Nitric oxide and inflammatory mediators in the perpetuation of osteoarthritis

Biochemistry of nitric oxide and its redox-activated forms

Stamler, J. S., Singel, D. J., & Loscalzo, J. (1992) · Science · doi:10.1126/science.1281928 · Cited by 2,744

The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide

Pryor, W. A., & Squadrito, G. L. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.5.l699 · Cited by 1,511

Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial

Reginster, J., Deroisy, R., Rovati, L. C., Lee, R. L., Lejeune, E., Bruyère, O., Giacovelli, G., Henrotin, Y. E., Dacre, J. E., & Gosset, C. (2001) · The Lancet · doi:10.1016/s0140-6736(00)03610-2 · Cited by 1,233

Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide

Myers, P. R., Minor, R. L., Guerra, R., Bates, J. N., & Harrison, D. G. (1990) · Nature · doi:10.1038/345161a0 · Cited by 973

Inducible nitric oxide synthase: what difference does it make?

Nathan, C. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119782 · Cited by 935

Glucosamine therapy for treating osteoarthritis

Towheed, T., Maxwell, L. J., Anastassiades, T., Shea, B., Houpt, J., Welch, V. A., Hochberg, M. C., & Wells, G. A. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002946.pub2 · Cited by 688

Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

Clancy, R. M., Leszczynska-Piziak, J., & Abramson, S. B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115929 · Cited by 686

Nitric oxide and bone

Van'T Hof, R. J., & Ralston, S. H. (2001) · Immunology · doi:10.1046/j.1365-2567.2001.01261.x · Cited by 518

Determining minimally important changes in generic and disease-specific health-related quality of life questionnaires in clinical trials of rheumatoid arthritis

Kosinski, M. R., Zhao, S. Z., Dedhiya, S. D., Osterhaus, J. T., & Ware, J. E. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200007)43:7 · Cited by 502

Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis

Hashimoto, S., Ochs, R., Komiya, S., & Lotz, M. (1998) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199809)41:9 · Cited by 500

The Role of Genetics and Epigenetic Regulation in the Pathogenesis of Osteoarthritis

Kiełbowski, K., Herian, M., Bakinowska, E., Banach, B., Sroczyński, T., & Pawlik, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411655 · Cited by 43

Hydroxysafflor yellow A (HSYA) targets the NF-κB and MAPK pathways and ameliorates the development of osteoarthritis

Hu, Z., Xie, Z.-J., Tang, Q., Li, X., Fu, X., Feng, Z., Xuan, J., Ni, W.-F., & Wu, A. (2018) · Food & Function · doi:10.1039/c8fo00732b · Cited by 39

Rationale for the potential use of calcitonin in osteoarthritis.

Manicourt, D.-H., Devogelaer, J. P., Azria, M., & Silverman, S. L. (2005) · PubMed · Cited by 39

5-aminosalicylic acid suppresses osteoarthritis through the OSCAR-PPARγ axis

Kim, J., Ryu, G., Seo, J., Go, M., Kim, G., Yi, S., Kim, S., Lee, H., Lee, J., Kim, H. S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45174-6 · Cited by 43

Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of Dendropanax morbifera Mediated by the Nrf2/HO-1 Pathway

Akram, M., Kim, K.-A., Kim, E. S., Syed, A. S., Kim, C. Y., Lee, J., & Bae, O. (2016) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b15-00823 · Cited by 38

Wogonoside inhibits IL-1β induced catabolism and hypertrophy in mouse chondrocyte and ameliorates murine osteoarthritis

Tang, Q., Zheng, G., Feng, Z., Tong, M., Xu, J., Hu, Z., Shang, P., Chen, Y., Wang, C., Lou, Y., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.18374 · Cited by 38

Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: Implication for osteoarthritis therapy

More, A. S., KUMARI, R. R., Gupta, G., Lingaraju, M. C., Balaganur, V., Pathak, N. N., Kumar, D., Kumar, D., Sharma, A. K., & Tandan, S. K. (2012) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2012.12.013 · Cited by 38

