Cited by 103Neuroprotection in Cerebral IschemiaFatty Acid Research and HealthNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 61 of the 62 references it cites were found in a registry or an index.

Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke

Open access

Belayev, Ludmila, Hong, Sung-Ha, Menghani, Hemant, Marcell, Shawn J., Obenaus, Andre, Freitas, Raul S., Khoutorova, Larissa, Balaszczuk, Veronica, Jun, Bokkyoo, Oriá, Reinaldo B., Bazan, Nicolas G.·2018·Molecular Neurobiology

DOI 10.1007/s12035-018-1136-3PMC PMC6054805

Open this paper in CoChat — free account Open PDF

Abstract

Docosahexaenoic acid (DHA) and neuroprotectin D1 (NPD1) are neuroprotective after experimental ischemic stroke. To explore underlying mechanisms, SD rats underwent 2 h of middle cerebral artery occlusion (MCAo) and treated with DHA (5 mg/kg, IV) or NPD1 (5 μg/per rat, ICV) and vehicles 1 h after. Neuro-behavioral assessments was conducted on days 1, 2, and 3, and on week 1, 2, 3, or 4. BrdU was injected on days 4, 5, and 6, immunohistochemistry was performed on week 2 or 4, MRI on day 7, and lipidomic analysis at 4 and 5 h after onset of stroke. DHA improved short- and long-term behavioral functions and reduced cortical, subcortical, and total infarct volumes (by 42, 47, and 31%, respectively) after 2 weeks and reduced tissue loss by 50% after 4 weeks. DHA increased the number of BrdU+/Ki-67+, BrdU+/DCX+, and BrdU+/NeuN+ cells in the cortex, subventricular zone, and dentate gyrus and potentiated NPD1 synthesis in the penumbra at 5 h after MCAo. NPD1 improved behavior, reduced lesion volumes, protected ischemic penumbra, increased NeuN, GFAP, SMI-71-positive cells and vessels, axonal regeneration in the penumbra, and attenuated blood-brain barrier (BBB) after MCAo. We conclude that docosanoid administration increases neurogenesis and angiogenesis, activates NPD1 synthesis in the penumbra, and diminishes BBB permeability, which correlates to long-term neurobehavioral recovery after experimental ischemic stroke.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1007/s12035-018-1136-3

Cites

61 of 61 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Guidelines for the Early Management of Patients With Acute Ischemic Stroke
Jauch, E. C., Saver, J. L., Adams, H. P., Bruno, A., Connors, J. J. “., Demaerschalk, B. M., Khatri, P., McMullan, P. W., Qureshi, A. I., Rosenfield, K., et al. (2013) · Stroke · doi:10.1161/str.0b013e318284056a · Cited by 7,698
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797
The Importance of the Omega-6/Omega-3 Fatty Acid Ratio in Cardiovascular Disease and Other Chronic Diseases
Simopoulos, A. P. (2008) · Experimental Biology and Medicine · doi:10.3181/0711-mr-311 · Cited by 3,003
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Neuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799
The immunology of stroke: from mechanisms to translation
Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596
Long-chain omega-3 fatty acids and the brain: A review of the independent and shared effects of EPA, DPA and DHA
Dyall, S. C. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00052 · Cited by 943
Middle Cerebral Artery Occlusion in the Rat by Intraluminal Suture
Belayev, L., Alonso, O. F., Busto, R., Zhao, W., & Ginsberg, M. D. (1996) · Stroke · doi:10.1161/01.str.27.9.1616 · Cited by 815
Self-citation
Blood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease
Yang, Y. R., & Rosenberg, G. A. (2011) · Stroke · doi:10.1161/strokeaha.110.608257 · Cited by 808
Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression
Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802
Self-citation

Show all 62 references

Sorted by citations

Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?
