The DOI matches its Crossref record; 124 of the 124 references it cites were found in a registry or an index.
Chronic Traumatic Encephalopathy: Where Are We and Where Are We Going?
Open accessAbstract
Chronic traumatic encephalopathy (CTE, previously called punch drunk and dementia pugilistica) has a rich history in the medical literature in association with boxing, but has only recently been recognized with other contact sports, such as football and ice hockey, as well as with military blast injuries. CTE is thought to be a neurodegenerative disease associated with repeated concussive and subconcussive blows to the head. There is characteristic gross and microscopic pathology found in the brain, including frontal and temporal atrophy, axonal degeneration, and hyperphosphorylated tau and TAR DNA-binding protein 43 pathology. Clinically, there are characteristic progressive deficits in cognition (memory, executive dysfunction), behavior (explosivity, aggression), mood (depression, suicidality), and motor function (parkinsonism), which correlate with the anatomic distribution of brain pathology. While CTE shares clinical and neuropathological traits with other neurodegenerative diseases, the clinical syndrome and the neuropathology as a whole are distinct from other neurodegenerative diseases. Here we review the CTE literature to date. We also draw on the literature from mild traumatic brain injury and other neurodegenerative dementias, particularly when these studies provide guidance for future CTE research. We conclude by suggesting seven essential areas for future CTE research.
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“In conclusion, the prevailing theory of CTE, often expressed in articles as fact, is that it is a distinct (1, 3, 9-11) and unique (10) neurodegenerative disease (9-13).”
From Mild Chronic Traumatic Encephalopathy Neuropathology in People With No Known Participation in Contact Sports or History of Repetitive Neurotrauma (2019) · cites this paper as [11]
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Slotnick, S. D. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316026687.005
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Elucidating Mechanisms of Neurobehavioral Dysfunction in a Rodent Model of Traumatic Brain Injury
Logsdon, A. F. (2016) · The Research Repository @ WVU (West Virginia University) · doi:10.33915/etd.6106
Brain Regions Associated with Long-Term Memory
Slotnick, S. D. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316026687.004
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Slotnick, S. D. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316026687.011
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Slotnick, S. D. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316026687.015
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(2017) · Cambridge University Press eBooks · doi:10.1017/9781316026687.014
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Metadata
- Authors
- Mez, J., Stern, R. A., & McKee, A. C.
- Affiliations
- Boston University (US)
- Corresponding author
- Mez, Jesse
- Venue
- Current Neurology and Neuroscience Reports
- Published
- 2013-10-18
- Volume
- 13
- Issue
- 12
- Pages
- 407-407
- ISSN
- 1528-4042 (ISSN-L)
- 1534-6293
- PMC
- PMC4550089
- OpenAlex
- W2043633971
- Cited by
- 120
- References
- 124
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 9 · 2021: 5 · 2020: 2 · 2019: 15 · 2018: 10 · 2017: 26 · 2016: 19 · 2015: 18 · 2014: 5
- FWCI
- 1.66
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Neurology and Neuroscience Reports (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (P30AG013846, P30-AG13846))
- National Institute of Neurological Disorders and Stroke (T32NS007153, R01NS078337)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- chronic traumatic encephalopathy, repetitive head impacts, concussion, subconcussive impacts, tau hyperphosphorylation, TDP-43, axonal degeneration, cognitive impairment, executive dysfunction, parkinsonism, mild traumatic brain injury, neurodegenerative dementia, contact sports, future research directions
- MeSH terms
- Animals, Boxing, Humans, Magnetic Resonance Imaging, Neuropsychological Tests, Tomography, X-Ray Computed, Biomarkers, Tomography, Emission-Computed, Single-Photon, Brain Injury, Chronic, Positron-Emission Tomography, Neuroimaging
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