Androgens stimulate preoptic area Na+,K+-ATPase activity in male rats
Abstract
This paper describes the effects of castration and testosterone replacement on the Na+,K+-ATPase activity levels of the cerebral cortex (CC), preoptic-suprachiasmatic region (POSC) and mediobasal hypothalamus (MBH) in male rats. Na+,K+-ATPase activity was estimated as the ouabain-sensitive fraction of ADP and AMP generation rate, measured by high-pressure liquid chromatography (HPLC) with UV detection, from a standard incubation mixture containing 3 mM ATP. Orchidectomy, performed 4 weeks before sacrifice, decreased ATPase activity of MBH. Testosterone propionate treatment (50 micrograms/day X 2 days) to castrated animals resulted in a 4-fold increase in enzyme activity in the POSC, an effect that might be related to the behavioral effects of androgens. None of the treatments seemed to influence the enzyme activity of the cerebral cortex.
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Androgens, muscle mass, and serum catecholamine levels in response to stress may explain the male predominance in TPP.
“Androgens, muscle mass, and serum catecholamine levels in response to stress may explain the gender difference (28, 29, 30, 31, 32).”
From A 10-year analysis of thyrotoxic periodic paralysis in 135 patients: focus on symptomatology and precipitants (2013) · cites this paper as [28]
Androgens increase the expression and activity of the Na+/K+-ATPase.
“Androgens have been reported to increase the expression and activity of the Na+/K+-ATPase [11, 12].”
From Thyrotoxic Periodic Paralysis: Clinical Challenges (2014) · cites this paper as [11]
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- Authors
- Guerra, M., Rodriguez Del Castillo, A., Battaner, E., & Mas, M.
- Affiliations
- Universidad de La Laguna (ES)
- Corresponding author
- Mas, Manuel
- ORCID
- Mas, Manuel
- Venue
- Neuroscience Letters
- Publisher
- Elsevier BV
- Published
- 1987-07
- Volume
- 78
- Issue
- 1
- Pages
- 97-100
- ISSN
- 0304-3940 (ISSN-L)
- OpenAlex
- W2030332109
- Cited by
- 80
- References
- 22
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 4 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 6 · 2012: 2
- FWCI
- 1.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Keywords
- androgens, testosterone, Na+/K+-ATPase, preoptic area, suprachiasmatic nucleus, mediobasal hypothalamus, cerebral cortex, castration, testosterone propionate, ouabain-sensitive ATPase, enzyme activity, male rats
- MeSH terms
- Sodium-Potassium-Exchanging ATPase, Aggression, Androgens, Animals, Cerebral Cortex, Copulation, Hypothalamus, Male, Orchiectomy, Preoptic Area, Rats, Inbred Strains, Testosterone, Rats
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