Qiu, Y., Zhang, C., Chen, A., Wang, H.-L., Zhou, Y., Li, Y., & Hu, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.678744 · Cited by 414
Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies
Chew, H., Solomon, V. A., & Fonteh, A. N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00598 · Cited by 353
Omega−3 Polyunsaturated Fatty Acids (PUFAs): Emerging Plant and Microbial Sources, Oxidative Stability, Bioavailability, and Health Benefits—A Review
Saini, R. K., Prasad, P., Sreedhar, R. V., Akhilender Naidu, K., Shang, X., & Keum, Y.-S. (2021) · Antioxidants · doi:10.3390/antiox10101627 · Cited by 337
Short-chain fatty acids as modulators of redox signaling in health and disease
González‐Bosch, C., Boorman, E., Zunszain, P. A., & Mann, G. E. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102165 · Cited by 298
The anti-inflammatory role of Omega-3 polyunsaturated fatty acids metabolites in pre-clinical models of psychiatric, neurodegenerative, and neurological disorders
Giacobbe, J., Benoiton, B., Zunszain, P., Pariante, C. M., & Borsini, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00122 · Cited by 159
Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection
Bazan, N. G. (2018) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2018.09.003 · Cited by 148
Self-citation
Neurogenesis After Stroke: A Therapeutic Perspective
Rahman, A. A., Amruta, N., Pinteaux, E., & Bix, G. J. (2020) · Translational Stroke Research · doi:10.1007/s12975-020-00841-w · Cited by 147
Unsaturated fatty acids in natural edible resources, a systematic review of classification, resources, biosynthesis, biological activities and application
Liu, Y., Shen, N., Xin, H., Yu, L., Xu, Q., & Cui, Y. (2023) · Food Bioscience · doi:10.1016/j.fbio.2023.102790 · Cited by 107
DL-3-n-butylphthalide (NBP) alleviates poststroke cognitive impairment (PSCI) by suppressing neuroinflammation and oxidative stress
Zhang, H., Wang, L., Yang, Y., Cai, C., Wang, X., Deng, L., He, B., Zhou, W., & Cui, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.987293 · Cited by 100
MALAT1 Up-Regulator Polydatin Protects Brain Microvascular Integrity and Ameliorates Stroke Through C/EBPβ/MALAT1/CREB/PGC-1α/PPARγ Pathway
Ruan, W., Li, J., Xu, Y., Wang, Y., Zhao, F. H., Yang, X., Jiang, H., Zhang, L., Saavedra, J. M., Shi, L., et al. (2019) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-018-00646-4 · Cited by 78
Yin-Yang Mechanisms Regulating Lipid Peroxidation of Docosahexaenoic Acid and Arachidonic Acid in the Central Nervous System
Yang, B., Fritsche, K. L., Beversdorf, D. Q., Gu, Z., Lee, J. C., Folk, W. R., Greenlief, C. M., & Sun, G. Y. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00642 · Cited by 78
A comparative study of the neuroprotective effects of dl-3-n-butylphthalide and edaravone dexborneol on cerebral ischemic stroke rats
Zhang, H., Wang, L., Zhu, B., Yang, Y., Cai, C., Wang, X., Deng, L., He, B., Cui, Y., & Zhou, W. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175801 · Cited by 73
The Neuroprotective Effect of Tea Polyphenols on the Regulation of Intestinal Flora
Zhang, Z., Zhang, Y., Li, J., Fu, C., & Zhang, X. (2021) · Molecules · doi:10.3390/molecules26123692 · Cited by 55
Specialized Pro-Resolving Mediators in Neuroinflammation: Overview of Studies and Perspectives of Clinical Applications
Valente, M., Dentoni, M., Bellizzi, F., Kuris, F., & Gigli, G. L. (2022) · Molecules · doi:10.3390/molecules27154836 · Cited by 52
Lipid mediators and sterile inflammation in ischemic stroke
Nakamura, A., Otani, K., & Shichita, T. (2020) · International Immunology · doi:10.1093/intimm/dxaa027 · Cited by 42
Stroke-Related Mortality at Different Altitudes: A 17-Year Nationwide Population-Based Analysis From Ecuador
Ortiz‐Prado, E., Espinosa, P. S., Borrero, A., Cordovez, S., Vásconez-González, J., Barreto-Grimaldos, A., Coral-Almeida, M., Henriquez-Trujillo, A. R., Simbaña‐Rivera, K., Gómez‐Barreno, L., et al. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.733928 · Cited by 41
Novel Approaches for Omega-3 Fatty Acid Therapeutics: Chronic Versus Acute Administration to Protect Heart, Brain, and Spinal Cord
Zirpoli, H., Chang, C. L., Carpentier, Y., Michael-Titus, A. T., Ten, V. S., & Deckelbaum, R. J. (2020) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124539 · Cited by 40
Bioactive Lipid Mediators in the Initiation and Resolution of Inflammation after Spinal Cord Injury
David, S., & López‐Vales, R. (2021) · Neuroscience · doi:10.1016/j.neuroscience.2021.04.026 · Cited by 41
Inflammation, Dopaminergic Brain and Bilirubin
