3D Morphometric Analysis of Human Fetal Cerebellar Development
Open accessAbstract
To date, growth of the human fetal cerebellum has been estimated primarily from linear measurements from ultrasound and 2D magnetic resonance imaging (MRI). In this study, we use 3D analytical methods to develop normative growth trajectories for the cerebellum in utero. We measured cerebellar volume, linear dimensions, and local surface curvature from 3D reconstructed MRI of the human fetal brain (N = 46). We found that cerebellar volume increased approximately 7-fold from 20 to 31 gestational weeks. The better fit of the exponential curve (R (2) = 0.96) compared to the linear curve (R (2) = 0.92) indicated acceleration in growth. Within-subject cerebellar and cerebral volumes were highly correlated (R (2) = 0.94), though the cerebellar percentage of total brain volume increased from approximately 2.4% to 3.7% (R (2) = 0.63). Right and left hemispheric volumes did not significantly differ. Transcerebellar diameter, vermal height, and vermal anterior to posterior diameter increased significantly at constant rates. From the local curvature analysis, we found that expansion along the inferior and superior aspects of the hemispheres resulted in decreased convexity, which is likely due to the physical constraints of the dura surrounding the cerebellum and the adjacent brainstem. The paired decrease in convexity along the inferior vermis and increased convexity of the medial hemisphere represents development of the paravermian fissure, which becomes more visible during this period. In this 3D morphometric analysis of the human fetal cerebellum, we have shown that cerebellar growth is accelerating at a greater pace than the cerebrum and described how cerebellar growth impacts the shape of the structure.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Expansion along the inferior and superior aspects of the cerebellar hemispheres results in decreased convexity along the inferior vermis and increased convexity of the medial hemisphere representing development of the paravermian fissure.
“Expansion along the inferior and superior aspects of the cerebellar hemispheres results in decreased convexity along the inferior vermis and increased convexity of the medial hemisphere representing development of the paravermian fissure [51].”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [51]
The Abstract distinguishes two findings: expansion along the inferior and superior hemispheric surfaces resulted in decreased convexity of those surfaces, while paired curvature changes at the inferior vermis and medial hemisphere represent development of the paravermian fissure. The Discussion (“Curvature Reflects Gross Morphology of the Cerebellum”) also links hemispheric expansion to fissure deepening, but the claim conflates the distinct curvature patterns. Page numbers are not provided in our copy. (LLM, conf=0.88)
Experimental — accuracy not yet measured3D morphometric analysis of the human fetal cerebellum shows that cerebellar growth outpaces that of the cerebrum and describes how cerebellar growth impacts the shape of the structure between 20-31 GW.
“In addition to volumetric measures, 3D morphometric analysis of the human fetal cerebellum shows that cerebellar growth outpaces that of the cerebrum and describes how cerebellar growth impacts the shape of the structure between 20–31 GW [51].”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [51]
Transcerebellar diameter, vermal height, and vermal anterior to posterior diameter increase significantly at constant rates.
“Specifically, transcerebellar diameter, vermal height, and vermal anterior to posterior diameter increase significantly at constant rates.”
