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mRNA Destabilization Is the Dominant Effect of Mammalian MicroRNAs by the Time Substantial Repression Ensues
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Degradation of target mRNA accounts for 66-90% of the miRNA-mediated gene silencing in mammalian cells.
“degradation of target mRNA accounts for 66–90% of the miRNA-mediated gene silencing in mammalian cells [84–86]”
From Neurodegenerative disease-associated microRNAs acting as signaling molecules modulate CNS neuron structure and viability (2025) · cites this paper as [84]
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Most mammalian mRNAs are conserved targets of microRNAs
Friedman, R. C., Farh, K. K.-H., Burge, C. B., & Bartel, D. P. (2009) · Genome Research · doi:10.1101/gr.082701.108 · Cited by 8,462
Self-citationWightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. S., & Weissman, J. S. (2009) · Science · doi:10.1126/science.1168978 · Cited by 3,853
The impact of microRNAs on protein output
Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592
Self-citationWidespread changes in protein synthesis induced by microRNAs
Selbach, M., Schwanhäusser, B., Thierfelder, N., Fang, Z., Khanin, R., & Rajewsky, N. (2008) · Nature · doi:10.1038/nature07228 · Cited by 3,429
A pancreatic islet-specific microRNA regulates insulin secretion
Poy, M. N., Eliasson, L., Krutzfeldt, J., Kuwajima, S., Ma, X., MacDonald, P. E., Pfeffer, S., Tuschl, T., Rajewsky, N., Rorsman, P., et al. (2004) · Nature · doi:10.1038/nature03076 · Cited by 2,102
Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish
Bazzini, A. A., Lee, M. T., & Giraldez, A. J. (2012) · Science · doi:10.1126/science.1215704 · Cited by 709
Poly(A)-tail profiling reveals an embryonic switch in translational control
Subtelny, A. O., Eichhorn, S. W., Chen, G. R., Sive, H., & Bartel, D. P. (2014) · Nature · doi:10.1038/nature13007 · Cited by 664
Self-citationConcordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA
Hendrickson, D. G., Hogan, D. J., McCullough, H. L., Myers, J. W., Herschlag, D., Ferrell, J. E., & Brown, P. O. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000238 · Cited by 418
Global analysis of cellular protein translation by pulsed SILAC
Schwanhäusser, B., Gossen, M., Dittmar, G., & Selbach, M. (2009) · PROTEOMICS · doi:10.1002/pmic.200800275 · Cited by 356
Flagged first, then by citations
Research works printed but not linked: 47
- Bagga, 2005, Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation, Cell, 122, 553, 10.1016/j.cell.2005.07.031 · DOI
- Bartel, 2009, MicroRNAs: target recognition and regulatory functions, Cell, 136, 215, 10.1016/j.cell.2009.01.002 · DOI · Paper page
- Behm-Ansmant, 2006, mRNA degradation by miRNAs and GW182 requires both CCR4:NOT deadenylase and DCP1:DCP2 decapping complexes, Genes Dev., 20, 1885, 10.1101/gad.1424106 · DOI
- Béthune, 2012, Kinetic analysis reveals successive steps leading to miRNA-mediated silencing in mammalian cells, EMBO Rep., 13, 716, 10.1038/embor.2012.82 · DOI
- Braun, 2011, GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets, Mol. Cell, 44, 120, 10.1016/j.molcel.2011.09.007 · DOI
- Braun, 2012, A molecular link between miRISCs and deadenylases provides new insight into the mechanism of gene silencing by microRNAs, Cold Spring Harb. Perspect. Biol., 4, 4, 10.1101/cshperspect.a012328 · DOI · Paper page
- Castilla-Llorente, 2012, Mammalian GW220/TNGW1 is essential for the formation of GW/P bodies containing miRISC, J. Cell Biol., 198, 529, 10.1083/jcb.201201153 · DOI
- Chekulaeva, 2011, miRNA repression involves GW182-mediated recruitment of CCR4-NOT through conserved W-containing motifs, Nat. Struct. Mol. Biol., 18, 1218, 10.1038/nsmb.2166 · DOI
- Chen, 2006, The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation, Nat. Genet., 38, 228, 10.1038/ng1725 · DOI
