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Mindfulness Meditation Alleviates Fibromyalgia Symptoms in Women: Results of a Randomized Clinical Trial
Open accessAbstract
BACKGROUND: Several recent reviews have evaluated evidence on the efficacy of Mindfulness-Based Stress Reduction (MBSR) among fibromyalgia sufferers, and concluded that more research should test effects on both psychological and physiological functioning. PURPOSE: We conducted a randomized prospective trial of MBSR among female fibromyalgia patients. METHODS: Effects on perceived stress, pain, sleep quality, fatigue, symptom severity, and salivary cortisol were tested in treatment (n=51) versus wait-list control participants (n=40) using data at baseline, post-program, and 2-month follow-up. RESULTS: Analyses revealed that MBSR significantly reduced perceived stress, sleep disturbance, and symptom severity, with gains maintained at follow-up. Greater home practice at follow-up was associated with reduced symptom severity. MBSR did not significantly alter pain, physical functioning, or cortisol profiles. CONCLUSION: MBSR ameliorated some of the major symptoms of fibromyalgia and reduced subjective illness burden. Further exploration of MBSR effects on physiological stress responses is warranted. These results support use of MBSR as a complementary treatment for women with fibromyalgia ( ISRCTN: 34628811).
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“FM was diagnosed with ACR 1990 classification criteria in seven trials [34–40], and with ACR 2010 criteria in two trials [41, 42].”
From Mindfulness- And acceptance-based interventions for patients with fibromyalgia - A systematic review and meta-analyses (2019) · cites this paper as [41]
In the citing paper
“Three of the nine included trials, Schmidt et al. [38], Cash et al. [41] and Simister et al. [42], measured sleep quality.”
From Mindfulness- And acceptance-based interventions for patients with fibromyalgia - A systematic review and meta-analyses (2019) · cites this paper as [41]
In the citing paper
“Two trials [38, 41] analyzed different outcomes within the same study population. Both were therefore included in the meta-analysis with the number of participants counted only once.”
From Mindfulness- And acceptance-based interventions for patients with fibromyalgia - A systematic review and meta-analyses (2019) · cites this paper as [41]
In the citing paper
“Only one trial [41] measured fatigue and consequently, this outcome was not included in the meta-analysis.”
From Mindfulness- And acceptance-based interventions for patients with fibromyalgia - A systematic review and meta-analyses (2019) · cites this paper as [41]
In the citing paper
“Attendance averaged ∼75%, or three out of four sessions, which is within the range of 5.5 to 7.6 sessions attended (out of eight) found in previous studies of MBIs for chronic pain [19, 47–49].”
From Feasibility and Acceptability of an Abbreviated, Four-Week Mindfulness Program for Chronic Pain Management. (2020) · cites this paper as [49]
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“Abbreviations: PSS Perceived Stress Scale; UCLA-LS Loneliness Scale; PCL-C PTSD Checklist Civilian Version; CES-D The Center for Epidemiologic Studies Depression; SPS Social Provisions Scale; IL-6 and INF-γ are pg/ml of plasma production; AUC area under the curve; SE standard error of the coefficient Abbreviations: FF…”
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Metadata
- Authors
- Cash, E., Salmon, P., Weissbecker, I., Rebholz, W. N., Bayley-Veloso, R., Zimmaro, L. A., Floyd, A., Dedert, E., & Sephton, S. E.
- Affiliations
- University of Louisville (US)
- International Medical Corps (US)
- Louisville VA Medical Center (US)
- Duke Medical Center (US)
- Corresponding author
- Sephton, Sandra E.
- ORCID
- Venue
- Annals of Behavioral Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-11-26
- Volume
- 49
- Issue
- 3
- Pages
- 319-330
- ISSN
- 0742-5554 (ISSN-L)
- 0883-6612
- 1532-4796
- PMC
- PMC4802162
- OpenAlex
- W2039280304
- Cited by
- 146
- References
- 94
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 6 · 2023: 11 · 2022: 22 · 2021: 13 · 2020: 18 · 2019: 25 · 2018: 8 · 2017: 13 · 2016: 14 · 2015: 4 · 2014: 1
- FWCI
- 12.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annals of Behavioral Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (IK2CX000718)
- Office of Research and Development
- University of Louisville
- Clinical Science Research and Development
- National Institute on Aging
- National Cancer Institute
- Topics
- Social Sciences › Psychology › Clinical Psychology › Mindfulness and Compassion Interventions
- Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
- Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
- Keywords
- mindfulness-based stress reduction, fibromyalgia, women, perceived stress, sleep disorders, fatigue, symptom severity, salivary cortisol, home practice, complementary therapy
- MeSH terms
- Adult, Female, Fibromyalgia, Follow-Up Studies, Humans, Outcome Assessment, Health Care, Cost of Illness, Meditation, Mindfulness
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