From Brain structural and functional outcomes in the offspring of women experiencing psychological distress during pregnancy (2024) · cites this paper as [51]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Nonparametric permutation tests for functional neuroimaging: A primer with examples
Nichols, T. E., & Holmes, A. P. (2002) · Human Brain Mapping · doi:10.1002/hbm.1058 · Cited by 6,256 · see citing works
Differential geometry of curves and surfaces
(2011) · Choice Reviews Online · doi:10.5860/choice.48-3330 · Cited by 3,776 · see citing works
Quantitative growth and development of human brain
Dobbing, J., & Sands, J. (1973) · Archives of Disease in Childhood · doi:10.1136/adc.48.10.757 · Cited by 1,442 · see citing works
Neurogenic radial glia in the outer subventricular zone of human neocortex
Hansen, D. V., Lui, J. H., Parker, P. R. L., & Kriegstein, A. R. (2010) · Nature · doi:10.1038/nature08845 · Cited by 1,388 · see citing works
Neuronal migration, with special reference to developing human brain: a review
Sidman, R. L., & RAKIC, P. T. (1973) · Brain Research · doi:10.1016/0006-8993(73)90617-3 · Cited by 1,251 · see citing works
A Structural MRI Study of Human Brain Development from Birth to 2 Years
Knickmeyer, R. C., Gouttard, S., Kang, C., Evans, D., Wilber, K., Smith, J. K., Hamer, R. M., Lin, W., Gerig, G., & Gilmore, J. H. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3479-08.2008 · Cited by 1,151 · see citing works
Smart, I. H. M. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.1.37 · Cited by 687 · see citing works
The Ontogeny of Human Gyrification
Armstrong, E., Schleicher, A., Omran, H., Curtis, M., & Zilles, K. (1995) · Cerebral Cortex · doi:10.1093/cercor/5.1.56 · Cited by 646 · see citing works
A Role for Intermediate Radial Glia in the Tangential Expansion of the Mammalian Cerebral Cortex
Reillo, I., Romero, C. D. J., García‐Cabezas, M. Á., & Borrell, V. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq238 · Cited by 631 · see citing works
Cerebellum of the Premature Infant: Rapidly Developing, Vulnerable, Clinically Important
Volpe, J. J. (2009) · Journal of Child Neurology · doi:10.1177/0883073809338067 · Cited by 505 · see citing works
Mapping the Early Cortical Folding Process in the Preterm Newborn Brain
Dubois, J., Benders, M. J. N. L., Cachia, A., Lazeyras, F., Leuchter, R. H., Sizonenko, S. V., Borradori-Tolsa, C., Mangin, J., & Hüppi, P. S. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm180 · Cited by 468 · see citing works
(1913) · JAMA · doi:10.1001/jama.1913.04340020064039 · Cited by 432 · see citing works
Histogenesis of cortical layers in human cerebellum, particularly the lamina dissecans
RAKIC, P. T., & Sidman, R. L. (1970) · The Journal of Comparative Neurology · doi:10.1002/cne.901390407 · Cited by 412 · see citing works
Late Gestation Cerebellar Growth Is Rapid and Impeded by Premature Birth
Limperopoulos, C., Soul, J. S., Gauvreau, K., Hüppi, P. S., Warfield, S. K., Bassan, H., Robertson, R. L., Volpe, J. J., & du Plessis, A. J. (2005) · PEDIATRICS · doi:10.1542/peds.2004-1169 · Cited by 410 · see citing works
(1972) · Annals of Internal Medicine · doi:10.7326/0003-4819-77-5-826_1 · Cited by 379 · see citing works
A dynamic 4D probabilistic atlas of the developing brain
Deprez, M., Aljabar, P., Srinivasan, L., Counsell, S. J., Doria, V., Serag, A., Gousias, I. S., Boardman, J. P., Rutherford, M., Edwards, A. D., et al. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.019 · Cited by 287 · see citing works
