Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!

Virmani, Ashraf; Pinto, Luigi; Binienda, Zbigniew; Ali, Syed

doi:10.1007/s12035-013-8498-3

Cited by 137Nutrition, Genetics, and DiseasePhytochemicals and Antioxidant ActivitiesNeurological Disorders and Treatments

Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!

Virmani, Ashraf, Pinto, Luigi, Binienda, Zbigniew, Ali, Syed·2013·Molecular Neurobiology

DOI 10.1007/s12035-013-8498-3

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Abstract

Diet in human health is no longer simple nutrition, but in light of recent research, especially nutrigenomics, it is linked via evolution and genetics to cell health status capable of modulating apoptosis, detoxification, and appropriate gene response. Nutritional deficiency and disease especially lack of vitamins and minerals is well known, but more recently, epidemiological studies suggest a role of fruits and vegetables, as well as essential fatty acids and even red wine (French paradox), in protection against disease. In the early 1990s, various research groups started considering the use of antioxidants (e.g., melatonin, resveratrol, green tea, lipoic acid) and metabolic compounds (e.g., nicotinamide, acetyl-L-carnitine, creatine, coenzyme Q10) as possible candidates in neuroprotection. They were of course considered on par with snake oil salesman (women) at the time. The positive actions of nutritional supplements, minerals, and plant extracts in disease prevention are now mainstream and commercial health claims being made are subject to regulation in most countries. Apart from efficacy and finding, the right dosages, the safety, and especially the level of purification and lack of contamination are all issues that are important as their use becomes widespread. From the mechanistic point of view, most of the time these substances replenish the body's deficiency and restore normal function. However, they also exert actions that are not sensu stricto nutritive and could be considered pharmacological especially that, at times, higher intake than recommended (RDA) is needed to see these effects. Free radicals and neuroinflammation processes underlie many neurodegenerative conditions, even Parkinson's disease and Alzheimer's disease. Curcumin, carotenoids, acetyl-L-carnitine, coenzyme Q10, vitamin D, and polyphenols and other nutraceuticals have the potential to target multiple pathways in these conditions. In summary, augmenting neuroprotective pathways using diet and finding new natural substances that can be more efficacious, i.e., induction of health-promoting genes and reduction of the expression of disease-promoting genes, could be incorporated into neuroprotective strategies of the future.

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An effective anti-ALS food or compound typically appears to have at least one of either anti-inflammatory or antioxidant properties, as oxidative stress and inflammation play an important role in neuronal degeneration.
“An effective anti-ALS food or compound typically appears to have at least one of either anti-inflammatory or antioxidant properties, as oxidative stress and inflammation play an important role in neuronal degeneration (111).”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [111]

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[Nutrigenomics - perspectives of personalized nutrition].