Peroxynitrite-modified collagen-II induces p38/ERK and NF-κB-dependent synthesis of prostaglandin E2 and nitric oxide in chondrogenically differentiated mesenchymal progenitor cells

Whiteman, M., Spencer, J. P. E., Zhu, Y. Z., Armstrong, J. S., & Schantz, J. T. (2006) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2005.11.002 · Cited by 37

Isofraxidin targets the TLR4/MD-2 axis to prevent osteoarthritis development

Jin, J., Yu, X., Hu, Z., Tang, S., Zhong, X., Xu, J., Shang, P., Huang, Y., & Liu, H. (2018) · Food & Function · doi:10.1039/c8fo01445k · Cited by 37

Isofraxidin inhibits interleukin‐1&bgr; induced inflammatory response in human osteoarthritis chondrocytes

Lin, J., Li, X., Qi, W., Yan, Y.-Z., Chen, K., Xue, X., Xu, X.-X., Feng, Z.-H., & Pan, X. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.09.003 · Cited by 33

Maltol prevents the progression of osteoarthritis by targeting PI3K/Akt/NF‐κB pathway: In vitro and in vivo studies

Lü, H., Fu, C., Kong, S., Wang, X., Sun, L. N., Zeng, L., Luo, P., & Jin, H. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16104 · Cited by 36

Melatonin inhibits Sirt1-dependent NAMPT and NFAT5 signaling in chondrocytes to attenuate osteoarthritis

Guo, J., Li, F., Wen, Y. B., Cui, H. X., Guo, M., Zhang, L., Zhang, Y. F., Guo, Y., & Guo, Y. X. (2017) · Oncotarget · doi:10.18632/oncotarget.18356 · Cited by 36

In Vitro and In Vivo Anti-inflammatory Activity of Bovine Milkfat Globule (MFGM)-derived Complex Lipid Fractions

Palmano, K., MacGibbon, A. K. H., Gunn, C. A., & Schollum, L. M. (2020) · Nutrients · doi:10.3390/nu12072089 · Cited by 36

Schisandrae Fructus Inhibits IL‐1β‐Induced Matrix Metalloproteinases and Inflammatory Mediators Production in SW1353 Human Chondrocytes by Suppressing NF‐κB and MAPK Activation

Jeong, J., Lee, H. H., Choi, E., Lee, K. W., Kim, K. Y., Kim, S. G., Hong, S. H., Kim, G., Park, C., Kim, H. K., et al. (2015) · Drug Development Research · doi:10.1002/ddr.21283 · Cited by 36

Gallic acid can play a chondroprotective role against AGE-induced osteoarthritis progression

Wen, L., Qu, T., Zhai, K., Ding, J., Hai, Y., & Zhou, J. (2015) · Journal of Orthopaedic Science · doi:10.1007/s00776-015-0718-4 · Cited by 35

The Protective Effect of Ligustilide in Osteoarthritis: An in Vitro and in Vivo Study

Li, X., Wu, D., Hu, Z., Xuan, J.-W., Ding, X.-X., Zheng, G., Feng, Z.-H., Ni, W., & Wu, A. (2018) · Cellular Physiology and Biochemistry · doi:10.1159/000492701 · Cited by 33

Hydrogen sulfide protects against IL‐1β‐induced inflammation and mitochondrial dysfunction‐related apoptosis in chondrocytes and ameliorates osteoarthritis

Wang, B., Shao, Z., Gu, M., Ni, L., Shi, Y.-F., Yan, Y.-Z., Wu, A., Jin, H., Chen, J.-X., Pan, X., et al. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.30154 · Cited by 35

Betulin Alleviates the Inflammatory Response in Mouse Chondrocytes and Ameliorates Osteoarthritis via AKT/Nrf2/HO-1/NF-κB Axis

Ren, C., Jin, J., Hu, W. M., Chen, Q., Yang, J., Wu, Y., Zhou, Y., Sun, L., Gao, W., Zhang, X., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.754038 · Cited by 35

Resveratrol Inhibits Nitric Oxide-Induced Apoptosis via the NF-Kappa B Pathway in Rabbit Articular Chondrocytes

