The UCP2-866G/A Polymorphism Could be Considered as a Genetic Marker of Different Functional Prognosis in Ischemic Stroke after Recanalization
Abstract
Recent studies based on experimental animal models of stroke have suggested that uncoupling protein 2 (UCP2), an inner mitochondrial membrane protein that is thought to regulate energy metabolism and reduce reactive oxygen species generation, provides protection against reperfusion damage. We aimed to investigate whether -866G/A polymorphism in the promoter of the UCP2 gene, which enhances its transcriptional activity, is associated with functional prognosis in patients with embolic ischemic stroke after early recanalization. We investigate a hospital-based prospective cohort of patients with acute ischemic stroke due to occlusion of the middle cerebral artery diagnosed by transcranial Doppler who obtained a partial/complete recanalization 24 h after administration of intravenous thrombolysis. The main end point of the study was functional independence defined as modified Rankin Scale 0-2 on day 90. A total of 80 patients were enrolled. The UCP2-866G/A polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism technique (14 genotype A/A (18%), 45 genotype A/G (56%) and 21 genotype G/G (26%). The percentage of patients with good functional outcome at 3 months was significantly higher in patients harboring the A/A genotype than in those with A/G or G/G genotypes (85 vs 41%, p = 0.01). The A/A genotype was found to be an independent marker of good prognosis after adjustment for secondary variables (age, sex, glucose level, NIHSS score at baseline, complete recanalization and early neurological improvement) in a logistic regression analysis (OR 0.05, 95% CI 0.01-0.48, p = 0.01). Our results suggest that the AA genotype of UCP2-866 may predict a better functional outcome in ischemic stroke after recanalization of proximal MCA occlusion.
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A -866G/A polymorphism in the promoter of the UCP2 gene (enhancing its transcription) is associated with functional prognosis in patients with embolic ischemic stroke after early recanalization.
“A clear role of UCP2 in the reduction of ROS generation allowing protection against reperfusion damage comes from a study showing that -866G/A polymorphism in the promoter of the UCP2 gene (enhancing its transcription) is associated with functional prognosis in patients with embolic ischemic stroke after early recanalization [291].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [291]
In humans, increased expression of UCP2 is neuroprotective.
“This study clearly demonstrates that, in humans, increased expression of UCP2 is neuroprotective [291].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [291]
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- Authors
- Díaz-Maroto Cicuéndez, I., Fernández-Díaz, E., García-García, J., Jordán, J., Fernández-Cadenas, I., Montaner, J., Serrano-Heras, G., & Segura, T.
- Affiliations
- University of Castilla-La Mancha (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Complejo Hospitalario Universitario de Albacete (ES)
- Venue
- NeuroMolecular Medicine
- Published
- 2017-10-17
- Volume
- 19
- Issue
- 4
- Pages
- 571-578
- ISSN
- 1535-1084 (ISSN-L)
- 1559-1174
- OpenAlex
- W2766638667
- Cited by
- 12
- References
- 38
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3
- FWCI
- 1.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroMolecular Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Keywords
- UCP2, ischemic stroke, functional prognosis, genetic markers, intravenous thrombolysis, recanalization, middle cerebral artery occlusion, modified Rankin Scale, ischemia-reperfusion injury, mitochondrial bioenergetics
- MeSH terms
- Uncoupling Protein 2, Aged, Aged, 80 and over, Cardiovascular Diseases, Diabetes Mellitus, Female, Genetic Markers, Humans, Male, Middle Aged, Prognosis, Promoter Regions, Genetic, Prospective Studies, Polymorphism, Restriction Fragment Length, Risk Factors, Comorbidity, Thrombolytic Therapy, Recovery of Function, Infarction, Middle Cerebral Artery, Polymorphism, Single Nucleotide, Genetic Association Studies
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