The DOI matches its Crossref record; 61 of the 62 references it cites were found in a registry or an index.
Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke
Open accessAbstract
Docosahexaenoic acid (DHA) and neuroprotectin D1 (NPD1) are neuroprotective after experimental ischemic stroke. To explore underlying mechanisms, SD rats underwent 2 h of middle cerebral artery occlusion (MCAo) and treated with DHA (5 mg/kg, IV) or NPD1 (5 μg/per rat, ICV) and vehicles 1 h after. Neuro-behavioral assessments was conducted on days 1, 2, and 3, and on week 1, 2, 3, or 4. BrdU was injected on days 4, 5, and 6, immunohistochemistry was performed on week 2 or 4, MRI on day 7, and lipidomic analysis at 4 and 5 h after onset of stroke. DHA improved short- and long-term behavioral functions and reduced cortical, subcortical, and total infarct volumes (by 42, 47, and 31%, respectively) after 2 weeks and reduced tissue loss by 50% after 4 weeks. DHA increased the number of BrdU+/Ki-67+, BrdU+/DCX+, and BrdU+/NeuN+ cells in the cortex, subventricular zone, and dentate gyrus and potentiated NPD1 synthesis in the penumbra at 5 h after MCAo. NPD1 improved behavior, reduced lesion volumes, protected ischemic penumbra, increased NeuN, GFAP, SMI-71-positive cells and vessels, axonal regeneration in the penumbra, and attenuated blood-brain barrier (BBB) after MCAo. We conclude that docosanoid administration increases neurogenesis and angiogenesis, activates NPD1 synthesis in the penumbra, and diminishes BBB permeability, which correlates to long-term neurobehavioral recovery after experimental ischemic stroke.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Guidelines for the Early Management of Patients With Acute Ischemic Stroke
Jauch, E. C., Saver, J. L., Adams, H. P., Bruno, A., Connors, J. J. “., Demaerschalk, B. M., Khatri, P., McMullan, P. W., Qureshi, A. I., Rosenfield, K., et al. (2013) · Stroke · doi:10.1161/str.0b013e318284056a · Cited by 7,698
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797
Simopoulos, A. P. (2008) · Experimental Biology and Medicine · doi:10.3181/0711-mr-311 · Cited by 3,003
Functional neurogenesis in the adult hippocampus
van Praag, H., Schinder, A. F., Christie, B. R., Toni, N., Palmer, T. D., & Gage, F. H. (2002) · Nature · doi:10.1038/4151030a · Cited by 2,853
Neuronal replacement from endogenous precursors in the adult brain after stroke
Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z., & Lindvall, O. (2002) · Nature Medicine · doi:10.1038/nm747 · Cited by 2,799
The immunology of stroke: from mechanisms to translation
Iadecola, C., & Anrather, J. (2011) · Nature Medicine · doi:10.1038/nm.2399 · Cited by 2,596
Dyall, S. C. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00052 · Cited by 943
Middle Cerebral Artery Occlusion in the Rat by Intraluminal Suture
Belayev, L., Alonso, O. F., Busto, R., Zhao, W., & Ginsberg, M. D. (1996) · Stroke · doi:10.1161/01.str.27.9.1616 · Cited by 815
Self-citationBlood–Brain Barrier Breakdown in Acute and Chronic Cerebrovascular Disease
Yang, Y. R., & Rosenberg, G. A. (2011) · Stroke · doi:10.1161/strokeaha.110.608257 · Cited by 808
Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305841200 · Cited by 802
Self-citation
Cited by
Sorted by citations
Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?
Qiu, Y., Zhang, C., Chen, A., Wang, H.-L., Zhou, Y., Li, Y., & Hu, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.678744 · Cited by 414
Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies
Chew, H., Solomon, V. A., & Fonteh, A. N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00598 · Cited by 353
Saini, R. K., Prasad, P., Sreedhar, R. V., Akhilender Naidu, K., Shang, X., & Keum, Y.-S. (2021) · Antioxidants · doi:10.3390/antiox10101627 · Cited by 337
Short-chain fatty acids as modulators of redox signaling in health and disease
González‐Bosch, C., Boorman, E., Zunszain, P. A., & Mann, G. E. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102165 · Cited by 298
Giacobbe, J., Benoiton, B., Zunszain, P., Pariante, C. M., & Borsini, A. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00122 · Cited by 159
Metadata
- Authors
- Belayev, L., Hong, S.-H., Menghani, H., Marcell, S. J., Obenaus, A., Freitas, R. S., Khoutorova, L., Balaszczuk, V., Jun, B., Oriá, R. B., & Bazan, N. G.
- Affiliations
- Louisiana State University (US)
- Corresponding author
- Belayev, Ludmila
- Venue
- Molecular Neurobiology
- Published
- 2018-06-01
- Volume
- 55
- Issue
- 8
- Pages
- 7090-7106
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- PMC
- PMC6054805
- OpenAlex
- W2807382073
- Cited by
- 103
- References
- 62
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 13 · 2023: 13 · 2022: 15 · 2021: 17 · 2020: 17 · 2019: 6 · 2018: 1
- FWCI
- 4.60
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- National Institute of Neurological Disorders and Stroke (NS046741)
- National Institute of General Medical Sciences (GM103340)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroprotection in Cerebral Ischemia
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- docosanoids, docosahexaenoic acid, neuroprotectin D1, ischemic stroke, neurogenesis, angiogenesis, blood-brain barrier integrity, neurobehavioral recovery, middle cerebral artery occlusion, infarct size, axon regeneration, subventricular zone, dentate gyrus, lipidomics
- MeSH terms
- Doublecortin Protein, Animals, Axons, Behavior, Animal, Blood-Brain Barrier, Brain Ischemia, Docosahexaenoic Acids, Fatty Acids, Male, Nerve Regeneration, Permeability, Survival Analysis, Rats, Sprague-Dawley, Neovascularization, Physiologic, Infarction, Middle Cerebral Artery, Stroke, Neurogenesis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
