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Psychosocial Stress and Cardiovascular Disease
Open accessAbstract
Purpose of review This manuscript reviews the epidemiological data linking psychosocial stress to cardiovascular disease (CVD), describes recent advances in understanding the biological pathway between them, discusses potential therapies against stress-related CVD, and identifies future research directions.Recent findings Metabolic activity of the amygdala (a neural center that is critically involved in the response to stress) can be measured on 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (18 F-FDG-PET/CT) yielding a neurobiological signal that independently predicts subsequent CVD events. Furthermore, a serial pathway from ↑amygdalar activity → ↑hematopoietic tissue activity → ↑arterial inflammation → ↑CVD events has been elucidated, providing new insights into the mechanism linking stress to CVD. Psychosocial stress and stress conditions are independently associated with CVD in a manner that depends on the degree and duration of stress as well as the individual response to a stressor. Nevertheless, the fundamental biology remains incompletely defined, and stress is often confounded by adverse health behaviors. Thus, most clinical guidelines do not yet recognize psychosocial stress as an independent CVD risk factor or advocate for its treatment in CVD prevention. Clarification of this neurobiological pathway provides a better understanding of the underlying pathophysiology and suggests opportunities to develop novel preventive strategies and therapies.
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“Therefore, such intersubjective dyadic practices and specific socio-emotional ones may be particularly efficient in reducing social stress, one of the most prominent causes of stress-related diseases (68–70).”
From Reducing neuroendocrine psychosocial stress response through socio-emotional dyadic but not mindfulness online training (2024) · cites this paper as [69]
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“Moreover, psychological stress has been shown to influence the onset of several cardiovascular diseases (Dar et al., 2019; Esler, 2017; Leo et al., 2023).”
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Cites
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482
European Guidelines on cardiovascular disease prevention in clinical practice (version 2012)
Authors/Task Force Members:, Perk, J., De Backer, G., Gohlke, H., Graham, I., Reiner, Ž., Verschuren, M., Albus, C., Benlian, P., Boysen, G., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs092 · Cited by 8,490
Protective and Damaging Effects of Stress Mediators
McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733
Cholesterol Treatment Trialists' (CTT) Collaboration (2010) · The Lancet · doi:10.1016/s0140-6736(10)61350-5 · Cited by 6,550
2016 European Guidelines on cardiovascular disease prevention in clinical practice
Piepoli, M. F., Hoes, A. W., Agewall, S., Albus, C., Brotons, C., Catapano, A. L., Cooney, M.-T., Corrà, U., Cosyns, B., Deaton, C., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw106 · Cited by 6,457
European guidelines on cardiovascular disease prevention in clinical practice: executive summary
Graham, I., Atar, D., Borch‐Johnsen, K., Boysen, G., Burell, G. K., Cífková, R., Dallongeville, J., Backer, G. D., Ebrahim, S. B. J., Gjelsvik, B., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm316 · Cited by 3,865
Neurohumoral Features of Myocardial Stunning Due to Sudden Emotional Stress
Wittstein, I. S., Thiemann, D. R., Lima, J. A. C., Baughman, K. L., Schulman, S. P., Gerstenblith, G., Wu, K. C., Rade, J. J., Bivalacqua, T. J., & Champion, H. C. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043046 · Cited by 3,108
Rozanski, A., Blumenthal, J. A., & Kaplan, J. (1999) · Circulation · doi:10.1161/01.cir.99.16.2192 · Cited by 2,846
Rosengren, A., Hawken, S., Ôunpuu, S., Sliwa, K., Zubaid, M., Almahmeed, W. A., Blackett, K. N., Sitthi-amorn, C., Sato, H., & Yusuf, S. (2004) · The Lancet · doi:10.1016/s0140-6736(04)17019-0 · Cited by 2,414
AHA Guidelines for Primary Prevention of Cardiovascular Disease and Stroke: 2002 Update
Pearson, T. A., Blair, S. N., Daniels, S. R., Eckel, R. H., Fair, J. M., Fortmann, S. P., Franklin, B. A., Goldstein, L. B., Greenland, P., Grundy, S. M., et al. (2002) · Circulation · doi:10.1161/01.cir.0000020190.45892.75 · Cited by 1,837
Cited by
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Items 201–245 of 245
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Effect of DNA damage mediating psychosocial stress on aging
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Mulyati, M., Syariatin, L., Sofyantoro, F., & Rahim, M. H. A. (2024) · Pertanika journal of tropical agricultural science · doi:10.47836/pjtas.47.1.10
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Veiga, D., Peralta, M., Gouveia, É. R., Nascimento, M. D. M., de Carvalho, L. L., Encantado, J., & Marques, A. (2024) · Geriatrics · doi:10.3390/geriatrics9020036
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Bernad, B.-C., Tomescu, M., Hogea, L., Velimirovici, D. E., Andor, M., Lungeanu, D., ENĂTESCU, V. R., Bucur, A., Lascu, A., Rață, A. L., et al. (2024) · Preprints.org · doi:10.20944/preprints202403.1067.v1
