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Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae
Open accessAbstract
Ergosterol, an important component of the fungal cell membrane, is not only essential for fungal growth and development but also very important for adaptation to stress in fungi. Ergosterol is also a direct precursor for steroid drugs. The biosynthesis of ergosterol can be divided into three modules: mevalonate, farnesyl pyrophosphate (farnesyl-PP) and ergosterol biosynthesis. The regulation of ergosterol content is mainly achieved by feedback regulation of ergosterol synthase activity through transcription, translation and posttranslational modification. The synthesis of HMG-CoA, catalyzed by HMGR, is a major metabolic check point in ergosterol biosynthesis. Excessive sterols can be subsequently stored in lipid droplets or secreted into the extracellular milieu by esterification or acetylation to avoid toxic effects. As sterols are insoluble, the intracellular transport of ergosterol in cells requires transporters. In recent years, great progress has been made in understanding ergosterol biosynthesis and its regulation in Saccharomyces cerevisiae. However, few reviews have focused on these studies, especially the regulation of biosynthesis and intracellular transport. Therefore, this review summarizes recent research progress on the physiological functions, biosynthesis, regulation of biosynthesis and intracellular transportation of ergosterol in S. cerevisiae.
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“Conversely, hyperosmotic stress adaptation (such as salt or sorbitol treatment) leads to the decrease in ergosterol abundance [6,7].”
From Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae (2020) · cites this paper as [6]
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Metadata
- Authors
- Hu, Z., He, B., Ma, L., Sun, Y., Niu, Y., & Zeng, B.
- Affiliations
- Jiangxi Science and Technology Normal University (CN)
- Corresponding author
- Zeng, Bin
- Venue
- Indian Journal of Microbiology
- Published
- 2017-07-04
- Volume
- 57
- Issue
- 3
- Pages
- 270-277
- ISSN
- 0046-8991 (ISSN-L)
- 0973-7715
- PMC
- PMC5574775
- OpenAlex
- W2733705455
- Cited by
- 225
- References
- 64
- Citations by year
- 2026: 30 · 2025: 37 · 2024: 42 · 2023: 25 · 2022: 26 · 2021: 28 · 2020: 15 · 2019: 17 · 2018: 5
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Indian Journal of Microbiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31171731, 31460447)
- International S&T Cooperation Project of Jiangxi Provincial (20142BDH80003)
- General Science and Technology Project of Nanchang City (3000035402)
- “555 Talent Project” of Jiangxi Province
- Science and Technology Research Project of Jiangxi Provincial Department of Education (GJJ160765, GJJ160794)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- ergosterol biosynthesis, Saccharomyces cerevisiae, feedback regulation, mevalonate pathway, HMGR, lipid droplets, sterol esterification, sterol transporters, fungal cell membrane, stress adaptation
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