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miR-135a Regulates Synaptic Transmission and Anxiety-Like Behavior in Amygdala

Mannironi, Cecilia, Biundo, Antonio, Rajendran, Samyutha, De Vito, Francesca, Saba, Luana, Caioli, Silvia, Zona, Cristina, Ciotti, Teresa, Caristi, Silvana, Perlas, Emerald, Del Vecchio, Giorgia, Bozzoni, Irene, Rinaldi, Arianna, Mele, Andrea, Presutti, Carlo·2018·Molecular Neurobiology
DOI 10.1007/s12035-017-0564-9
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Abstract

MicroRNAs are a class of non-coding RNAs with a growing relevance in the regulation of gene expression related to brain function and plasticity. They have the potential to orchestrate complex phenomena, such as the neuronal response to homeostatic challenges. We previously demonstrated the involvement of miR-135a in the regulation of early stress response. In the present study, we examine the role of miR-135a in stress-related behavior. We show that the knockdown (KD) of miR-135a in the mouse amygdala induces an increase in anxiety-like behavior. Consistently with behavioral studies, electrophysiological experiments in acute brain slices indicate an increase of amygdala spontaneous excitatory postsynaptic currents, as a result of miR-135a KD. Furthermore, we presented direct evidences, by in vitro assays and in vivo miRNA overexpression in the amygdala, that two key regulators of synaptic vesicle fusion, complexin-1 and complexin-2, are direct targets of miR-135a. In vitro analysis of miniature excitatory postsynaptic currents on miR-135a KD primary neurons indicates unpaired quantal excitatory neurotransmission. Finally, increased levels of complexin-1 and complexin-2 proteins were detected in the mouse amygdala after acute stress, accordingly to the previously observed stress-induced miR-135a downregulation. Overall, our results unravel a previously unknown miRNA-dependent mechanism in the amygdala for regulating anxiety-like behavior, providing evidences of a physiological…

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Metadata

Authors
Mannironi, C., Biundo, A., Rajendran, S., De Vito, F., Saba, L., Caioli, S., Zona, C., Ciotti, T., Caristi, S., Perlas, E., Del Vecchio, G., Bozzoni, I., Rinaldi, A., Mele, A., & Presutti, C.
ORCID
Mannironi, Cecilia
Venue
Molecular Neurobiology
Publisher
Springer Science and Business Media LLC
Published
2017-05-09
Volume
55
Issue
4
Pages
3301-3315
ISSN
  • 0893-7648
  • 1559-1182
DOI
10.1007/s12035-017-0564-9
Cited by
49
References
7
Language
en
Licence
www.springer.com/tdm (unspecified)
Funders
  • Filas (Project F57I12000110009)
  • ERC-2013 (AdG 340172-MUNCODD)
  • Arisla (full grant 2014 “RNA circuitries in Amyotrophic Lateral Sclerosis pathogenesis”)

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