The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae
Open accessAbstract
Ergosterol, an important component of the fungal cell membrane, is not only essential for fungal growth and development but also very important for adaptation to stress in fungi. Ergosterol is also a direct precursor for steroid drugs. The biosynthesis of ergosterol can be divided into three modules: mevalonate, farnesyl pyrophosphate (farnesyl-PP) and ergosterol biosynthesis. The regulation of ergosterol content is mainly achieved by feedback regulation of ergosterol synthase activity through transcription, translation and posttranslational modification. The synthesis of HMG-CoA, catalyzed by HMGR, is a major metabolic check point in ergosterol biosynthesis. Excessive sterols can be subsequently stored in lipid droplets or secreted into the extracellular milieu by esterification or acetylation to avoid toxic effects. As sterols are insoluble, the intracellular transport of ergosterol in cells requires transporters. In recent years, great progress has been made in understanding ergosterol biosynthesis and its regulation in Saccharomyces cerevisiae. However, few reviews have focused on these studies, especially the regulation of biosynthesis and intracellular transport. Therefore, this review summarizes recent research progress on the physiological functions, biosynthesis, regulation of biosynthesis and intracellular transportation of ergosterol in S. cerevisiae.
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“Conversely, hyperosmotic stress adaptation (such as salt or sorbitol treatment) leads to the decrease in ergosterol abundance [6,7].”
From Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae (2020) · cites this paper as [6]
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Osh Proteins Regulate Phosphoinositide Metabolism at ER-Plasma Membrane Contact Sites
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ERGOSTEROL BIOSYNTHESIS: A FUNGAL PATHWAY FOR LIFE ON LAND?
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Research works printed but not linked: 1
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Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae
Jordá, T., & Puig, S. (2020) · Genes · doi:10.3390/genes11070795 · Cited by 489
Biosynthesis and the Roles of Plant Sterols in Development and Stress Responses
Du, Y., Fu, X., Chu, Y., Wu, P., Liu, Y., Ma, L., Tian, H., & Zhu, B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23042332 · Cited by 172
Self-citationZhu, Z.-T., Du, M.-M., Gao, B., Tao, X., Zhao, M., Ren, Y., Wang, F., & Wei, D. (2021) · Metabolic Engineering · doi:10.1016/j.ymben.2021.10.011 · Cited by 153
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Self-citationOutline of the biosynthesis and regulation of ergosterol in yeast
Liu, J., Xia, J., Nie, K., Wang, F., & Deng, L. (2019) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-019-2673-2 · Cited by 109
Metadata
- Authors
- Hu, Z., He, B., Ma, L., Sun, Y., Niu, Y., & Zeng, B.
- Affiliations
- Jiangxi Science and Technology Normal University (CN)
- Corresponding author
- Zeng, Bin
- Venue
- Indian Journal of Microbiology
- Published
- 2017-07-04
- Volume
- 57
- Issue
- 3
- Pages
- 270-277
- ISSN
- 0046-8991 (ISSN-L)
- 0973-7715
- PMC
- PMC5574775
- OpenAlex
- W2733705455
- Cited by
- 225
- References
- 64
- Citations by year
- 2026: 30 · 2025: 37 · 2024: 42 · 2023: 25 · 2022: 26 · 2021: 28 · 2020: 15 · 2019: 17 · 2018: 5
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Indian Journal of Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31171731, 31460447)
- International S&T Cooperation Project of Jiangxi Provincial (20142BDH80003)
- General Science and Technology Project of Nanchang City (3000035402)
- “555 Talent Project” of Jiangxi Province
- Science and Technology Research Project of Jiangxi Provincial Department of Education (GJJ160765, GJJ160794)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- ergosterol biosynthesis, Saccharomyces cerevisiae, feedback regulation, mevalonate pathway, HMGR, lipid droplets, sterol esterification, sterol transporters, fungal cell membrane, stress adaptation
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