A developmental and genetic classification for midbrain-hindbrain malformations
Barkovich, A. J., Millen, K. J., & Dobyns, W. B. (2009) · Brain · doi:10.1093/brain/awp247 · Cited by 285 · see citing works
Self-citationDifferential Geometry of Curves and Surfaces
Umehara, M., Yamada, K., & Rossman, W. (2015) · WORLD SCIENTIFIC eBooks · doi:10.1142/9901 · Cited by 281 · see citing works
Contributions of cortical subventricular zone to the development of the human cerebral cortex
Zecevic, N., Chen, Y., & Filipovic, R. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20714 · Cited by 269 · see citing works
Early Folding Patterns and Asymmetries of the Normal Human Brain Detected from in Utero MRI
Habas, P. A., Scott, J. A., Roosta, A., Rajagopalan, V., Kim, K., Rousseau, F., Barkovich, A. J., Glenn, O. A., & Studholme, C. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr053 · Cited by 256 · see citing works
Self-citationMRI of the fetal posterior fossa
Adamsbaum, C., Moutard, M. L., Andr�, C., Merzoug, V., Ferey, S., Qu�r�, M. P., Lewin, F., & Fallet‐Bianco, C. (2004) · Pediatric Radiology · doi:10.1007/s00247-004-1316-3 · Cited by 201 · see citing works
Intersection Based Motion Correction of Multislice MRI for 3-D in Utero Fetal Brain Image Formation
Kim, K., Habas, P. A., Rousseau, F., Glenn, O. A., Barkovich, A. J., & Studholme, C. (2009) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2009.2030679 · Cited by 171 · see citing works
Self-citationCerebral biometry in fetal magnetic resonance imaging: new reference data
Tilea, B., Alberti, C., Adamsbaum, C., Armoogum, P., Oury, J., CABROL, D., Sebag, G. H., Kalifa, G., & Garel, C. (2009) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.6276 · Cited by 170 · see citing works
Local Tissue Growth Patterns Underlying Normal Fetal Human Brain Gyrification QuantifiedIn Utero
Rajagopalan, V., Scott, J. A., Habas, P. A., Kim, K., Corbett-Detig, J., Rousseau, F., Barkovich, A. J., Glenn, O. A., & Studholme, C. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5458-10.2011 · Cited by 166 · see citing works
Self-citationFetal MRI: normal gestational landmarks for cerebral biometry, gyration and myelination
Garel, C., Elmaleh, M., Chantrel, E., Sebag, G. H., & Brisse, H. J. (2003) · Child s Nervous System · doi:10.1007/s00381-003-0767-4 · Cited by 166 · see citing works
Quantitative in vivo MRI measurement of cortical development in the fetus
Clouchoux, C., Kudelski, D., Gholipour, A., Warfield, S. K., Viseur, S., Bouyssi-Kobar, M., Mari, J.-L., Evans, A. C., du Plessis, A. J., & Limperopoulos, C. (2012) · Brain Structure and Function · doi:10.1007/s00429-011-0325-x · Cited by 164 · see citing works
Developmental pathology of the neonate
Larroche, J. (1977) · Medical Entomology and Zoology · Cited by 162 · see citing works
Habas, P. A., Kim, K., Corbett-Detig, J., Rousseau, F., Glenn, O. A., Barkovich, A. J., & Studholme, C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.054 · Cited by 160 · see citing works
Self-citationImproving the robustness and accuracy of the marching cubes algorithm for isosurfacing
Lopes, A., & Brodlie, K. (2003) · IEEE Transactions on Visualization and Computer Graphics · doi:10.1109/tvcg.2003.1175094 · Cited by 160 · see citing works
Disruption of cerebellar development: potential complication of extreme prematurity.
