Randomized Controlled Trial of an Interactive Internet Smoking Cessation Program with Long-Term Follow-up
Abstract
BACKGROUND: Internet programs for smoking cessation are widely available but few controlled studies demonstrate long-term efficacy. PURPOSE: To determine the 13-month effectiveness of an Internet program presenting a set sequence of interactive steps, and the role of depressed affect. METHODS: In a randomized controlled trial sponsored by the American Cancer Society, a treatment condition (n = 1,106) was compared to a control site (n = 1,047). RESULTS: More treatment condition participants were abstinent (30-day point prevalence) than control site participants (12.9% vs. 10.1%, p < .05) at 13 months. This effect was greater among participants not reporting depressed affect (15.0% vs. 10.1%, p < .01). Among smokers who reported depressed affect, there was no difference in abstinence between the treatment and control conditions. CONCLUSIONS: Data support the long-term efficacy of an Internet intervention for cessation modeled on a structured, in-person treatment approach, especially for participants not experiencing daily depressed affect.
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The number of modules completed was found to correlate with outcomes in interventions that targeted cigarette smoking, depression, and anxiety disorders.
“The number of modules completed was found to correlate with outcomes in interventions that targeted cigarette smoking [42,46,47], depression [45,48-51], and anxiety disorders [52-57].”
From A Systematic Review of the Impact of Adherence on the Effectiveness of e-Therapies (2011) · cites this paper as [47]
Cites
Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433 · see citing works
The Patient Health Questionnaire-2: Validity of a Two-Item Depression Screener
Kroenke, K., Spitzer, R. L., & Williams, J. B. W. (2003) · Medical Care · doi:10.1097/01.mlr.0000093487.78664.3c · Cited by 6,359 · see citing works
Treating Tobacco Use and Dependence: 2008 Update
Panel, T. U. A. D. G. (2008) · PsycEXTRA Dataset · doi:10.1037/e566222009-001 · Cited by 3,864 · see citing works
Treating tobacco use and dependence-Clinical practice guideline
Mc, F. (2000) · Medical Entomology and Zoology · Cited by 3,616 · see citing works
Treating Tobacco Use and Dependence
(2008) · PEDIATRICS · doi:10.1542/peds.2008-1627 · Cited by 2,701 · see citing works
Clinical Practice Guideline: Otitis Media with Effusion (Update)
Rosenfeld, R. M., Shin, J. J., Schwartz, S. R., Coggins, R., Gagnon, L., Hackell, J. M., Hoelting, D., Hunter, L. L., Kummer, A. W., Payne, S. C., et al. (2016) · Otolaryngology–Head and Neck Surgery · doi:10.1177/0194599815623467 · Cited by 2,006 · see citing works
Measuring nicotine dependence: A review of the Fagerstrom Tolerance Questionnaire
Fagerstrom, K. O., & Schneider, N. G. (1989) · Journal of Behavioral Medicine · doi:10.1007/bf00846549 · Cited by 1,598 · see citing works
Gilbody, S., Richards, D., Brealey, S., & Hewitt, C. (2007) · Journal of General Internal Medicine · doi:10.1007/s11606-007-0333-y · Cited by 1,290 · see citing works
Outcome criteria in smoking cessation trials: proposal for a common standard
West, R., Hajek, P., Stead, L., & Stapleton, J. (2005) · Addiction · doi:10.1111/j.1360-0443.2004.00995.x · Cited by 1,285 · cited 2× · see citing works
“Our analyses also followed the conservative intent-to-treat protocol whereby non-respondents are coded as not abstinent [40].”
BackgroundMethodTreating tobacco use and dependence: 2008 update: Clinical practice guideline
(2008) · PsycEXTRA Dataset · doi:10.1037/e481882008-001 · Cited by 1,219 · see citing works
Individual behavioural counselling for smoking cessation
Lancaster, T., & Stead, L. F. (2005) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd001292.pub2 · Cited by 1,015 · see citing works
Using Internet technology to deliver a behavioral weight loss program
Tate, D. F. (2001) · JAMA · doi:10.1001/jama.285.9.1172 · Cited by 925 · cited 1× · see citing works
“Internet programs for health behavior change, including smoking cessation, have been developed and tested [5–22].”
Assessing outcome in smoking cessation studies.
