CoChat
Sign Up
Cited by 19Thyroid Disorders and TreatmentsHormonal and reproductive studiesThyroid and Parathyroid Surgery

Episodes of Paralysis in Chinese Men with Thyrotoxic Periodic Paralysis Are Associated with Elevated Serum Testosterone

Yao, Yu, Fan, Linbo, Zhang, Xiangxun, Xiao, Zhu, Long, Yang, Tian, Haoming·2013·Thyroid
DOI 10.1089/thy.2011.0493
Open this paper in CoChat — free account

Abstract

BACKGROUND: The strong predilection for thyrotoxic periodic paralysis (TPP) to occur in males suggests androgen may contribute to its pathogenesis. We therefore sought to determine if serum total and free testosterone (TT and FT) concentrations differed among patients with TPP during episodes of paralysis, patients with TPP between episodes of paralysis, and patients with Graves' disease (GD) not having TPP. METHODS: A total of 105 Chinese men were included in the study, and were divided into three groups. Group 1 consisted of men with TPP who were studied during episodes of paralysis; group 2 consisted of men with TPP who were studied between episodes of paralysis; group 3 consisted of men with GD not having TPP. Patients in each were different persons. Serum electrolytes, free triiodothyronine (FT3), free thyroxine (FT4), TT, and FT were measured. Multiple regression analyses and analysis of covariance were performed to analyze the relationship of serum parameters, group status, and age. RESULTS: One multiple regression analysis was used to determine if serum TT concentrations were associated with age, FT3, FT4, or group status. This analysis indicated that age, FT4 level, and group status were significantly and independently associated with serum TT concentrations. With regard to group status, patients in group 1 had serum TT concentrations 0.92 ng/mL higher than patients in group 3 (p=0.033). As to FT4 level, TT concentrations increased by 0.016 ng/mL for each additional pmol/L of FT4 (p=0.002). Another multiple regression analysis was used to determine if serum FT concentrations were associated with age, FT3, FT4, group status, or serum TT concentrations. This analysis revealed that serum TT concentrations and group status were significantly and independently associated with serum FT concentrations. In terms of group status, patients in group 1 had serum FT concentrations of 2.11 pg/mL greater on average than patients in group 3 (p=0.006). CONCLUSIONS: We infer that episodes of paralysis in Chinese men with TPP are associated with elevated serum testosterone. We also found serum TT and FT concentrations of men with GD are both affected by group status; serum TT rather than FT concentrations are associated with thyroid function.

Integrity signals

Registry

Crossref · 10.1089/thy.2011.0493

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Yao, Y., Fan, L., Zhang, X., Xiao, Z., Long, Y., & Tian, H.
Affiliations
  • Sichuan University (CN)
  • School of Public Health, Kumming Medical University, Kunming, China.
ORCID
Venue
Thyroid
Publisher
SAGE Publications
Published
2013-04
Volume
23
Issue
4
Pages
420-427
ISSN
  • 1050-7256 (ISSN-L)
  • 1557-9077
DOI
10.1089/thy.2011.0493
OpenAlex
W2007187913
Cited by
19
References
38
Citations by year
2024: 2 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 4 · 2015: 1 · 2014: 2 · 2013: 2
FWCI
1.31
Type
journal article
Language
en
Open access
closed
Licence
www.liebertpub.com/nv/resources-tools/text-and-data-mining-policy/121/ (tdm)
Locations
  • Thyroid (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
Keywords
thyrotoxic periodic paralysis, serum testosterone, free testosterone, androgens, Graves' disease, Chinese men, thyroid function, free thyroxine, free triiodothyronine
MeSH terms
Adult, China, Humans, Male, Middle Aged, Paralyses, Familial Periodic, Testosterone, Thyroid Function Tests, Thyrotoxicosis, Thyroxine, Triiodothyronine, Asian People

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review