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Cited by 604Cancer Risks and FactorsCancer survivorship and carePhysical Activity and Health

Physical activity and survival after breast cancer diagnosis: Meta-analysis of published studies

Ibrahim, Ezzeldin M., Al-Homaidh, Abdelaziz·2011·Medical Oncology
DOI 10.1007/s12032-010-9536-x
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Abstract

Published data have shown that physical activity (PA) has a positive role on the primary prevention of breast cancer risk. However, the role of PA on breast cancer outcome has been controversial with inconsistent data. The lack of a meta-analysis that addresses that issue prompted the current report. A comprehensive literature search identified eight studies, of which two studies were excluded. The remaining six studies (12,108 patients with breast cancer) were included in this meta-analysis. Pre-diagnosis PA reduced all causes mortality by 18% but had no effect on breast cancer deaths. Post-diagnosis PA reduced breast cancer deaths by 34% (HR=0.66, 95% CI, 0.57-0.77, P<0.00001), all causes mortality by 41% (HR=0.59, 95% CI, 0.53-0.65, P<0.00001), and disease recurrence by 24% (HR=0.76, 95% CI, 0.66-0.87, P=0.00001). Breast cancer mortality was reduced by pre-diagnosis PA in women with body mass index (BMI)<25 kg/m2, while post-diagnosis PA reduced that risk among those with BMI≥25 kg/m2. On the other hand, post-diagnosis PA reduced all causes mortality regardless of the BMI. The analysis showed that post-diagnosis PA reduced breast cancer deaths (HR=0.50, 95% CI, 0.34-0.74, P=0.0005), and all causes mortality (HR=0.36, 95% CI, 0.12-1.03, P=0.06) among patients with estrogen receptor (ER)-positive tumor, while women with ER-negative disease showed no gain. The current meta-analysis provides evidence for an inverse relationship between PA and mortality in patients with breast cancer and supports the notion that appropriate PA should be embraced by breast cancer survivors.

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Crossref · 10.1007/s12032-010-9536-x

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  • Scientific evidence supports the safety and effectiveness of physical activity for people with cancer, indicating health benefits such as reduced anxiety, reduced depressive symptoms, reduced fatigue, improved quality of life, and improved physical function.

    “Scientific evidence supports the safety and effectiveness of physical activity, indicating—for people with cancer experience—health benefits such as reduced anxiety, reduced depressive symptoms, reduced fatigue, improved quality of life, and improved physical function [40,41,42,43].”

    From The Effect of Vinyasa Yoga Practice on the Well-Being of Breast-Cancer Patients during COVID-19 Pandemic (2023) · cites this paper as [42]

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Authors
Ibrahim, E. M., & Al-Homaidh, A.
Affiliations
International Medical Center in Jeddah (SA)
Corresponding author
Ibrahim, Ezzeldin M.
ORCID
Ibrahim, Ezzeldin M.
Venue
Medical Oncology
Publisher
Springer Science and Business Media LLC
Published
2010-04-22
Volume
28
Issue
3
Pages
753-765
ISSN
  • 1357-0560 (ISSN-L)
  • 1559-131X
DOI
10.1007/s12032-010-9536-x
OpenAlex
W2136405350
Cited by
604
References
32
Citations by year
2026: 4 · 2025: 22 · 2024: 26 · 2023: 18 · 2022: 40 · 2021: 43 · 2020: 54 · 2019: 44 · 2018: 54 · 2017: 54 · 2016: 50 · 2015: 47 · 2014: 48 · 2013: 36 · 2012: 35
FWCI
3.43
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Medical Oncology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Oncology › Cancer Risks and Factors
  • Health Sciences › Medicine › Oncology › Cancer survivorship and care
  • Health Sciences › Medicine › Physiology › Physical Activity and Health
Keywords
physical activity, breast cancer, survival, breast cancer mortality, all-cause mortality, recurrence, body mass index, estrogen receptor status, breast cancer survivors
MeSH terms
Breast Neoplasms, Female, Humans, Exercise

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