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Microbiome, probiotics and neurodegenerative diseases: deciphering the gut brain axis
Westfall, S., Lomis, N., Kahouli, I., Dia, S. Y., Singh, S. P., & Prakash, S. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2550-9 · Cited by 551 · see citing works
Natural Dietary Supplementation of Anthocyanins via PI3K/Akt/Nrf2/HO-1 Pathways Mitigate Oxidative Stress, Neurodegeneration, and Memory Impairment in a Mouse Model of Alzheimer’s Disease
Ali, T., Kim, T. H., Rehman, S. U., Khan, M. S., Amin, F. U., Khan, M., Ikram, M. A., & Kim, M. O. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0798-6 · Cited by 477 · see citing works
Antioxidants, inflammation and cardiovascular disease
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Review of methods for analysis of carotenoids
Amorim-Carrilho, K. T., Cepeda, A., Fente, C. A., & Regal, P. (2014) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2013.12.011 · Cited by 314 · see citing works
Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues
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The Role of l-Carnitine in Mitochondria, Prevention of Metabolic Inflexibility and Disease Initiation
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Self-citation
Current evidence on the effect of dietary polyphenols intake on chronic diseases
Costa, C., Tsatsakis, A. M., Mamoulakis, C., Teodoro, M., Briguglio, G., Caruso, E., Tsoukalas, D., Margina, D. M., Dardiotis, E., Kouretas, D., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.10.023 · Cited by 262 · see citing works
Resveratrol: review on therapeutic potential and recent advances in drug delivery
Pangeni, R., Sahni, J. K., Ali, J., Sharma, S., & Baboota, S. (2014) · Expert Opinion on Drug Delivery · doi:10.1517/17425247.2014.919253 · Cited by 255 · see citing works
Nutritional patterns associated with the maintenance of neurocognitive functions and the risk of dementia and Alzheimer's disease: a focus on human studies
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Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases
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Role of intestinal microbiota in the generation of polyphenol‐derived phenolic acid mediated attenuation of Alzheimer's disease β‐amyloid oligomerization
Wang, D., Ho, L., Faith, J. J., Ono, K., Janle, E. M., Lachcik, P. J., Cooper, B. R., Jannasch, A., D’Arcy, B., Williams, B. A., et al. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400544 · Cited by 227 · see citing works
Role of the Blood–Brain Barrier in the Nutrition of the Central Nervous System
Campos‐Bedolla, P., Walter, F. R., Veszelka, S., & Deli, M. A. (2014) · Archives of Medical Research · doi:10.1016/j.arcmed.2014.11.018 · Cited by 196 · see citing works
Successful therapies for Alzheimerâ€™s disease: why so many in animal models and none in humans?
Franco, R., & Cedazo-Minguez, A. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00146 · Cited by 183 · see citing works
Neuroinflammation as a Factor of Neurodegenerative Disease: Thalidomide Analogs as Treatments
Jung, Y. J., Tweedie, D., Scerba, M. T., & Greig, N. H. (2019) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2019.00313 · Cited by 154 · see citing works
RETRACTED ARTICLE: Anthocyanins Improve Hippocampus-Dependent Memory Function and Prevent Neurodegeneration via JNK/Akt/GSK3β Signaling in LPS-Treated Adult Mice
Khan, M. S., Ali, T., Kim, M. W., Jo, M. H., Chung, J. I., & Kim, M. O. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1101-1 · Cited by 129 · see citing works
Retracted
Rosmarinic acid up-regulates the noise-activated Nrf2/HO-1 pathway and protects against noise-induced injury in rat cochlea
Fetoni, A. R., Paciello, F., Rolesi, R., Eramo, S. L. M., Mancuso, C., Troiani, D., & Paludetti, G. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.04.021 · Cited by 116 · see citing works
Nutrition in the Actual COVID-19 Pandemic. A Narrative Review
Clemente‐Suárez, V. J., Ramos‐Campo, D. J., Mielgo‐Ayuso, J., Dalamitros, A. A., Nikolaidis, P. Τ., Hormeño-Holgado, A. J., & Tornero-Aguilera, J. F. (2021) · Nutrients · doi:10.3390/nu13061924 · Cited by 119 · see citing works
Neuroprotective potency of some spice herbs, a literature review
Khazdair, M. R., Anaeigoudari, A., Hashemzehi, M., & Mohebbati, R. (2018) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2018.01.002 · Cited by 112 · see citing works
The neurobiology of acetyl-L-carnitine
Traina, G. (2016) · Frontiers in bioscience · doi:10.2741/4459 · Cited by 109 · see citing works
Nano-delivery systems for encapsulation of dietary polyphenols: An experimental approach for neurodegenerative diseases and brain tumors
Squillaro, T., Cimini, A., Peluso, G., Giordano, A., & Melone, M. A. B. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.05.016 · Cited by 102 · see citing works
Lipid peroxidation in neurodegeneration
Peña‐Bautista, C., Vento, M., Baquero, M., & Cháfer‐Pericás, C. (2019) · Clinica Chimica Acta · doi:10.1016/j.cca.2019.07.037 · Cited by 100 · see citing works
Plant-derived neuroprotective agents in Parkinson's disease.