Messerschmidt, A., Brugger, P. C., Boltshauser, E., Zoder, G., Sterniste, W., Birnbacher, R., & Prayer, D. (2005) · PubMed Central · Cited by 157 · see citing works
Assessment of fetal cerebellar volume using three-dimensional ultrasound
Chang, C., Chang, F., Yu, C.-H., Ko, H., & Chen, H.-Y. (2000) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(00)00225-8 · Cited by 139 · see citing works
The development of the cerebellum in man in relation to its comparative anatomy
Larsell, O. (1947) · The Journal of Comparative Neurology · doi:10.1002/cne.900870203 · Cited by 135 · see citing works
Tam, E., Miller, S. P., Studholme, C., Chau, V., Glidden, D. V., Poskitt, K. J., Ferriero, D. M., & Barkovich, A. J. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.09.005 · Cited by 133 · see citing works
Self-citationScott, J. A., Habas, P. A., Kim, K., Rajagopalan, V., Hamzelou, K. S., Corbett‐Detig, J. M., Barkovich, A. J., Glenn, O. A., & Studholme, C. (2011) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2011.04.001 · Cited by 119 · see citing works
Self-citationStudholme, C. (2011) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071910-124654 · Cited by 94 · see citing works
Self-citationHabas, P. A., Kim, K., Rousseau, F., Glenn, O. A., Barkovich, A. J., & Studholme, C. (2010) · Human Brain Mapping · doi:10.1002/hbm.20935 · Cited by 92 · see citing works
Self-citationQuantitative MRI measurements of human fetal brain development in utero
Grossman, R., Hoffman, C., Mardor, Y., & Biegon, A. R. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.07.005 · Cited by 89 · see citing works
Viñals, F., Muñoz, M., Naveas, R., Schalper, J., & Giuliano, A. (2005) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.2606 · Cited by 85 · see citing works
A template free approach to volumetric spatial normalization of brain anatomy
Studholme, C., & Cardenas, V. A. (2004) · Pattern Recognition Letters · doi:10.1016/j.patrec.2004.03.015 · Cited by 76 · see citing works
Self-citationGilman, S. (1973) · Archives of Neurology · doi:10.1001/archneur.1973.00490200090017 · Cited by 71 · see citing works
Magnetic resonance imaging of fetal cerebellar development
Triulzi, F. M., Parazzini, C., & Righini, A. (2006) · The Cerebellum · doi:10.1080/14734220600589210 · Cited by 54 · see citing works
A Magnetic Resonance Template for Normal Cerebellar Development in the Human Fetus
Chong, B. W., Babcook, C. J., Pang, D., & Ellis, W. G. (1997) · Neurosurgery · doi:10.1097/00006123-199710000-00029 · Cited by 53 · see citing works
MR volume of the fetal cerebellum in relation to growth
Hatab, M. R., Kamourieh, S., & Twickler, D. M. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21290 · Cited by 46 · see citing works
Growth Velocity of Some Fetal Parameters
Guihard-Costa, A.-M., & Larroche, J. (2009) · Biology of the Neonate · doi:10.1159/000243887 · Cited by 43 · see citing works
Rutten, M. J., Pistorius, L. R., Mulder, E. J. H., Stoutenbeek, P., de Vries, L. S., & Visser, G. H. A. (2009) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2009.03.016 · Cited by 41 · see citing works
Nomograms of the axial fetal cerebellar hemisphere circumference and area throughout gestation
Sherer, D. M., Sokolovski, M., Dalloul, M., Pezzullo, J. C., Osho, J. A., & Abulafia, O. (2006) · Ultrasound in Obstetrics and Gynecology · doi:10.1002/uog.3879 · Cited by 38 · see citing works
Fetal Central Nervous System Biometry on MR Imaging
Reichel, T. F., Ramus, R. M., Caire, J. T., Hynan, L. S., Magee, K., & Twickler, D. M. (2003) · American Journal of Roentgenology · doi:10.2214/ajr.180.4.1801155 · Cited by 36 · see citing works
The development of the nervous system
Sterratt, D. C., Graham, B. P., Gillies, A., & Willshaw, D. J. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511975899.011 · Cited by 26 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Consensus Paper: Cerebellar Development
Leto, K., Arancillo, M., Becker, E. B. E., Buffo, A., Chiang, C. C., Ding, B., Dobyns, W. B., Dusart, I., Haldipur, P., Hatten, M. E., et al. (2015) · The Cerebellum · doi:10.1007/s12311-015-0724-2 · Cited by 484 · see citing works
Complex Trajectories of Brain Development in the Healthy Human Fetus
Andescavage, N. N., du Plessis, A., McCarter, R., Serag, A., Evangelou, I., Vezina, G., Robertson, R., & Limperopoulos, C. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw306 · Cited by 163 · see citing works
Midbrain and hindbrain malformations: advances in clinical diagnosis, imaging, and genetics
Doherty, D., Millen, K. J., & Barkovich, A. J. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70024-3 · Cited by 137 · see citing works
Self-citationWu, Y., De Asis-Cruz, J., & Limperopoulos, C. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02449-0 · Cited by 124 · see citing works
“In addition to volumetric measures, 3D morphometric analysis of the human fetal cerebellum shows that cerebellar growth out-paces that of the cerebrum and describes how cerebellar growth impacts the shape of the structure between 20 – 31 GW [51].”