Jayanti, S. D., Verde, C. D., Tiribelli, C., & Gazzin, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411478 · Cited by 39
PI3K/AKT pathway mediates the antidepressant- and anxiolytic-like roles of hydrogen sulfide in streptozotocin-induced diabetic rats via promoting hippocampal neurogenesis
Wu, J., Tang, Y.-Y., Zhu, W., Li, C., Zhang, P., Li, R.-Q., Chen, Y., Zou, W., & Tang, X. (2021) · NeuroToxicology · doi:10.1016/j.neuro.2021.05.016 · Cited by 35
Conditioned medium obtained from mesenchymal stem cells attenuates focal cerebral ischemia reperfusion injury through activation of ERK1/ERK2-BDNF signaling pathway
Aboutaleb, N., Faezi, M., Maleki, S. N., Nazarinia, D., Tousi, S. M. T. R., & Hashemirad, N. (2019) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2019.02.003 · Cited by 34
DHA modulates MANF and TREM2 abundance, enhances neurogenesis, reduces infarct size, and improves neurological function after experimental ischemic stroke
Belayev, L., Hong, S., Freitas, R. S., Menghani, H., Marcell, S. J., Khoutorova, L., Mukherjee, P. K., Reid, M. M., Oriá, R. B., & Bazan, N. G. (2020) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13444 · Cited by 34
Self-citation
Role of polyunsaturated fatty acids in ischemic stroke – A perspective of specialized pro-resolving mediators
Miao, Z., Schultzberg, M., Wang, X., & Zhao, Y. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2020.12.037 · Cited by 34
Neuroprotectin D1 Protects Against Postoperative Delirium-Like Behavior in Aged Mice
Zhou, Y., Wang, J., Li, X., Li, K., Chen, L., Zhang, Z., & Peng, M. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.582674 · Cited by 33
Role of the non‐invasive imaging techniques in monitoring and understanding the evolution of brain edema
Obenaus, A., & Badaut, J. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24837 · Cited by 32
Self-citation
Molecular mediators of angiogenesis and neurogenesis after ischemic stroke
Paro, M. R., Chakraborty, A. R., Angelo, S. J., Nambiar, S., Bulsara, K. R., & Verma, R. (2022) · Reviews in the Neurosciences · doi:10.1515/revneuro-2022-0049 · Cited by 31
NPD1 rapidly targets mitochondria-mediated apoptosis after acute injection protecting brain against ischemic injury
Zirpoli, H., Sosunov, S. A., Niatsetskaya, Z. V., Mayurasakorn, K., Kollareth, D. J. M., Serhan, C. N., Ten, V. S., & Deckelbaum, R. J. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113495 · Cited by 32
Lipid Mediators in Critically Ill Patients: A Step Towards Precision Medicine
Cioccari, L., Luethi, N., & Masoodi, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.599853 · Cited by 31
Omega-3 fatty acid supplementation in severe brain trauma: case for a large multicenter trial
Bailes, J. E., Abusuwwa, R., Arshad, M. A., Chowdhry, S. A., Schleicher, D., Hempeck, N., Gandhi, Y. N., Jaffa, Z., Bokhari, F., Karahalios, D. G., et al. (2020) · Journal of neurosurgery · doi:10.3171/2020.3.jns20183 · Cited by 31
Repetitive transcranial photobiomodulation but not long‐term omega‐3 intake reduces epileptiform discharges in rats with stroke‐induced epilepsy
Vogel, D., Ortiz‐Villatoro, N. N., de Freitas, L., Aimbire, F., Scorza, F. A., Albertini, R., & Scorza, C. A. (2020) · Journal of Biophotonics · doi:10.1002/jbio.202000287 · Cited by 30
Transcranial low‐level laser therapy in an in vivo model of stroke: Relevance to the brain infarct, microglia activation and neuroinflammation
Vogel, D., Ortiz‐Villatoro, N. N., Araújo, N. S., Marques, M., Aimbire, F., Scorza, F. A., Scorza, C. A., & Albertini, R. (2021) · Journal of Biophotonics · doi:10.1002/jbio.202000500 · Cited by 30
Edaravone dexborneol protected neurological function by targeting NRF2/ARE and NF-κB/AIM2 pathways in cerebral ischemia/reperfusion injury
Zhang, H., Zhu, C., Zhou, X., Wang, L., Deng, L., He, B., & Li, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1581320 · Cited by 30
Omega-3 Polyunsaturated Fatty Acids and Stroke Burden
Ueno, Y., Miyamoto, N., Yamashiro, K., Tanaka, R., & Hattori, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225549 · Cited by 30
Fish, n-3 fatty acids, cognition and dementia risk: not just a fishy tale
Saleh, R. N. M., & Minihane, A. M. (2021) · Proceedings of The Nutrition Society · doi:10.1017/s0029665121003700 · Cited by 28
Neuroprotectin D1 and GPR37 protect against chemotherapy-induced peripheral neuropathy and the transition from acute to chronic pain
Xu, J., Bang, S., Ouyang, C., Li, Y., McGinnis, A., Zhang, Q., & Ji, R. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107746 · Cited by 28
mTOR (Mammalian Target of Rapamycin): Hitting the Bull’s Eye for Enhancing Neurogenesis After Cerebral Ischemia?