- Chen, 2009, Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps, Nat. Struct. Mol. Biol., 16, 1160, 10.1038/nsmb.1709 · DOI
- Coccia, 1992, Modulation of ferritin H-chain expression in Friend erythroleukemia cells: transcriptional and translational regulation by hemin, Mol. Cell. Biol., 12, 3015, 10.1128/MCB.12.7.3015 · DOI
- Cooke, 2010, Translational repression by deadenylases, J. Biol. Chem., 285, 28506, 10.1074/jbc.M110.150763 · DOI
- Deana, 2005, Lost in translation: the influence of ribosomes on bacterial mRNA decay, Genes Dev., 19, 2526, 10.1101/gad.1348805 · DOI
- Djuranovic, 2012, miRNA-mediated gene silencing by translational repression followed by mRNA deadenylation and decay, Science, 336, 237, 10.1126/science.1215691 · DOI · Paper page
- Doench, 2004, Specificity of microRNA target selection in translational repression, Genes Dev., 18, 504, 10.1101/gad.1184404 · DOI
- Eulalio, 2007, Target-specific requirements for enhancers of decapping in miRNA-mediated gene silencing, Genes Dev., 21, 2558, 10.1101/gad.443107 · DOI
- Eulalio, 2008, GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay, Nat. Struct. Mol. Biol., 15, 346, 10.1038/nsmb.1405 · DOI
- Eulalio, 2009, Deadenylation is a widespread effect of miRNA regulation, RNA, 15, 21, 10.1261/rna.1399509 · DOI
- Fabian, 2009, Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation, Mol. Cell, 35, 868, 10.1016/j.molcel.2009.08.004 · DOI
- Garcia, 2011, Weak seed-pairing stability and high target-site abundance decrease the proficiency of lsy-6 and other microRNAs, Nat. Struct. Mol. Biol., 18, 1139, 10.1038/nsmb.2115 · DOI
- Giraldez, 2005, MicroRNAs regulate brain morphogenesis in zebrafish, Science, 308, 833, 10.1126/science.1109020 · DOI · Paper page
- Giraldez, 2006, Zebrafish MiR-430 promotes deadenylation and clearance of maternal mRNAs, Science, 312, 75, 10.1126/science.1122689 · DOI · Paper page
- Grimson, 2007, MicroRNA targeting specificity in mammals: determinants beyond seed pairing, Mol. Cell, 27, 91, 10.1016/j.molcel.2007.06.017 · DOI · Paper page
- Guo, 2010, Mammalian microRNAs predominantly act to decrease target mRNA levels, Nature, 466, 835, 10.1038/nature09267 · DOI · Paper page
- Hentze, 1987, A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron, Proc. Natl. Acad. Sci. USA, 84, 6730, 10.1073/pnas.84.19.6730 · DOI · Paper page
- Holtz, 2009, Uncoupling of lin-14 mRNA and protein repression by nutrient deprivation in Caenorhabditis elegans, RNA, 15, 400, 10.1261/rna.1258309 · DOI
- Huo, 2012, Stable isotope-labelling analysis of the impact of inhibition of the mammalian target of rapamycin on protein synthesis, Biochem. J., 444, 141, 10.1042/BJ20112107 · DOI
- Kim, 1996, Identification of a conserved and functional iron-responsive element in the 5′-untranslated region of mammalian mitochondrial aconitase, J. Biol. Chem., 271, 24226, 10.1074/jbc.271.39.24226 · DOI · Paper page
- Kiriakidou, 2004, A combined computational-experimental approach predicts human microRNA targets, Genes Dev., 18, 1165, 10.1101/gad.1184704 · DOI
- Lim, 2005, Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs, Nature, 433, 769, 10.1038/nature03315 · DOI · Paper page
- Melefors, 1993, Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells, J. Biol. Chem., 268, 5974, 10.1016/S0021-9258(18)53414-1 · DOI
- Mishima, 2006, Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430, Curr. Biol., 16, 2135, 10.1016/j.cub.2006.08.086 · DOI · Paper page
- Muhlrad, 1995, Turnover mechanisms of the stable yeast PGK1 mRNA, Mol. Cell. Biol., 15, 2145, 10.1128/MCB.15.4.2145 · DOI
- Nelson, 2004, miRNP:mRNA association in polyribosomes in a human neuronal cell line, RNA, 10, 387, 10.1261/rna.5181104 · DOI
- O’Donnell, 2005, c-Myc-regulated microRNAs modulate E2F1 expression, Nature, 435, 839, 10.1038/nature03677 · DOI · Paper page