BackgroundFetal MRI: A technical update with educational aspirations
Gholipour, A., Estroff, J. A., Barnewolt, C. E., Robertson, R. L., Grant, P. E., Gagoski, B. A., Warfield, S. K., Afacan, O., Connolly, S. A., Neil, J. J., et al. (2014) · Concepts in Magnetic Resonance Part A · doi:10.1002/cmr.a.21321 · Cited by 121 · see citing works
Keser, Z., Hasan, K. M., Mwangi, B., Kamali, A., Ucisik, F. E., Riascos, R., Yozbatıran, N., Francisco, G. E., & Narayana, P. A. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00041 · Cited by 93 · see citing works
Altered local cerebellar and brainstem development in preterm infants
Wu, Y., Stoodley, C., Brossard-Racine, M., Kapse, K., Vezina, G., Murnick, J., du Plessis, A. J., & Limperopoulos, C. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.116702 · Cited by 57 · see citing works
Subcortical segmentation of the fetal brain in 3D ultrasound using deep learning
Hesse, L. S., Aliasi, M., Moser, F., Haak, M. C., Xie, W., Jenkinson, M., & Namburete, A. I. L. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119117 · Cited by 44 · see citing works
Studholme, C., Kroenke, C. D., & Dighe, M. (2020) · Nature Communications · doi:10.1038/s41467-020-16763-y · Cited by 43 · see citing works
Self-citationDandy-Walker Malformation: is the ‘tail sign’ the key sign?
Bernardo, S., Vinci, V., Saldari, M., Servadei, F., Silvestri, E., Giancotti, A., Aliberti, C., Porpora, M. G., Triulzi, F. M., Rizzo, G., et al. (2015) · Prenatal Diagnosis · doi:10.1002/pd.4705 · Cited by 37 · see citing works
Multidimensional Analysis of Fetal Posterior Fossa in Health and Disease
Vatansever, D., Kyriakopoulou, V., Allsop, J. M., Fox, M. J., Chew, A. T. M., Hajnal, J. V., & Rutherford, M. (2013) · The Cerebellum · doi:10.1007/s12311-013-0470-2 · Cited by 36 · see citing works
Morphometric development of the human fetal cerebellum during the early second trimester
Xu, F., Ge, X., Shi, Y., Zhang, Z., Tang, Y., Lin, X., Teng, G., Zang, F., Gao, N., Liu, H., et al. (2019) · NeuroImage · doi:10.1016/j.neuroimage.2019.116372 · Cited by 30 · see citing works
Normal Fetal Posterior Fossa in MR Imaging: New Biometric Data and Possible Clinical Significance
Ber, R., Bar‐Yosef, O., Hoffmann, C., Shashar, D., Achiron, R., & Katorza, E. (2015) · American Journal of Neuroradiology · doi:10.3174/ajnr.a4258 · Cited by 29 · see citing works
Naseem, F., Fatima, N., Yasmeen, S., & Saleem, S. (2013) · PubMed · Cited by 28 · see citing works
Association of gestational age with MRI-based biometrics of brain development in fetuses
Shi, Y., Xue, Y., Chen, C., Lin, K., & Zhou, Z. (2020) · BMC Medical Imaging · doi:10.1186/s12880-020-00525-9 · Cited by 27 · see citing works
Fetal Magnetic Resonance Imaging at 3.0 T
Welsh, R. C., Nemec, U., & Thomason, M. E. (2011) · Topics in Magnetic Resonance Imaging · doi:10.1097/rmr.0b013e318267f932 · Cited by 27 · see citing works
Longitudinal cerebellar growth following very preterm birth
Lee, W., Al‐Dossary, H., Raybaud, C., Young, J. M., Morgan, B. R., Whyte, H. E. A., Sled, J. G., Taylor, M. J., & Shroff, M. M. (2015) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25098 · Cited by 23 · see citing works
