Cited by 228Fungal and yeast genetics researchPlant biochemistry and biosynthesisLipid metabolism and biosynthesis

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Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae

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Hu, Zhihong, He, Bin, Ma, Long, Sun, Yunlong, Niu, Yali, Zeng, Bin·2017·Indian Journal of Microbiology

DOI 10.1007/s12088-017-0657-1PMC PMC5574775

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Abstract

Ergosterol, an important component of the fungal cell membrane, is not only essential for fungal growth and development but also very important for adaptation to stress in fungi. Ergosterol is also a direct precursor for steroid drugs. The biosynthesis of ergosterol can be divided into three modules: mevalonate, farnesyl pyrophosphate (farnesyl-PP) and ergosterol biosynthesis. The regulation of ergosterol content is mainly achieved by feedback regulation of ergosterol synthase activity through transcription, translation and posttranslational modification. The synthesis of HMG-CoA, catalyzed by HMGR, is a major metabolic check point in ergosterol biosynthesis. Excessive sterols can be subsequently stored in lipid droplets or secreted into the extracellular milieu by esterification or acetylation to avoid toxic effects. As sterols are insoluble, the intracellular transport of ergosterol in cells requires transporters. In recent years, great progress has been made in understanding ergosterol biosynthesis and its regulation in Saccharomyces cerevisiae. However, few reviews have focused on these studies, especially the regulation of biosynthesis and intracellular transport. Therefore, this review summarizes recent research progress on the physiological functions, biosynthesis, regulation of biosynthesis and intracellular transportation of ergosterol in S. cerevisiae.

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Authors: Hu, Z., He, B., Ma, L., Sun, Y., Niu, Y., & Zeng, B.
Affiliations: Jiangxi Science and Technology Normal University (CN)
Corresponding author: Zeng, Bin
ORCID: Hu, Zhihong
He, Bin
Sun, Yunlong
Zeng, Bin
Venue: Indian Journal of Microbiology
Publisher: Springer Science and Business Media LLC
Published: 2017-07-04
Volume: 57
Issue: 3
Pages: 270-277
ISSN: 0046-8991 (ISSN-L)
0973-7715
DOI: 10.1007/s12088-017-0657-1
PMC: PMC5574775
OpenAlex: W2733705455
Cited by: 225
References: 64
Citations by year: 2026: 30 · 2025: 37 · 2024: 42 · 2023: 25 · 2022: 26 · 2021: 28 · 2020: 15 · 2019: 17 · 2018: 5
FWCI: 0.95
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (unspecified)
Locations: Indian Journal of Microbiology (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Natural Science Foundation of China (31171731, 31460447)
International S&T Cooperation Project of Jiangxi Provincial (20142BDH80003)
General Science and Technology Project of Nanchang City (3000035402)
“555 Talent Project” of Jiangxi Province
Science and Technology Research Project of Jiangxi Provincial Department of Education (GJJ160765, GJJ160794)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
Keywords: ergosterol biosynthesis, Saccharomyces cerevisiae, feedback regulation, mevalonate pathway, HMGR, lipid droplets, sterol esterification, sterol transporters, fungal cell membrane, stress adaptation

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Recent Advances in Ergosterol Biosynthesis and Regulation Mechanisms in Saccharomyces cerevisiae

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