Gao, J., Yao, M., Chang, D., & Liu, J. (2022) · Stroke · doi:10.1161/strokeaha.122.040376 · Cited by 26
Post-ischemic administration of dopamine D2 receptor agonist reduces cell death by activating mitochondrial pathway following ischemic stroke
Kaushik, P., Ali, M., Tabassum, H., & Parvez, S. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118349 · Cited by 26
Bacterial cellulose nanofibrils for the physical and oxidative stability of fish oil-loaded Pickering emulsions
Wang, M., Liu, Q., Zeng, X., Chen, R., Wang, C., Li, M., Wu, X., Weng, W., & Zhang, Y. (2024) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2024.134154 · Cited by 24
Serum Exosomal mir-340-5p Promotes Angiogenesis in Brain Microvascular Endothelial Cells During Oxygen-Glucose Deprivation
Xu, C., Yu, H., Chen, B., Ma, Y., & Lv, P. (2022) · Neurochemical Research · doi:10.1007/s11064-021-03492-x · Cited by 23
Inhibition of the cGAS–STING pathway: contributing to the treatment of cerebral ischemia-reperfusion injury
Yang, H., Xia, Y., Ma, Y., Gao, M., Hou, S., Xu, S., & Wang, Y. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-00015 · Cited by 24
NPD1 Plus RvD1 Mediated Ischemic Stroke Penumbra Protection Increases Expression of Pro-homeostatic Microglial and Astrocyte Genes
Reid, M. M., Kautzmann, M.-A. I., Andrew, G., Obenaus, A., Mukherjee, P. K., Khoutorova, L., Ji, J. X., Roque, C. R., Oriá, R. B., Habeb, B. F., et al. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01363-3 · Cited by 20
Self-citation
The role of neuroglial cells communication in ischemic stroke
Yu, Y., Liao, X., Xie, X., Qihua, L., Chen, X., & Liu, R. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.110910 · Cited by 20
Fraxetin protects rat brains from the cerebral stroke via promoting angiogenesis and activating PI3K/Akt pathway
Yuhuan, C., Liu, M., Zuo, L., Wang, H., & Liu, J. (2022) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2022.2052893 · Cited by 18
TLR4 Deletion Improves Cognitive Brain Function and Structure in Aged Mice
Fei, X., Dou, Y., Lv, W., Ding, B., Wei, J., Wu, X., He, X., Fei, Z., & Fei, F. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.04.007 · Cited by 18
Aging, sex, metabolic and life experience factors: Contributions to neuro-inflammaging in Alzheimer’s disease research
Singhaarachchi, P. H., Antal, P., Calon, F., Culmsee, C., Delpech, J.-C., Feldotto, M., Geertsema, J., Hoeksema, E. E., Kőrösi, A., Layé, S., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105724 · Cited by 20
Possibility of averting cytokine storm in SARS-COV 2 patients using specialized pro-resolving lipid mediators
Yasmeen, N., Selvaraj, H., Lakhawat, S. S., Datta, M., Sharma, P. K., Jain, A., Khanna, R., Srinivasan, J., & Kumar, V. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115437 · Cited by 17
RETRACTED: Sanhua Decoction, a Classic Herbal Prescription, Exerts Neuroprotection Through Regulating Phosphorylated Tau Level and Promoting Adult Endogenous Neurogenesis After Cerebral Ischemia/Reperfusion Injury
Fu, D.-L., Li, J.-H., Shi, Y., Zhang, X.-L., Lin, Y., & Zheng, G. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00057 · Cited by 17
Retracted
Editorial: Is it time to separate EPA from DHA when using omega-3 fatty acids to protect heart and brain?
