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The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Comparison of the prognostic models for mortality in idiosyncratic drug-induced liver injury

Wang, Yan, Zou, Cailun, Wee, Aileen, Liu, Jimin, Ma, Zikun, Guo, Tiantian, Li, Min, Wang, Yu, Liu, Liwei, Jia, Jidong, Zou, Zhengsheng, Zhao, Xinyan·2023·Hepatology International
DOI 10.1007/s12072-022-10405-9
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Abstract

Background Several models have been proposed to predict acute liver failure/death in patients with drug-induced liver injury (DILI), but the predictive performances of them have not been systematically compared. We aim to compare the current models for their predictive potency of mortality at DILI onset. Methods DILI patients hospitalized at both Beijing Friendship Hospital and the Fifth Medical Center of PLA General Hospital were categorized into death/liver transplantation (LT) or survival without LT group. Predictive potency of 28-day, 90-day, 6-month and 12-month death/LT outcomes of Hy's Law, nHy's Law, Robles-Diaz Model, drug-induced liver toxicity (DrILTox ALF) Score, Model for End-stage Liver Disease (MELD) Score, and Ghabril Model was compared by Delong method. Results A total of 6.3% (83/1314) patients died or received LT within 12 months after DILI onset. The area under receiver operating characteristic of Hy's Law, nHy's Law, and Robles-Diaz Model was all lower than 0.750 for the prediction of within 12 months' mortality. DrILTox ALF Score, MELD Score and Ghabril Model showed better predictive potency of 28-day [0.896 (0.878-0.912), 0.934 (0.919-0.947), 0.935 (0.921-0.948), respectively], 90-day [0.883 (0.864-0.899), 0.951 (0.938-0.962), 0.952 (0.939-0.963), respectively], 6-month [0.820 (0.799-0.841), 0.905 (0.888-0.921) and 0.908 (0.891-0.923), respectively] and 12-month [0.801 (0.779-0.823), 0.882 (0.863-0.899) and 0.885 (0.866-0.902), respectively] mortality.…

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Crossref · 10.1007/s12072-022-10405-9

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3 of 3 references verified0 citation errors · 0 not checkable

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  • Cases fulfilling Hy's law are associated with increased mortality or need for liver transplantation.

    “Studies have shown that approximately 10% of cases that fulfill Hy's law will progress to ALF [5,64], and is associated increased mortality or need for liver transplantation [65][66][67][68].”

    From Chinese guideline for the diagnosis and treatment of drug-induced liver injury: an update (2024) · cites this paper as [65]

Citations

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Metadata

Authors
Wang, Y., Zou, C., Wee, A., Liu, J., Ma, Z., Guo, T., Li, M., Wang, Y., Liu, L., Jia, J., Zou, Z., & Zhao, X.
Venue
Hepatology International
Publisher
Springer Science and Business Media LLC
Published
2022-11-03
Volume
17
Issue
2
Pages
488-498
ISSN
  • 1936-0533
  • 1936-0541
DOI
10.1007/s12072-022-10405-9
Cited by
10
References
3
Language
en
Licence
Funders
National Natural Science Foundation of China (81900526)

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