Eo, S.-H., Cho, H., & Kim, S. J. (2013) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2013.029 · Cited by 34

A Novel Rose Hip Preparation with Enhanced Anti-Inflammatory and Chondroprotective Effects

Schwager, J., Richard, N., Schoop, R., & Wolfram, S. (2014) · Mediators of Inflammation · doi:10.1155/2014/105710 · Cited by 39

Cerium oxide nanoparticles protect against chondrocytes and cartilage explants from oxidative stress via Nrf2/HO-1 pathway in temporomandibular joint osteoarthritis

Xiong, L., Bao, H., Li, S., Gu, D., Li, Y., Yin, Q., Li, W., Miao, L., & Liu, C. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1076240 · Cited by 33

Effect of seabuckthorn on sodium nitroprusside-induced cytotoxicity in murine macrophages

Geetha, S., Ram, M. S., Singh, V., Ilavazhagan, G., & Sawhney, R. C. (2002) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(02)00290-1 · Cited by 33

Mori Folium water extract alleviates articular cartilage damages and inflammatory responses in monosodium iodoacetate-induced osteoarthritis rats

Jeong, J.-W., Lee, H., Kim, J., Choi, E., Hwang-Bo, H., Kim, H., Kim, M. Y., Ahn, K., Kim, G.-Y., Lee, K.-W., et al. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7075 · Cited by 33

The chemical biology of nitric oxide — an outsider's reflections about its role in osteoarthritis

Feelisch, M. (2008) · Osteoarthritis and Cartilage · doi:10.1016/s1063-4584(08)60007-2 · Cited by 32

Nitric oxide boosts TLR‐4 mediated lipocalin 2 expression in chondrocytes

Gómez, R., Scotece, M., Conde, J., López, V. A. M., Pino, J., Lago, F., Gómez-Reino, J. J., & Gualillo, O. (2013) · Journal of Orthopaedic Research® · doi:10.1002/jor.22331 · Cited by 32

Current Disease-Targets for Oleocanthal as Promising Natural Therapeutic Agent

Segura‐Carretero, A., & Curiel, J. A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19102899 · Cited by 31

Stevioside targets the NF-κB and MAPK pathways for inhibiting inflammation and apoptosis of chondrocytes and ameliorates osteoarthritis in vivo.

Cai, T., Ye, H.-T., Jiang, H.-Y., Lin, C., Lou, C., Wang, W.-D., Yan, Z., Xue, X., Pan, X., & Lin, J. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109683 · Cited by 32

Inhibition of small HA fragment activity and stimulation of A2A adenosine receptor pathway limit apoptosis and reduce cartilage damage in experimental arthritis

Campo, G. M., Micali, A. G., Avenoso, A., D’Ascola, A., Scuruchi, M., Pisani, A., Bruschetta, A., Calatroni, A., Puzzolo, D., & Campo, S. (2014) · Histochemistry and Cell Biology · doi:10.1007/s00418-014-1298-7 · Cited by 29

Efficacy and Tolerability of Advanced Glycation End-Products Inhibitor in Osteoarthritis

Garg, S., Syngle, A., & Vohra, K. (2013) · Clinical Journal of Pain · doi:10.1097/ajp.0b013e318272ebec · Cited by 29

Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes

Kim, M.-K., Lee, H., Park, K. S., Shin, E. H., Jo, S. H., Yun, J., Lee, S. W., Yoo, Y. H., Lee, Y., Baek, S., et al. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.09.015 · Cited by 29

Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial

Kingsbury, S. R., Tharmanathan, P., Adamson, J., Arden, N., Birrell, F. N., Cockayne, S., Dickson, J., Doherty, M., Dziedzic, K., Grainger, A. J., et al. (2013) · Trials · doi:10.1186/1745-6215-14-64 · Cited by 28

MicroRNA-203 up-regulates nitric oxide expression in temporomandibular joint chondrocytes via targeting TRPV4.

