The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease
Open accessAbstract
It has become clear that the endocannabinoid system is a potent regulator of immune responses, with the cannabinoid receptor 2 (CB2) as the key component due to its high expression by all immune subtypes. CB2 has been shown to regulate immunity by a number of mechanisms including development, migration, proliferation, and effector functions. In addition, CB2 has been shown to modulate the function of all immune cell types examined to date. CB2 is a Gi-protein-coupled receptor and thus exhibits a complex pharmacology allowing both stimulatory and inhibitory signaling that depends on receptor expression levels, ligand concentration, and cell lineage specificities. Here, we discuss both in vitro and in vivo experimental evidence that CB2 is a potent regulator of immune responses making it a prime target for the treatment of inflammatory diseases.
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Cites
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Cited by
Reducing safety-related drug attrition: the use of in vitro pharmacological profiling
Bowes, J., Brown, A. J., Hamon, J., Jarolimek, W., Sridhar, A., Waldron, G., & Whitebread, S. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3845 · Cited by 748
Petrosino, S., & Di Marzo, V. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13580 · Cited by 328
Bioactive lipids as modulators of immunity, inflammation and emotions
Chiurchiù, V., & Maccarrone, M. (2016) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2016.06.005 · Cited by 64
Metadata
- Authors
- Basu, S., & Dittel, B. N.
- Venue
- Immunologic Research
- Published
- 2011-05-29
- Volume
- 51
- Issue
- 1
- Pages
- 26-38
- ISSN
- 0257-277X (ISSN-L)
- 1559-0755
- OpenAlex
- W2056943042
- Cited by
- 192
- References
- 8
- FWCI
- 8.97
- Type
- journal article
- Language
- en
- Open access
- green
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- Basu, S., & Dittel, B. N. (2011). Unraveling the complexities of cannabinoid receptor 2 (CB2) immune regulation in health and disease. Immunologic Research. https://doi.org/10.1007/s12026-011-8210-5
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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