Cited by 742Cannabis and Cannabinoid ResearchInflammatory mediators and NSAID effectsNatural Compounds in Disease Treatment

Cannabinoid-based drugs as anti-inflammatory therapeutics

Klein, Thomas W.·2005·Nature Reviews Immunology

Abstract

In the nineteenth century, marijuana was prescribed by physicians for maladies ranging from eating disorders to rabies. However, as newer, more effective drugs were discovered and as the potential for abuse of marijuana was recognized, its use as a therapeutic became restricted, and only recently has its therapeutic potential been re-evaluated. Recent studies in animal models and in humans have produced promising results for the treatment of various disorders - such as obesity, cancer, and spasticity and tremor due to neuropathology - with drugs based on marijuana-derived cannabinoids. Moreover, as I discuss here, a wealth of information also indicates that these drugs have immunosuppressive and anti-inflammatory properties; therefore, on the basis of this mode of action, the therapeutic usefulness of these drugs in chronic inflammatory diseases is now being reassessed.

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Crossref · 10.1038/nri1602

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Authors
Klein, T. W.
Affiliations
University of South Florida (US)
Corresponding author
Klein, Thomas W.
Venue
Nature Reviews Immunology
Published
2005-05
Volume
5
Issue
5
Pages
400-411
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2072422429
Cited by
728
References
128
Citations by year
2026: 15 · 2025: 29 · 2024: 25 · 2023: 27 · 2022: 31 · 2021: 46 · 2020: 46 · 2019: 35 · 2018: 26 · 2017: 42 · 2016: 31 · 2015: 33 · 2014: 39 · 2013: 32 · 2012: 32
FWCI
5.06
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
  • Health Sciences › Medicine › Complementary and alternative medicine › Natural Compounds in Disease Treatment
Keywords
anti-inflammatory therapy, chronic inflammatory diseases, immunosuppression, cannabis, obesity, cancer, spasticity, tremor, neuropathology
MeSH terms
Animals, Anti-Inflammatory Agents, Cannabinoids, Cell Movement, T-Lymphocytes, Helper-Inducer, Humans, Immunity, Innate, Inflammation, Cytokines, Receptors, Cannabinoid

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