Hu, F., Zhu, W.-H., & Wang, L. (2013) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2012.08.013 · Cited by 26

Mangiferin Inhibits IL-1β-Induced Inflammatory Response by Activating PPAR-γ in Human Osteoarthritis Chondrocytes

Qu, Y., Zhou, L., & Wang, C. (2016) · Inflammation · doi:10.1007/s10753-016-0451-y · Cited by 28

A System Biology Approach to Bioinformatics and Functional Genomics in Complex Human Diseases: Arthritis

Attur, M. G., Dave, M. N., Tsunoyama, K., Akamatsu, M., Kobori, M., Miki, J., Abramson, S. B., Katoh, M., & Amin, A. R. (2002) · Current Issues in Molecular Biology · doi:10.21775/cimb.004.129 · Cited by 27

Small non-coding RNAs-based bone regulation and targeting therapeutic strategies

Yang, Y., & Fang, S. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2016.11.018 · Cited by 26

Pathogenesis of Osteoarthritis

Cesare, P. E. D., Abramson, S. B., & Samuels, J. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-3285-4.10089-0 · Cited by 26

Fibronectin fragments elevate nitric oxide (NO) and inducible NO synthetase (iNOS) levels in bovine cartilage and iNOS inhibitors block fibronectin fragment mediated damage and promote repair

Pichika, R., & Homandberg, G. A. (2004) · Inflammation Research · doi:10.1007/s00011-004-1279-8 · Cited by 26

Pachymic acid suppresses the inflammatory response of chondrocytes and alleviates the progression of osteoarthritis via regulating the Sirtuin 6/NF-κB signal axis

Wu, Y., Ying, J., Zhu, X., Xu, C.-Q., & Wu, L. H. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110854 · Cited by 25

Ginsenoside Rb1 inhibits monoiodoacetate-induced osteoarthritis in postmenopausal rats through prevention of cartilage degradation

Aravinthan, A., Hossain, M. A., Kim, B., Kang, C. W., Kim, N. S., Hwang, K., & Kim, J. (2020) · Journal of Ginseng Research · doi:10.1016/j.jgr.2020.01.004 · Cited by 27

The protective effect of myricitrin in osteoarthritis: An in vitro and in vivo study

Yan, Z., Zeng, L., Wu, Y., Zhan, J., Qi, W., Lin, J. J., Shen, J., Xue, X., & Pan, X. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106511 · Cited by 25

Effects of nonsteroidal anti-inflammatory drugs on the expression of urokinase plasminogen activator and inhibitor and gelatinases in the early osteoarthritic knee of humans

Yang, S., Hsieh, Y., Lue, K., Chu, S., Chang, I., & Lu, K. (2007) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2007.10.011 · Cited by 24

Linalool inhibits the progression of osteoarthritis via the Nrf2/HO-1 signal pathway both in vitro and in vivo

Miao, Z., Dong, M., Wang, Z., Ma, J., Lin, Y., & Wu, Y. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109338 · Cited by 23

Effect of S-methylisothiourea, an inducible nitric oxide synthase inhibitor, in joint pain and pathology in surgically induced model of osteoarthritis

Balaganur, V., Pathak, N. N., Lingaraju, M. C., More, A. S., Latief, N., KUMARI, R. R., Kumar, D., & Tandan, S. K. (2014) · Connective Tissue Research · doi:10.3109/03008207.2014.953629 · Cited by 23

Knockdown of PRMT1 suppresses IL-1β-induced cartilage degradation and inflammatory responses in human chondrocytes through Gli1-mediated Hedgehog signaling pathway

Xia, L., Zhang, H.-X., Xing, M.-L., Xu, Y., Li, P., Huang, L.-K., Bai, J., Tian, Z., & Zhao, Z. (2017) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-017-3109-7 · Cited by 23

Atorvastatin exhibits anti-inflammatory and anti-oxidant properties in adjuvant-induced monoarthritis

Kumar, V. L., Guruprasad, B., & Wahane, V. D. (2010) · Inflammopharmacology · doi:10.1007/s10787-010-0057-1 · Cited by 23

Resveratrol regulates type II collagen and COX-2 expression via the ERK, p38 and Akt signaling pathways in rabbit articular chondrocytes