Fu, W., Zhuang, W., Zhou, S., & Wang, X. (2015) · Europe PMC (PubMed Central) · Cited by 98 · see citing works
Biochemical Properties and Neuroprotective Effects of Compounds in Various Species of Berries
Kelly, E., Vyas, P., & Weber, J. T. (2017) · Molecules · doi:10.3390/molecules23010026 · Cited by 96 · see citing works
Resveratrol and neuroprotection: an insight into prospective therapeutic approaches against Alzheimer’s disease from bench to bedside
Islam, F., Nafady, M. H., Islam, M. R., Saha, S., Rashid, S., Akter, A., Harun-Or-Rashid, M., Akhtar, M. F., Perveen, A., Ashraf, G. M., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02859-7 · Cited by 92 · see citing works
Dietary Antioxidants and Parkinson’s Disease
Park, H., & Ellis, A. C. (2020) · Antioxidants · doi:10.3390/antiox9070570 · Cited by 90 · see citing works
Epigenetics and neurodegeneration: role of early-life nutrition
Gabbianelli, R., & Damiani, E. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.01.014 · Cited by 81 · see citing works
Curcumin inhibits glial scar formation by suppressing astrocyte-induced inflammation and fibrosis in vitro and in vivo
Yuan, J., Liu, W., Zhu, H., Chen, Y., Zhang, X., Li, L., Chu, W., Wen, Z., Feng, H., & Lin, J. (2016) · Brain Research · doi:10.1016/j.brainres.2016.11.002 · Cited by 81 · see citing works
Food-Derived Antioxidant Polysaccharides and Their Pharmacological Potential in Neurodegenerative Diseases
Li, H., Ding, F., Xiao, L., Shi, R., Wang, H., Han, W., & Huang, Z. (2017) · Nutrients · doi:10.3390/nu9070778 · Cited by 80 · see citing works
Potential Therapeutic Effects of Lipoic Acid on Memory Deficits Related to Aging and Neurodegeneration
Molz, P., & Schröder, N. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00849 · Cited by 79 · see citing works
Mesenchymal stromal cells loading curcumin-INVITE-micelles: A drug delivery system for neurodegenerative diseases
Tripodo, G., Chlapanidas, T., Perteghella, S., Vigani, B., Mandracchia, D., Trapani, A., Galuzzi, M., Tosca, M. C., Antonioli, B., Gaetani, P., et al. (2014) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2014.11.034 · Cited by 79 · see citing works
Potential for brain accessibility and analysis of stability of selected flavonoids in relation to neuroprotection in vitro
Pogačnik, L., Pirc, K., Palmela, I., Skrt, M., Kim, K. S., Brites, D. M. T. O., Brito, M. A., Ulrih, N. P., & Silva, R. F. M. (2016) · Brain Research · doi:10.1016/j.brainres.2016.09.020 · Cited by 76 · see citing works
Hibiscus sabdariffa L.: A potent natural neuroprotective agent for the prevention of streptozotocin-induced Alzheimer’s disease in mice
El‐Shiekh, R. A., Ashour, R. M. S., El-Haleim, E. A. A., Ahmed, K. A., & Abdel-Sattar, E. A. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110303 · Cited by 78 · see citing works
Neuroprotection comparison of chlorogenic acid and its metabolites against mechanistically distinct cell death-inducing agents in cultured cerebellar granule neurons
Taram, F., Winter, A. N., & Linseman, D. A. (2016) · Brain Research · doi:10.1016/j.brainres.2016.07.028 · Cited by 73 · see citing works
Rice bran derivatives alleviate microglia activation: possible involvement of MAPK pathway
Bhatia, H. S., Baron, J., Hagl, S., Eckert, G. P., & Fiebich, B. L. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0615-6 · Cited by 72 · see citing works
Role of plant-based diets in the prevention and regression of metabolic syndrome and neurodegenerative diseases