Deckelbaum, R. J., & Calder, P. C. (2020) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000632 · Cited by 17
Opto‐Lipidomics of Tissues
Jensen, M., Liu, S., Stepula, E., Martella, D. A., Birjandi, A. A., Farrell‐Dillon, K., Chan, K. L. A., Parsons, M., Chiappini, C., Chapple, S. J., et al. (2023) · Advanced Science · doi:10.1002/advs.202302962 · Cited by 16
Dexmedetomidine‐up‐regulated microRNA‐381 exerts anti‐inflammatory effects in rats with cerebral ischaemic injury via the transcriptional factor IRF4
Hua, F., Li, H., Yan, J., Yang, M., & Zhang, J. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16153 · Cited by 16
Intensification Strategies for the Extraction of Polyunsaturated Fatty Acids and Other Lipophilic Fractions From Seaweeds
Rodríguez-González, I., Díaz-Reinoso, B., & Domı́nguez, H. (2022) · Food and Bioprocess Technology · doi:10.1007/s11947-021-02757-1 · Cited by 15
A novel prognosis prediction model, including cytotoxic T lymphocyte‐associated antigen‐4, ischemia‐modified albumin, lipoprotein‐associated phospholipase A2, glial fibrillary acidic protein, and homocysteine, for ischemic stroke in the Chinese hypertensive population
Ma, J., Shen, L., Bao, L., Yuan, H. M., Wang, Y., Liu, H., & Wang, Q. (2021) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.23756 · Cited by 15
9-Methylfascaplysin exerts anti-ischemic stroke neuroprotective effects via the inhibition of neuroinflammation and oxidative stress in rats
Zhang, D., Feng, Y., Pan, H., Xuan, Z., Yan, S., Mao, Y., Xiao, X., Huang, X., Zhang, H., Fei, Z., et al. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107656 · Cited by 14
Aggregation Behavior of Amyloid Beta Peptide Depends Upon the Membrane Lipid Composition
Mirdha, L. (2024) · The Journal of Membrane Biology · doi:10.1007/s00232-024-00314-3 · Cited by 14
Repetitive transcranial magnetic stimulation increases neurological function and endogenous neural stem cell migration via the SDF‑1α/CXCR4 axis after cerebral infarction in rats
Deng, Y., Guo, F., Han, X., & Huang, X. (2021) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2021.10469 · Cited by 12
Integrated inflammatory signaling landscape response after delivering Elovanoid free-fatty-acid precursors leading to experimental stroke neuroprotection
Reid, M. M., Belayev, L., Khoutorova, L., Mukherjee, P. K., Obenaus, A., Shelvin, K., Knowles, S., Hong, S., & Bazan, N. G. (2023) · Scientific Reports · doi:10.1038/s41598-023-42126-w · Cited by 11
Self-citation
Enzymatic Formation of Protectin Dx and Its Production by Whole-Cell Reaction Using Recombinant Lipoxygenases
Shin, K., Lee, T., Kim, S., Ko, Y., Seo, M., & Oh, D. (2022) · Catalysts · doi:10.3390/catal12101145 · Cited by 10
Association between GFAP-positive astrocytes with clinically important parameters including neurological deficits and/or infarct volume in stroke-induced animals
Akhoundzadeh, K., & Shafia, S. (2021) · Brain Research · doi:10.1016/j.brainres.2021.147566 · Cited by 10
Anticancer Potential of Lipophilic Constituents of Eleven Shellfish Species Commonly Consumed in Korea
Shin, J., Song, M., Yu, J.-W., Ko, E. Y., Shang, X., Oh, J., Keum, Y., & Saini, R. K. (2021) · Antioxidants · doi:10.3390/antiox10101629 · Cited by 10
Neuroprotection of N-benzyl Eicosapentaenamide in Neonatal Mice Following Hypoxic–Ischemic Brain Injury
Jiao, M., Dong, Q., Zhang, Y., Lin, M., Zhou, W. P., Liu, T., Yuan, B., & Yin, H. (2021) · Molecules · doi:10.3390/molecules26113108 · Cited by 10
Connexin 43 Promotes Neurogenesis via Regulating Aquaporin-4 after Cerebral Ischemia
Chu, H., Dong, J., Tang, Y., Huang, C., & Guo, Q. (2023) · Neurotoxicity Research · doi:10.1007/s12640-023-00646-3 · Cited by 9
PLGA-PEG-fucoxanthin nanoparticles protect against ischemic stroke in vivo
