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Neuroprotective Role of Mitochondrial Uncoupling Protein 2 in Cerebral Stroke

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Deletion of Mitochondrial Uncoupling Protein-2 Increases Ischemic Brain Damage after Transient Focal Ischemia by Altering Gene Expression Patterns and Enhancing Inflammatory Cytokines

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The mitochondrial uncoupling protein‐2 is a master regulator of both M1 and M2 microglial responses

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Resveratrol Preconditioning Induces a Novel Extended Window of Ischemic Tolerance in the Mouse Brain

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Increased Infarct Size and Lack of Hyperphagic Response after Focal Cerebral Ischemia in Peroxisome Proliferator-Activated Receptor β-Deficient Mice

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The genomic response of the ipsilateral and contralateral cortex to stroke in aged rats

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Sirt1 in cerebral ischemia

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Mitochondrial Uncoupling Protein-2 Mediates Steatotic Liver Injury following Ischemia/Reperfusion

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N-Palmitoylethanolamide-Oxazoline Protects against Middle Cerebral Artery Occlusion Injury in Diabetic Rats by Regulating the SIRT1 Pathway

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Heterogeneity of nervous system mitochondria: Location, location, location!

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Role of sirtuins in ischemia-reperfusion injury

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Peroxisome proliferator activated receptor-γ agonists protect oligodendrocyte progenitors against tumor necrosis factor-alpha-induced damage: Effects on mitochondrial functions and differentiation

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New role of silent information regulator 1 in cerebral ischemia

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Quantification of Uncoupling Protein 2 Reveals Its Main Expression in Immune Cells and Selective Up-Regulation during T-Cell Proliferation

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Mitochondrial Uncoupling Protein 2 Knockout Promotes Mitophagy to Decrease Retinal Ganglion Cell Death in a Mouse Model of Glaucoma

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Uncoupling protein 2 modulates cell viability in adult rat cardiomyocytes

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UCP2, a Member of the Mitochondrial Uncoupling Proteins: An Overview from Physiological to Pathological Roles

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Microglial glutamate uptake is coupled to glutathione synthesis and glutamate release

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Reduced expression of citrate synthase leads to excessive superoxide formation and cell apoptosis

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Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection

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Immuno-metabolic dendritic cell vaccine signatures associate with overall survival in vaccinated melanoma patients

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Heterogeneous Nuclear Ribonucleoprotein K Enhances Insulin-induced Expression of Mitochondrial UCP2 Protein

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Genetic variants in nuclear-encoded mitochondrial proteins are associated with oxidative stress in obsessive compulsive disorders

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Uncoupling protein 2 protects testicular germ cells from hyperthermia-induced apoptosis

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Enhancement of Cyanide-Induced Mitochondrial Dysfunction and Cortical Cell Necrosis by Uncoupling Protein-2

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Signaling pathways leading to ischemic mitochondrial neuroprotection

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UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress

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UCP2 Modulates Cell Proliferation through the MAPK/ERK Pathway during Erythropoiesis and Has No Effect on Heme Biosynthesis

Elorza, Á. A., Hyde, B. B., Mikkola, H. K. A., Collins, S., & Shirihai, O. S. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805400200 · Cited by 32 · see citing works

Uncoupling and reactive oxygen species (ROS) – A double-edged sword for β-cell function? “Moderation in all things”

Collins, S., Pi, J., & Yehuda‐Shnaidman, E. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.08.002 · Cited by 32 · see citing works

Up-Regulation of Uncoupling Protein 2 by Cyanide Is Linked with Cytotoxicity in Mesencephalic Cells

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Mito-Q promotes porcine oocytes maturation by maintaining mitochondrial thermogenesis via UCP2 downregulation

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Hyperglycemia, Hypoglycemia and Dementia: Role of Mitochondria and Uncoupling Proteins

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Estrogen reduces the severity of autonomic dysfunction in spinal cord-injured male mice

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Isoliquiritigenin mitigates intervertebral disc degeneration induced by oxidative stress and mitochondrial impairment through a PPARγ-dependent pathway

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Methyl‐4‐phenylpyridinium ion modulates expression of mitochondrial uncoupling proteins 2, 4, and 5 in catecholaminergic (SK‐N‐SH) cells

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Mitochondrial Uncoupling Protein-2 Ameliorates Ischemic Stroke by Inhibiting Ferroptosis-Induced Brain Injury and Neuroinflammation

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Antagonistic effect of TNF-alpha and insulin on uncoupling protein 2 (UCP-2) expression and vascular damage

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Mitochondrial Targeting of Antioxidants Alters Pancreatic Acinar Cell Bioenergetics and Determines Cell Fate