Pistollato, F., & Battino, M. A. (2014) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2014.07.012 · Cited by 71 · see citing works
Oleuropein aglycone and hydroxytyrosol interfere differently with toxic Aβ1-42 aggregation
Leri, M., Natalello, A., Bruzzone, E., Stefani, M., & Bucciantini, M. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.04.015 · Cited by 70 · see citing works
The Carnitine Palmitoyl Transferase (CPT) System and Possible Relevance for Neuropsychiatric and Neurological Conditions
Virmani, A., Pinto, L., Bauermann, O., Zerelli, S., Diedenhofen, A., Binienda, Z. K., Ali, S. F., & van der Leij, F. R. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9238-7 · Cited by 69 · see citing works
Self-citation
Ammonia-induced oxidative damage in neurons is prevented by resveratrol and lipoic acid with participation of heme oxygenase 1
Bobermin, L. D., Wartchow, K. M., Flores, M. P., Leite, M. C., Quincozes‐Santos, A., & Gonçalves, C. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.05.005 · Cited by 66 · see citing works
Micronization potentiates curcumin’s anti-seizure effect and brings an important advance in epilepsy treatment
Bertoncello, K. T., Aguiar, G. P. S., de Oliveira, J. V., & Siebel, A. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-20897-x · Cited by 65 · see citing works
Resveratrol supplementation confers neuroprotection in cortical brain tissue of nonhuman primates fed a high-fat/sucrose diet
Bernier, M., Wahl, D., Ali, A., Allard, J. S., Faulkner, S., Wnorowski, A., Sanghvi, M., Moaddel, R., Alfaras, I., Mattison, J. A., et al. (2016) · Aging · doi:10.18632/aging.100942 · Cited by 63 · see citing works
Inhibition of bladder cancer cell proliferation by allyl isothiocyanate (mustard essential oil)
Sávio, A. L. V., da Silva, G. N., & Salvadori, D. M. F. (2014) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2014.11.004 · Cited by 63 · see citing works
Oleuropein Prevents Neuronal Death, Mitigates Mitochondrial Superoxide Production and Modulates Autophagy in a Dopaminergic Cellular Model
Achour, I., Arel-Dubeau, A.-M., Renaud, J., Legrand, M., Attard, E., Germain, M., & Martinoli, M. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17081293 · Cited by 64 · see citing works
Melatonin controversies, an update
Boutin, J. A., & Jockers, R. (2020) · Journal of Pineal Research · doi:10.1111/jpi.12702 · Cited by 64 · see citing works
Brain ageing and neurodegenerative disease: The role of cellular waste management
Daniele, S., Giacomelli, C., & Martini, C. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.10.030 · Cited by 59 · see citing works
Prospects and progress in the production of valuable carotenoids: Insights from metabolic engineering, synthetic biology, and computational approaches
Mohan, S., Rao, P. R., Hemachandran, H., Pullela, P. K., Doss, C. G. P., Tayubi, I. A., Subramanian, B., Muthukaliannan, G. K., Singh, P., & Ramamoorthy, S. (2017) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2017.12.010 · Cited by 52 · see citing works
A review of the bioactive ingredients of berries and their applications in curing diseases
Bilawal, A., Ishfaq, M., Gantumur, M., Qayum, A., Shi, R., Fazilani, S. A., Anwar, A., Jiang, Z., & Hou, J. (2021) · Food Bioscience · doi:10.1016/j.fbio.2021.101407 · Cited by 50 · see citing works