Eo, S.-H., Cho, H., & Kim, S. J. (2014) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2014.1484 · Cited by 23

Site-specific analysis of gene expression in early osteoarthritis using the Pond-Nuki model in dogs

Stoker, A. M., Cook, J. L., Kuroki, K., & Fox, D. B. (2006) · Journal of Orthopaedic Surgery and Research · doi:10.1186/1749-799x-1-8 · Cited by 22

Increased Anti-Inflammatory Effects on LPS-Induced Microglia Cells by Spirulina maxima Extract from Ultrasonic Process

Choi, W. Y., Sim, J.-H., Lee, J.-Y., Kang, D. H., & Lee, H.-Y. (2019) · Applied Sciences · doi:10.3390/app9102144 · Cited by 22

Celecoxib inhibits nitric oxide production in chondrocytes of ligament-damaged osteoarthritic rat joints

Matsuda, K., Nakamura, S., & Matsushita, T. (2006) · Rheumatology International · doi:10.1007/s00296-006-0107-6 · Cited by 22

Maltol inhibits the progression of osteoarthritis via the nuclear factor-erythroid 2–related factor-2/heme oxygenase-1 signal pathway in vitro and in vivo

Zhu, D., Wang, Y., Lin, J., Miao, Z., Xu, J.-J., & Wu, Y. (2020) · Food & Function · doi:10.1039/d0fo02325f · Cited by 21

Evaluation of coexpression of microsomal prostaglandin E synthase-1 and cyclooxygenase-2 in interleukin-1– stimulated equine articular chondrocytes

Farley, J., Sirois, J., MacFarlane, P.-H., Kombé, A., & Laverty, S. (2005) · American Journal of Veterinary Research · doi:10.2460/ajvr.2005.66.1985 · Cited by 20

Anticonvulsant effect of celecoxib on pentylenetetrazole-induced convulsion: Modulation by NO pathway

Zandieh, A., Maleki, F., Hajimirzabeigi, A., Zandieh, B., Khalilzadeh, O., & Dehpour, A. R. (2010) · Acta Neurobiologiae Experimentalis · doi:10.55782/ane-2010-1811 · Cited by 20

The Protective Effect of Magnolol in Osteoarthritis: In vitro and in vivo Studies

Hu, Z., Luo, Z., Jiang, B., Fu, X., Xuan, J., Li, X., Bian, Y.-J., Ni, W.-F., & Xue, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00393 · Cited by 20

Protective effects of polydatin against bone and joint disorders: thein vitroandin vivoevidence so far

Zhang, Z., Sun, Z., Jia, R., Jiang, D., Xu, Z., Zhang, Y., Wu, Y., & Wang, X. (2023) · Nutrition Research Reviews · doi:10.1017/s0954422423000082 · Cited by 19

Phillygenin protects against osteoarthritis by repressing inflammation via PI3K/Akt/NF-κB signaling: In vitro and vivo studies

Zhou, S., Wen, H., Han, X., & Li, H. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104456 · Cited by 19

Effect of Colchicine on Total Antioxidant Capacity, Antioxidant Enzymes and Oxidative Stress Markers in Patients with Knee Osteoarthritis

Erden, M., Ediz, L., Hız, Ö., Tülüce, Y., Özkol, H., Toprak, M., & Demirdag, F. (2012) · International Journal of Clinical Medicine · doi:10.4236/ijcm.2012.35071 · Cited by 19

Glutamine exerts a protective effect on osteoarthritis development by inhibiting the Jun N-terminal kinase and nuclear factor kappa-B signaling pathways

Zhong, L., Cao, L., Song, R., Yang, X.-F., Li, J., Yang, H., Zhou, H., & Fan, H.-T. (2022) · Scientific Reports · doi:10.1038/s41598-022-16093-7 · Cited by 19

Enhancing Industrial Hemp (Cannabis sativa) Leaf By-Products: Bioactive Compounds, Anti-Inflammatory Properties, and Potential Health Applications