Velicer, W. F., Prochaska, J. O., Rossi, J. S., & Snow, M. G. (1992) · Psychological Bulletin · doi:10.1037/0033-2909.111.1.23 · Cited by 828 · see citing works
Tate, D. F., Jackvony, E. H., & Wing, R. R. (2003) · JAMA · doi:10.1001/jama.289.14.1833 · Cited by 666 · see citing works
Evidence of Real-World Effectiveness of a Telephone Quitline for Smokers
Zhu, S., Anderson, C. M., Tedeschi, G. J., Rosbrook, B. P., Johnson, C., Byrd, M., & Gutiérrez-Terrell, E. (2002) · New England Journal of Medicine · doi:10.1056/nejmsa020660 · Cited by 462 · see citing works
Portnoy, D. B., Scott-Sheldon, L. A. J., Johnson, B. T., & Carey, M. P. (2008) · Preventive Medicine · doi:10.1016/j.ypmed.2008.02.014 · Cited by 451 · see citing works
Miller, E. T., Neal, D. J., Roberts, L. J., Baer, J. S., Cressler, S. O., Metrik, J., & Marlatt, G. A. (2002) · Psychology of Addictive Behaviors · doi:10.1037/0893-164x.16.1.56 · Cited by 332 · see citing works
Depression and depressive symptoms in smoking cessation
Covey, L. S., Glassman, A. H., & Stetner, F. (1990) · Comprehensive Psychiatry · doi:10.1016/0010-440x(90)90042-q · Cited by 329 · see citing works
Postcessation cigarette use: The process of relapse
Brandon, T. H., Tiffany, S. T., Obremski, K. M., & Baker, T. B. (1990) · Addictive Behaviors · doi:10.1016/0306-4603(90)90013-n · Cited by 313 · see citing works
Strecher, V. J., Shiffman, S. M., & West, R. (2005) · Addiction · doi:10.1111/j.1360-0443.2005.01093.x · Cited by 308 · see citing works
Zhu, S.-H., Stretch, V., Balabanis, M., Rosbrook, B., Sadler, G., & Pierce, J. P. (1996) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.64.1.202 · Cited by 302 · see citing works
Web-Based Smoking-Cessation Programs
Strecher, V. J., McClure, J. B., Alexander, G. L., Chakraborty, B., Nair, V. N., Konkel, J. M., Greene, S. M., Collins, L. M., Carlier, C. C., Wiese, C. J., et al. (2008) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2007.12.024 · Cited by 266 · see citing works
Impact of over-the-counter sales on effectiveness of pharmaceutical aids for smoking cessation
Pierce, J. P. (2002) · JAMA · doi:10.1001/jama.288.10.1260 · Cited by 240 · see citing works
McManus, D. D., Pipkin, S. S., & Whooley, M. A. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2005.06.037 · Cited by 222 · see citing works
Etter, J. (2005) · Journal of Medical Internet Research · doi:10.2196/jmir.7.1.e2 · Cited by 211 · see citing works
Muñoz, R., Lenert, L., Delucchi, K., Stoddard, J., Perez, J., Penilla, C., & Pérez‐Stable, E. (2006) · Nicotine & Tobacco Research · doi:10.1080/14622200500431940 · Cited by 208 · see citing works
Affect regulation, nicotine addiction, and smoking cessation
Carmody, T. P. (1992) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1992.10471632 · Cited by 206 · see citing works
A cluster-analytic classification of smoking relapse episodes
Shiffman, S. S. (1986) · Addictive Behaviors · doi:10.1016/0306-4603(86)90057-2 · Cited by 202 · see citing works
The effects of depressed mood on smoking cessation: Mediation by postcessation self-efficacy.
Cinciripini, P. M., Wetter, D. W., Fouladi, R. T., Blalock, J. A., Carter, B. L., Cinciripini, L. G., & Baile, W. F. (2003) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.71.2.292 · Cited by 181 · see citing works
Oenema, A., Brug, J., Dijkstra, A., de Weerdt, I., & de Vries, H. (2008) · Annals of Behavioral Medicine · doi:10.1007/s12160-008-9023-1 · Cited by 159 · see citing works
Design and Pilot Evaluation of an Internet Smoking Cessation Program
Lenert, L. A., Muñoz, R. F., Stoddard, J., Delucchi, K., Bansod, A., Skoczen, S., & Pérez‐Stable, E. J. (2003) · Journal of the American Medical Informatics Association · doi:10.1197/jamia.m1128 · Cited by 140 · see citing works
International Spanish/English Internet smoking cessation trial yields 20% abstinence rates at 1 year
Muñoz, R. F., Barrera, A. Z., Delucchi, K., Penilla, C., Torres, L. D., & Pérez-Stable, E. J. (2009) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntp090 · Cited by 127 · see citing works
Smoking cessation: Progress, priorities, and prospectus.