Ren, J., Zhu, M., & Dong, S. (2021) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27526 · Cited by 23 · see citing works
Quantification of total fetal brain volume using 3D MR imaging data acquired in utero
Jarvis, D. A., Akram, R., Mandefield, L., Paddock, M. T., Armitage, P. A., & Griffiths, P. D. (2016) · Prenatal Diagnosis · doi:10.1002/pd.4961 · Cited by 22 · see citing works
Asis‐Cruz, J. D., & Limperopoulos, C. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.11.019 · Cited by 22 · see citing works
Wong, A., Chavez, T., O’Neil, S., Votava‐Smith, J. K., Miller, D. A. W., delCastillo, S., Panigrahy, A., & Paquette, L. B. (2017) · American Journal of Perinatology Reports · doi:10.1055/s-0036-1597934 · Cited by 21 · see citing works
Normal Cerebellar Development by Qualitative and Quantitative MR Imaging
Brossard‐Racine, M., & Limperopoulos, C. (2016) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2016.03.004 · Cited by 20 · see citing works
The Non-coding Side of Medulloblastoma
Laneve, P., & Caffarelli, E. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00275 · Cited by 16 · see citing works
Interhemispheric Relationship of Genetic Influence on Human Brain Connectivity
Zhong, S., Wei, L., Zhao, C., Yang, L., Di, Z., Francks, C., & Gong, G. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa207 · Cited by 20 · see citing works
El-Fattah, A. T. A., Shaaban, H. S., & Younis, E. A. A. (2018) · The Egyptian Journal of Hospital Medicine · doi:10.21608/ejhm.2018.15112 · Cited by 12 · see citing works
Automated Segmentation of Cerebellum Using Brain Mask and Partial Volume Estimation Map
Lee, D.-K., Yoon, U., Kwak, K., & Lee, J. (2015) · Computational and Mathematical Methods in Medicine · doi:10.1155/2015/167489 · Cited by 12 · see citing works
Novel insights from quantitative imaging of the developing cerebellum
Allin, M. P. G. (2016) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2016.06.003 · Cited by 12 · see citing works
Variation of the slope of the tentorium during childhood
Rehder, R., Yang, E., & Cohen, A. R. (2015) · Child s Nervous System · doi:10.1007/s00381-015-2899-8 · Cited by 12 · see citing works
Development of External Surfaces of Human Cerebellar Lobes in the Fetal Period
Nowakowska-Kotas, M. M., Kedzia, A., & Dudek, K. D. (2014) · The Cerebellum · doi:10.1007/s12311-014-0566-3 · Cited by 11 · see citing works
Mathematical models of human cerebellar development in the fetal period
Dudek, K. D., Nowakowska-Kotas, M. M., & Kedzia, A. (2018) · Journal of Anatomy · doi:10.1111/joa.12767 · Cited by 11 · see citing works
Ye, J., Rong, R., Dou, Y.-B., Jiang, J. P., & Wang, X. (2020) · Medicine · doi:10.1097/md.0000000000019786 · Cited by 10 · see citing works
Date-Independent Parameters: an Innovative Method to Assess Fetal Cerebellar Vermis
Lei, T., Xie, H., Zhu, Y., Zheng, J., Zhang, F., & Feng, J. (2015) · The Cerebellum · doi:10.1007/s12311-014-0632-x · Cited by 9 · see citing works
Rice, L. C., Rochowiak, R., Plotkin, M. R., Rosch, K. S., Mostofsky, S. H., & Crocetti, D. (2023) · The Cerebellum · doi:10.1007/s12311-023-01569-7 · Cited by 8 · see citing works
Biometric assessments of the posterior fossa by fetal MRI : A systematic review