Wang, Q., Zhang, D., Lu, J., Zhang, J., Xuan, Z., Gong, L., Yang, M., Jin, L., Le, J., Zhu, A., et al. (2022) · Journal of Functional Foods · doi:10.1016/j.jff.2022.105359 · Cited by 9
Research progress in the mechanisms and functions of specialized pro-resolving mediators in neurological diseases
Deng, Y., Wang, F., Wang, T., Zhang, X., Chen, D., Wang, Y., Chen, C., & Pan, G. (2024) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2024.106905 · Cited by 9
Prediction Model Construction for Ischemic Stroke Recurrence with BP Network and Multivariate Logistic Regression and Effect of Individualized Health Education
Lu, T. Y., & Wang, Y. (2022) · Computational and Mathematical Methods in Medicine · doi:10.1155/2022/4284566 · Cited by 8
Effects of acupuncture on angiogenesis-associated factor expression in ischemic brain tissue following cerebral infarction in rats
Sun, Y., Li, J., Georgi, R., Kolberg, B., & Yang, L. (2023) · Acupuncture and Herbal Medicine · doi:10.1097/hm9.0000000000000054 · Cited by 8
Fat for thought: Lipid regulation of neural stem cell fate
Cabot, J., Santillan, A. J., Fernández‐García, P., Lladó, V., Torres, M., Escribá, P. V., & Castroflorio, E. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118785 · Cited by 7
Ghrelin Regulates Expression of the Transcription Factor Pax6 in Hypoxic Brain Progenitor Cells and Neurons
Stoyanova, I. I., Klymenko, A., Willms, J., Doeppner, T. R., Tonchev, A. B., & Lutz, D. (2022) · Cells · doi:10.3390/cells11050782 · Cited by 7
Maternal n-3 enriched diet reprograms the offspring neurovascular transcriptome and blunts inflammation induced by endotoxin in the neonate
Chumak, T., Jullienne, A., Ek, C. J., Ardalan, M., Svedin, P., Quan, R., Salehi, A., Salari, S., Obenaus, A., Vexler, Z. S., et al. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03191-8 · Cited by 6
Self-citation
Common lipidomic signatures across distinct acute brain injuries in patient outcome prediction
Hellström, S., Sajanti, A., Srinath, A., Bennett, C., Girard, R., Jhaveri, A., Cao, Y., Falter, J., Frantzén, J., Koskimäki, F., et al. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106762 · Cited by 6
Dietary fish oil increases catalase activity in patients with probable Alzheimer’s disease
Pacheco-Moisés, F. P., Torres-Mendoza, B. M., Ortíz, G. G., Sánchez-Romero, L., Delgado-Lara, D. L. C., Martínez, M. T. G., Mireles-Ramírez, M. A., & Serrano, J. A. C. (2022) · Nutrición Hospitalaria · doi:10.20960/nh.04153 · Cited by 8
Ghrelin promotes neurologic recovery and neurogenesis in the chronic phase after experimental stroke
Beuker, C., Schreiner, U., Strecker, J.-K., Altach, E., Rätzel, V., Schmidt-Pogoda, A., Wiendl, H., Minnerup, J., & Diederich, K. (2025) · Neurological Research and Practice · doi:10.1186/s42466-025-00371-6 · Cited by 5
Application of Multimodal Magnetic Resonance Imaging in Green Channel of Acute and Hyperacute Ischemic Stroke
Zhou, J., Li, G., Meng, Y., Fu, D., Lu, M., & Tang, Z. (2022) · Contrast Media & Molecular Imaging · doi:10.1155/2022/2452282 · Cited by 5
Widely targeted metabolomics unveils baicalin-induced hippocampal metabolic alternations in a rat model of chronic unpredictable mild stress
Ma, J., Li, X., Yang, Z., Liu, Q., Liu, Y., & Liu, A. (2023) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2023.115766 · Cited by 4
Targeting Lipid Metabolism in Alzheimer’s Disease: Emerging Insights and Future Directions
Balakrishnan, J., Kannan, S., Shanmugam, K., & Dhavamani, S. (2026) · Journal of Integrative Neuroscience · doi:10.31083/jin48436 · Cited by 4
DHA A Key Supplement for Neurologic Health—An Insight
Suvarna, V., & Singh, V. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815238-6.00026-2 · Cited by 4
High-throughput Sequencing and Bioinformatics Analysis Reveals the Neurogenesis Key Targets of Curcumin Action in Mouse Brain with MCAO