NIAURA, R. S., & Abrams, D. B. (2002) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.70.3.494 · Cited by 121 · see citing works
Evaluation of an Internet-based smoking cessation program: Lessons learned from a pilot study
Feil, E. G., Noell, J. W., Available, N. A. N., Lichtenstein, E., Available, N. A. N., Boles, S., Available, N. A. N., Ph.D., G. M. H., & Available, N. A. N. (2003) · Nicotine & Tobacco Research · doi:10.1080/1462220031000073694 · Cited by 118 · see citing works
Mood Management Mail Intervention Increases Abstinence Rates for Spanish‐Speaking Latino Smokers
Muñoz, R. F., Marín, B. V., Posner, S. F., & Pérez‐Stable, E. J. (1997) · American Journal of Community Psychology · doi:10.1023/a:1024676626955 · Cited by 116 · see citing works
Affect Regulation, Tobacco Addiction, and Smoking Cessation
Carmody, T. P. (1989) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1989.10472175 · Cited by 114 · see citing works
The Quest for α: Developments in Multiple Comparison Procedures in the Quarter Century Since
Hancock, G. R., & Klockars, A. J. (1996) · Review of Educational Research · doi:10.3102/00346543066003269 · Cited by 108 · see citing works
Blue mood, blackened lungs. Depression and smoking
Glass, R. M. (1990) · JAMA · doi:10.1001/jama.264.12.1583 · Cited by 101 · see citing works
Kaper, J., Wagena, E. J., Willemsen, M. C., & van Schayck, O. C. P. (2005) · Addiction · doi:10.1111/j.1360-0443.2005.01097.x · Cited by 90 · see citing works
Berlin, I., & Covey, L. S. (2006) · Addiction · doi:10.1111/j.1360-0443.2006.01616.x · Cited by 88 · see citing works
Rabius, V. A., Pike, K. J., Wiatrek, D. E., & McAlister, A. L. (2008) · Journal of Medical Internet Research · doi:10.2196/jmir.1008 · Cited by 82 · see citing works
Self-citationAmerican Cancer Society's QuitLink: Randomized trial of Internet assistance
Pike, K. J., Rabius, V. A., McAlister, A. L., & Geiger, A. (2007) · Nicotine & Tobacco Research · doi:10.1080/14622200701188877 · Cited by 80 · see citing works
Self-citationGlass, R. M. (1990) · JAMA · doi:10.1001/jama.1990.03450120095038 · Cited by 80 · see citing works
Tobacco cessation in dental settings: research findings and future directions
Gordon, J. S., Lichtenstein, E. H., Severson, H. H., & Andrews, J. A. (2006) · Drug and Alcohol Review · doi:10.1080/09595230500459495 · Cited by 77 · see citing works
The Role of Peer E-mail Support As Part of a College Smoking-Cessation Website
Klatt, C. M., Berg, C. J., Thomas, J., Ehlinger, E. P., Ahluwalia, J. S., & An, L. C. (2008) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2008.09.001 · Cited by 38 · see citing works
Hancock, G. R., & Klockars, A. J. (1996) · Review of Educational Research · Cited by 35 · see citing works
(1999) · Routledge eBooks · doi:10.4324/9781410601209 · Cited by 34 · see citing works
Reducing the Cancer Burden of Lifestyle Factors: Opportunities and Challenges of the Internet
Graham, A. L., & Abrams, D. B. (2005) · Journal of Medical Internet Research · doi:10.2196/jmir.7.3.e26 · Cited by 33 · see citing works
Aubin, H., Tilikete, S., & Barrucand, D. (1996) · PubMed · Cited by 32 · see citing works
Treating depression in medical conditions may improve quality of life.