Mckinnon, K., Kendall, G. S., Tann, C. J., Dyet, L. E., Sokolska, M., Baruteau, K. P., Marlow, N., Robertson, N. J., Peebles, D., & Srinivasan, L. (2020) · Prenatal Diagnosis · doi:10.1002/pd.5874 · Cited by 8 · see citing works
Three-dimensional volumetric study with VOCAL in normal and abnormal posterior fossa fetuses
Doğan, Y., Yücesoy, G., Özkan, S., & Yücesoy, İ. (2018) · The Journal of Maternal-Fetal & Neonatal Medicine · doi:10.1080/14767058.2018.1526902 · Cited by 7 · see citing works
THE VOLUME OF THE CEREBELLUM IN THE SECOND SEMESTER OF GESTATION
Vulturar, D.-M., Fărcășanu, A. Ș., Turcu, F., Borza, D. B., & Crivii, C. B. (2018) · Medicine and Pharmacy Reports · doi:10.15386/cjmed-922 · Cited by 7 · see citing works
(2021) · Donald School Journal of Ultrasound in Obstetrics & Gynecology · doi:10.5005/jp-journals-10009-1678 · Cited by 6 · see citing works
Neuromorphological Atlas of Human Prenatal Brain Development: White Paper
Proshchina, A. E., Kharlamova, A. S., Krivova, Y. S., Godovalova, O. S., Otlyga, D., Gulimova, V. I., Otlyga, E., Junemann, O., Sonin, G., & Saveliev, S. V. (2023) · Life · doi:10.3390/life13051182 · Cited by 10 · see citing works
Ho, F.-C., Chung, H., Yu, C., Huang, C.-Y., & Liang, F. (2025) · European Journal of Pediatrics · doi:10.1007/s00431-025-05994-0 · Cited by 5 · see citing works
Arrigoni, F., Calloni, S. F., Huisman, T. A. G. M., & Chiapparini, L. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63956-1.00013-8 · Cited by 5 · see citing works
Cellular and Genetic Programs Underlying Cerebellum Development
Joyner, A. L., Willett, R. T., & Lawton, A. K. (2017) · Contemporary clinical neuroscience · doi:10.1007/978-3-319-59749-2_3 · Cited by 5 · see citing works
Cellular and Genetic Programs Underlying Cerebellum Development
Lawton, A. K., Willett, R. T., & Joyner, A. L. (2023) · Contemporary clinical neuroscience · doi:10.1007/978-3-031-23104-9_3 · Cited by 4 · see citing works
Pontocerebellar hypoplasia: a review from 1912 to 2022
Kukulka, N. A., Singh, S., Whitehead, M. T., Dobyns, W. B., Chang, T., & Kousa, Y. A. (2025) · Brain Communications · doi:10.1093/braincomms/fcaf298 · Cited by 3 · see citing works
Fetal neurodevelopmental recovery in donors after laser surgery for twin‐twin transfusion syndrome
Rajagopalan, V., Ashouri, K., Llanes, A. S., Vanderbilt, D. L., Leporé, N., Blüml, S., Lai, H., Wisnowski, J. L., Chon, A. H., & Chmait, R. H. (2020) · Prenatal Diagnosis · doi:10.1002/pd.5866 · Cited by 3 · see citing works
Self-citationVermal Length and Transcerebellar Diameter in Gestational Age Estimation: A Guide to Forensic Expert
Ahmad, N., Jethani, S. L., Singh, D., & Nautiyal, R. (2019) · National Journal of Clinical Anatomy · doi:10.1055/s-0039-1697895 · Cited by 2 · see citing works
Fetal Organ Volume Measurements by Three-dimensional Ultrasonography in Clinical Practice
Ruano, R. (2015) · Donald School Journal of Ultrasound in Obstetrics & Gynecology · doi:10.5005/jp-journals-10009-1426 · Cited by 2 · see citing works
taha, Y., El‐Refaie, T. A., Samy, M., & Khattab, R. T. (2021) · Evidence Based Women s Health Journal · doi:10.21608/ebwhj.2021.78284.1140 · Cited by 1 · see citing works