Li, L., Cheng, J., Ji, Y., Liu, J., Zhai, R., & Wang, H. (2022) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207325666220803090112 · Cited by 4
A Modified Model Preparation for Middle Cerebral Artery Occlusion Reperfusion
Ma, R., Yang, H., Liang, J., Lu, D., Xie, Q., Zeng, X., & Guo, J. (2024) · Journal of Visualized Experiments · doi:10.3791/67060 · Cited by 3
Neuroticism, omega-3 fatty acids, and risk of incident dementia
Gao, Y., van Duijn, C. M., Littlejohns, T. J., & Amin, N. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119733 · Cited by 3
Metabolic alterations after traumatic neural injury: Mechanistic insights and potential translational targets for axon regeneration
Cao, Q., Zhao, W., Yan, J., Belin, S., Yu, B., Nawabi, H., & Mao, S. (2026) · Science Signaling · doi:10.1126/scisignal.adx9003 · Cited by 3
From diet to brain repair: natural bioactive compounds in post-ischemic stroke recovery
Bu, F., Zhang, Z. H., Qi, S., & Xu, L. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1778396 · Cited by 3
Human pluripotent stem cell–derived neuronal progenitor cells promote neurogenesis and functional recovery by attenuating neuroinflammation and via extracellular vesicles in a subacute stroke model
Kim, H. J., Kim, D. H., Choi, J. I., Sim, H., Jung, S., Hwang, D., & Kim, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1650092 · Cited by 2
From anti-inflammation to pro-resolution: a new paradigm for specialized pro-resolving mediators in regulating neuroinflammation and repair after cerebral ischemia-reperfusion
Wang, X. L., Chen, H., Xu, Y., Cui, H., & Liu, F. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1709410 · Cited by 3
Dietary fatty acids and their functions
Dongmo, F. F. D., Ngamga, F. H. N., Fogang, A. R., Tchabong, S. R., Tchuenbou-Magaia, F. L., Etame, R. M. E., & Ngane, R. A. N. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-33296-8.00027-7 · Cited by 1
Chronic sleep deprivation induces spatial memory impairment, chromatolysis, and histoarchitectural changes in the CA3 region of the hippocampus
Ochai, J., Umana, U. E., Musa, S. A., & Oladele, S. B. (2024) · Journal of Experimental and Clinical Anatomy · doi:10.4314/jeca.v21i2.15 · Cited by 1
Fatty Acid Ratios Versus Conventional Risk Factors in Stroke: Insights into Severe Disability and Mortality Outcomes
Andone, S. R., Farczádi, L., Imre, S., Dumitreasă, M., & Bălașa, R. (2025) · Nutrients · doi:10.3390/nu17091518 · Cited by 1
Exploring the causal role of fatty acids in ischemic stroke: Insights from Mendelian randomization and inflammatory mediator analysis
Zheng, D., & Chen, Z. (2025) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2025.109037 · Cited by 1
Brain Self-protection by Bioactive Lipids
Ng, B. (2025) · Springer eBooks · doi:10.1007/978-3-031-94431-4_11 · Cited by 1
Anti-Inflammatory and Antioxidant Effects of ω-3 Polyunsaturated Fatty Acids on Astrocytes and Their Implications for the Blood–Brain Barrier’s Integrity and Function
Parnova, R. G., & Fock, E. M. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27062835 · Cited by 1
Available Therapeutics after a Stroke: Current and Promising Options
Cruz, Y., Saldaña, K. A. C., & Arias, J. J. A. I. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.91282 · Cited by 1
Neuroprotection induced by omega-3 polyunsaturated fatty acids: focus on neuropsychiatric disorders
Bujtor, M., Su, K., & Borsini, A. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-23763-8.00048-8 · Cited by 1
Aneurysmal Subarachnoid Hemorrhage and Resolution of Inflammation
Saito, G., & Zapata, R. (2019) · IntechOpen eBooks · doi:10.5772/intechopen.88297 · Cited by 1
Dietary lipids: The effect of docosahexaenoic acid on stroke-related neuronal damage
Yamagata, K. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89834-8.00035-0 · Cited by 1