Lamberg, L. (1996) · PubMed · Cited by 23 · see citing works
Physicians' counseling of patients when prescribing nicotine replacement therapy
Shiffman, S. M., Ferguson, S. G., & Hellebusch, S. J. (2006) · Addictive Behaviors · doi:10.1016/j.addbeh.2006.06.021 · Cited by 17 · see citing works
Helping the Hard-core Smoker: A Clinician's Guide
Lucas, K. (2000) · Health Education Research · doi:10.1093/her/15.1.118 · Cited by 17 · see citing works
Treating Depression in Medical Conditions May Improve Quality of Life
Lamberg, L. (1996) · JAMA · doi:10.1001/jama.1996.03540110011006 · Cited by 17 · see citing works
Implications of nonresponse patterns in the analysis of smoking cessation trials
Twardella, D., & Brenner, H. (2008) · Nicotine & Tobacco Research · doi:10.1080/14622200802027149 · Cited by 13 · see citing works
A Psychotherapeutic Approach for Smoking Cessation Counseling
(1999) · Routledge eBooks · doi:10.4324/9781410601209-18 · Cited by 2 · see citing works
Flagged first, then by citations
2 of the 57 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
A Systematic Review of the Impact of Adherence on the Effectiveness of e-Therapies
Donkin, L., Christensen, H., Naismith, S. L., Neal, B., Hickie, I. B., & Glozier, N. (2011) · Journal of Medical Internet Research · doi:10.2196/jmir.1772 · Cited by 876 · see citing works
Good intentions are not enough: how informatics interventions can worsen inequality
Veinot, T. C., Mitchell, H., & Ancker, J. S. (2018) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocy052 · Cited by 704 · see citing works
Hedman, E., Ljótsson, B., & Lindefors, N. (2012) · Expert Review of Pharmacoeconomics & Outcomes Research · doi:10.1586/erp.12.67 · Cited by 672 · see citing works
Internet-based interventions for smoking cessation
Taylor, G. M. J., Dalili, M. N., Semwal, M., Čivljak, M., Sheikh, A., & Car, J. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007078.pub5 · Cited by 651 · see citing works
Hill, S. E., Amos, A., Clifford, D., & Platt, S. D. (2013) · Tobacco Control · doi:10.1136/tobaccocontrol-2013-051110 · Cited by 397 · see citing works
Internet-based interventions for smoking cessation
Civljak, M., Stead, L. F., Hartmann-Boyce, J., Sheikh, A., & Car, J. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd007078.pub4 · Cited by 249 · see citing works
Smoking cessation interventions for smokers with current or past depression
van der Meer, R. M., Willemsen, M. C., Smit, F., & Cuijpers, P. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006102.pub2 · Cited by 159 · see citing works
Get with the program: Adherence to a smartphone app for smoking cessation
Zeng, E. Y., Heffner, J. L., Copeland, W. K., Mull, K. E., & Bricker, J. B. (2016) · Addictive Behaviors · doi:10.1016/j.addbeh.2016.07.007 · Cited by 117 · see citing works
Engagement Promotes Abstinence in a Web-based Cessation Intervention: Cohort Study
Richardson, A. K., Graham, A. L., Cobb, N. K., Xiao, H., Mushro, A., Abrams, D. B., & Vallone, D. (2013) · Journal of Medical Internet Research · doi:10.2196/jmir.2277 · Cited by 100 · see citing works
Two Decades of Smoking Cessation Treatment Research on Smokers with Depression: 1990-2010
Weinberger, A. H., Mazure, C. M., Morlett, A., & McKee, S. A. (2013) · Nicotine & Tobacco Research · doi:10.1093/ntr/nts213 · Cited by 96 · see citing works
Internet-based contingency management to promote smoking cessation: A randomized controlled study
Dallery, J., Raiff, B. R., & Grabinski, M. J. (2013) · Journal of Applied Behavior Analysis · doi:10.1002/jaba.89 · Cited by 94 · see citing works
Which eHealth interventions are most effective for smoking cessation? A systematic review
Do, H. P., Tran, B. X., Pham, Q. T. L., Nguyen, L. H., Tran, T. T., Latkin, C. A., Dunne, M. P., & Baker, P. (2018) · Patient Preference and Adherence · doi:10.2147/ppa.s169397 · Cited by 65 · see citing works
Danielsson, A.-K., Eriksson, A.-K., & Allebeck, P. (2014) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.06.007 · Cited by 51 · see citing works
A meta-analysis of the effect of substance use interventions on emotion outcomes.