Frusciante, L., Geminiani, M., Shabab, B., Olmastroni, T., Roncucci, N., Mastroeni, P., Salvini, L., Lamponi, S., Trezza, A., & Santucci, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26020548 · Cited by 20

The DNA Repair Enzyme Apurinic/Apyrimidinic Endonuclease (Apex Nuclease) 2 Has the Potential to Protect against Down-Regulation of Chondrocyte Activity in Osteoarthritis

Yui, N., Yoshioka, H., Fujiya, H., Musha, H., Beppu, M., Karasawa, R., & Yudoh, K. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150914921 · Cited by 18

Biological Therapies in Osteoarthritis

Wenham, C. Y. J., McDermott, M., & Conaghan, P. G. (2015) · Current Pharmaceutical Design · doi:10.2174/1381612821666150310144940 · Cited by 18

β-Hydroxyisovalerylshikonin inhibits IL-1β-induced chondrocyte inflammation via Nrf2 and retards osteoarthritis in mice

Chen, X., Gu, M., Jin, J., Ren, C., Pan, Z., Wu, Y., Tian, N., Wu, A., Sun, L., Gao, W., et al. (2020) · Food & Function · doi:10.1039/d0fo02192j · Cited by 18

Pomegranate (Punica Granatum L.) Peel Hydroalcoholic Extract Supplementation Reduces Pain and Improves Clinical Symptoms of Knee Osteoarthritis: A Randomized Double-Blind Placebo Controlled Study

Rafraf, M., Hemmati, S., Jafarabadi, M. A., Moghaddam, A., & Haghighian, M. K. (2016) · Iranian Red Crescent Medical Journal · doi:10.5812/ircmj.38577 · Cited by 18

Prostaglandin E2 receptors EP1 and EP4 are up-regulated in rabbit chondrocytes by IL-1β, but not by TNFα

Alvarez-Soria, M. A., Largo, R., Sánchez‐Pernaute, O., Calvo, E., Egido, J., & Herrero‐Beaumont, G. (2007) · Rheumatology International · doi:10.1007/s00296-007-0328-3 · Cited by 18

Deep Coverage Tissue and Cellular Proteomics Revealed IL-1β Can Independently Induce the Secretion of TNF-Associated Proteins from Human Synoviocytes

Tang, S., Deng, S., Guo, J., Chen, X., Zhang, W., Cui, Y., Luo, Y., Yan, Z., He, Q., Shen, S., et al. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700480 · Cited by 17

Ketamine attenuates osteoarthritis of the knee via modulation of inflammatory responses in a rabbit model

Lu, W., Wang, L., Wo, C., & Yao, J. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.5164 · Cited by 16

Mangiterpenes A–C and 2′,3′-seco-manginoid C, four sesquiterpene/monoterpene–shikimate–conjugated spirocyclic meroterpenoids from Guignardia mangiferae

Chen, K., Chen, C., Guo, J., Sun, W., Liu, J., Yang, J., Liu, X., Wang, J., Luo, Z., Zhu, H., et al. (2019) · Phytochemistry · doi:10.1016/j.phytochem.2019.05.018 · Cited by 16

FSTL1 promotes nitric oxide-induced chondrocyte apoptosis via activating the SAPK/JNK/caspase3 signaling pathway

Xu, C., Jiang, T., Ni, S., Chen, C., Li, C., Zhuang, C., Zhao, G., Jiang, S., Wang, L., Zhu, R., et al. (2020) · Gene · doi:10.1016/j.gene.2020.144339 · Cited by 16

Functional characterization of an orphan nuclear receptor, Rev‐ErbAα, in chondrocytes and its potential role in osteoarthritis

Chaturvedi, P., Pratta, M. A., Steplewski, K. M., Connor, J., & Kumar, S. (2006) · Arthritis & Rheumatism · doi:10.1002/art.22170 · Cited by 16

Prostanoid pattern and iNOS expression during chondrogenic differentiation of human mesenchymal stem cells

Mais, A., Klein, T., Ullrich, V., Schudt, C., & Lauer, G. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20786 · Cited by 16

