman, D. E. (1980) · Brain Research · doi:10.1016/0006-8993(80)90221-8 · Cited by 39