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DEP domain‐containing mTOR‐interacting protein in the rat brain: Distribution of expression and potential implication

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Mitochondrial uncoupling protein-2 deficiency protects steatotic mouse hepatocytes from hypoxia/reoxygenation

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UCP2 protects against amyloid beta toxicity and oxidative stress in primary neuronal culture

Jun, Z., Ibrahim, M. M., dezheng, G., Yuan, B., Wu, Q., & Zou, Y. (2015) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2015.08.001 · Cited by 18 · see citing works

A possible pivotal role of mitochondrial free calcium in neurotoxicity mediated by N-methyl-d-aspartate receptors in cultured rat hippocampal neurons

Kambe, Y., Nakamichi, N., Takarada, T., Fukumori, R., Nakazato, R., Hinoi, E., & Yoneda, Y. (2011) · Neurochemistry International · doi:10.1016/j.neuint.2011.03.018 · Cited by 18 · see citing works

Naked mole-rat skeletal muscle mitochondria exhibit minimal functional plasticity in acute or chronic hypoxia

Cheng, H., Munro, D., Huynh, K. W., & Pamenter, M. E. (2021) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2021.110596 · Cited by 18 · see citing works

Selective Inhibition by Ethanol of Mitochondrial Calcium Influx Mediated by Uncoupling Protein-2 in Relation to N-Methyl-D-Aspartate Cytotoxicity in Cultured Neurons

Fukumori, R., Takarada, T., Nakazato, R., Fujikawa, K., Kou, M., Hinoi, E., & Yoneda, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0069718 · Cited by 16 · see citing works

Cyanide-induced death of dopaminergic cells is mediated by uncoupling protein-2 up-regulation and reduced Bcl-2 expression

Zhang, X., Li, L., Zhang, L., Borowitz, J. L., & Isom, G. E. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.03.020 · Cited by 16 · see citing works

Uncoupling Protein 2 Increases Blood Pressure in DJ‐1 Knockout Mice

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Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: An essential role of IFN-γ and an association with negative energy balance

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Transporter-Mediated Mitochondrial GSH Depletion Leading to Mitochondrial Dysfunction and Rescue with αB Crystallin Peptide in RPE Cells

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Decreased infarct size after focal cerebral ischemia in mice chronically infected with Toxoplasma gondii

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PPARα-Mediated Upregulation of Uncoupling Protein-2 Switches Cyanide-Induced Apoptosis to Necrosis in Primary Cortical Cells

Li, L., Prabhakaran, K., Zhang, X., Borowitz, J. L., & Isom, G. E. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfl039 · Cited by 13 · see citing works

The UCP2-866G/A Polymorphism Could be Considered as a Genetic Marker of Different Functional Prognosis in Ischemic Stroke after Recanalization

Díaz-Maroto Cicuéndez, I., Fernández-Díaz, E., García-García, J., Jordán, J., Fernández-Cadenas, I., Montaner, J., Serrano-Heras, G., & Segura, T. (2017) · NeuroMolecular Medicine · doi:10.1007/s12017-017-8470-x · Cited by 12 · see citing works

Supplementation of Enriched Polyunsaturated Fatty Acids and CLA Cheese on High Fat Diet: Effects on Lipid Metabolism and Fat Profile

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Mitochondrial Impairments in Peripheral Blood Mononuclear Cells of Multiple Sclerosis Patients

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Enterostatin decreases postprandial pancreatic UCP2 mRNA levels and increases plasma insulin and amylin

Arsenijevic, D., Gallmann, E., Moses, W. W., Lutz, T. A., Erlanson‐Albertsson, C., & Langhans, W. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00367.2004 · Cited by 11 · see citing works

Role for nerve growth factor in the in vivo regulation of glutathione in response to LPS in mice.

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Expression of genes encoding mitochondrial proteins can distinguish nonalcoholic steatosis from steatohepatitis.

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The role of nuclear factor E2-Related factor 2 and uncoupling protein 2 in glutathione metabolism: Evidence from an in vivo gene knockout study

Chen, Y., Xu, Y., Zheng, H., Fu, J., Hou, Y., Wang, H., Zhang, Q., Yamamoto, M. P., & Pi, J. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.088 · Cited by 9 · see citing works

Mitochondrial Uncoupling Proteins and Oxidative Stress: Implications for Diabetes and Neurodegeneration

Cardoso, S., Santos, R. X., Carvalho, C., Correia, S. C., Santos, M. S., & Moreira, P. I. (2011) · Free Radicals and Antioxidants · doi:10.5530/ax.2011.2.3 · Cited by 8 · see citing works