Pathogenesis of Osteoarthritis

Cesare, P. E. D., Haudenschild, D. R., Samuels, J., & Abramson, S. B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-31696-5.00098-x · Cited by 16

Mangiferin: Possible uses in the prevention and treatment of mixed osteoarthritic pain

Garrido‐Suárez, B. B., Garrido, G., Piñeros, O., & Delgado, R. (2019) · Phytotherapy Research · doi:10.1002/ptr.6546 · Cited by 15

In vitro inhibition of compression-induced catabolic gene expression in meniscal explants following treatment with IL-1 receptor antagonist

Killian, M. L., Zielinska, B., Gupta, T., & Donahue, T. L. H. (2011) · Journal of Orthopaedic Science · doi:10.1007/s00776-011-0026-6 · Cited by 14

Peimine suppresses interleukin‑1β‑induced inflammation via MAPK downregulation in chondrocytes

Chen, K., Lv, Z., Zhou, C., Liang, S., Huang, W., Wang, Z., Zhu, W., Wang, Y., Jing, X., Lin, H., et al. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4141 · Cited by 14

Meniscal transection rather than excision increases pain behavior and structural damage in experimental osteoarthritis in mice

Leite, A. C. R. D. M., Teotonio, M. A. A., Girão‐Carmona, V. C. C., Pompeu, M. M. D. L., Nunes, R. D. M., Cunha, T. M., Pinto, A. C. M. D., Cunha, F. Q., & Rocha, F. A. C. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.07.019 · Cited by 14

Hop Extract Anti-Inflammatory Effect on Human Chondrocytes Is Potentiated When Encapsulated in Rapeseed Lecithin Nanoliposomes

Velot, É., Ducrocq, F., Girardeau, L., Hehn, A., Piutti, S., Kahn, C. J. F., Linder, M., Bianchi, A., & Arab‐Tehrany, E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012423 · Cited by 12

Urolithin B reduces cartilage degeneration and alleviates osteoarthritis by inhibiting inflammation

Xue, H., Zhou, H., Lou, Q., Yuan, P., Feng, Z., Li, Q., Zhang, J., Xie, H., Shen, Y., Ma, Q., et al. (2024) · Food & Function · doi:10.1039/d3fo03793b · Cited by 14

Saikosaponin A inhibits IL-1β-induced inflammatory mediators in human osteoarthritis chondrocytes by activating LXRα

Gao, H., Song, Y., Li, D., Feng, W., & Liu, J. (2017) · Oncotarget · doi:10.18632/oncotarget.21495 · Cited by 13

Antisense strategies in degenerative joint diseases: Sense or nonsense?☆

Huber, L. C., Distler, O., Gay, R., & Gay, S. (2006) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2006.01.010 · Cited by 13

Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-κB pathway

Li, Z., Shi, H., Li, Y., Wang, W., Li, Z., Chen, B., & Nie, D. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174971 · Cited by 12

Polygonatum sibiricum polysaccharide inhibits IL-1β-induced inflammation in human chondrocytes

Wu, J., Zhang, X., Hu, S., Suohua, P. A. N., & Wang, C. (2021) · Food Science and Technology · doi:10.1590/fst.44021 · Cited by 11

Pathogenesis of Osteoarthritis

Cesare, P. E. D., Haudenschild, D. R., Samuels, J., & Abramson, S. B. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-1738-9.00098-0 · Cited by 11

The influence of irradiation on the potential chondroprotective effect of aqueous extract of propolis in rats

El‐Ghazaly, M. A., Abdel‐Naby, D. H., & Khayyal, M. T. (2010) · International Journal of Radiation Biology · doi:10.3109/09553002.2011.530337 · Cited by 11

Reduced synovial inflammation and inhibition of matrix metalloproteinases explicates anti-osteoarthritis activity of polyherbal formulations

Ingale, D., Kulkarni, P., Koppikar, S. J., Harsulkar, A., Moghe, A., & Jagtap, S. (2018) · Indian Journal of Pharmacology · doi:10.4103/ijp.ijp_29_17 · Cited by 10