Modulation of Hydrogen Peroxide‐Induced Oxidative Stress in Human Neuronal Cells by Thymoquinone‐Rich Fraction and Thymoquinone via Transcriptomic Regulation of Antioxidant and Apoptotic Signaling Genes
Ismail, N., Ismail, M., Azmi, N. H., Bakar, M. F. A., Basri, H., & Abdullah, M. A. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2528935 · Cited by 48 · see citing works
Protective effects of berry polyphenols against age-related cognitive impairment
Bensalem, J., Dal‐Pan, A., Gillard, E., Calon, F., & Pallet, V. (2015) · Nutrition and Aging · doi:10.3233/nua-150051 · Cited by 46 · see citing works
Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson’s disease in the rat
Afshin‐Majd, S., Bashiri, K., Kiasalari, Z., Baluchnejadmojarad, T., Sedaghat, R., & Roghani, M. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.02.007 · Cited by 45 · see citing works
Fruit and vegetable consumption is associated with improved mental and cognitive health in older adults from non-Western developing countries
Gehlich, K. H., Beller, J., Lange‐Asschenfeldt, B., Köcher, W., Meinke, M. C., & Lademann, J. M. (2018) · Public Health Nutrition · doi:10.1017/s1368980018002525 · Cited by 40 · see citing works
Molecular and Cellular Interactions in Pathogenesis of Sporadic Parkinson Disease
Долгачева, Л. П., Зинченко, В. П., & Goncharov, N. V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113043 · Cited by 41 · see citing works
Nutraceuticals-based therapeutic approach: recent advances to combat pathogenesis of Alzheimer’s disease
Talebi, M., Kakouri, E., Talebi, M., Tarantilis, P. Α., Farkhondeh, T., İlgün, S., Pourbagher‐Shahri, A. M., & Samarghandian, S. (2021) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2021.1923479 · Cited by 39 · see citing works
Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis
Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38 · see citing works
Nutrigenomics and its Impact on Life Style Associated Metabolic Diseases
Rana, S., Kumar, S., Rathore, N., Padwad, Y. S., & Bhushan, S. (2016) · Current Genomics · doi:10.2174/1389202917666160202220422 · Cited by 38 · see citing works
Oleuropein aglycone: A polyphenol with different targets against amyloid toxicity
Leri, M., Oropesa, R., Canale, C., Raimondi, S., Giorgetti, S., Bruzzone, E., Bellotti, V., Stefani, M., & Bucciantini, M. (2018) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2018.03.023 · Cited by 38 · see citing works
Supplementation with different teas from Camellia sinensis prevents memory deficits and hippocampus oxidative stress in ischemia-reperfusion
Martins, A., Schimidt, H. L., Garcia, A., Altermann, C. D. C., Cibin, F. W. S., Carpes, F. P., da Silva, W. C. F. N., & Mello‐Carpes, P. B. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.04.019 · Cited by 34 · see citing works
Comprehensive Review of Nutraceuticals against Cognitive Decline Associated with Alzheimer’s Disease
Reza-Zaldívar, E. E., & Jacobo-Velázquez, D. A. (2023) · ACS Omega · doi:10.1021/acsomega.3c04855 · Cited by 27 · see citing works
Eruca sativa seed extract: A novel natural product able to counteract neuroinflammation
Gugliandolo, A., Giacoppo, S., Ficicchia, M., ⁄, A. A., Bramanti, P., & Mazzon, E. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8695 · Cited by 33 · see citing works
Beneficial effects of TQRF and TQ nano- and conventional emulsions on memory deficit, lipid peroxidation, total antioxidant status, antioxidants genes expression and soluble Aβ levels in high fat-cholesterol diet-induced rats.
