Cited by 31Medicinal Plants and NeuroprotectionAlzheimer's disease research and treatmentsMedicinal Plant Pharmacodynamics Research

Steroid-ENRICHED FRAction of Achyranthes bidentata protects Amyloid β peptide 1–40-induced cognitive dysfunction and neuroinflammation in rats

Lin, Li-Wei, Tsai, Fan-Hsuan, Lan, Wan-Cheng, Cheng, Yih-Dih, Lee, Sheng-Chi, Wu, Chi-Rei·2019·Molecular Neurobiology

Abstract

The roots of Achyranthes bidentata Blume (AB) is commonly used in the treatment of osteoporosis and dementia in traditional Chinese medicine. Pharmacological reports evidenced that AB possessed anti-osteoarthritis effects. However, there is little literature about the anti-dementia activities of AB. The present study was designed to prepare steroid-enriched fraction of AB (ABS) and investigate whether ABS can protect from cognitive dysfunction and neuroinflammation against Aβ 1-40-induced Alzheimer's disease (AD) model in rats. ABS only contained 135.11 ± 4.28 mg of ecdysterone per gram. ABS (50 mg/kg) reversed the dysfunction of exploratory activity and memory function on plus-maze and Morris water maze caused by Aβ 1-40 in rats. ABS (50 mg/kg) also decreased amyloid deposition, neurofibrillary tangle, neural damage, activated astrocyte, and microglial caused by Aβ 1-40. Furthermore, ABS reversed the phenomenon of neural oxidative damage and neuroinflammation, including the higher levels of MDA and cytokines, and the lower activities of antioxidant enzymes and GSH levels caused by Aβ 1-40 in rat cortex and hippocampus. Finally, ABS restored the activation of ERK pathway and decreased NF-κB phosphorylation and translocation altered by Aβ 1-40. ABS alone (50 mg/kg) promoted cognitive function, activated brain antioxidant defense system, and decreased brain TNF-α levels in sham group. Therefore, ABS has the cognition-promoting and antidementia potential. Steroids especial ecdysterone are major active components of AB. The action mechanism is due to decreasing oxidative stress and neuroinflammation through modulating ERK pathway, NF-κB phosphorylation, and translocation in Aβ 1-40-induced AD rat model.

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Crossref · 10.1007/s12035-018-1436-7

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Authors
Lin, L.-W., Tsai, F.-H., Lan, W.-C., Cheng, Y.-D., Lee, S.-C., & Wu, C.-R.
Affiliations
  • I-Shou University (TW)
  • China Medical University (TW)
  • China Medical University Hospital (TW)
  • Kaohsiung Veterans General Hospital (TW)
Corresponding author
  • Lee, Sheng-Chi
  • Wu, Chi-Rei
Venue
Molecular Neurobiology
Published
2019-01-21
Volume
56
Issue
8
Pages
5671-5688
ISSN
  • 0893-7648 (ISSN-L)
  • 1559-1182
OpenAlex
W2917128008
Cited by
31
References
40
Citations by year
2026: 1 · 2025: 5 · 2024: 7 · 2023: 5 · 2022: 7 · 2021: 3 · 2020: 2 · 2019: 1
FWCI
4.17
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
Ministry of Science and Technology (NSC 100-2320-B-214-001)
Topics
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Medicinal Plant Pharmacodynamics Research
Keywords
Achyranthes bidentata, 20-hydroxyecdysone, Aβ40, Alzheimer's disease, cognitive impairment, neuroinflammation, oxidative stress, ERK signaling, NF-κB, astrocytes, microglia, neuroprotection, antioxidant defense, memory impairment, TNF-α
MeSH terms
Ursolic Acid, Acetylcholinesterase, Animals, Antioxidants, Astrocytes, Behavior, Animal, Brain, Ecdysterone, Glutathione, Hippocampus, Inflammation, Male, Malondialdehyde, Memory, Oleanolic Acid, Peptide Fragments, Steroids, Triterpenes, Cytokines, Amyloid beta-Peptides, NF-kappa B, Rats, Sprague-Dawley, Microglia, Neuroprotective Agents, Maze Learning, MAP Kinase Signaling System, Achyranthes, Cognitive Dysfunction

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