- Olsen, 1999, The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation, Dev. Biol., 216, 671, 10.1006/dbio.1999.9523 · DOI · Paper page
- Pillai, 2005, Inhibition of translational initiation by Let-7 MicroRNA in human cells, Science, 309, 1573, 10.1126/science.1115079 · DOI
- Rehwinkel, 2005, A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing, RNA, 11, 1640, 10.1261/rna.2191905 · DOI
- Rissland, 2011, MicroRNA destabilization enables dynamic regulation of the miR-16 family in response to cell-cycle changes, Mol. Cell, 43, 993, 10.1016/j.molcel.2011.08.021 · DOI
- Schwartz, 1999, Mutations in translation initiation factors lead to increased rates of deadenylation and decapping of mRNAs in Saccharomyces cerevisiae, Mol. Cell. Biol., 19, 5247, 10.1128/MCB.19.8.5247 · DOI
- Seggerson, 2002, Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiation, Dev. Biol., 243, 215, 10.1006/dbio.2001.0563 · DOI
- Thai, 2007, Regulation of the germinal center response by microRNA-155, Science, 316, 604, 10.1126/science.1141229 · DOI
- Wakiyama, 2007, Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system, Genes Dev., 21, 1857, 10.1101/gad.1566707 · DOI
- Wu, 2006, MicroRNAs direct rapid deadenylation of mRNA, Proc. Natl. Acad. Sci. USA, 103, 4034, 10.1073/pnas.0510928103 · DOI
- Yekta, 2004, MicroRNA-directed cleavage of HOXB8 mRNA, Science, 304, 594, 10.1126/science.1097434 · DOI · Paper page
- Zekri, 2013, GW182 proteins cause PABP dissociation from silenced miRNA targets in the absence of deadenylation, EMBO J., 32, 1052, 10.1038/emboj.2013.44 · DOI
- Zhao, 2005, Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis, Nature, 436, 214, 10.1038/nature03817 · DOI
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Jonas, S., & Izaurralde, E. (2015) · Nature Reviews Genetics · doi:10.1038/nrg3965 · Cited by 1,872
Pairing beyond the Seed Supports MicroRNA Targeting Specificity
Broughton, J. P., Lovci, M. T., Huang, J. L., Yeo, G. W., & Pasquinelli, A. E. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.09.004 · Cited by 487
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Iwakawa, H.-O., & Tomari, Y. (2022) · Molecular Cell · doi:10.1016/j.molcel.2021.11.026 · Cited by 488
Weinberg, D. E., Shah, P., Eichhorn, S. W., Hussmann, J. A., Plotkin, J. B., & Bartel, D. P. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.043 · Cited by 392
Self-citationNew frontiers in translational control of the cancer genome
Truitt, M. L., & Ruggero, D. (2016) · Nature Reviews Cancer · doi:10.1038/nrc.2016.27 · Cited by 378
Baer, C., Squadrito, M. L., Laoui, D., Thompson, D., Hansen, S. K., Kiialainen, A., Hoves, S., Ries, C. H., Ooi, C.-H., & De Palma, M. (2016) · Nature Cell Biology · doi:10.1038/ncb3371 · Cited by 259
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Medley, J. C., Panzade, G., & Zinovyeva, A. Y. (2021) · WIREs RNA · doi:10.1002/wrna.1627 · Cited by 225
Reexamining assumptions about miRNA-guided gene silencing
Kilikevicius, A., Meister, G., & Corey, D. R. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkab1256 · Cited by 194
MicroRNAs as Regulators of Phagocytosis
Gierlikowski, W., & Gierlikowska, B. (2022) · Cells · doi:10.3390/cells11091380 · Cited by 25
Kumbol, V., Ivanov, A., McGurran, H., Schüler, J., Zhai, Y., Ludwik, K., Hinkelmann, L., Brehm, M., Krüger, C., Küchler, J., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02199-8 · Cited by 8
Metadata
- Authors
- Eichhorn, S. W., Guo, H., McGeary, S. E., Rodriguez-Mias, R. A., Shin, C., Baek, D., Hsu, S.-H., Ghoshal, K., Villén, J., & Bartel, D. P.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 56
- Issue
- 1
- Pages
- 104-115
- ISSN
- 1097-2765
- PMC
- PMC4292926
- Cited by
- 503
- References
- 11
- Language
- en
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