Ismail, N., Ismail, M., Azmi, N. H., Bakar, M. F. A., Zhang, Y.-D., Stanslas, J., Sani, D., bin Basri, H., & Abdullah, M. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.07.014 · Cited by 26 · see citing works
Neuroprotective Effects of Rhynchophylline Against Aβ1–42-Induced Oxidative Stress, Neurodegeneration, and Memory Impairment Via Nrf2–ARE Activation
Jiang, P. H., Chen, L., Xu, J., Liu, W., Feng, F., & Qu, W. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03343-9 · Cited by 32 · see citing works
Potential of casein as a nutrient intervention to alleviate lead (Pb) acetate-mediated oxidative stress and neurotoxicity: First evidence in Drosophila melanogaster
Kumar, V. L., & ., M. (2015) · NeuroToxicology · doi:10.1016/j.neuro.2015.03.014 · Cited by 29 · see citing works
Tetracycline hydrochloride: A potential clinical drug for radioprotection
Alok, A., & Chaudhury, N. K. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.01.001 · Cited by 29 · see citing works
Racial differences in distribution of fatty acids in prostate cancer and benign prostatic tissues
Zhou, X., Mei, H., Agee, J., Brown, T., & Mao, J. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-1130-4 · Cited by 25 · see citing works
Towards early detection of neurodegenerative diseases: A gut feeling
Makdissi, S., Parsons, B., & Cara, F. D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1087091 · Cited by 27 · see citing works
Schinus terebinthifolius administration prevented behavioral and biochemical alterations in a rotenone model of Parkinson's disease
Sereniki, A., Linard, C. F. B. M., Silva, S. N., Silva, J. B. R., Sobrinho, T. J. D. S. P., da Silva, J. R., Alves, L. D. S., Smaili, S. S., Wanderley, A. G., & Lafayette, S. S. L. (2016) · Revista Brasileira de Farmacognosia · doi:10.1016/j.bjp.2015.11.005 · Cited by 24 · see citing works
Combination Therapy in Alzheimer’s Disease: Is It Time?
Salehipour, A., Bagheri, M., Sabahi, M., Dolatshahi, M., & Boche, D. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215680 · Cited by 22 · see citing works
The Role of L-Carnitine in Kidney Disease and Related Metabolic Dysfunctions
Ulinski, T., Cirulli, M., & Virmani, A. (2023) · Kidney and Dialysis · doi:10.3390/kidneydial3020016 · Cited by 22 · see citing works
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A Human-Based Integrated Framework forAlzheimer’s Disease Research
Pistollato, F., Cavanaugh, S. E., & Chandrasekera, P. C. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150281 · Cited by 21 · see citing works
Diet–gut microbiome interaction and ferulic acid bioavailability: implications on neurodegenerative disorders
Kunnummal, S. P., & Khan, M. (2023) · European Journal of Nutrition · doi:10.1007/s00394-023-03247-0 · Cited by 20 · see citing works
Characterization of Portuguese Centenarian Eating Habits, Nutritional Biomarkers, and Cardiovascular Risk: A Case Control Study
da Silva, A. P., Valente, A., Chaves, C., Matos, A., Gil, Á., Santos, A. C., Gorjão-Clara, J. P., & Bicho, M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/5296168 · Cited by 19 · see citing works
L-carnitine exerts a nutrigenomic effect via direct modulation of nuclear receptor signaling in adipocytes, hepatocytes and SKMC, demonstrating its nutritional impact
Förster, L., Indra, D., Rosenberger, K., Zver, L., & Hofbauer, R. (2020) · Nutrition Research · doi:10.1016/j.nutres.2020.11.003 · Cited by 18 · see citing works
Nutritional aspects of epigenetic inheritance
Alam, S. E., Singh, R. B., Gupta, S. S., Dherange, P., Meester, F. D., Wilczyńska, A., Dharwadkar, S. M., Wilson, D. W., & Hungin, P. (2012) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y2012-105 · Cited by 17 · see citing works
Amyloids of multiple species: are they helpful in survival?