Neuroprotectin D1 Protects Against Postoperative Delirium-like Behaviors in Aged Mice by Regulating Neuroinflammation Induced by Surgical TraumaPreprint
Zhou, Y., Wang, J., Li, X., Li, K., Chen, L., Zhang, Z., & Peng, M. (2020) · doi:10.21203/rs.3.rs-28936/v1
Activation of PPARβ/δ by DHA induces VEGF-A expression to promote angiogenesis in the cerebral ischemia penumbraPreprint
Zhao, Y., Jia, S., Li, X., Pang, M., Lv, E., Zhuang, W., Zhang, X., & Wang, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1499741/v1
Vasculature cells control neuroglial co-localization and synaptic connection in a central nervous system tissue mimic system
Moon, S., & Ito, Y. (2023) · Human Cell · doi:10.1007/s13577-023-00955-x
Impacts of Oxylipins on ischemic stroke: from pathophysiology to clinical phenotypes
Cheng, L., & Xia, J. (2025) · Metabolomics · doi:10.1007/s11306-025-02324-1 · Cited by 1
Additional file 1 of Maternal n-3 enriched diet reprograms the offspring neurovascular transcriptome and blunts inflammation induced by endotoxin in the neonate
Chumak, T., Jullienne, A., Ek, C. J., Ardalan, M., Svedin, P., Quan, R., Salehi, A., Salari, S., Obenaus, A., Vexler, Z. S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26536656
Self-citation
Docosahexaenoic and eicosapentaenoic acids differentially enhance the blood–brain barrier function via distinct PPAR-dependent upregulation of tight junction proteins in brain endothelial cells
Iwao, T., Takata, F., Tanaka, Y., Aridome, H., Mizoguchi, J., & Dohgu, S. (2026) · Microvascular Research · doi:10.1016/j.mvr.2026.104948 · Cited by 1
Alterations in Phospholipid Levels and Spatial Distribution in the Motor Cortex and Their Correlation with Motor Performance in an MPTP-Induced Parkinsonian Mouse Model
Sroyraya, M., Noonong, K., Sobhon, P., Siangcham, T., Waiyaput, W., Sansri, V., Chaithirayanon, K., & Chonpathompikunlert, P. (2026) · Molecules · doi:10.3390/molecules31071175
Potential Neuroprotective Effects of Docosahexaenoic Acid on Glutamate-Induced Neurotoxicity: A Systematic Review of Pre-Clinical Studies
Rusleen, M. H. R., Mansor, N. I., Hamid, A. A., Nor, N. H. M., & Mohamed, Z. (2026) · Nutrients · doi:10.3390/nu18111819

Authors: Belayev, L., Hong, S.-H., Menghani, H., Marcell, S. J., Obenaus, A., Freitas, R. S., Khoutorova, L., Balaszczuk, V., Jun, B., Oriá, R. B., & Bazan, N. G.
Affiliations: Louisiana State University (US)
Corresponding author: Belayev, Ludmila
ORCID: Belayev, Ludmila
Hong, Sung-Ha
Freitas, Raul S.
Oriá, Reinaldo B.
Bazan, Nicolas G.
Venue: Molecular Neurobiology
Publisher: Springer Science and Business Media LLC
Published: 2018-06-01
Volume: 55
Issue: 8
Pages: 7090-7106
ISSN: 0893-7648 (ISSN-L)
1559-1182
DOI: 10.1007/s12035-018-1136-3
PMC: PMC6054805
OpenAlex: W2807382073
Cited by: 103
References: 62
Citations by year: 2026: 10 · 2025: 11 · 2024: 13 · 2023: 13 · 2022: 15 · 2021: 17 · 2020: 17 · 2019: 6 · 2018: 1
FWCI: 4.60
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Molecular Neurobiology (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
Funders: National Institute of Neurological Disorders and Stroke (NS046741)
National Institute of General Medical Sciences (GM103340)
Topics: Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: docosanoids, docosahexaenoic acid, neuroprotectin D1, ischemic stroke, neurogenesis, angiogenesis, blood-brain barrier integrity, neurobehavioral recovery, middle cerebral artery occlusion, infarct size, axon regeneration, subventricular zone, dentate gyrus, lipidomics
MeSH terms: Doublecortin Protein, Animals, Axons, Behavior, Animal, Blood-Brain Barrier, Brain Ischemia, Docosahexaenoic Acids, Fatty Acids, Male, Nerve Regeneration, Permeability, Survival Analysis, Rats, Sprague-Dawley, Neovascularization, Physiologic, Infarction, Middle Cerebral Artery, Stroke, Neurogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks