Cited by 341Traumatic Brain Injury and Neurovascular DisturbancesTraumatic Brain Injury ResearchAutomotive and Human Injury Biomechanics

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Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets

Thapa, Komal, Khan, Heena, Singh, Thakur Gurjeet, Kaur, Amarjot·2021·Journal of Molecular Neuroscience

DOI 10.1007/s12031-021-01841-7

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Abstract

Traumatic brain injury (TBI) causes brain damage, which involves primary and secondary injury mechanisms. Primary injury causes local brain damage, while secondary damage begins with inflammatory activity followed by disruption of the blood-brain barrier (BBB), peripheral blood cells infiltration, brain edema, and the discharge of numerous immune mediators including chemotactic factors and interleukins. TBI alters molecular signaling, cell structures, and functions. Besides tissue damage such as axonal damage, contusions, and hemorrhage, TBI in general interrupts brain physiology including cognition, decision-making, memory, attention, and speech capability. Regardless of the deep understanding of the pathophysiology of TBI, the underlying mechanisms still need to be assessed with a desired therapeutic agent to control the consequences of TBI. The current review gives a brief outline of the pathophysiological mechanism of TBI and various biochemical pathways involved in brain injury, pharmacological treatment approaches, and novel targets for therapy.

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RETRACTED: Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K/Akt/mTOR signaling pathway in rats with traumatic brain injury
Shen, M., Wang, S., Wen, X., Han, X., Wang, Y., Zhou, X., Zhang, M., Wu, D., Lu, J. L., & Zheng, Y. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.08.125 · Cited by 95
Retracted
RETRACTED: Curcumin, encapsulated in nano-sized PLGA, down-regulates nuclear factor κB (p65) and subarachnoid hemorrhage induced early brain injury in a rat model
Chang, C.-Z., Wu, S., Lin, C., & Kwan, A. (2015) · Brain Research · doi:10.1016/j.brainres.2015.02.039 · Cited by 42
Retracted
NF-κB signaling in inflammation
Liu, T., Zhang, L., Joo, D., & Sun, S.-C. (2017) · Signal Transduction and Targeted Therapy · doi:10.1038/sigtrans.2017.23 · Cited by 8,791
Biodegradable polymeric nanoparticles as drug delivery devices
Soppimath, K. S., Aminabhavi, T. M., Kulkarni, A. R., & Rudzinski, W. E. (2001) · Journal of Controlled Release · doi:10.1016/s0168-3659(00)00339-4 · Cited by 3,549
Moderate and severe traumatic brain injury in adults
Maas, A. I., Stocchetti, N., & Bullock, R. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70164-9 · Cited by 2,123
The impact of traumatic brain injuries: A global perspective
Hyder, A. A., Wunderlich, C. A., Puvanachandra, P., Gururaj, G., & Kobusingye, O. C. (2007) · Neurorehabilitation · doi:10.3233/nre-2007-22502 · Cited by 1,816
Pathophysiology of traumatic brain injury
Werner, C., & Engelhard, K. (2007) · British Journal of Anaesthesia · doi:10.1093/bja/aem131 · Cited by 1,712
Glutamate as a neurotransmitter in the brain: review of physiology and pathology
Meldrum, B. S. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.4.1007s · Cited by 1,667
Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity
Fünfschilling, U., Supplie, L. M., Mahad, D., Boretius, S., Saab, A. S., Edgar, J., Brinkmann, B. G., Kassmann, C. M., Tzvetanova, I. D., Möbius, W., et al. (2012) · Nature · doi:10.1038/nature11007 · Cited by 1,523
Inflammation and white matter degeneration persist for years after a single traumatic brain injury
Johnson, V. E., Stewart, J. E., Begbie, F. D., Trojanowski, J. Q., Smith, D. H., & Stewart, W. (2013) · Brain · doi:10.1093/brain/aws322 · Cited by 1,045

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Aktories K and Just I eds (2004) Special Issue on Emerging Bacterial Toxins. https://www.springer.com/gp/book/9783540231318
Talsky A, Pacione LR, Shaw T, Wasserman L, Lenny A, Verma A, Hurwitz G, Waxman R, Morgan A, Bhalerao S (2010) Pharmacological interventions for traumatic brain injury. BCMJ 53:26–31. https://doi.org/10.1089/scd.2015.0160 · DOI