Upadhyay, A., & Mishra, A. (2018) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/brv.12399 · Cited by 17 · see citing works
The Advent of Nutrigenomics: A Narrative Review with an Emphasis on Psychological Disorders
Birla, M., Choudhary, C., Singh, G., Gupta, S., Bhawana, B., & Pratyusha, V. A. (2022) · Preventive Nutrition and Food Science · doi:10.3746/pnf.2022.27.2.150 · Cited by 16 · see citing works
Wearable Sensors to Evaluate Autonomic Response to Olfactory Stimulation: The Influence of Short, Intensive Sensory Training
Billeci, L., Sanmartin, C., Tonacci, A., Taglieri, I., Bachi, L., Ferroni, G., Braceschi, G. P., Odello, L., & Venturi, F. (2023) · Biosensors · doi:10.3390/bios13040478 · Cited by 16 · see citing works
Oxidative Modulation of K + Channels in the Central Nervous System in Neurodegenerative Diseases and Aging
Peers, C., & Boyle, J. P. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6007 · Cited by 16 · see citing works
Comparative effect ofCamellia sinensisteas on object recognition test deficit and metabolic changes induced by cafeteria diet
Soares, M. B., Ramalho, J. B., Izaguirry, A. P., Pavin, N. F., Spiazzi, C. C., Schimidt, H. L., Mello‐Carpes, P. B., & Cibin, F. W. S. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1418726 · Cited by 16 · see citing works
The protective role of l-carnitine on oxidative stress, neurotransmitter perturbations, astrogliosis, and apoptosis induced by thiamethoxam in the brains of male rats
Elkader, H. A. E. A., Hussein, M. M., Mohammed, N. A., & Abdou, H. M. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02887-7 · Cited by 15 · see citing works
Cooperative Effects of Q10, Vitamin D3, and L -Arginine on Cardiac and Endothelial Cells
Molinari, C., Morsanuto, V., Polli, S., & Uberti, F. (2018) · Journal of Vascular Research · doi:10.1159/000484928 · Cited by 15 · see citing works
Nutrigenomics and Trace Elements: Hopes and Hypes for Parkinson’s Treatment
Wadan, A.-H. S., & Mohamed, W. M. Y. (2023) · Nutritional neurosciences · doi:10.1007/978-981-99-1513-2_3 · Cited by 14 · see citing works
Understanding Pathophysiology of Sporadic Parkinson's Disease in Drosophila Model: Potential Opportunities and Notable Limitations
Modi, P., Ayajuddin, M., Phom, L., Koza, Z., Das, A., Chaurasia, R., Samadder, S., Achumi, B., ., M., Pukhrambam, R. S., et al. (2016) · InTech eBooks · doi:10.5772/63767 · Cited by 12 · see citing works
Fundamental neurochemistry review: Old brain stories ‐ Influence of age and sex on the neurodegeneration‐associated lipid changes
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Authors: Virmani, A., Pinto, L., Binienda, Z., & Ali, S.
Affiliations: Sigma Tau (Italy) (IT)
National Center for Toxicological Research (US)
Corresponding author: Virmani, Ashraf
ORCID: Virmani, Ashraf
Ali, Syed
Venue: Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2013-06-28
Volume: 48
Issue: 2
Pages: 353-362
ISSN: 0893-7648 (ISSN-L)
1559-1182
DOI: 10.1007/s12035-013-8498-3
OpenAlex: W2024679196
Cited by: 137
References: 82
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 16 · 2022: 12 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 17 · 2017: 14 · 2016: 14 · 2015: 16 · 2014: 21 · 2012: 1
FWCI: 2.09
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Molecular Neurobiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
Keywords: nutrigenomics, neuroprotection, neurodegeneration, diet, antioxidants, nutraceuticals, free radicals, neuroinflammation, Parkinson's disease, Alzheimer's disease, curcumin, carotenoids, acetyl-L-carnitine, coenzyme Q10, vitamin D, polyphenols, resveratrol, melatonin, alpha-lipoic acid, essential fatty acids, French paradox, red wine, dietary supplements, gene expression regulation
MeSH terms: Aging, Animals, Food, Humans, Nerve Degeneration, Neuroprotective Agents, Systems Biology, Nutrigenomics

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Food, Nutrigenomics, and Neurodegeneration—Neuroprotection by What You Eat!

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