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Cited by 0Flavonoids in Medical ResearchFerroptosis and cancer prognosisCancer Immunotherapy and Biomarkers

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Exploring medicinal mechanism of baicalin in tumor microenvironment of melanoma via bioinformatic and in vitro study

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Liu, Zuohao, Dang, Bingrong, Wang, Xingsheng, Liu, Yuhan, Wang, Chunming, Lin, Changjun·2025·Medical Oncology
DOI 10.1007/s12032-025-03205-2

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Abstract

The occurrence and advancement of skin cutaneous melanoma (SKCM) is closely associated with tumor microenvironment (TME). Evaluating the condition of immune cell infiltration is pivotal to the comprehension regarding the features of TME in SKCM. Baicalin has been demonstrated to have anti-tumor effects by regulating the TME in tumors. However, its pharmacological potential in melanoma still needs to be elucidated. In this study, through unsupervised clustering analysis and network pharmacology, 32 potential baicalin targets have been identified. The prognostic model effectively stratifies patients, and an individualized clinical prediction model can be developed from it. Single-cell analysis demonstrated the expression of prognostic targets was associated with TME and mainly accumulated in mono/macro subset. Finally, in vitro experiments demonstrated that baicalin significantly reduced the viability, proliferation, and migration capabilities of melanoma cells. Additionally, baicalin promoted pro-inflammatory polarization of macrophages under co-culture with melanoma cells and baicalin exerted relatively high biological safety. In conclusion, this study demonstrates that baicalin inhibits melanoma by modulating the TME and establishes a prognostic model with predictive potential. These findings expand the therapeutic potential of baicalin and provide novel insights for melanoma treatment strategies.

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Metadata

Authors
Liu, Z., Dang, B., Wang, X., Liu, Y., Wang, C., & Lin, C.
Affiliations
  • Lanzhou University (CN)
  • Chinese Academy of Sciences (CN)
Corresponding author
Lin, Changjun
ORCID
Venue
Medical Oncology
Publisher
Springer Science and Business Media LLC
Published
2025-12-26
Volume
43
Issue
2
Pages
85-85
ISSN
  • 1357-0560 (ISSN-L)
  • 1559-131X
DOI
10.1007/s12032-025-03205-2
OpenAlex
W7117320944
Cited by
0
References
3
FWCI
0.00
Type
journal article
Language
en
Open access
Licence
Locations
  • Medical Oncology (publishedVersion)
  • Research Square (acceptedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
LZU-IMPCAS cooperation ((20)0920)
Topics
  • Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
  • Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Keywords
baicalin, cutaneous melanoma, tumor microenvironment, immune cell infiltration, macrophage polarization, prognostic model, network pharmacology, single-cell RNA sequencing, anticancer activity
MeSH terms
Cell Movement, Female, Flavonoids, Humans, Melanoma, Prognosis, Skin Neoplasms, Coculture Techniques, Computational Biology, Cell Line, Tumor, Cell Proliferation, Tumor Microenvironment

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