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Marcolla, V. D. F., de Albuquerque, D. C., de Oliveira, D. C., de Aragão, A. A. B., de Aragão, I. P. B., & Ferreira, E. (2024) · Mosaico · doi:10.21727/rm.v15i3.4706
Michal, M. (2024) · Springer eBooks · doi:10.1007/978-3-662-67687-5_23
Fallahzadeh, V., Taghian, F., & Dehkordi, K. J. (2023) · Jorjani Biomedicine Journal · doi:10.61186/jorjanibiomedj.11.3.1
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Trung, T. Đ., Ngoc, N. T. B., Thien, H. K., Trần, T. D. H., Quoc, T. A., Linh, H., Hải, H. H., Thao, H. T., Ha, N. T. M., Dan, T. L. K., et al. (2025) · medRxiv · doi:10.1101/2025.07.18.25329170
Wang, Q., Liu, D., Liu, J., Tang, P., Wang, X., Liu, Q., Fan, B., Hu, M., & Meng, L. (2025) · Intelligent Medicine · doi:10.1016/j.imed.2025.06.002
Калаев, В. Н., Иванова, О. А., Курчатова, М. Н., Игнатова, И. В., & Калаева, Е. А. (2025) · Человеческий капитал. · doi:10.25629/hc.2025.12.19
Hendricks, B., Quinn, T. D., Price, B. S., Dotson, T., Claydon, E. A., & Miller, R. (2023) · Figshare · doi:10.6084/m9.figshare.24257499
Dimond, A. J., Krantz, D. S., Waters, A. J., Liew, K. S., & Gottlieb, S. S. (2021) · medRxiv · doi:10.1101/2021.09.14.21263592 · Cited by 1
Song, Z., Takada, M., Hong, Y.-J., Endale, B. T., Nishio, N., Horikoshi, M., Khine, M. T., MATSUNAGA, M., He, Y., Ota, A., et al. (2025) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-025-02189-w
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Atique, F., Waris, S., Khan, N. U., Shafique, K., Kousar, R., Ateeque, H., jafar, M. M., & Farooq, M. (2025) · doi:10.61748/apit.2025/14
Jaśko, M., Pławski, K., Wiśniewski, M., & Matysek, J. (2026) · Psychiatria i Psychologia Kliniczna · doi:10.15557/pipk.2025.0038
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O’Brien, S., Gillman, M. G., Green, M. D., Cruz, D. E., Floyd, J. S., Hankinson, S. E., Katz, D. H., Liu, X., Odden, M. C., Psaty, B. M., et al. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.324125
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Le, H., & Gaye, A. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00241.2026
Volynskyi, D. A., & Павлюк, І. О. (2026) · Прикарпатський вісник наукового товариства імені Шевченка ПУЛЬС · doi:10.21802/2304-7437-2026-25(84)-60-70
Barros-Osorio, C., Villoria, E., Vargas, E. C., Becerra, R. M. Á., & Bulnes, A. M. M. (2026) · Lecture notes in networks and systems · doi:10.1007/978-3-031-99702-0_11
Jeon, J., An, H., Lee, H., Choi, H., Ha, K. H., Shim, J., Youm, Y., Park, S., Kim, D. J., Lee, H., et al. (2026) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwag340
Periferakis, A., Troumpata, L., Periferakis, A.-T., Periferakis, K., Timofticiuc, I.-A., Georgatos-Garcia, S., Touriki, G., Bozatzi, A., Săvulescu-Fiedler, I., & Iftime, A. (2026) · Balneo and PRM Research Journal · doi:10.12680/balneo.2026.1019
Reinsberg, N., Borlepawar, A., Hajieva, P., & Mueller‐Alcazar, A. (2026) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2026.100364
Koroner Arter Hastalığında Mental Stres ve Hemşirelik Yönetimi
Günaydin, A. H., & Aktaş, Y. Y. (2026) · Doğu Karadeniz Sağlık Bilimleri Dergisi · doi:10.59312/ebshealth.1916475
Lax, M., & Williams, J. S. (2026) · Physiological Reports · doi:10.14814/phy2.71028
Psychosocial Stressors and Heart Failure Risk Among Black Women in the US
Davis, D. N., Aghi, A., Gajjar, P., Miller, P., Holder, E. X., Nayor, M. G., & Palmer, J. R. (2026) · JAMA Network Open · doi:10.1001/jamanetworkopen.2026.29320
Psychosocial stress and persistent postpartum hypertension after preeclampsia
Sheikh, L., Kwapong, Y. A., Yilma, A., Boyer, T. M., & Minhas, A. A. (2026) · Pregnancy Hypertension · doi:10.1016/j.preghy.2026.101502
Chen, Q., Chen, J., Chen, X., Yan, G., Niu, P., Shujuan, L., & Zhou, Y. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1942262
DAIRO, M. D., Olawuni, D. A., Alayande, A. A., Onuoha, P. O., Williams, J. E., Adesina, D. H., Samuel, A. J., Adeyemi, A. M., Ademola, A. D., Adediran, K., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10869425/v1
Stimulating a NTS to LC circuit elicits anxiety-like behavior and state-dependent autonomic outputPreprint
Butler, A. G., Bassi, J. K., Connelly, A. A., Melo, M. R. G., Allen, A. M., & McDougall, S. J. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.30.755810
Metadata
- Authors
- Dar, T., Radfar, A., Abohashem, S., Pitman, R. K., Tawakol, A., & Osborne, M. T.
- Affiliations
- Harvard University (US)
- Corresponding author
- Osborne, Michael T.
- Venue
- Current Treatment Options in Cardiovascular Medicine
- Published
- 2019-04-26
- Volume
- 21
- Issue
- 5
- Pages
- 23-23
- ISSN
- 1092-8464 (ISSN-L)
- 1534-3189
- PMC
- PMC6568256
- OpenAlex
- W2940673845
- Cited by
- 248
- References
- 122
- Citations by year
- 2026: 23 · 2025: 56 · 2024: 42 · 2023: 42 · 2022: 41 · 2021: 24 · 2020: 16 · 2019: 2
- FWCI
- 3.76
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Treatment Options in Cardiovascular Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- American Heart Association (18CDA34110366)
- National Institutes of Health (KL2TR002542)
- National Heart, Lung, and Blood Institute (P01HL131478)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- psychosocial stress, cardiovascular disease, amygdala, arterial inflammation, hematopoietic tissue, stress response, cardiovascular risk factors, stress biomarkers
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