Uncoupling protein-2 increases nitric oxide production and TNFAIP3 pathway activation in pancreatic islets

Nino‐Fong, R., Fatehi‐Hassanabad, Z., Lee, S. C., Lu, H., Wheeler, M. B., & Chan, C. B. (2011) · Journal of Molecular Endocrinology · doi:10.1530/jme-10-0117 · Cited by 8 · see citing works

Protection of Regenerating Liver After Partial Hepatectomy from Carbon Tetrachloride Hepatotoxicity in Rats: Roles of Mitochondrial Uncoupling Protein 2 and ATP Stores

Wu, Q., Gong, D., Tian, N., Zhu, L., Guan, L., Yang, M., Yuan, B., Qiu, Q., Lv, H., & Zou, Y. (2008) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0650-y · Cited by 8 · see citing works

Possible involvement of mitochondrial uncoupling protein-2 in cytotoxicity mediated by acquired N-methyl-d-aspartate receptor channels

Fukumori, R., Takarada, T., Kambe, Y., Nakazato, R., Fujikawa, K., & Yoneda, Y. (2012) · Neurochemistry International · doi:10.1016/j.neuint.2012.03.019 · Cited by 7 · see citing works

Poppy seed oil protection of the hippocampus after cerebral ischemia and re-perfusion in rats

Çevik-Demirkan, A., Öztaşan, N., Oguzhan, E., Çil, N., & Cevher, Ş. C. (2012) · Biotechnic & Histochemistry · doi:10.3109/10520295.2012.701763 · Cited by 6 · see citing works

Role for glutathione in the hyposensitivity of LPS-pretreated mice to LPS anorexia.

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Effects of 2,4-dinitrophenol on ischemia-induced blood-brain barrier disruption

Ennis, S. R., & Keep, R. F. (2006) · Springer eBooks · doi:10.1007/3-211-30714-1_63 · Cited by 3 · see citing works

Free Cholesterol — A Double-Edge Sword in Alzheimer Disease

Fernández-Checa, J. C. (2015) · InTech eBooks · doi:10.5772/59935 · Cited by 2 · see citing works

Mitochondrial Uncoupling Proteins: Therapeutic Targets in Neurodegeneration?

Cardoso, S., Carvalho, C., Correia, S. C., Santos, R. X., Santos, M. S., & Moreira, P. I. (2010) · Cited by 2 · see citing works

Microglial Mitochondrial Dysfunction: The Storm Center of Post‐Stroke Neuroinflammation

Fan, R., Wang, C., Lin, Z. B., Chen, S., Pan, C., Nie, H., Qin, C., Wu, X., & Tang, Z. (2026) · CNS Neuroscience & Therapeutics · doi:10.1002/cns.71060 · Cited by 1 · see citing works

Deletion of Mitochondrial Uncoupling Protein-2 Increases Ischemic Brain Damage after Transient Focal Ischemia by Altering Gene Expression Patterns and Enhancing Inflammatory Cytokines

Haines, B. A., Mehta, S. L., Pratt, S. M., Warden, C. H., & Li, P. A. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.52 · Cited by 78 · see citing works

Mitochondrial Uncoupling Protein-2 Ameliorates Ischemic Stroke by Inhibiting Ferroptosis-Induced Brain Injury and Neuroinflammation

Wang, L., Li, X., Chen, L., Mei, S., Shen, Q., Liu, L., Liu, X., Liao, S., Zhao, B., Chen, Y., et al. (2024) · Molecular Neurobiology · doi:10.1007/s12035-024-04288-0 · Cited by 23 · see citing works

Genipin protects against cerebral ischemia-reperfusion injury by regulating the UCP2-SIRT3 signaling pathway

Zhao, B., Sun, L., Jiang, X., Zhang, Y., Kang, J., Meng, H., Li, H., & Su, J. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.12.028 · Cited by 53 · see citing works

Reduced Cerebral Infarct Volume in Young UCP2−/− Mice and Preserved Synaptic Transmission by Genipin

Reichart, G., Koch, H., Sellmann, T., Einsle, A., Mayer, J., Jaster, R., Kirschstein, T., Lange, F., & Köhling, R. (2026) · Cells · doi:10.3390/cells15141299

Deletion of Mitochondrial Uncoupling Protein 2 Exacerbates Mitochondrial Damage in Mice Subjected to Cerebral Ischemia and Reperfusion Injury under both Normo- and Hyperglycemic Conditions

He, M.-T., Ma, Y.-M., Wang, R., Zhang, J.-Z., Jing, L., & Li, P. A. (2020) · International Journal on Biological Sciences · doi:10.7150/ijbs.48204 · Cited by 24 · see citing works