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Cited by 59Growth Hormone and Insulin-like Growth FactorsVitamin D Research StudiesHormonal and reproductive studies

Cardiovascular risk in adult hypopituitaric patients with growth hormone deficiency: is there a role for vitamin D?

Savanelli, Maria Cristina, Scarano, Elisabetta, Muscogiuri, Giovanna, Barrea, Luigi, Vuolo, Laura, Rubino, Manila, Savastano, Silvia, Colao, Annamaria +1 more·2016·Endocrine
DOI 10.1007/s12020-015-0779-3
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Abstract

Hypovitaminosis D represent an environmental risk factors for cardiovascular (CV) disease. To investigate the prevalence of hypovitaminosis D and the correlation between GH/IGF-I deficiency and hypovitaminosis D with CV risk in GH deficiency (GHD) patients. A link between these hormones has been shown. Forty-one hypopituitaric patients with GHD (22 males, age 18-84 years) and 41 controls were enrolled in the study. Anthropometric parameters, blood pressure, glucose and lipid profile, parathyroid hormone (PTH), 25(OH) vitamin D (vitamin D), metabolic syndrome (MS), GH peak after GHRH + ARG, IGF-I, and standard deviation score (SDS) of IGF-I (zIGF-I) were assessed. Vitamin D levels were lower in patients than in controls (21.3 ± 12.3 vs. 28.2 ± 9.4, p = 0.006). Deficiency was found in 51 % of patients versus 14.6 % of controls (p < 0.01), insufficiency in 26.8 versus 41.4 % (p = 0.269) and normal vitamin D levels in 21.9 versus 43.9 % (p = 0.060). The prevalence of dyslipidemia was 51.2 % in patients versus 12.1 % in controls (p < 0.001), type 2 diabetes mellitus (DM) was 7.3 versus 17 % (p = 0.292), hypertension was 44 versus 22 % (p = 0.060), and MS was 17 versus 14.6 % (p = 0.957). In patients, an association was found between the presence of hypovitaminosis D and the prevalence of dyslipidemia, hypertension and MS and between zIGF-I and the prevalence of hypertension. Hypovitaminosis D was the most powerful predictor of the prevalence of dyslipidemia and hypertension. GHD patients have an increased prevalence of hypovitaminosis D compared with controls. The presence of hypovitaminosis D was the most powerful predictor of the prevalence of dyslipidemia and hypertension in GHD patients, suggesting the involvement of both factors in the CV risk in these patients.

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  • Low vitamin D status is associated with increased blood pressure, dyslipidemia, impaired insulin metabolism, sleep disturbances, thus increasing the risk of cardiovascular atherosclerosis.

    “Therefore, low vitamin D status has been associated with increased BP [139, 140], dyslipidemia [139, 140], impaired insulin metabolism [138], sleep disturbances [141, 142], thus increasing the risk of cardiovascular atherosclerosis [139, 140].”

    From Mediterranean Diet and Obesity-related Disorders: What is the Evidence? (2022) · cites this paper as [140]

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Authors
Savanelli, M. C., Scarano, E., Muscogiuri, G., Barrea, L., Vuolo, L., Rubino, M., Savastano, S., Colao, A., & Di Somma, C.
Affiliations
Federico II University Hospital (IT)
Corresponding author
Savanelli, Maria Cristina
ORCID
Venue
Endocrine
Publisher
Springer Science and Business Media LLC
Published
2015-10-29
Volume
52
Issue
1
Pages
111-119
ISSN
  • 0969-711X (ISSN-L)
  • 1355-008X
  • 1559-0100
DOI
10.1007/s12020-015-0779-3
OpenAlex
W2199096407
Cited by
59
References
58
Citations by year
2026: 2 · 2025: 2 · 2024: 5 · 2023: 3 · 2022: 8 · 2021: 14 · 2020: 7 · 2019: 7 · 2018: 3 · 2017: 5 · 2016: 3
FWCI
3.18
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Endocrine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
hypopituitarism, growth hormone deficiency, vitamin D deficiency, cardiovascular risk, dyslipidemia, hypertension, metabolic syndrome, insulin-like growth factor I, parathyroid hormone, type 2 diabetes
MeSH terms
Adolescent, Adult, Aged, Aged, 80 and over, Cardiovascular Diseases, Diabetes Mellitus, Type 2, Female, Humans, Hypertension, Hypopituitarism, Insulin-Like Growth Factor I, Male, Middle Aged, Prognosis, Risk, Vitamin D, Vitamin D Deficiency, Prevalence, Human Growth Hormone, Dyslipidemias, Young Adult

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