Masod, L., Metawie, M. A.-H., Reyad, I. A., & Younis, M. (2023) · Medicine Updates · doi:10.21608/muj.2023.190321.1128 · Cited by 1 · see citing works
Role of Vermal Anteroposterior Length and Width in Age Determination of Fetus
Ahmad, N., Singh, D., & Jethani, S. L. (2023) · Journal of Anatomical Society of India · doi:10.4103/jasi.jasi_89_22 · Cited by 1 · see citing works
Manto, M. U., & Habas, C. (2013) · Springer eBooks · doi:10.1007/978-2-8178-0447-7_1
Magnetic resonance imaging (MRI)
Thomason, M. E. (2017) · Cambridge University Press eBooks · doi:10.1017/9781316216491.021
Fetal cerebellar development: 3D morphometric analysis of fetal postmortem MRI among Chinese fetusesPreprint
Suluba, E., & Shuwei, L. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.10.462694
Normal Fetal Fourth Ventricle Biometry Measured On Mri Mid-Sagittal Images
Haibin, P., Xiaochun, K., Jianyan, T., Shiming, W., Chen, L., Yan, F., & Xiaobing, L. (2022) · Insights of Biomedical Research · doi:10.36959/584/462
Gebril, M. M., Mohamed, M. F., & Mohamed, M. H. E. (2024) · Al-Azhar International Medical Journal /Al-Azhar International Medical Journal · doi:10.58675/2682-339x.2212
Sadeghinezhad, J., Borgheie, F., Zehtabvar, O., & Bayat, A. (2025) · Anatomia Histologia Embryologia · doi:10.1111/ahe.70064
Development of the human cerebellum from midgestation to the perinatal period: A morphological study
Yamaguchi, K., & Yazawa, T. (2025) · Brain and Development · doi:10.1016/j.braindev.2025.104453
Shi, Y., Xue, Y., Chen, C., Lin, K., & Zhou, Z. (2020) · Figshare · doi:10.6084/m9.figshare.13290686
AlBaghdadi, F. A. (2025) · Journal of Biomedicine and Biochemistry · doi:10.57238/jbb.2025.7432.1155
van der Waal, D., Burgess, A. Z. Z., van der Zwaag, W., Badura, A., Xu, B., Defina, S., Neumann, A., Jansen, P. W., Muetzel, R. L., & Gaiser, C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.24.746825
- Authors
- Scott, J. A., Hamzelou, K. S., Rajagopalan, V., Habas, P. A., Kim, K., Barkovich, A. J., Glenn, O. A., & Studholme, C.
- Affiliations
- University of Washington (US)
- University of California, Berkeley (US)
- University of California, San Francisco (US)
- Corresponding author
- Scott, Julia A.
- Venue
- The Cerebellum
- Published
- 2011-12-24
- Volume
- 11
- Issue
- 3
- Pages
- 761-770
- ISSN
- 1473-4222 (ISSN-L)
- 1473-4230
- PMC
- PMC3389138
- OpenAlex
- W2097164072
- Cited by
- 59
- References
- 48
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 9 · 2014: 2 · 2013: 4
- FWCI
- 2.07
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- The Cerebellum (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS061957, K23 NS52506-03, K23NS052506, R01NS055064)
- National Center for Research Resources (UL1RR024131)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Spinal Dysraphism and Malformations
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- fetal cerebellum, cerebellar development, cerebellar volume, vermis, cerebellar hemispheres, fetal brain morphology
- MeSH terms
- Adult, Cerebellum, Female, Gestational Age, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Maternal Age, Pregnancy, Ultrasonography, Prenatal, Imaging, Three-Dimensional, Fetal Development, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
