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Cited by 21Thyroid Disorders and TreatmentsThyroid and Parathyroid SurgeryOphthalmology and Eye Disorders

Effects of sex steroid hormones, thyroid hormone levels, and insulin regulation on thyrotoxic periodic paralysis in Chinese men

Open access
Li, Wang, Changsheng, Chen, Jiangfang, Fu, Bin, Gao, Nanyan, Zhang, Xiaomiao, Li, Deqiang, Li, Ying, Xing +2 more·2010·Endocrine
DOI 10.1007/s12020-010-9396-3PMC PMC5454485
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Abstract

Our study is to determine the expression of thyroid hormone, sex hormone, insulin, and C-peptide in Chinese male patients with thyrotoxic periodic paralysis (TPP). This study covered 102 patients with hyperthyroidism from Xijing Hospital. According to whether occurrence of TPP or not, patients were divided into two groups (those that were hyperthyroid with and without TPP) that were, matched with age, blood pressure, urea, and creatinine. We found the body mass index (BMI) in patients with TPP was higher than that in pure hyperthyroidism patients. The levels of the total thyroxine (T4), free triiodothyronine (FT3), and free thyroxine (FT4) were significantly lower in patients with TPP compared with pure hyperthyroidism patients, while serum testosterone levels were higher compared with pure hyperthyroidism patients. Moreover, after glucose administration, the concentration of insulin at 60, 120, and 180 min were significantly higher in patients with TPP than those in pure hyperthyroidism patients. The insulin area under the curve (AUC) was significantly increased in patients with TPP compared with pure hyperthyroidism patients. The levels of thyroid hormone, sex hormone, and insulin were different in Chinese male patients with TPP compared to those with only hyperthyroidism.

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  • Hyperinsulinemia is observed during acute attacks of TPP and TPP patients have exaggerated insulin responses to oral glucose challenge compared with patients with pure hyperthyroidism.

    “The role of insulin in TPP was revealed by the finding that hyperinsulinemia was observed during acute attacks of TPP and that TPP patients had exaggerated insulin responses to oral glucose challenge in comparison with patients with pure hyperthyroidism (17, 18, 19).”

    From A 10-year analysis of thyrotoxic periodic paralysis in 135 patients: focus on symptomatology and precipitants (2013) · cites this paper as [19]

    The Results (page unavailable) report higher insulin levels after oral glucose and a higher insulin area under the curve in the TPP group than in the pure-hyperthyroidism group. The paper does not establish hyperinsulinemia during acute attacks: the Subjects section says TPP patients received potassium before examination and were in stable condition when tested. (LLM, conf=0.91)

    Experimental — accuracy not yet measured

  • In a recent study, none of the 51 cases of TPP developed symptoms after glucose loading test.

    “Also in a recent study none of the 51 cases of TPP developed symptoms after glucose loading test [25].”

    From Thyrotoxic Periodic Paralysis: Clinical Challenges (2014) · cites this paper as [25]

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Research works printed but not linked: 4

  1. [5]Tinker TD Vannatta JB J Okla State Med Assoc 80 76 83 1987 3550012
  2. [10]Magsino CH Jr Ryan AJ Jr South Med J 93 996 1003 2000 11147484
  3. [12]Seshadri P Frank KD Iqbal N Endocr Pract 8 362 363 2002 15259121
  4. [18]Zheng TS Ye LX Wu ZY Natl J Androl 11 936 938 2005 16398369

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Authors
Li, W., Changsheng, C., Jiangfang, F., Bin, G., Nanyan, Z., Xiaomiao, L., Deqiang, L., Ying, X., Wensong, Z., & Qiuhe, J.
Affiliations
  • Xijing Hospital (CN)
  • Air Force Medical University (CN)
ORCID
Li, Wang
Venue
Endocrine
Publisher
Springer Science and Business Media LLC
Published
2010-10-23
Volume
38
Issue
3
Pages
386-390
ISSN
  • 0969-711X (ISSN-L)
  • 1355-008X
  • 1559-0100
DOI
10.1007/s12020-010-9396-3
PMC
PMC5454485
OpenAlex
W2059568591
Cited by
21
References
23
Citations by year
2022: 1 · 2021: 4 · 2020: 1 · 2018: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 6 · 2012: 2
FWCI
1.93
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Endocrine (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
Fogarty International Center (R24TW007988)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Ophthalmology and Eye Disorders
Keywords
thyrotoxic periodic paralysis, hyperthyroidism, sex hormones, testosterone, thyroid hormones, insulin, C-peptide, body mass index, Chinese men
MeSH terms
Adult, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Paralysis, Familial Mediterranean Fever, Gonadal Steroid Hormones, Thyroid Function Tests, Thyroid Hormones, Thyrotoxicosis, Asian People, Young Adult

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