Plasma 25-Hydroxyvitamin D and Regulation of the Renin-Angiotensin System in Humans
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Vitamin D regulates the renin-angiotensin system (RAS) in experimental animals, but corresponding human data are limited. We examined the relation between plasma 25-hydroxyvitamin D and elements of the RAS in 184 normotensive individuals in high sodium balance; these included circulating levels of plasma renin activity and angiotensin II (Ang II) and the renal plasma flow response to infused Ang II, which is an indirect measure of the intrinsic RAS activity in the kidney. Compared with individuals with sufficient 25-hydroxyvitamin D levels (≥30.0 ng/mL), those with insufficiency (15.0 to 29.9 ng/mL) and deficiency (<15.0 ng/mL) had higher circulating Ang II levels ( P for trend=0.03). Moreover, those with vitamin D deficiency had significantly blunted renal plasma flow responses to infused Ang II (mean decrease of 115 mL/min per 1.73 m 2 in renal plasma flow versus 145 mL/min per 1.73 m 2 among those with sufficient vitamin D levels; P for trend=0.009). Although plasma renin activity was higher among individuals with insufficient levels of vitamin D, the result was not statistically significant. These data suggest that low plasma 25-hydroxyvitamin D levels may result in upregulation of the RAS in otherwise healthy humans.
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Vitamin D deficiency blunts tissue-responsiveness to exogenous angiotensin II by inducing a state of high tissue-RAAS activity.
“We previously showed that vitamin D deficiency blunts tissue-responsiveness to exogenous AngII by inducing a state of high tissue-RAAS activity4,6,31; this blunted sensitivity to AngII could be corrected by lowering the tissue-RAAS with an ACE inhibitor or vitamin D3 therapy4,33.”
From Human Interventions to Characterize Novel Relationships Between the Renin–Angiotensin–Aldosterone System and Parathyroid Hormone (2014) · cites this paper as [31]
When integrated with Study 1, an incremental relationship between the RAAS and PTH was observed, modulated by angiotensin II dose, ACE inhibition, and vitamin D status.
“When integrated with the findings from Study 1 (Figure 1a–c), an incremental relationship between the RAAS and PTH was observed, which was modulated by AngII dose, as well as by ACE inhibition and vitamin D status (both of which sensitize the tissue responsiveness to AngII infusion)4,6,31–33.”
From Human Interventions to Characterize Novel Relationships Between the Renin–Angiotensin–Aldosterone System and Parathyroid Hormone (2014) · cites this paper as [31]
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New Insights on the Role of Vitamin D in the Progression of Renal Damage
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Vitamin D Levels Are Associated with Cardiac Autonomic Activity in Healthy Humans
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- Authors
- Forman, J. P., Williams, J. S., & Fisher, N. D. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Hypertension
- Published
- 2010-05
- Volume
- 55
- Issue
- 5
- Pages
- 1283-1288
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- PMC
- PMC3023301
- OpenAlex
- W2133707802
- Cited by
- 331
- References
- 54
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 12 · 2023: 21 · 2022: 24 · 2021: 27 · 2020: 24 · 2019: 14 · 2018: 22 · 2017: 23 · 2016: 19 · 2015: 31 · 2014: 25 · 2013: 25 · 2012: 26
- FWCI
- 16.90
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Hypertension (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (K23HL084236, HL-079929, K08HL079929, HL084236)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- 25-hydroxyvitamin D, vitamin D deficiency, renin-angiotensin system, angiotensin II, plasma renin activity, renal plasma flow, normotensive subjects
- MeSH terms
- Adult, Angiotensin II, Female, Homeostasis, Humans, Infusions, Intravenous, Male, Middle Aged, p-Aminohippuric Acid, Reference Values, Renal Circulation, Renin-Angiotensin System, Sodium, Sodium, Dietary, Vitamin D, Patient Selection, Black People, White People
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