Kang, D., Fairbairn, C. E., & Ariss, T. A. (2019) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000450 · Cited by 25 · see citing works
Mañanes, G., & Vallejo, M. Á. (2014) · Journal of Medical Internet Research · doi:10.2196/jmir.3091 · Cited by 23 · see citing works
Socioeconomic predictors of smoking cessation in a worldwide online smoking cessation trial
Bravin, J. I., Bunge, E. L., Evare, B. S., Wickham, R. E., Pérez‐Stable, E. J., & Muñoz, R. F. (2015) · Internet Interventions · doi:10.1016/j.invent.2015.10.001 · Cited by 18 · see citing works
Cantrell, J., Ilakkuvan, V., Graham, A. L., Richardson, A. K., Xiao, H., Mermelstein, R. J., Curry, S. J., Sporer, A. K., & Vallone, D. (2016) · JMIR Research Protocols · doi:10.2196/resprot.4881 · Cited by 17 · see citing works
Protocol of a randomized controlled trial of the Tobacco Tactics website for operating engineers
Duffy, S. A., Ronis, D. L., Richardson, C. R., Waltje, A. H., Ewing, L. A., Noonan, D., Hong, O., & Meeker, J. D. (2012) · BMC Public Health · doi:10.1186/1471-2458-12-335 · Cited by 15 · see citing works
Tobacco control, inequalities in health and action at the local level in England
Amos, A., Bauld, L., Clifford, D., Fidler, J. A., Hill, S. E., Hiscock, R., Laverty, L., Platt, S. D., & Robinson, J. E. (2011) · Cited by 15 · see citing works
Cohn, A. M., Zhou, Y., Cha, S., Perreras, L., & Graham, A. L. (2018) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2018.11.001 · Cited by 8 · see citing works
Theodoulou, A., Fanshawe, T. R., Leavens, E. L. S., Theodoulou, E., Wu, A. D., Heath, L., Stewart, C., Nollen, N. L., Ahluwalia, J. S., Butler, A. R., et al. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd015120.pub2 · Cited by 9 · see citing works
Watson, N. L., Heffner, J. L., Mull, K. E., McClure, J. B., & Bricker, J. B. (2019) · Journal of Medical Internet Research · doi:10.2196/13500 · Cited by 6 · see citing works
Jo, Y. S., Pyeon, A., Hu, M.-K., Kim, S. I., Choi, I. Y., Kim, D., & Chun, J. (2025) · JMIR mhealth and uhealth · doi:10.2196/66411 · Cited by 5 · see citing works
Demand for and availability of online support to stop smoking
Carlini, B. H., Ronzani, T. M., Martins, L. F., Gomide, H. P., & de Souza, I. C. W. (2012) · Revista de Saúde Pública · doi:10.1590/s0034-89102012000600018 · Cited by 5 · see citing works
Cell phone-based mindfulness interventions for smoking cessation: Randominised control study
Tülücü, F. (2022) · Cyprus Turkish Journal of Psychiatry and Psychology · doi:10.35365/ctjpp.22.4.08 · Cited by 1 · see citing works
Demand for and availability of online support to stop smoking Suporte online para parar de fumar
Carlini, H., Mota, T. C., & Cristina, I. (2012)
Pulido, N. G. (2014) · Dialnet (Universidad de la Rioja)
- Authors
- Seidman, D. F., Westmaas, J. L., Goldband, S., Rabius, V., Katkin, E. S., Pike, K. J., Wiatrek, D., & Sloan, R. P.
- Affiliations
- Columbia University (US)
- American Cancer Society (US)
- Stanford University (US)
- Stony Brook University (US)
- Corresponding author
- Seidman, Daniel F.
- Venue
- Annals of Behavioral Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2010-02
- Volume
- 39
- Issue
- 1
- Pages
- 48-60
- ISSN
- 0742-5554 (ISSN-L)
- 0883-6612
- 1532-4796
- OpenAlex
- W2040885719
- Cited by
- 29
- References
- 57
- Citations by year
- 2025: 2 · 2022: 1 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 4 · 2013: 5 · 2012: 5
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annals of Behavioral Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Social Sciences › Psychology › Applied Psychology › Behavioral Health and Interventions
- Keywords
- smoking cessation, online intervention, long-term abstinence, depressive affect, depression, tobacco use, treatment efficacy
- MeSH terms
- Smoking Prevention, Adolescent, Adult, Aged, Aged, 80 and over, American Cancer Society, Computer-Assisted Instruction, Depression, Female, Follow-Up Studies, Humans, Male, Middle Aged, Smoking, Therapy, Computer-Assisted, Time Factors, United States, Program Evaluation, Incidence, Smoking Cessation, Treatment Outcome, Internet, Young Adult
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