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Coagulopathy prediction in traumatic brain injury
Kalogirou, E., Voulgaris, S., & Alexiou, G. Α. (2025) · Advances in clinical chemistry · doi:10.1016/bs.acc.2025.01.003 · Cited by 3
The effect of methylphenidate and amantadine co-administration on functional outcome of patients with blunt traumatic brain injury: A randomized controlled trial
Farrokhi, A., Mosaed, R., Khalili, H., Niakan, A., & Mirsaeed, S. S. G. (2025) · Acta Neurologica Belgica · doi:10.1007/s13760-025-02803-1 · Cited by 3
Advances in optical imaging in the diagnosis of traumatic brain injury
Gong, Q., Deng, L. J., Ru, J., Wen, L., Zhang, Y., Chen, Z., Wei, X., Dong, J., Song, X., & Liang, C. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.09.004 · Cited by 4
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Palha, A. T., LIMA, M. A. R., Carvalho, M., Campos, J., Sampaio‐Marques, B., & Salgado, A. J. (2026) · Journal of Translational Medicine · doi:10.1186/s12967-026-07933-5 · Cited by 3
Thiamine administration and in-hospital mortality in patients with traumatic brain injury: analysis of the MIMIC-IV database
Gao, S., Zhu, Z., & Zheng, W. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1448439 · Cited by 3
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Ren, B., Liang, J., Yang, L., Wei, X., Guo, M., & Li, H. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1531317 · Cited by 3
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Syaban, M. F. R., Putra, G. F. A., Vadhana, R. A., Muhyiddin, A. A. A., Farida, L. D., Sabila, F. L., Haitsam, M., & Santoso, W. M. (2023) · World Academy of Sciences Journal · doi:10.3892/wasj.2023.191 · Cited by 3
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Evaluating the state of non-invasive imaging biomarkers for traumatic brain injury
Pugazenthi, S., Hernandez‐Rovira, M. A., Mitha, R., Rogers, J. L., Lavadi, R. S., Kann, M. R., Ruiz-Cardozo, M. A., Hardi, A., Elsayed, G. A., Joseph, J. R., et al. (2023) · Neurosurgical Review · doi:10.1007/s10143-023-02085-2 · Cited by 3
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Suman, P., Paul, A., & Mishra, A. (2023) · Springer eBooks · doi:10.1007/978-981-99-6807-7_7 · Cited by 3
Transfer Learning based Deep Neural Network for Autonomous identification of Brain Tumor Disease
Lamba, K., & Rani, S. (2023) · International Conference on New Frontiers in Communication, Automation, Management and Security (ICCAMS) · doi:10.1109/iccams60113.2023.10525803 · Cited by 3
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Shramahara Mahakasya, a traditional polyherbal formulation, induces anti-anxiety activity in hippocampal neurons by effectuating SOD2-mediated protection against oxidative stress
Saini, S., Kumar, V., Haldar, S., Chauhan, S., Demiwal, P., Ghosh, S., Gupta, S., Sircar, D., Mahajon, B., & Roy, P. (2024) · Phytomedicine Plus · doi:10.1016/j.phyplu.2024.100682 · Cited by 3
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Reverse shock index multiplied by Glasgow coma scale (rSIG) to predict mortality in traumatic brain injury: systematic review and meta-analysis
Vásquez-Tirado, G. A., Meregildo-Rodríguez, E. D., Quispe-Castañeda, C. V., Cuadra-Campos, M. D. C., Guzmán-Aguilar, W. M., Abanto-Montalván, P. H., Alva-Guarniz, H. N., Liñán-Díaz, L. J., & Rodríguez-Chávez, L. Á. (2025) · Medicina Intensiva · doi:10.1016/j.medin.2025.502149 · Cited by 3
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Boskabadi, S. J., Heydari, F., Mohammadnejad, F., Baradari, A. G., Moosazadeh, M., & Dashti, A. (2024) · Annals of Medicine and Surgery · doi:10.1097/ms9.0000000000002143 · Cited by 2
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Zhang, J., Jiao, X., Ma, X., Yu, R., Pan, J., Yuan, M., Wang, S., Hua, C., & HongMei, P. (2024) · Medicine · doi:10.1097/md.0000000000039896 · Cited by 2
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Kang, P., Gao, Y., Zheng, J., Chen, J., Li, Z., & Cong, G. (2025) · Molecular & Cellular Toxicology · doi:10.1007/s13273-025-00526-1 · Cited by 2
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Norris, C., Garimella, H. T., Carr, W. S., Boutté, A. M., Gupta, R. K., & Przekwas, A. J. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1548589 · Cited by 4
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López-Preza, F., Nuñez-Lumbreras, M. D. L. A., Sosa-Testé, I., Fernández-Guasti, A., Concha, L., Rodríguez-Obaya, T., & Rocha, L. (2025) · Antioxidants · doi:10.3390/antiox14060710 · Cited by 3
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Mao, R., Wang, L., Zhang, H., Gong, J., & Liu, H. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1604670 · Cited by 2
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Matsuda, K., Kato, Y., Okawara, Y., Sakamoto, M., Horikoshi, Y., Nakamura, K., Nakayama, Y., Sato, H., Homma, M., Ueda, T., et al. (2025) · Yonago acta medica · doi:10.33160/yam.2025.08.011 · Cited by 3
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Shi, Y., Qian, X., Chen, T., Yang, L., Zhu, J., Feng, X., & Wang, Y. (2025) · Surgery · doi:10.1016/j.surg.2025.109636 · Cited by 2

Authors: Thapa, K., Khan, H., Singh, T. G., & Kaur, A.
Affiliations: Chitkara University (IN)
Corresponding author: Singh, Thakur Gurjeet
ORCID: Thapa, Komal
Khan, Heena
Singh, Thakur Gurjeet
Venue: Journal of Molecular Neuroscience
Publisher: Springer Science and Business Media LLC
Published: 2021-05-06
Volume: 71
Issue: 9
Pages: 1725-1742
ISSN: 0895-8696 (ISSN-L)
1559-1166
DOI: 10.1007/s12031-021-01841-7
OpenAlex: W3158138032
Cited by: 341
References: 171
Citations by year: 2026: 55 · 2025: 88 · 2024: 88 · 2023: 60 · 2022: 41 · 2021: 9
FWCI: 6.33
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Journal of Molecular Neuroscience (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury Research
Physical Sciences › Engineering › Biomedical Engineering › Automotive and Human Injury Biomechanics
Keywords: traumatic brain injury, primary injury, secondary injury, neuroinflammation, blood-brain barrier disruption, cerebral edema, axonal injury, hemorrhagic contusion, cognitive impairment, therapeutic target, pharmacotherapy
MeSH terms: Brain Injuries, Traumatic, Animals, Humans, Signal Transduction, NF-kappa B, Oxidative Stress, Neuroprotective Agents

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Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets

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