Inhibition of tyrosine kinase-mediated cellular signalling by Tyrphostins AG126 and AG556 modulates secondary damage in experimental spinal cord trauma

Genovese, T., Mazzon, E., Esposito, E., Muià, C., Paola, R. D., Crisafulli, C., Bramanti, P., & Cuzzocrea, S. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2007.01.017 · Cited by 10

Cartilage and Chondrocytes

Goldring, M. B. (2013) · Elsevier eBooks · doi:10.1016/b978-1-4377-1738-9.00003-7 · Cited by 10

Effects of macro-cracks on the load bearing capacity of articular cartilage

Komeili, A., Chau, W., & Herzog, W. (2019) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-019-01149-x · Cited by 10

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Hu, W. M., Mao, C., & Sheng, W. (2022) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-022-03063-y · Cited by 9

Mechanical and oxidative stress in osteoarthritis

Yui, N., Yudoh, K., Fujiya, H., & Musha, H. (2016) · The Journal of Physical Fitness and Sports Medicine · doi:10.7600/jpfsm.5.81 · Cited by 9

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Roach, H. I. (2008) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.3.5.475 · Cited by 9

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Shikhman, A. R. (2006) · Future Rheumatology · doi:10.2217/17460816.1.1.67 · Cited by 8

SEMA6D, Negatively Regulated by miR‐7, Contributes to C28/I2 chondrocyte’s Catabolic and Anabolic Activities via p38 Signaling Pathway

Yang, H., Yang, Z., Yu, Z., Xiong, C., Zhang, Y., Zhang, J., Huang, Y., Zhou, X., Li, J., & Xu, N. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9674221 · Cited by 8

The effects of radial shock waves on the metabolism of equine cartilage explantsin vitro

Benson, B., Byron, C. R., Pondenis, H. C., & Stewart, A. A. (2007) · New Zealand Veterinary Journal · doi:10.1080/00480169.2007.36733 · Cited by 8

Evidencia de mecanismos inflamatorios en la osteoartritis

López-Armada, M. J., Vaamonde‐García, C., Caramés, B., Lires-Deán, M., Cillero‐Pastor, B., & García, F. J. B. (2007) · Reumatología Clínica · doi:10.1016/s1699-258x(07)73651-3 · Cited by 7

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Jousheghan, S. S., Sajjadi, M. M., Jousheghan, S. S., Hosseininejad, S.-M., & Maleki, A. (2021) · Journal of Molecular Histology · doi:10.1007/s10735-021-10017-x · Cited by 6

Evaluation of anti-inflammatory and chondroprotective effects of peroxisome proliferator-activated receptor gamma agonists in cartilage and synovial explants from dogs

Hanks, B. C., Kuroki, K., Stoker, A. M., & Cook, J. L. (2010) · American Journal of Veterinary Research · doi:10.2460/ajvr.71.10.1142 · Cited by 6

Piperlongumine attenuates IL-1β-induced inflammatory response in chondrocytes

Hu, Y., & Yan, J. (2018) · Biomedical Research - India · doi:10.4066/biomedicalresearch.29-17-3817 · Cited by 6

Nitric oxide synthases and osteoarthritis

Scher, J. U., Pillinger, M. H., & Abramson, S. B. (2007) · Current Rheumatology Reports · doi:10.1007/s11926-007-0016-z · Cited by 83

The role of nitric oxide in articular cartilage breakdown in osteoarthritis

Amin, A. R., & Abramson, S. B. (1998) · Current Opinion in Rheumatology · doi:10.1097/00002281-199805000-00018 · Cited by 217

P308 The type I nitric oxide synthase is expressed in normal but not in osteoarthritic human chondrocytes

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Amin, A. R., Dave, M. N., Attur, M. G., & Abramson, S. B. (2000) · Current Rheumatology Reports · doi:10.1007/s11926-000-0019-5 · Cited by 136

P306 The effects of nitric oxide on mediators of cartilage metabolism in human OA cartilage detected by antibody microarray

(2005) · Osteoarthritis and Cartilage · doi:10.1016/s1063-4584(05)80650-8